Refine
Year of publication
Institute
- Fachbereich Medizintechnik und Technomathematik (1686)
- Fachbereich Elektrotechnik und Informationstechnik (717)
- IfB - Institut für Bioengineering (620)
- Fachbereich Energietechnik (587)
- INB - Institut für Nano- und Biotechnologien (557)
- Fachbereich Chemie und Biotechnologie (551)
- Fachbereich Luft- und Raumfahrttechnik (495)
- Fachbereich Maschinenbau und Mechatronik (278)
- Fachbereich Wirtschaftswissenschaften (217)
- Solar-Institut Jülich (164)
- Fachbereich Bauingenieurwesen (157)
- ECSM European Center for Sustainable Mobility (88)
- MASKOR Institut für Mobile Autonome Systeme und Kognitive Robotik (67)
- Nowum-Energy (30)
- Fachbereich Gestaltung (25)
- Institut fuer Angewandte Polymerchemie (23)
- Sonstiges (21)
- Fachbereich Architektur (20)
- Freshman Institute (18)
- Kommission für Forschung und Entwicklung (18)
- ZHQ - Bereich Hochschuldidaktik und Evaluation (8)
- Arbeitsstelle fuer Hochschuldidaktik und Studienberatung (3)
- IMP - Institut für Mikrowellen- und Plasmatechnik (3)
- FH Aachen (2)
- IaAM - Institut für angewandte Automation und Mechatronik (2)
- Kommission für Planung und Finanzen (2)
- Digitalisierung in Studium & Lehre (1)
- IBB - Institut für Baustoffe und Baukonstruktionen (1)
Language
- English (4901) (remove)
Document Type
- Article (3272)
- Conference Proceeding (1161)
- Part of a Book (190)
- Book (144)
- Doctoral Thesis (30)
- Conference: Meeting Abstract (27)
- Patent (25)
- Other (10)
- Report (9)
- Conference Poster (6)
Keywords
- Biosensor (25)
- Finite-Elemente-Methode (12)
- Einspielen <Werkstoff> (10)
- CAD (8)
- civil engineering (8)
- Bauingenieurwesen (7)
- Blitzschutz (6)
- FEM (6)
- Gamification (6)
- Limit analysis (6)
Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface.