Refine
Year of publication
- 2014 (283) (remove)
Institute
- Fachbereich Medizintechnik und Technomathematik (59)
- Fachbereich Chemie und Biotechnologie (44)
- Fachbereich Elektrotechnik und Informationstechnik (41)
- Fachbereich Wirtschaftswissenschaften (41)
- Fachbereich Energietechnik (40)
- INB - Institut für Nano- und Biotechnologien (35)
- IfB - Institut für Bioengineering (19)
- Fachbereich Maschinenbau und Mechatronik (15)
- Fachbereich Luft- und Raumfahrttechnik (13)
- Fachbereich Bauingenieurwesen (11)
- Solar-Institut Jülich (5)
- Fachbereich Architektur (4)
- Sonstiges (3)
- Institut fuer Angewandte Polymerchemie (2)
- ECSM European Center for Sustainable Mobility (1)
- Fachbereich Gestaltung (1)
- ZHQ - Bereich Hochschuldidaktik und Evaluation (1)
Has Fulltext
- no (283) (remove)
Document Type
- Article (138)
- Conference Proceeding (55)
- Part of a Book (31)
- Book (22)
- Conference: Meeting Abstract (15)
- Report (8)
- Other (6)
- Patent (3)
- Conference Poster (1)
- Doctoral Thesis (1)
Keywords
Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop therapeutic vaccines no candidate has entered late clinical trials. An interesting approach is a DNA based vaccine encompassing the nucleotide sequence of the E6 and E7 viral oncoproteins. Because both proteins are consistently expressed in HPV infected cells they represent excellent targets for immune therapy. Here we report the development of 8 DNA vaccine candidates consisting of differently rearranged HPV-16 E6 and E7 sequences within one molecule providing all naturally occurring epitopes but supposedly lacking transforming activity. The HPV sequences were fused to the J-domain and the SV40 enhancer in order to increase immune responses. We demonstrate that one out of the 8 vaccine candidates induces very strong cellular E6- and E7- specific cellular immune responses in mice and, as shown in regression experiments, efficiently controls growth of HPV 16 positive syngeneic tumors. This data demonstrates the potential of this vaccine candidate to control persistent HPV 16 infection that may lead to malignant disease. It also suggests that different sequence rearrangements influence the immunogenecity by an as yet unknown mechanism.
Der Embedded Wireless-Report
(2014)
Feldbustechnologie
(2014)
Mehrwert
(2014)
Selective Laser Melting (SLM) is one of the Additive Manufacturing (AM) technologies applicable for producing complex geometries which are typically expensive or difficult to fabricate using conventional methods. This process has been extensively investigated experimentally for various metals and the fabrication process parameters have been established for different applications; however, fabricating 3D glass objects using SLM technology has remained a challenge so far although it could have many applications. This paper presents a summery on various experimental evaluations of a material database incorporating the build parameters of glass powder using the SLM process for jewelry applications.
Generation Y
(2014)