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Year of publication
Institute
- IfB - Institut für Bioengineering (564) (remove)
Has Fulltext
- no (564) (remove)
Language
- English (564) (remove)
Document Type
- Article (391)
- Conference Proceeding (110)
- Part of a Book (34)
- Doctoral Thesis (17)
- Book (7)
- Other (3)
- Patent (1)
- Talk (1)
Keywords
- solar sail (5)
- CellDrum (3)
- GOSSAMER-1 (3)
- MASCOT (3)
- Biocomposites (2)
- Iterative learning control (2)
- Limit analysis (2)
- Mars (2)
- Natural fibres (2)
- Polymer-matrix composites (2)
Kurulgan Demirci, Eylem ; Linder, Peter ; Demirci, Taylan ; Trzewik, Jürgen ; Digel, Ilya ; Artmann, Gerhard ; Temiz Artmann, Aysegül
Kurz, R. ; Linder, Peter ; Trzewik, Jürgen ; Rüffer, M. ; Artmann, Gerhard ; Digel, Ilya ; Rothermel, A. ; Robitzki, A. ; Temiz Artmann, Aysegül
The CellDrum technology (The term 'CellDrum technology' includes a couple of slightly different technological setups for measuring lateral mechanical tension in various types of cell monolayers or 3D-tissue constructs) was designed to quantify the contraction rate and mechanical tension of self-exciting cardiac myocytes. Cells were grown either within flexible, circular collagen gels or as monolayer on top of respective 1-mum thin silicone membranes. Membrane and cells were bulged outwards by air pressure. This biaxial strain distribution is rather similar the beating, blood-filled heart. The setup allowed presetting the mechanical residual stress level externally by adjusting the centre deflection, thus, mimicking hypertension in vitro. Tension was measured as oscillating differential pressure change between chamber and environment. A 0.5-mm thick collagen-cardiac myocyte tissue construct induced after 2 days of culturing (initial cell density 2 x 10(4) cells/ml), a mechanical tension of 1.62 +/- 0.17 microN/mm(2). Mechanical load is an important growth regulator in the developing heart, and the orientation and alignment of cardiomyocytes is stress sensitive. Therefore, it was necessary to develop the CellDrum technology with its biaxial stress-strain distribution and defined mechanical boundary conditions. Cells were exposed to strain in two directions, radially and circumferentially, which is similar to biaxial loading in real heart tissues. Thus, from a biomechanical point of view, the system is preferable to previous setups based on uniaxial stretching.
Lanzl, Ines M. ; Seidova, Seid-Fatima ; Maier, Mathias ; Schmidt-Trucksäss, Arno ; Halle, Martin ; Kotliar, Konstantin
False spectra formation in the differential two-channel scheme of the laser Doppler flowmeter
(2018)
Noise in the differential two-channel scheme of a classic laser Doppler flowmetry (LDF) instrument was studied. Formation of false spectral components in the output signal due to beating of electrical signals in the differential amplifier was found out. The improved block-diagram of the flowmeter was developed allowing to reduce the noise.
Leimena, W. ; Artmann, Gerhard ; Dachwald, Bernd ; Temiz Artmann, Aysegül ; Gossmann, Matthias ; Digel, Ilya
Leipold, M. ; Fichtner, H. ; Heber, B. ; Groepper, P. ; Lascar, S. ; Burger, F. ; Eiden, M. ; Niederstadt, T. ; Sickinger, C. ; Herbeck, L. ; Dachwald, Bernd ; Seboldt, Wolfgang
Lenz, Maximilian ; Kahmann, Stephanie Lucina ; Behbahani, Mehdi ; Pennig, Lenhard ; Hackl, Michael ; Leschinger, Tim ; Müller, Lars Peter ; Wegmann, Kilian
Introduction
In regard of surgical training, the reproducible simulation of life-like proximal humerus fractures in human cadaveric specimens is desirable. The aim of the present study was to develop a technique that allows simulation of realistic proximal humerus fractures and to analyse the influence of rotator cuff preload on the generated lesions in regards of fracture configuration.
Materials and methods
Ten cadaveric specimens (6 left, 4 right) were fractured using a custom-made drop-test bench, in two groups. Five specimens were fractured without rotator cuff preload, while the other five were fractured with the tendons of the rotator cuff preloaded with 2 kg each. The humeral shaft and the shortened scapula were potted. The humerus was positioned at 90° of abduction and 10° of internal rotation to simulate a fall on the elevated arm. In two specimens of each group, the emergence of the fractures was documented with high-speed video imaging. Pre-fracture radiographs were taken to evaluate the deltoid-tuberosity index as a measure of bone density. Post-fracture X-rays and CT scans were performed to define the exact fracture configurations. Neer’s classification was used to analyse the fractures.
Results
In all ten cadaveric specimens life-like proximal humerus fractures were achieved. Two III-part and three IV-part fractures resulted in each group. The preloading of the rotator cuff muscles had no further influence on the fracture configuration. High-speed videos of the fracture simulation revealed identical fracture mechanisms for both groups. We observed a two-step fracture mechanism, with initial impaction of the head segment against the glenoid followed by fracturing of the head and the tuberosities and then with further impaction of the shaft against the acromion, which lead to separation of the tuberosities.
Conclusion
A high energetic axial impulse can reliably induce realistic proximal humerus fractures in cadaveric specimens. The preload of the rotator cuff muscles had no influence on initial fracture configuration. Therefore, fracture simulation in the proximal humerus is less elaborate. Using the presented technique, pre-fractured specimens are available for real-life surgical education.
Leschinger, Tim ; Besch, Katharina ; Aydin, Cansu ; Staat, Manfred ; Scaal, Martin ; Müller, Lars Peter ; Wegmann, Kilian