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Year of publication
- 2011 (182) (remove)
Institute
- Fachbereich Medizintechnik und Technomathematik (69)
- INB - Institut für Nano- und Biotechnologien (36)
- Fachbereich Elektrotechnik und Informationstechnik (25)
- Fachbereich Chemie und Biotechnologie (22)
- IfB - Institut für Bioengineering (22)
- Fachbereich Wirtschaftswissenschaften (19)
- Fachbereich Energietechnik (13)
- Fachbereich Bauingenieurwesen (12)
- Fachbereich Maschinenbau und Mechatronik (10)
- Fachbereich Luft- und Raumfahrttechnik (9)
Document Type
- Article (182) (remove)
Keywords
- Arthosetherapie (1)
- Bioreaktor (1)
- Blutzellenlagerung (1)
- Gonarthrose (1)
- Harnleiter (1)
- Hemoglobin structure (1)
- High field MRI (1)
- Hämoglobin (1)
- Hämoglobinstruktur (1)
- Kniegelenkarthrose (1)
The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.
Manea, Marilena ; Leurs, Ulrike ; Orban, Erika ; Baranyai, Zsuzsa ; Öhlschläger, Peter ; Marquardt, Andreas ; Schulcz, Akos ; Tejeda, Miguel
Digital elevation models (DEMs), represent the three-dimensional terrain and are the basic input for numerical snow avalanche dynamics simulations. DEMs can be acquired using topographic maps or remote-sensing technologies, such as photogrammetry or lidar. Depending on the acquisition technique, different spatial resolutions and qualities are achieved. However, there is a lack of studies that investigate the sensitivity of snow avalanche simulation algorithms to the quality and resolution of DEMs. Here, we perform calculations using the numerical avalance dynamics model RAMMS, varying the quality and spatial resolution of the underlying DEMs, while holding the simulation parameters constant. We study both channelized and open-terrain avalanche tracks with variable roughness. To quantify the variance of these simulations, we use well-documented large-scale avalanche events from Davos, Switzerland (winter 2007/08), and from our large-scale avalanche test site, Valĺee de la Sionne (winter 2005/06). We find that the DEM resolution and quality is critical for modeled flow paths, run-out distances, deposits, velocities and impact pressures. Although a spatial resolution of ~25 m is sufficient for large-scale avalanche modeling, the DEM datasets must be checked carefully for anomalies and artifacts before using them for dynamics calculations.