Article
Refine
Year of publication
- 2012 (127) (remove)
Document Type
- Article (127) (remove)
Has Fulltext
- no (127) (remove)
Keywords
- (Bio)degradation (1)
- 802.15.4 (1)
- Acceleration (1)
- Afterload (1)
- Alginate beads (1)
- Anastomotic leakage (1)
- Autolysis (1)
- Avalanche (1)
- Bank-issued Warrants (1)
- Bluetooth (1)
- Borehole heat exchanger (1)
- Calorimetric gas sensor (1)
- Cell permeability (1)
- CellDrum (1)
- Cellular force (1)
- Chemical imaging sensor (1)
- Circular Dichroism (1)
- Compliance (1)
- Consensus (1)
- Contractile tension (1)
- Contractility (1)
- C–V method (1)
- Decomposition (1)
- Detergent protease (1)
- Discourse ethics (1)
- Disposition Effect (1)
- Distributed Control Systems, (1)
- Elemental (1)
- End-to-end colorectal anastomosis (1)
- Endothelial cells (1)
- Esophageal Doppler monitor (1)
- Extracellular enzymes (1)
- Field-effect sensor (1)
- Finite differences (1)
- Finite element modelling (1)
- Force (1)
- Freeze–thaw process (1)
- Guerrillawerbung (1)
- Heat transport (1)
- Hydrogen peroxide (1)
- Hypersecretion (1)
- IP-based networks (1)
- Impedance spectroscopy (1)
- Individual Investors (1)
- Industrial Automation Technology, (1)
- Kinetic energy (1)
- LAPS (1)
- Light-addressable potentiometric sensor (1)
- Lipopolysaccharide (1)
- Liver (1)
- Low-field NMR (1)
- Marker-free mutagenesis (1)
- NGN (1)
- NMR exchange relaxometry (1)
- NONOate (1)
- Negative Feedback Trading (1)
- Nitric Oxide (1)
- Nitric Oxide Donor (1)
- Numerical linear algebra (1)
- Organic light-emitting diode display (1)
- PIV (1)
- PROFINET (1)
- Parasitäre Strategie (1)
- Poly(d,l-lacticacid) (1)
- Polyimide (1)
- Real-time monitoring (1)
- Recombinant activated protein C (1)
- Requirements prioritization (1)
- Requirements relations (1)
- SLM (1)
- ScaLAPACK (1)
- Selektives Laser Schmelzen (1)
- Silber (1)
- Snow (1)
- Spleen (1)
- Stenotrophomonas maltophilia (1)
- Sterilisation process (1)
- Surgical staplers (1)
- Tool support (1)
- Trading Behavior (1)
- Uracil-phosphoribosyltransferase (1)
- VOF (1)
- Variable height stapler design (1)
- Velocity (1)
- Volume status (1)
- Wireless Networks (1)
- brachytherapy (1)
- dam-break (1)
- drag force (1)
- eigensolvers (1)
- incontinence (1)
- next generation network (1)
- numerical model (1)
- performance analysis (1)
- physical model (1)
- product bundling (1)
- prostate cancer (1)
- prostatectomy (1)
- quality of life (1)
- telecommunication (1)
Institute
- Fachbereich Medizintechnik und Technomathematik (40)
- Fachbereich Wirtschaftswissenschaften (26)
- INB - Institut für Nano- und Biotechnologien (25)
- Fachbereich Chemie und Biotechnologie (15)
- Fachbereich Elektrotechnik und Informationstechnik (14)
- IfB - Institut für Bioengineering (13)
- Fachbereich Maschinenbau und Mechatronik (11)
- Fachbereich Bauingenieurwesen (5)
- Fachbereich Energietechnik (5)
- Fachbereich Architektur (3)
- Fachbereich Luft- und Raumfahrttechnik (3)
- Sonstiges (3)
- Solar-Institut Jülich (2)
- Fachbereich Gestaltung (1)
- Freshman Institute (1)
- Nowum-Energy (1)
The chemical imaging sensor is a chemical sensor which is capable of visualizing the spatial distribution of chemical species in sample solution. In this study, a novel measurement system based on the chemical imaging sensor was developed to observe the inside of a Y-shaped microfluidic channel while injecting two sample solutions from two branches. From the collected chemical images, it was clearly observed that the injected solutions formed laminar flows in the microfluidic channel. In addition, ion diffusion across the laminar flows was observed. This label-free method can acquire quantitative data of ion distribution and diffusion in microfluidic devices, which can be used to determine the diffusion coefficients, and therefore, the molecular weights of chemical species in the sample solution.
Real-time and reliable monitoring of the biogas process is crucial for a stable and efficient operation of biogas production in order to avoid digester breakdowns. The concentration of dissolved hydrogen (H₂) represents one of the key parameters for biogas process control. In this work, a one-chip integrated combined amperometric/field-effect sensor for monitoring the dissolved H₂ concentration has been developed for biogas applications. The combination of two different transducer principles might allow a more accurate and reliable measurement of dissolved H₂ as an early warning indicator of digester failures. The feasibility of the approach has been demonstrated by simultaneous amperometric/field-effect measurements of dissolved H₂ concentrations in electrolyte solutions. Both, the amperometric and the field-effect transducer show a linear response behaviour in the H₂ concentration range from 0.1 to 3% (v/v) with a slope of 198.4 ± 13.7 nA/% (v/v) and 14.9 ± 0.5 mV/% (v/v), respectively.
