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In Deutschland verfügen mehr als 95 % aller Haushalte über einen Internetzugang und das Interesse an Smart Home Anwendungen steigt. Je vernetzter das Zuhause wird, desto mehr Devices müssen dort ihren Platz finden. WLAN Router wirken durch ihre technische Designsprache meist wie Fremdkörper im Raum, sodass oft versucht wird, sie zu verstecken. Das soll sich mit „Cobo“, dem smarten WLAN Router, ändern. Neben der Bereitstellung einer Internetanbindung wird er zum Hub für alle Smart Home Anwendungen. Als Herzstück des Zuhauses sorgt er für die Vernetzung aller Devices und schafft zudem eine Verbindung zwischen Technologie und Interior. Mit seinem minimalistischen Design und der gezielten Auswahl an Materialien und Farben fügt sich der intelligente Router in die eigenen vier Wände ein. „Cobo“ ist kein WLAN Router, der im Schuhregal versteckt werden muss, denn er wird zum Teil der Einrichtung.
Wohlfühlen in den eigenen vier Wänden : ein Produkt, welches die Wohn- und Lebensqualität steigert.
(2023)
Viele Menschen fühlen sich in ihren eigenen vier Wänden nicht wohl. Sie sind gestresst und können nicht entspannen. Ziel dieser Arbeit ist es, ein Produkt zu erschaffen, welches in seinen Funktionen und seinem Design dafür sorgt, dass die Nutzer:innen sich zu Hause wohler fühlen. Es soll alle Funktionen vereinen, die dafür sorgen, dass der Alltagsstress besser bewältigt werden kann und man in seinem Zuhause entspannen kann und den Moment mehr genießt. Entstanden ist Iwa, ein Produkt, welches zum einen als Luftreiniger arbeitet und die Raumluft filtert und im Zusammenspiel mit Licht und Musik die Raumatmosphäre verbessert und so Stress mindert. Das Design soll genau wie die Funktionen beruhigend, entspannend und erdend wirken. Es ist angelehnt am Zen-Design. So bietet Iwa einen großen Mehrwert. Die Funktionen sorgen im Zusammenspiel mit dem Design für eine verbesserte Wohn- und Lebensqualität.
There is a growing demand for more flexibility in manufacturing to counter the volatility and unpredictability of the markets and provide more individualization for customers. However, the design and implementation of flexibility within manufacturing systems are costly and only economically viable if applicable to actual demand fluctuations. To this end, companies are considering additive manufacturing (AM) to make production more flexible. This paper develops a conceptual model for the impact quantification of AM on volume and mix flexibility within production systems in the early stages of the factory-planning process. Together with the model, an application guideline is presented to help planners with the flexibility quantification and the factory design process. Following the development of the model and guideline, a case study is presented to indicate the potential impact additive technologies can have on manufacturing flexibility Within the case study, various scenarios with different production system configurations and production programs are analyzed, and the impact of the additive technologies on volume and mix flexibility is calculated. This work will allow factory planners to determine the potential impacts of AM on manufacturing flexibility in an early planning stage and design their production systems accordingly.
Herein, fibroin, polylactide (PLA), and carbon are investigated for their suitability as biocompatible and biodegradable materials for amperometric biosensors. For this purpose, screen-printed carbon electrodes on the biodegradable substrates fibroin and PLA are modified with a glucose oxidase membrane and then encapsulated with the biocompatible material Ecoflex. The influence of different curing parameters of the carbon electrodes on the resulting biosensor characteristics is studied. The morphology of the electrodes is investigated by scanning electron microscopy, and the biosensor performance is examined by amperometric measurements of glucose (0.5–10 mM) in phosphate buffer solution, pH 7.4, at an applied potential of 1.2 V versus a Ag/AgCl reference electrode. Instead of Ecoflex, fibroin, PLA, and wound adhesive are tested as alternative encapsulation compounds: a series of swelling tests with different fibroin compositions, PLA, and Ecoflex has been performed before characterizing the most promising candidates by chronoamperometry. Therefore, the carbon electrodes are completely covered with the particular encapsulation material. Chronoamperometric measurements with H2O2 concentrations between 0.5 and 10 mM enable studying the leakage current behavior.
