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On the basis of bivariate data, assumed to be observations of independent copies of a random vector (S,N), we consider testing the hypothesis that the distribution of (S,N) belongs to the parametric class of distributions that arise with the compound Poisson exponential model. Typically, this model is used in stochastic hydrology, with N as the number of raindays, and S as total rainfall amount during a certain time period, or in actuarial science, with N as the number of losses, and S as total loss expenditure during a certain time period. The compound Poisson exponential model is characterized in the way that a specific transform associated with the distribution of (S,N) satisfies a certain differential equation. Mimicking the function part of this equation by substituting the empirical counterparts of the transform we obtain an expression the weighted integral of the square of which is used as test statistic. We deal with two variants of the latter, one of which being invariant under scale transformations of the S-part by fixed positive constants. Critical values are obtained by using a parametric bootstrap procedure. The asymptotic behavior of the tests is discussed. A simulation study demonstrates the performance of the tests in the finite sample case. The procedure is applied to rainfall data and to an actuarial dataset. A multivariate extension is also discussed.
Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here.
This study reviews the practice of brake tests in freight railways, which is time consuming and not suitable to detect certain failure types. Public incident reports are analysed to derive a reasonable brake test hardware and communication architecture, which aims to provide automatic brake tests at lower cost than current solutions. The proposed solutions relies exclusively on brake pipe and brake cylinder pressure sensors, a brake release position switch as well as radio communication via standard protocols. The approach is embedded in the Wagon 4.0 concept, which is a holistic approach to a smart freight wagon. The reduction of manual processes yields a strong incentive due to high savings in manual
labour and increased productivity.
Inhaltsverzeichnis - Bachelorarbeiten
1. The impact of the EU non-financial reporting directive on sustainability reporting practices of DAX 30 companies
- Lene Christin Blöcker 4 - 29
2. Kurzarbeit als Krisenbewältigungsinstrument – Die arbeitsrechtlichen Voraussetzungen für die wirksame Einführung von Kurzarbeit
- Julia Esser 30 - 87
3. Die virtuelle Hauptversammlung der Aktiengesellschaft – Notlösung während der Corona-Pandemie oder dauerhafte Alternative?
- Pauline Hengstebeck 88 - 152
4. Die psychische Gesundheit am Arbeitsplatz – Aktuelle Problematik, Ursachenforschung, Folgen, rechtliche Rahmenbedingungen und geeignete Präventionsmaßnahmen aus Arbeitgebersicht
- Carolin Venrath 153 - 224
Inhaltsverzeichnis – Masterarbeiten
The influence of religion on the representation of women in politics
- Eva Scholtes 225 - 345
Inhaltsverzeichnis - Bachelorarbeiten
1. Testamentsgestaltung bei Patchworkfamilien – Lösungsansätze für typische
Praxisprobleme unter Berücksichtigung der Interessenlagen der Parteien
- Ronja Bundrock 4 - 58
2. Die Haftung des AG-Vorstands gegenüber der Gesellschaft in unterneh-
mensinternen und -externen Krisen
- Nico Kremers 59 - 122
3. The Relationship of the Ex-Ante Uncertainty about the Value of a Stock
and its IPO Underpricing – An Analysis of the German Market
- Lennard Pankok 123 - 179
4. Attractiveness Bias in Venture Capital – An Analysis of Investor Decision
Making in “Die Höhle der Löwen”
- Theresa Maria Weisheit 180 - 242
Inhaltsverzeichnis – Masterarbeiten
Erhöhung der Energieautarkie in der Backbranche – Anwendung von bidi-
rektionalem Laden und dessen Auswirkungen auf die Geschäftsprozesse
und Informationssysteme
- Jasper Spoede 243 - 355
The fourth industrial revolution presents a multitude of challenges for industries, one of which being the increased flexibility required of manufacturing lines as a result of increased consumer demand for individualised products. One solution to tackle this challenge is the digital twin, more specifically the standardised model of a digital twin also known as the asset administration shell. The standardisation of an industry wide communications tool is a critical step in enabling inter-company operations. This paper discusses the current state of asset administration shells, the frameworks used to host them and their problems that need to be addressed. To tackle these issues, we propose an event-based server capable of drastically reducing response times between assets and asset administration shells and a multi-agent system used for the orchestration and deployment of the shells in the field.
aco : eine digitale Anwendung zur Verbesserung der Lebensqualität
von Neurodermitis-Patient:innen
(2022)
Neurodermitis hat in den letzten Jahrzehnten deutlich zugenommen. Etwa 10 bis 15 Prozent der Kinder und 2,5 bis 3,5 Prozent der Erwachsenen sind davon betroffen. Für sie stellen Auswirkungen der Hautkrankheit auf Körper und Psyche eine enorme Einschränkung der Lebensqualität dar.
Die App „aco“ möchte Neurodermitis-Patient:Innen dabei unterstützen, ihre Behandlung selbst in die Hand zu nehmen. Eine ganzheitliche Therapie umfasst eben nicht nur Fachpersonen, sondern auch Patient:Innen selbst. Durch eine regelmäßige Dokumentation ermöglicht die Anwendung eine aktive Auseinandersetzung mit der Krankheit. Triggerfaktoren werden ausgewertet und es wird Wissen über Behandlungsmöglichkeiten vermittelt. Zudem wird ein Austausch ermöglicht, der emotionale und praktische Unterstützung bieten soll. Damit möchte „aco“ Betroffenen eine Möglichkeit geben, das Ruder selbst in die Hand zu nehmen und leistet damit einen wichtigen Beitrag zur Therapie von Neurodermitis.
Wo einst fast lückenlos Laubwälder wuchsen, steht heute nur noch ein Drittel der ursprünglichen Waldfläche. Echte Urwälder gibt es hier schon lange nicht mehr: Die Rede ist vom deutschen Wald.
Unsere Welt ist im Wandel. Auch in unseren heimischen Wäldern lassen sich die Einflüsse von Mensch und Klimawandel auf die Biodiversität beobachten.
Die illustrierte Publikation „Adapt or die“ lädt mit mehr als 80 großformatigen Artenportraits, Habitat-Kartierungen und gestalteten Themenklappenseiten zur Auseinandersetzung mit dem Wandel unserer heimischen Wälder ein. Dabei sensibilisiert sie für einen bewussteren Umgang mit Umwelt und Natur. Erweiterungen durch Augmented Reality bieten vereinzelt neben dem Printprodukt aktualisierbare Prognosen, digital und ressourcenschonend.
Das komplexe Ökosystem des Waldes reagiert empfindlich auf Veränderungen: Wer sich nicht anpassen kann, wird verschwinden.
Sleep spindles are neurophysiological phenomena that appear to be linked to memory formation and other functions of the central nervous system, and that can be observed in electroencephalographic recordings (EEG) during sleep. Manually identified spindle annotations in EEG recordings suffer from substantial intra- and inter-rater variability, even if raters have been highly trained, which reduces the reliability of spindle measures as a research and diagnostic tool. The Massive Online Data Annotation (MODA) project has recently addressed this problem by forming a consensus from multiple such rating experts, thus providing a corpus of spindle annotations of enhanced quality. Based on this dataset, we present a U-Net-type deep neural network model to automatically detect sleep spindles. Our model’s performance exceeds that of the state-of-the-art detector and of most experts in the MODA dataset. We observed improved detection accuracy in subjects of all ages, including older individuals whose spindles are particularly challenging to detect reliably. Our results underline the potential of automated methods to do repetitive cumbersome tasks with super-human performance.