Refine
Year of publication
Document Type
- Article (162) (remove)
Keywords
- Label-free detection (3)
- capacitive field-effect sensor (3)
- tobacco mosaic virus (TMV) (3)
- Capacitive field-effect sensor (2)
- field-effect sensor (2)
- gold nanoparticles (2)
- (Bio)degradation (1)
- CNOT (1)
- Capacitive field-effect (1)
- Capacitive model (1)
- C–V method (1)
- DNA biosensor (1)
- Electrolyte–insulator–semiconductor (1)
- Enzyme coverage (1)
- Enzyme logic gate (1)
- Field effect (1)
- Field-effect biosensor (1)
- Field-effect sensor (1)
- Gold nanoparticles (1)
- Impedance spectroscopy (1)
- LAPS (1)
- Layer-by-layer adsorption (1)
- Multianalyte detection (1)
- Multicell (1)
- Multiplexing (1)
- Penicillin (1)
- Plant virus (1)
- Poly(allylamine hydrochloride) (1)
- Poly(d,l-lacticacid) (1)
- Real-time monitoring (1)
- TMV adsorption (1)
- Ta₂O₅ gate (1)
- Tobacco mosaic virus (TMV) (1)
- XOR (1)
- Zeta potential (1)
- aminooctanethiol (1)
- atomic layer deposition (1)
- bi-enzyme biosensor (1)
- biosensor (1)
- capacitive EIS sensor (1)
- capacitive field-effect sensors (1)
- capacitive model (1)
- control gate (1)
- detection of charged macromolecules (1)
- electrolyte-insulator-semiconductor capacitors (1)
- enzyme cascade (1)
- enzyme-logic gate (1)
- equivalent circuit (1)
- glucose oxidase (GOx) (1)
- horseradish peroxidase (HRP) (1)
- multianalyte detection (1)
- nanoparticle coverage (1)
- on-chip integrated addressable EISCAP sensors (1)
- pH sensors (1)
- penicillinase (1)
- plant virus detection (1)
- polystyrene sulfonate (1)
- turnip vein clearing virus (TVCV) (1)
- ultrathin gate insulators (1)
- urease (1)
Institute
- INB - Institut für Nano- und Biotechnologien (162) (remove)
Electrolyte-insulator-semiconductor capacitors (EISCAP) belong to field-effect sensors having an attractive transducer architecture for constructing various biochemical sensors. In this study, a capacitive model of enzyme-modified EISCAPs has been developed and the impact of the surface coverage of immobilized enzymes on its capacitance-voltage and constant-capacitance characteristics was studied theoretically and experimentally. The used multicell arrangement enables a multiplexed electrochemical characterization of up to sixteen EISCAPs. Different enzyme coverages have been achieved by means of parallel electrical connection of bare and enzyme-covered single EISCAPs in diverse combinations. As predicted by the model, with increasing the enzyme coverage, both the shift of capacitance-voltage curves and the amplitude of the constant-capacitance signal increase, resulting in an enhancement of analyte sensitivity of the EISCAP biosensor. In addition, the capability of the multicell arrangement with multi-enzyme covered EISCAPs for sequentially detecting multianalytes (penicillin and urea) utilizing the enzymes penicillinase and urease has been experimentally demonstrated and discussed.