Refine
Year of publication
Document Type
- Article (171)
- Conference Proceeding (23)
- Part of a Book (10)
- Book (1)
Has Fulltext
- no (205) (remove)
Keywords
- Field-effect sensor (3)
- capacitive field-effect sensor (3)
- field-effect sensor (3)
- tobacco mosaic virus (TMV) (3)
- LAPS (2)
- gold nanoparticles (2)
- (Bio)degradation (1)
- Biomolecular logic gate (1)
- CNOT (1)
- Capacitive field-effect (1)
- Capacitive model (1)
- Chemical imaging (1)
- Coat protein (1)
- C–V method (1)
- DNA (1)
- DNA biosensor (1)
- DNA hybridization (1)
- Electrolyte–insulator–semiconductor (1)
- Enzyme biosensor (1)
- Enzyme coverage (1)
- Enzyme logic gate (1)
- Enzyme nanocarrier (1)
- Field effect (1)
- Field-effect biosensor (1)
- Field-effect device (1)
- Glucose biosensor (1)
- Glucose oxidase (1)
- Gold nanoparticle (1)
- Impedance spectroscopy (1)
- Label-free detection (1)
- Layer-by-layer adsorption (1)
- Light-addressable potentiometric sensor (1)
- Multianalyte detection (1)
- Penicillin (1)
- Poly(allylamine hydrochloride) (1)
- Poly(d,l-lacticacid) (1)
- Potentiometry (1)
- Real-time monitoring (1)
- TMV adsorption (1)
- Ta₂O₅ gate (1)
- Tobacco mosaic virus (1)
- Tobacco mosaic virus (TMV) (1)
- XOR (1)
- acetoin (1)
- aminooctanethiol (1)
- barium strontium titanate (1)
- bi-enzyme biosensor (1)
- biosensor (1)
- capacitive EIS sensor (1)
- capacitive field-effect biosensor (1)
- capacitive model (1)
- contactless conductivity sensor (1)
- control gate (1)
- detection of charged macromolecules (1)
- electrolyte-insulator-semiconductor capacitors (1)
- enzymatic (bio)degradation (1)
- enzyme cascade (1)
- enzyme immobilization (1)
- enzyme-logic gate (1)
- equivalent circuit (1)
- glucose oxidase (GOx) (1)
- high-k material (1)
- horseradish peroxidase (HRP) (1)
- hydrogen peroxide (1)
- impedance spectroscopy (1)
- in-situ monitoring (1)
- lable-free detection (1)
- multi-functional material (1)
- multianalyte detection (1)
- nanoparticle coverage (1)
- on-chip integrated addressable EISCAP sensors (1)
- penicillinase (1)
- plant virus detection (1)
- poly(d, l-lactic acid) (1)
- polystyrene sulfonate (1)
- turnip vein clearing virus (TVCV) (1)
- urease (1)
An ISFET-based penicillin sensor with high sensitivity, low detection limit and long lifetime
(2001)
The coupling of charged molecules, nanoparticles, and more generally, inorganic/organic nanohybrids with semiconductor field-effect devices based on an electrolyte–insulator–semiconductor (EIS) system represents a very promising strategy for the active tuning of electrochemical properties of these devices and, thus, opening new opportunities for label-free biosensing by the intrinsic charge of molecules. The simplest field-effect sensor is a capacitive EIS sensor, which represents a (bio-)chemically sensitive capacitor. In this chapter, selected examples of recent developments in the field of label-free biosensing using nanomaterial-modified capacitive EIS sensors are summarized. In the first part, we present applications of EIS sensors modified with negatively charged gold nanoparticles for the label-free electrostatic detection of positively charged small proteins and macromolecules, for monitoring the layer-by-layer formation of oppositely charged polyelectrolyte (PE) multilayers as well as for the development of an enzyme-based biomolecular logic gate. In the second part, examples of a label-free detection by means of EIS sensors modified with a positively charged weak PE layer are demonstrated. These include electrical detection of on-chip and in-solution hybridized DNA (deoxyribonucleic acid) as well as an EIS sensor with pH-responsive weak PE/enzyme multilayers for enhanced field-effect biosensing.
Among the variety of transducer concepts proposed for label-free detection of biomolecules, the semiconductor field-effect device (FED) is one of the most attractive platforms. As medical techniques continue to progress towards diagnostic and therapies based on biomarkers, the ability of FEDs for a label-free, fast and real-time detection of multiple pathogenic and physiologically relevant molecules with high specificity and sensitivity offers very promising prospects for their application in point-of-care and personalized medicine for an early diagnosis and treatment of diseases. The presented paper reviews recent advances and current trends in research and development of different FEDs for label-free, direct electrical detection of charged biomolecules by their intrinsic molecular charge. The authors are mainly focusing on the detection of the DNA hybridization event, antibody-antigen affinity reaction as well as clinically relevant biomolecules such as cardiac and cancer biomarkers.
Electrolyte-insulator-semiconductor (EIS) field-effect sensors belong to a new generation of electronic chips for biochemical sensing, enabling a direct electronic readout. The review gives an overview on recent advances and current trends in the research and development of chemical sensors and biosensors based on the capacitive field-effect EIS structure—the simplest field-effect device, which represents a biochemically sensitive capacitor. Fundamental concepts, physicochemical phenomena underlying the transduction mechanism and application of capacitive EIS sensors for the detection of pH, ion concentrations, and enzymatic reactions, as well as the label-free detection of charged molecules (nucleic acids, proteins, and polyelectrolytes) and nanoparticles, are presented and discussed.