Bioconjugates containing the GnRH-III hormone decapeptide as a targeting moiety are able to deliver chemotherapeutic agents specifically to cancer cells expressing GnRH receptors, thereby increasing their local efficacy while limiting the peripheral toxicity. However, the number of GnRH receptors on cancer cells is limited and they desensitize under continuous hormone treatment. A possible approach to increase the receptor mediated tumor targeting and consequently the cytostatic effect of the bioconjugates would be the attachment of more than one chemotherapeutic agent to one GnRH-III molecule. Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing GnRH-III as a targeting moiety and daunorubicin as a chemotherapeutic agent. Two different drug design approaches were pursued. The first one was based on the bifunctional [4Lys]-GnRH-III (Glp-His-Trp-Lys-His-Asp-Trp-Lys-Pro-Gly-NH2) containing two lysine residues in positions 4 and 8, whose ϵ-amino groups were used for the coupling of daunorubicin. In the second drug design, the native GnRH-III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2) was used as a scaffold; an additional lysine residue was coupled to the ϵ-amino group of 8Lys in order to generate two free amino groups available for conjugation of daunorubicin. The in vitro stability/degradation of all synthesized compounds was investigated in human serum, as well as in the presence of rat liver lysosomal homogenate. Their cellular uptake was determined on human breast cancer cells and the cytostatic effect was evaluated on human breast, colon and prostate cancer cell lines. Compared with a monofunctional compound, both drug design approaches resulted in multifunctional bioconjugates with increased cytostatic effect.
Im Beitrag wird zunächst das Verfahren eines dynamischen elektro-geometrischen Modells vorgestellt. Dieses arbeitet im Gegensatz zum klassischen Blitzkugel-Verfahren nicht mit konstanten Radien; vielmehr wird der Radius der Blitzkugel variiert. Dabei werden ausschließlich vorhandene und in internationalen Normen anerkannte Ergebnisse, blitzphysikalische Grundlagen und Untersuchungen verwendet, und auf deren Grundlage ein numerisches Verfahren erarbeitet. Mit dem dynamischen elektro-geometrischen Modell werden dann einige Beispiele des Schutzes mit Fangstangen, die gemäß dem klassischen Blitzkugel-Verfahren nach DIN EN 62305-3 für die Schutzklassen I – II – III – IV geplant sind, untersucht. Es wird gezeigt, dass die Einfangwirksamkeiten wesentlich höher sind als in der Normenreihe DIN EN 62305 selbst angegeben. Grund dafür ist die Tatsache, dass das Blitzkugel-Verfahren sehr konservativ aufgebaut ist und dem Planer von Blitzschutzsystemen nur die möglichen Stellen für einen Einschlag aufzeigt, ohne eine Bewertung der Einschlagshäufigkeit zu liefern. Andererseits bedeutet dies jedoch, dass man mit dem klassischen Blitzkugel-Verfahren stets auf der „sicheren Seite“ liegt.
Determination of the frictional coefficient of the implant-antler interface : experimental approach
(2012)
The similar bone structure of reindeer antler to human bone permits studying the osseointegration of dental implants in the jawbone. As the friction is one of the major factors that have a significant influence on the initial stability of immediately loaded dental implants, it is essential to define the frictional coefficient of the implant-antler interface. In this study, the kinetic frictional forces at the implant-antler interface were measured experimentally using an optomechanical setup and a stepping motor controller under different axial loads and sliding velocities. The corresponding mean values of the static and kinetic frictional coefficients were within the range of 0.5–0.7 and 0.3–0.5, respectively. An increase in the frictional forces with increasing applied axial loads was registered. The measurements showed an evidence of a decrease in the magnitude of the frictional coefficient with increasing sliding velocity. The results of this study provide a considerable assessment to clarify the suitable frictional coefficient to be used in the finite element contact analysis of antler specimens.
Chemical imaging systems allow the visualisation of the distribution of chemical species on the sensor surface. This work represents a new flexible approach to read out light-addressable potentiometric sensors (LAPS) with the help of a digital light processing (DLP) set-up. The DLP, known well for video projectors, consists of a mirror-array MEMS device, which allows fast and flexible generation of light patterns. With the help of these light patterns, the sensor surface of the LAPS device can be addressed. The DLP approach has several advantages compared to conventional LAPS set-ups, e.g., the spot size and the shape of the light pointer can be changed easily and no mechanical movement is necessary, which reduces the size of the set-up and increases the stability and speed of the measurement. In addition, the modulation frequency and intensity of the light beam are important parameters of the LAPS set-up. Within this work, the authors will discuss two different ways of light modulation by the DLP set-up, investigate the influence of different modulation frequencies and different light intensities as well as demonstrate the scanning capabilities of the new set-up by pH mapping on the sensor surface.
In industrial processes there is a variety of heavy metals (e.g., copper, zinc, cadmium, and lead) in use for wires, coatings, paints, alloys, batteries, etc. Since the application of these transition metals for industry is inevitable, it is a vital task to develop proper analytical techniques for their monitoring at low activity levels, especially because most of these elements are acutely toxic for biological organisms. The determination of ions in solution by means of a simple and inexpensive sensor array is, therefore, a promising task. In this work, a sensor array with heavy metal-sensitive chalcogenide glass membranes for the simultaneous detection of the four ions Ag⁺, Cu2⁺, Cd2⁺, and Pb2⁺ in solution is realized. The results of the physical characterization by means of microscopy, profilometry, Rutherford backscattering spectroscopy (RBS), and scanning electron microscopy (SEM) as well as the electrochemical characterization by means of potentiometric measurements are presented. Additionally, the possibility to expand the sensor array by polymeric sensor membranes is discussed.