Refine
Year of publication
Document Type
- Article (462)
- Conference Proceeding (50)
- Part of a Book (9)
- Book (2)
- Other (2)
- Report (1)
Language
- English (475)
- German (50)
- Multiple languages (1)
Keywords
- Biosensor (5)
- Graduiertentagung (4)
- LAPS (3)
- Label-free detection (3)
- Light-addressable potentiometric sensor (3)
- biosensors (3)
- capacitive field-effect sensor (3)
- field-effect sensor (3)
- hydrogen peroxide (3)
- tobacco mosaic virus (TMV) (3)
- Bacillus atrophaeus (2)
- Calorimetric gas sensor (2)
- Capacitive field-effect sensor (2)
- Hydrogen peroxide (2)
- Raman spectroscopy (2)
- Tobacco mosaic virus (TMV) (2)
- acetoin (2)
- capacitive field-effect sensors (2)
- gold nanoparticles (2)
- light-addressable potentiometric sensor (2)
- penicillinase (2)
- sterilisation (2)
- (Bio)degradation (1)
- Aachen / Fachhochschule Aachen (1)
- Bacillus atrophaeus spores (1)
- Bio-Sensors (1)
- Bioabsorbable (1)
- Biosensorik (1)
- CNOT (1)
- Capacitive field-effect (1)
- Capacitive model (1)
- Chemical images (1)
- Chemical imaging (1)
- Chemical imaging sensor (1)
- Chemical sensor (1)
- Coat protein (1)
- C–V method (1)
- DNA biosensor (1)
- DPA (dipicolinic acid) (1)
- Dehydrogenase (1)
- Diaphorase (1)
- EIS capacitive sensor (1)
- Electrolyte–insulator–semiconductor (1)
- Enzymatic biosensor (1)
- Enzyme coverage (1)
- Enzyme logic gate (1)
- Enzyme nanocarrier (1)
- Field effect (1)
- Field-effect biosensor (1)
- Field-effect device (1)
- Field-effect sensor (1)
- Gas sensor (1)
- Glucose biosensor (1)
- Glucose oxidase (1)
- Gold nanoparticles (1)
- Graduate symposium (1)
- Graduierter (1)
- Heavy metal detection (1)
- ISFET (1)
- Impedance spectroscopy (1)
- Layer-by-layer adsorption (1)
- LbL films (1)
- MOS (1)
- Multi-sensor system (1)
- Multianalyte detection (1)
- Multicell (1)
- Multiplexing (1)
- Nano Materials (1)
- Nanomaterial (1)
- Nanostructuring (1)
- Nanotechnologie (1)
- Negative impedance convertor (1)
- O2 plasma (1)
- Organic light-emitting diode display (1)
- Penicillin (1)
- Plant virus (1)
- Poly(allylamine hydrochloride) (1)
- Poly(d,l-lacticacid) (1)
- Polyimide (1)
- Polylactide acid (1)
- Potentiometry (1)
- Promotionsstudium (1)
- Real-time monitoring (1)
- Resistive temperature detector (1)
- Resonance-mode measurement (1)
- Silk fibroin (1)
- Simultaneous determination (1)
- Sn₃O₄ (1)
- Sterilisation process (1)
- TMV adsorption (1)
- Ta₂O₅ gate (1)
- Tobacco mosaic virus (1)
- Wafer (1)
- XOR (1)
- Zeta potential (1)
- acetoin reductase (1)
- actuator-sensor system (1)
- alcoholic beverages (1)
- aminooctanethiol (1)
- amperometric biosensors (1)
- annealing (1)
- artificial olfactory image (1)
- aseptic parameters (1)
- atomic layer deposition (1)
- bi-enzyme biosensor (1)
- bioburdens (1)
- biocompatible (1)
- biocompatible materials (1)
- biodegradabl (1)
- biodegradable electronic devices (1)
- biosensor (1)
- calorimetric gas sensor (1)
- calorimetric gas sensor;hydrogen peroxide;wireless sensor system (1)
- capacitive EIS sensor (1)
- capacitive electrolyte–insulator–semiconductor sensors (1)
- capacitive field-effect biosensor (1)
- capacitive model (1)
- capillary micro-droplet cell (1)
- carbon electrodes (1)
- catalytic decomposition (1)
- catalytic metal (1)
- chemical sensor (1)
- control gate (1)
- detection of charged macromolecules (1)
- electrolyte-insulator semiconductor sensor (EIS) (1)
- electrolyte-insulator-semiconductor capacitors (1)
- electronic nose (1)
- encapsulation materials (1)
- endospores (1)
- enzymatic biosensor (1)
- enzyme cascade (1)
- enzyme immobilization (1)
- enzyme kinetics (1)
- enzyme-logic gate (1)
- equivalent circuit (1)
- fibroin (1)
- field-effect structure (1)
- gas sensor (1)
- gaseous hydrogen peroxide (1)
- glucose (1)
- glucose oxidase (GOx) (1)
- graphene oxide (1)
- heavy metals (1)
- horseradish peroxidase (HRP) (1)
- hydroxylation (1)
- immobilization (1)
- layer expansion (1)
- layer-by-layer technique (1)
- light-addressable electrode (1)
- light-addressing technologies (1)
- metal-oxide-semiconductor structure (1)
- microfluidics (1)
- multi-sensing platform (1)
- multianalyte detection (1)
- nanobelts (1)
- nanomaterials (1)
- nanoparticle coverage (1)
- on-chip integrated addressable EISCAP sensors (1)
- optical sensor setup (1)
- optical spore trapping (1)
- optical trapping (1)
- organic PVC membranes (1)
- organosilanes (1)
- pH sensors (1)
- pattern-size reduction (1)
- penicillin (1)
- photoelectrochemistry (1)
- plant virus detection (1)
- plug-based microfluidic device (1)
