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Year of publication
- 2017 (255) (remove)
Institute
- Fachbereich Medizintechnik und Technomathematik (66)
- Fachbereich Elektrotechnik und Informationstechnik (37)
- IfB - Institut für Bioengineering (34)
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- Fachbereich Energietechnik (27)
- INB - Institut für Nano- und Biotechnologien (27)
- Fachbereich Maschinenbau und Mechatronik (23)
- Fachbereich Bauingenieurwesen (14)
- Fachbereich Chemie und Biotechnologie (12)
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- no (255) (remove)
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Keywords
- Autonomous mobile robots (2)
- Gamification (2)
- Industry 4.0 (2)
- MASCOT (2)
- Multi-robot systems (2)
- Smart factory (2)
- 3D nonlinear finite element model (1)
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Is part of the Bibliography
- no (255)
Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.
Chen, Chao ; Jost, Peter ; Volker, Hanno ; Kaminski, Marvin ; Wirtssohn, Matti R. ; Engelmann, Ulrich M. ; Krüger, K. ; Schlich, Franziska F. ; Schlockermann, Carl ; Lobo, Ricardo P.S.M. ; Wuttig, Matthias
Sousa, Marcos A. M. ; Siqueira, Jose R. Jr. ; Vercik, Andres ; Schöning, Michael Josef ; Oliveira, Osvaldo N. Jr.
The capacitive electrolyte–insulator–semiconductor (EIS) structure is a typical device based on a field-effect sensor platform. With a simple silicon-based structure, EIS have been useful for several sensing applications, especially with incorporation of nanostructured films to modulate the ionic transport and the flat-band potential. In this paper, we report on ion transport and changes in flat-band potential in EIS sensors made with layer-by-layer films containing poly(amidoamine) (PAMAM) dendrimer and single-walled carbon nanotubes (SWNTs) adsorbed on p-Si/SiO 2 /Ta 2 O 5 chips with an Al ohmic contact. The impedance spectra were fitted using an equivalent circuit model, from which we could determine parameters such as the double-layer capacitance. This capacitance decreased with the number of bilayers owing to space charge accumulated at the electrolyte–insulator interface, up to three PAMAM/SWNTs bilayers, after which it stabilized. The charge-transfer resistance was also minimum for three bilayers, thus indicating that this is the ideal architecture for an optimized EIS performance. The understanding of the influence of nanostructures and the fine control of operation parameters pave the way for optimizing the design and performance of new EIS sensors.