Refine
Year of publication
- 2012 (333) (remove)
Institute
- Fachbereich Medizintechnik und Technomathematik (72)
- Fachbereich Wirtschaftswissenschaften (42)
- Fachbereich Elektrotechnik und Informationstechnik (41)
- Fachbereich Chemie und Biotechnologie (40)
- INB - Institut für Nano- und Biotechnologien (32)
- IfB - Institut für Bioengineering (31)
- Fachbereich Bauingenieurwesen (30)
- Fachbereich Maschinenbau und Mechatronik (29)
- Fachbereich Energietechnik (20)
- Solar-Institut Jülich (15)
Document Type
- Article (130)
- Conference Proceeding (89)
- Part of a Book (36)
- Book (26)
- Conference: Meeting Abstract (17)
- Patent (12)
- Part of a Periodical (9)
- Doctoral Thesis (7)
- Report (4)
- Habilitation (1)
Keywords
- Elektromobilität (7)
- Elektrofahrzeug (5)
- Energieversorgungsnetz (5)
- Kraftfahrzeugelektronik (5)
- Aachen / Fachhochschule Aachen (3)
- Aachen University of Applied Sciences (2)
- Elektromobilität; Elektrofahrzeug; Energieversorungsnetz; Kraftfahrzeugtechnik (2)
- (Bio)degradation (1)
- 3. EU Legislativpaket (1)
- 802.15.4 (1)
- Acceleration (1)
- Adsorption (1)
- Afterload (1)
- Alginate beads (1)
- Anastomotic leakage (1)
- Aufschlagversuch (1)
- Autolysis (1)
- Avalanche (1)
- Bank-issued Warrants (1)
- Bio-Sensors (1)
- Biosensor (1)
- Bluetooth (1)
- Borehole heat exchanger (1)
- Calorimetric gas sensor (1)
- Cell permeability (1)
- CellDrum (1)
- Cellular force (1)
- Central receiver system (1)
- Chemical imaging sensor (1)
- Circular Dichroism (1)
- Cloud Computing (1)
- Cloud Service Broker (1)
- Compliance (1)
- Concentrated solar collector (1)
- Consensus (1)
- Contractile tension (1)
- Contractility (1)
- C–V method (1)
- Decomposition (1)
- Detergent protease (1)
- Discourse ethics (1)
- Disposition Effect (1)
- Distributed Control Systems, (1)
- Eisschicht (1)
- Elemental (1)
- End-to-end colorectal anastomosis (1)
- Endothelial cells (1)
- Energiewirtschaft (1)
- Esophageal Doppler monitor (1)
- Extracellular enzymes (1)
- FH Aachen (1)
- Fachhochschule Aachen (1)
- Field-effect sensor (1)
- Finite differences (1)
- Finite element modelling (1)
- Force (1)
- Forschungsbericht (1)
- Freeze–thaw process (1)
- Fresnel collector (1)
- Fußball (1)
- Gleichspannungswandler (1)
- Graduiertentagung (1)
- Grid Computing (1)
- Guerrillawerbung (1)
- Heat transport (1)
- Hydrogen peroxide (1)
- Hypersecretion (1)
- IP-based networks (1)
- Impedance spectroscopy (1)
- Individual Investors (1)
- IndraMotion (1)
- Industrial Automation Technology, (1)
- Kinetic energy (1)
- Konsumgesellschaft (1)
- Künstlerisches Handeln (1)
- LAPS (1)
- Light-addressable potentiometric sensor (1)
- Lipopolysaccharide (1)
- Liver (1)
- Low-field NMR (1)
- MATLAB , MLPI , Motion control , Open Core , industrial drives , rapid control prototypin , sercos automation bus (1)
- Marker-free mutagenesis (1)
- Medienforschung (1)
- Molkeproteine (1)
- Motion-Logic System (1)
- NGN (1)
- NMR exchange relaxometry (1)
- NONOate (1)
- Nano Materials (1)
- Nanomaterial (1)
- Nanotechnologie (1)
- Negative Feedback Trading (1)
- Nitric Oxide (1)
- Nitric Oxide Donor (1)
- Numerical linear algebra (1)
- Optical and thermal analysis (1)
- Organic light-emitting diode display (1)
- Ownership Unbundling (1)
- PIV (1)
- PROFINET (1)
- Parasitäre Strategie (1)
- Politische Kunst (1)
- Poly(d,l-lacticacid) (1)
- Polyimide (1)
- Real-time monitoring (1)
- Recombinant activated protein C (1)
- Requirements prioritization (1)
- Requirements relations (1)
- Research Report (1)
- Robotik (1)
- SLM (1)
- SPS (1)
- ScaLAPACK (1)
- Schienbeinschoner (1)
- Selektives Laser Schmelzen (1)
- Silber (1)
- Snow (1)
- Solar concentration (1)
- Sonde (1)
- Speicherprogrammierte Steuerung (1)
- Spleen (1)
- Stenotrophomonas maltophilia (1)
- Sterilisation process (1)
- Stromnetz (1)
- Surgical staplers (1)
- Tool support (1)
- Trading Behavior (1)
- Uracil-phosphoribosyltransferase (1)
- VOF (1)
- Variable height stapler design (1)
- Velocity (1)
- Volume status (1)
- Wireless Networks (1)
- Workflow (1)
- Workflow Orchestration (1)
- Wärmeübertragung (1)
- architectural design process (1)
- brachytherapy (1)
- dam-break (1)
- design theory (1)
- drag force (1)
- eigensolvers (1)
- incontinence (1)
- instruments (1)
- interdisciplinarity (1)
- methodologies (1)
- mobile robots (1)
- next generation network (1)
- numerical model (1)
- performance analysis (1)
- physical model (1)
- product bundling (1)
- prostate cancer (1)
- prostatectomy (1)
- quality of life (1)
- subglacial aquatic ecosystems (1)
- subsurface ice (1)
- telecommunication (1)
- Übertragungsnetz (1)
Chelate stabilization of a titanium(IV)–salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.
Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of ‘gene-shuffled’ (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies.
Abfallwirtschaft
(2012)
Siedlungswasserwirtschaft
(2012)
Geotechnik
(2012)
Stahlbau
(2012)
Stahlbetonbau
(2012)
Wendehorst Beispiele aus der Baupraxis / Ulrich Vismann (Hrsg.). - 4., durchges. und aktualis. Aufl.
(2012)
Aufbau von Handelseinheiten
(2012)