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- LAPS (4)
- hydrogen peroxide (3)
- Bacillus atrophaeus (2)
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- Light-addressable potentiometric sensor (2)
- Raman spectroscopy (2)
- field-effect sensor (2)
- tobacco mosaic virus (TMV) (2)
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- Capacitive field-effect (1)
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- Chemical images (1)
- Chemical imaging sensor (1)
- Chemical sensor (1)
- C–V method (1)
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- Electrolyte–insulator–semiconductor (1)
- Enzymatic biosensor (1)
- Enzyme coverage (1)
- Enzyme logic gate (1)
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- Field-effect biosensor (1)
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- Label-free detection (1)
- Layer-by-layer adsorption (1)
- LbL films (1)
- Light-addressable Potentiometric Sensor (1)
- MOS (1)
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- Negative impedance convertor (1)
- O2 plasma (1)
- Organic light-emitting diode display (1)
- Penicillin (1)
- Poly(allylamine hydrochloride) (1)
- Poly(d,l-lacticacid) (1)
- Polyimide (1)
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- annealing (1)
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- calorimetric gas sensor (1)
- calorimetric gas sensor;hydrogen peroxide;wireless sensor system (1)
- capacitive field-effect sensor (1)
- catalytic metal (1)
- chemical sensor (1)
- contactless conductivity sensor (1)
- electrolyte-insulator semiconductor sensor (EIS) (1)
- electronic nose (1)
- endospores (1)
- enzymatic (bio)degradation (1)
- enzyme cascade (1)
- field-effect structure (1)
- gas sensor (1)
- glucose oxidase (GOx) (1)
- heavy metals (1)
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- horseradish peroxidase (HRP) (1)
- hydroxylation (1)
- immobilization (1)
- impedance spectroscopy (1)
- in-situ monitoring (1)
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- light-addressing technologies (1)
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- multi-functional material (1)
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- novel photoexcitation method (1)
- optical sensor setup (1)
- optical spore trapping (1)
- optical trapping (1)
- organosilanes (1)
- plant virus detection (1)
- plug-based microfluidic device (1)
- poly(d, l-lactic acid) (1)
- scanned light pulse technique (1)
- silanization (1)
- spatial resolution (1)
- sterilisation (1)
- sterilization (1)
- sterilization conditions (1)
- surface functionalization (1)
- temperature (1)
- tilted constant illumination (1)
- turnip vein clearing virus (TVCV) (1)
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Institute
- Fachbereich Medizintechnik und Technomathematik (468) (remove)
A sensor system for investigating (bio)degradationprocesses of polymers is presented. The system utilizes semiconductor field-effect sensors and is capable of monitoring the degradation process in-situ and in real-time. The degradation of the polymer poly(d,l-lactic acid) is exemplarily monitored in solutions with different pH value, pH-buffer solution containing the model enzyme lipase from Rhizomucormiehei and cell-culture medium containing supernatants from stimulated and non-stimulated THP-1-derived macrophages mimicking activation of the immune system.
An amperometric enzyme biosensor has been applied for the detection of adrenaline. The adrenaline biosensor has been prepared by modification of an oxygen electrode with the enzyme laccase that operates at a broad pH range between pH 3.5 to pH 8. The enzyme molecules were immobilized via cross-linking with glutaraldehyde. The sensitivity of the developed adrenaline biosensor in different pH buffer solutions has been studied.
LAPS are field-effect-based potentiometric sensors which are able to monitor analyte concentrations in a spatially resolved manner. Hence, a LAPS sensor system is a powerful device to record chemical imaging of the concentration of chemical species in an aqueous solution, chemical reactions, or the growth of cell colonies on the sensor surface, to record chemical images. In this work, multi-chamber 3D-printed structures made out of polymer (PP-ABS) were combined with LAPS chips to analyse differentially and simultaneously the metabolic activity of Escherichia coli K12 and Chinese hamster ovary (CHO) cells, and the responds of those cells to the addition of glucose solution.
Detection of triacetone triperoxide using temperature cycled metal-oxide semiconductor gas sensors
(2015)
A concept for a new generation of an integrated multi-functional biosensor/actuator system is developed, which is based on biomolecular logic principles. Such a system is expected to be able to detect multiple biochemical input signals simultaneously and in real-time and convert them into electrical output signals with logical operations such as OR, AND, etc. The system can be designed as a closed-loop drug release device triggered by an enzyme logic gate, while the release of the drug induced by the actuator at the required dosage and timing will be controlled by an additional drug sensor. Thus, the system could help to make an accurate and specific diagnosis. The presented concept is exemplarily demonstrated by using an enzyme logic gate based on a glucose/glucose oxidase system, a temperature-responsive hydrogel mimicking the actuator function and an insulin (drug) sensor. In this work, the results of functional testing of individual amperometric glucose and insulin sensors as well as an impedimetric sensor for the detection of the hydrogel swelling/shrinking are presented.
A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.