OPUS 4 | Search

Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line (2011)

Maki Hasegawa ; Yury Kapelyukh ; Harunobu Tahara ; Jost Seibler ; Anja Rode ; Sylvia Krueger ; Dongtao N. Lee ; C. Roland Wolf ; Nico Scheer

Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines (2012)

Nico Scheer ; Yury Kapelyukh ; Anja Rode ; Sandra Buechel ; C. Roland Wolf

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model (2015)

Nico Scheer ; Yury Kapelyukh ; Anja Rode ; Stefan Oswald ; Diana Busch ; Lesley A. Mclaughlin ; De Lin ; Colin J. Henderson ; C. Roland Wolf

An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials (2019)

Nico Scheer ; Colin James Henderson ; Yury Kapelyukh ; Anja Rode ; Aileen W. Mclaren ; Alastair Kenneth MacLeod ; De Lin ; Jayne Wright ; Lesley Stanley ; C. Roland Wolf

In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice (2010)

Nico Scheer ; Jillian Ross ; Yury Kapelyukh ; Anja Rode ; C. Roland Wolf

Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines (2012)

Nico Scheer ; Yury Kapelyukh ; Jillian McEwan ; Vincent Beuger ; Lesley A. Stanley ; Anja Rode ; C. Roland Wolf

Defining the contribution of CYP1A1 and CYP1A2 to drug metabolism using humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 KO mice (2019)

Yury Kapelyukh ; Colin James Henderson ; Nico Scheer ; Anja Rode ; Charles Roland Wolf

Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs (2015)

C. Roland Wolf ; Yury Kapelyukh ; Nico Scheer ; Colin J. Henderson

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