The aim of the present study was the characterisation of three true subtilisins and one phylogenetically intermediate subtilisin from halotolerant and halophilic microorganisms. Considering the currently growing enzyme market for efficient and novel biocatalysts, data mining is a promising source for novel, as yet uncharacterised enzymes, especially from halophilic or halotolerant Bacillaceae, which offer great potential to meet industrial needs. Both halophilic bacteria Pontibacillus marinus DSM 16465ᵀ and Alkalibacillus haloalkaliphilus DSM 5271ᵀ and both halotolerant bacteria Metabacillus indicus DSM 16189 and Litchfieldia alkalitelluris DSM 16976ᵀ served as a source for the four new subtilisins SPPM, SPAH, SPMI and SPLA. The protease genes were cloned and expressed in Bacillus subtilis DB104. Purification to apparent homogeneity was achieved by ethanol precipitation, desalting and ion-exchange chromatography. Enzyme activity could be observed between pH 5.0–12.0 with an optimum for SPPM, SPMI and SPLA around pH 9.0 and for SPAH at pH 10.0. The optimal temperature for SPMI and SPLA was 70 °C and for SPPM and SPAH 55 °C and 50 °C, respectively. All proteases showed high stability towards 5% (w/v) SDS and were active even at NaCl concentrations of 5 M. The four proteases demonstrate potential for future biotechnological applications.
Inhaltsverzeichnis - Bachelorarbeiten
1. Zukunft der Rente – Kann eine Erwerbstätigenversicherung das
demografische Problem nachhaltig lösen?
- Marcel Sept | Seite 4-73
2. Die versammlungsgebundenen Aktionärsrechte in der neuen
virtuellen Hauptversammlung – eine Bewertung aus Unternehmer- und Aktionärssicht
- Christina Zillinger | Seite 74-130
3. Praxisleitfaden für den Arbeitgeber zum gesetzlichen
Sonderkündigungsschutz – Was muss der Arbeitgeber tun, um durch
Gesetz besonders geschützten Arbeitnehmern kündigen zu können?
- Johanna Wiechert | Seite 131-195
4. Die Steuervergünstigung bei Umstrukturierungen im Konzern nach
§ 6a GrEStG im Lichte der aktuellen Rechtsprechung
- Marius Thelen | Seite 196-265
The aerodynamic performance of propellers strongly depends on their geometry and, consequently, on aeroelastic deformations. Knowledge of the extent of the impact is crucial for overall aircraft performance. An integrated simulation environment for steady aeroelastic propeller simulations is presented. The simulation environment is applied to determine the impact of elastic deformations on the aerodynamic propeller performance. The aerodynamic module includes a blade element momentum approach to calculate aerodynamic loads. The structural module is based on finite beam elements, according to Timoshenko theory, including moderate deflections. Several fixed-pitch propellers with thin-walled cross sections made of both isotropic and non-isotropic materials are investigated. The essential parameters are varied: diameter, disc loading, sweep, material, rotational, and flight velocity. The relative change of thrust between rigid and elastic blades quantifies the impact of propeller elasticity. Swept propellers of large diameters or low disc loadings can decrease the thrust significantly. High flight velocities and low material stiffness amplify this tendency. Performance calculations without consideration of propeller elasticity can lead to decreased efficiency. To avoid cost- and time-intense redesigns, propeller elasticity should be considered for swept planforms and low disc loadings.
Schlüter Projekt X
(2023)
Schlüter Projekt X ist die fiktive Reanimation des Traktorenherstellers Schlüter. Dabei geht es darum, auf Basis der originalen Traktoren eine moderne Maschine zu entwerfen, welche die bewährte und beliebte Formsprache mit moderner Technologie und aktuellen Funktionen verbindet, um den Anforderungen der modernen Landwirtschaft gerecht zu werden. Dazu wurde Projekt X stark modular aufgebaut. Die Fahrzeugkabine lässt sich um 180° drehen und gegebenenfalls durch ein vollkommen autonomes Modul austauschen. Die Reifen lassen sich bei Bedarf durch Ketten ersetzen. Projekt X wird elektronisch angetrieben, zur Vermeidung langer Ladezeiten lässt sich der gesamte Akkublock in der Motorhaube austauschen.
