Refine
Year of publication
Institute
- Fachbereich Medizintechnik und Technomathematik (2072)
- Fachbereich Elektrotechnik und Informationstechnik (1183)
- Fachbereich Wirtschaftswissenschaften (1158)
- Fachbereich Energietechnik (1115)
- Fachbereich Chemie und Biotechnologie (912)
- Fachbereich Maschinenbau und Mechatronik (867)
- Fachbereich Luft- und Raumfahrttechnik (797)
- Fachbereich Bauingenieurwesen (711)
- IfB - Institut für Bioengineering (688)
- INB - Institut für Nano- und Biotechnologien (615)
Language
- German (5099)
- English (4905)
- Russian (14)
- Portuguese (6)
- Multiple languages (5)
- Spanish (3)
- Dutch (2)
- Italian (1)
Document Type
- Article (5642)
- Conference Proceeding (1639)
- Book (1079)
- Part of a Book (559)
- Bachelor Thesis (312)
- Patent (174)
- Report (101)
- Doctoral Thesis (79)
- Other (76)
- Administrative publication (76)
Keywords
- Amtliche Mitteilung (71)
- Bachelor (33)
- Aachen University of Applied Sciences (31)
- Master (31)
- Prüfungsordnung (31)
- Bauingenieurwesen (30)
- Lesbare Fassung (28)
- Biosensor (25)
- Fachhochschule Aachen (23)
- Illustration (22)
Zugriffsart
- campus (2140)
- weltweit (1858)
- bezahl (764)
- fachbereichsweit (FB4) (30)
Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface.
Inhaltsverzeichnis
1. Whistleblowing – Chancen & Risiken von Hinweisgebersystemen aus Arbeitnehmer- und Arbeitgebersicht
– Michelle Abraham 3-70
2. Die Bedeutung und rechtliche Bewertung von Vesting-Klauseln bei der Venture-Capital Finanzierung einer Start-Up GmbH
– Natalia Ahmadian 71-137
3. Bewertung der Möglichkeit zur Einführung von Tarifverträgen im deutschen Berufsfußball
– Thomas Büttgenbach 138-190
4. Pflichten und Haftungsrisiken des GmbH-Geschäftsführers bei Compliance-Verstößen
– Naja Keller 191-234
5. Aktienrückkäufe auf dem deutschen Markt nach der Finanzkrise 2008/2009
– Marc Paumer 235-287
6. Will Germany reach its 2030 climate goals in the transportation sector? – An investigation focusing on the new German Emission Trading System
– Axel Plum 288-369