Article
Refine
Year of publication
- 2007 (92) (remove)
Institute
- Fachbereich Medizintechnik und Technomathematik (36)
- Fachbereich Elektrotechnik und Informationstechnik (21)
- IfB - Institut für Bioengineering (19)
- INB - Institut für Nano- und Biotechnologien (15)
- Fachbereich Luft- und Raumfahrttechnik (13)
- Fachbereich Chemie und Biotechnologie (12)
- Fachbereich Wirtschaftswissenschaften (5)
- Fachbereich Energietechnik (4)
- Solar-Institut Jülich (2)
- Fachbereich Maschinenbau und Mechatronik (1)
Has Fulltext
- no (92) (remove)
Language
- English (92) (remove)
Document Type
- Article (92) (remove)
Keywords
- debris flow (1)
Detecting synchronization clusters in multivariate time series via coarse-graining of Markov chains
(2007)
Mannoheptulose is a seven-carbon sugar. It is an inhibitor of glucose-induced insulin secretion due to its ability to selectively inhibit the enzyme glucokinase. An improved procedure for mannoheptulose isolation from avocados is described in this study (based upon the original method by La Forge). The study focuses on the combination of biotransformation and downstream processing (preparative chromatography) as an efficient method to produce a pure extract of mannoheptulose. The experiments were divided into two major phases. In the first phase, several methods and parameters were compared to optimize the mannoheptulose extraction with respect to efficiency and purity. In the second phase, a mass balance of mannoheptulose over the whole extraction process was undertaken to estimate the yield and efficiency of the total extraction process. The combination of biotransformation and preparative chromatography allowed the production of a pure mannoheptulose extract. In a biological test, the sugar inhibited the glucokinase enzyme activity efficiently.