Several species of (poly)saccharides and organic acids can be found often simultaneously in various biological matrices, e.g., fruits, plant materials, and biological fluids. The analysis of such matrices sometimes represents a challenging task. Using Aloe vera (A. vera) plant materials as an example, the performance of several spectro-scopic methods (80 MHz benchtop NMR, NIR, ATR-FTIR and UV–vis) for the simultaneous analysis of quality parameters of this plant material was compared. The determined parameters include (poly)saccharides such as aloverose, fructose and glucose as well as organic acids (malic, lactic, citric, isocitric, acetic, fumaric, benzoic and sorbic acids). 500 MHz NMR and high-performance liquid chromatography (HPLC) were used as the reference methods.
UV–vis data can be used only for identification of added preservatives (benzoic and sorbic acids) and drying agent (maltodextrin) and semiquantitative analysis of malic acid. NIR and MIR spectroscopies combined with multivariate regression can deliver more informative overview of A. vera extracts being able to additionally quantify glucose, aloverose, citric, isocitric, malic, lactic acids and fructose. Low-field NMR measurements can be used for the quantification of aloverose, glucose, malic, lactic, acetic, and benzoic acids. The benchtop NMR method was successfully validated in terms of robustness, stability, precision, reproducibility and limit of detection (LOD) and quantification (LOQ), respectively. All spectroscopic techniques are useful for the screening of (poly)saccharides and organic acids in plant extracts and should be applied according to its availability as well as information and confidence required for the specific analytical goal. Benchtop NMR spectroscopy seems to be the most feasible solution for quality control of A. vera products.
Background
Aminoacylases are highly promising enzymes for the green synthesis of acyl-amino acids, potentially replacing the environmentally harmful Schotten-Baumann reaction. Long-chain acyl-amino acids can serve as strong surfactants and emulsifiers, with application in cosmetic industries. Heterologous expression of these enzymes, however, is often hampered, limiting their use in industrial processes.
Results
We identified a novel mycobacterial aminoacylase gene from Mycolicibacterium smegmatis MKD 8, cloned and expressed it in Escherichia coli and Vibrio natriegens using the T7 overexpression system. The recombinant enzyme was prone to aggregate as inclusion bodies, and while V. natriegens Vmax™ could produce soluble aminoacylase upon induction with isopropyl β-d-1-thiogalactopyranoside (IPTG), E. coli BL21 (DE3) needed autoinduction with lactose to produce soluble recombinant protein. We successfully conducted a chaperone co-expression study in both organisms to further enhance aminoacylase production and found that overexpression of chaperones GroEL/S enhanced aminoacylase activity in the cell-free extract 1.8-fold in V. natriegens and E. coli. Eventually, E. coli ArcticExpress™ (DE3), which co-expresses cold-adapted chaperonins Cpn60/10 from Oleispira antarctica, cultivated at 12 °C, rendered the most suitable expression system for this aminoacylase and exhibited twice the aminoacylase activity in the cell-free extract compared to E. coli BL21 (DE3) with GroEL/S co-expression at 20 °C. The purified aminoacylase was characterized based on hydrolytic activities, being most stable and active at pH 7.0, with a maximum activity at 70 °C, and stability at 40 °C and pH 7.0 for 5 days. The aminoacylase strongly prefers short-chain acyl-amino acids with smaller, hydrophobic amino acid residues. Several long-chain amino acids were fairly accepted in hydrolysis as well, especially N-lauroyl-L-methionine. To initially evaluate the relevance of this aminoacylase for the synthesis of N-acyl-amino acids, we demonstrated that lauroyl-methionine can be synthesized from lauric acid and methionine in an aqueous system.
Conclusion
Our results suggest that the recombinant enzyme is well suited for synthesis reactions and will thus be further investigated.