Article
Refine
Year of publication
- 2011 (182) (remove)
Institute
- Fachbereich Medizintechnik und Technomathematik (69)
- INB - Institut für Nano- und Biotechnologien (36)
- Fachbereich Elektrotechnik und Informationstechnik (25)
- Fachbereich Chemie und Biotechnologie (22)
- IfB - Institut für Bioengineering (22)
- Fachbereich Wirtschaftswissenschaften (19)
- Fachbereich Energietechnik (13)
- Fachbereich Bauingenieurwesen (12)
- Fachbereich Maschinenbau und Mechatronik (10)
- Fachbereich Luft- und Raumfahrttechnik (9)
Document Type
- Article (182) (remove)
Keywords
- Arthosetherapie (1)
- Bioreaktor (1)
- Blutzellenlagerung (1)
- Gonarthrose (1)
- Harnleiter (1)
- Hemoglobin structure (1)
- High field MRI (1)
- Hämoglobin (1)
- Hämoglobinstruktur (1)
- Kniegelenkarthrose (1)
- MBST (1)
- MR safety (1)
- MRI (1)
- Magneto alert sensor (1)
- Organkultur (1)
- Pflanzenphysiologie (1)
- Pflanzenscanner (1)
- Pflanzenstress (1)
- Pornographie (1)
- Red blood cell storage (1)
- Tissue Engineering (1)
- Uktrahigh field MRI (1)
- Zuschauer (1)
- arthrosis therapy (1)
- avalanche (1)
- gonarthrosis (1)
- plant scanner (1)
- plant stress (1)
- snow (1)
The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.