Refine
Year of publication
- 2019 (191) (remove)
Document Type
- Article (94)
- Conference Proceeding (74)
- Part of a Book (15)
- Book (4)
- Doctoral Thesis (3)
- Talk (1)
Language
- English (191) (remove)
Has Fulltext
- no (191) (remove)
Keywords
- Enterprise Architecture (2)
- Seismic design (2)
- Achilles tendon (1)
- Advanced driver assistance systems (ADAS/AD) (1)
- Aircraft design (1)
- Analytics (1)
- Architectural gear ratio (1)
- Assistive technology (1)
- Automatic control (1)
- BEV (1)
- Bioeconomy (1)
- Biorefinery definitions (1)
- Case Study (1)
- Change Management (1)
- Combustion (1)
- Components (1)
- Corporate Culture (1)
- Correlations (1)
- Decentral (1)
- Design examples (1)
Institute
- Fachbereich Medizintechnik und Technomathematik (62)
- IfB - Institut für Bioengineering (40)
- Fachbereich Luft- und Raumfahrttechnik (37)
- Fachbereich Elektrotechnik und Informationstechnik (30)
- Fachbereich Energietechnik (19)
- INB - Institut für Nano- und Biotechnologien (19)
- Fachbereich Maschinenbau und Mechatronik (16)
- Fachbereich Chemie und Biotechnologie (12)
- Fachbereich Bauingenieurwesen (8)
- MASKOR Institut für Mobile Autonome Systeme und Kognitive Robotik (8)
- Solar-Institut Jülich (6)
- Fachbereich Wirtschaftswissenschaften (3)
- ECSM European Center for Sustainable Mobility (2)
- Fachbereich Gestaltung (2)
- Nowum-Energy (2)
- Institut fuer Angewandte Polymerchemie (1)
Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich).
The increasing complexity of Advanced Driver Assistance Systems (ADAS) presents a challenging task to validate safe and reliable performance of these systems under varied conditions. The test and validation of ADAS/AD with real test drives, although important, involves huge costs and time. Simulation tools provide an alternative with the added advantage of reproducibility but often use ideal sensors, which do not reflect real sensor output accurately. This paper presents a new validation methodology using fault injection, as recommended by the ISO 26262 standard, to test software and system robustness. In our work, we investigated and developed a tool capable of inserting faults at different software and system levels to verify its robustness. The scope of this paper is to cover the fault injection test for the Visteon’s DriveCore™ system, a centralized domain controller for Autonomous driving which is sensor agnostic and SoC agnostic. With this new approach, the validation of safety monitoring functionality and its behavior can be tested using real-world data instead of synthetic data from simulation tools resulting in having better confidence in system performance before proceeding with in-vehicle testing.