- polyaniline (1)
- polystyrene sulfonate (1)
- scanned light pulse technique (1)
- self-aligned patterning (1)
- silanization (1)
- spore kill rate (1)
- sterility (1)
- sterility tests (1)
- sterilization (1)
- sterilization conditions (1)
- sterilization efficacy (1)
- sterilization methods (1)
- surface functionalization (1)
- temperature (1)
- thin-film microsensors (1)
- titanium dioxide photoanode (1)
- turnip vein clearing virus (TVCV) (1)
- ultrathin gate insulators (1)
- urease (1)
- validation methods (1)
- visualization (1)
- wafer-level testing (1)
Institute
- INB - Institut für Nano- und Biotechnologien (526) (remove)
The light-addressable potentiometric sensor (LAPS) is a semiconductor-based potentiometric sensor using a light probe with an ability of detecting the concentration of biochemical species in a spatially resolved manner. As an important biomedical sensor, research has been conducted to improve its performance, for instance, to realize high-speed measurement. In this work, the idea of facilitating the device-level simulation, instead of using an equivalent-circuit model, is presented for detailed analysis and optimization of the performance of the LAPS. Both carrier distribution and photocurrent response have been simulated to provide new insight into both amplitude-mode and phase-mode operations of the LAPS. Various device parameters can be examined to effectively design and optimize the LAPS structures and setups for enhanced performance.
As a semiconductor-based electrochemical sensor, the light-addressable potentiometric sensor (LAPS) can realize two dimensional visualization of (bio-)chemical reactions at the sensor surface addressed by localized illumination. Thanks to this imaging capability, various applications in biochemical and biomedical fields are expected, for which the spatial resolution is critically significant. In this study, therefore, the spatial resolution of the LAPS was investigated in detail based on the device simulation. By calculating the spatiotemporal change of the distributions of electrons and holes inside the semiconductor layer in response to a modulated illumination, the photocurrent response as well as the spatial resolution was obtained as a function of various parameters such as the thickness of the Si substrate, the doping concentration, the wavelength and the intensity of illumination.
The simulation results verified that both thinning the semiconductor substrate and increasing the doping concentration could improve the spatial resolution, which were in good agreement with known experimental results and theoretical analysis. More importantly, new findings of interests were also obtained. As for the dependence on the wavelength of illumination, it was found that the known dependence was not always the case. When the Si substrate was thick, a longer wavelength resulted in a higher spatial resolution which was known by experiments. When the Si substrate was thin, however, a longer wavelength of light resulted in a lower spatial resolution. This finding was explained as an effect of raised concentration of carriers, which reduced the thickness of the space charge region.
The device simulation was found to be helpful to understand the relationship between the spatial resolution and device parameters, to understand the physics behind it, and to optimize the device structure and measurement conditions for realizing higher performance of chemical imaging systems.
A novel photoexcitation method for the light-addressable potentiometric sensor (LAPS) is proposed to achieve a higher spatial resolution of chemical images. The proposed method employs a combined light source that consists of a modulated light probe, which generates the alternating photocurrent signal, and a ring of constant illumination surrounding it. The constant illumination generates a sheath of carriers with increased concentration which suppresses the spread of photocarriers by enhanced recombination. A device simulation was carried out to verify the effect of constant illumination on the spatial resolution, which demonstrated that a higher spatial resolution can be obtained.
Bonding of polymer-based microfluidics to polymer substrates still poses a challenge for Lab-On-a-Chip applications. Especially, when sensing elements are incorporated, patterned deposition of adhesives with curing at ambient conditions is required. Here, we demonstrate a fabrication method for fully printed microfluidic systems with sensing elements using inkjet and stereolithographic 3D-printing.