Part of a Book
Refine
Year of publication
Institute
- Fachbereich Medizintechnik und Technomathematik (43)
- Fachbereich Elektrotechnik und Informationstechnik (38)
- IfB - Institut für Bioengineering (34)
- Fachbereich Luft- und Raumfahrttechnik (26)
- Fachbereich Energietechnik (25)
- Fachbereich Chemie und Biotechnologie (18)
- Fachbereich Wirtschaftswissenschaften (15)
- Solar-Institut Jülich (11)
- Fachbereich Maschinenbau und Mechatronik (8)
- INB - Institut für Nano- und Biotechnologien (8)
Has Fulltext
- no (195)
Language
- English (195) (remove)
Document Type
- Part of a Book (195) (remove)
Keywords
- Papierkunst (4)
- Wind Tunnel (3)
- Aktionskunst (2)
- Central receiver power plant (2)
- Central receiver system (2)
- Concentrated solar collector (2)
- Concentrated systems (2)
- Engineering optimization (2)
- Flight Test (2)
- Gas turbine (2)
The use of transgenic animal models has transformed our knowledge of complex biochemical pathways in vivo. It has allowed disease processes to be modelled and used in the development of new disease prevention and treatment strategies. They can also be used to define cell- and tissue-specific pathways of gene regulation. A further major application is in the area of preclinical development where such models can be used to define pathways of chemical toxicity, and the pathways that regulate drug disposition. One major application of this approach is the humanisation of mice for the proteins that control drug metabolism and disposition. Such models can have numerous applications in the development of drugs and in their more sophisticated use in the clinic.
Changes in intestinal microflora in rats induced by oral exposure to low lead (II) concentrations
(2015)
Rugged terrain robot designs are important for field robotics missions. A number of commercial platforms are available, however, at an impressive price. In this paper, we describe the hardware and software component of a low-cost wheeled rugged-terrain robot. The robot is based on an electric children quad bike and is modified to be driven by wire. In terms of climbing properties, operation time and payload it can compete with some of the commercially available platforms, but at a far lower price.
We present an electromechanically coupled Finite Element model for cardiac tissue. It bases on the mechanical model for cardiac tissue of Hunter et al. that we couple to the McAllister-Noble-Tsien electrophysiological model of purkinje fibre cells. The corresponding system of ordinary differential equations is implemented on the level of the constitutive equations in a geometrically and physically nonlinear version of the so-called edge-based smoothed FEM for plates. Mechanical material parameters are determined from our own pressure-deflection experimental setup. The main purpose of the model is to further examine the experimental results not only on mechanical but also on electrophysiological level down to ion channel gates. Moreover, we present first drug treatment simulations and validate the model with respect to the experiments.
Hydraulic modeling is the classical approach to investigate and describe complex fluid motion. Many empirical formulas in the literature used for the hydraulic design of river training measures and structures have been developed using experimental data from the laboratory. Although computer capacities have increased to a high level which allows to run complex numerical simulations on standard workstation nowadays, non-standard design of structures may still raise the need to perform physical model investigations. These investigations deliver insight into details of flow patterns and the effect of varying boundary conditions. Data from hydraulic model tests may be used for calibration of numerical models as well. As the field of hydraulic modeling is very complex, this chapter intends to give a short overview on capacities and limits of hydraulic modeling in regard to river flows and hydraulic structures only. The reader shall get a first idea of modeling principles and basic considerations. More detailed information can be found in the references.