Refine
Year of publication
Document Type
- Article (5586)
- Conference Proceeding (1620)
- Book (1078)
- Part of a Book (548)
- Bachelor Thesis (297)
- Patent (172)
- Report (100)
- Doctoral Thesis (78)
- Other (77)
- Administrative publication (76)
- Part of Periodical (63)
- Lecture (30)
- Master's Thesis (20)
- Contribution to a Periodical (19)
- Review (17)
- Diploma Thesis (15)
- Working Paper (13)
- Course Material (9)
- Talk (7)
- Study Thesis (5)
Language
- German (5012)
- English (4801)
- Russian (14)
- Portuguese (6)
- Multiple languages (5)
- Spanish (3)
- nld (2)
- Italien (1)
Keywords
- Amtliche Mitteilung (71)
- Bachelor (33)
- Aachen University of Applied Sciences (31)
- Master (31)
- Prüfungsordnung (31)
- Bauingenieurwesen (30)
- Lesbare Fassung (28)
- Biosensor (25)
- Fachhochschule Aachen (23)
- Illustration (21)
- Studien- und Prüfungsordnung (21)
- Aachen / Fachhochschule Aachen (20)
- Änderungsordnung (20)
- Blitzschutz (18)
- Corporate Design (17)
- Elektromobilität (17)
- CAD (16)
- Finite-Elemente-Methode (16)
- Fotografie (16)
- civil engineering (14)
Institute
- Fachbereich Medizintechnik und Technomathematik (2052)
- Fachbereich Elektrotechnik und Informationstechnik (1150)
- Fachbereich Wirtschaftswissenschaften (1138)
- Fachbereich Energietechnik (1104)
- Fachbereich Maschinenbau und Mechatronik (866)
- Fachbereich Chemie und Biotechnologie (847)
- Fachbereich Luft- und Raumfahrttechnik (776)
- Fachbereich Bauingenieurwesen (705)
- IfB - Institut für Bioengineering (686)
- INB - Institut für Nano- und Biotechnologien (613)
- Fachbereich Gestaltung (484)
- Solar-Institut Jülich (339)
- Fachbereich Architektur (174)
- FH Aachen (153)
- ECSM European Center for Sustainable Mobility (112)
- ZHQ - Bereich Hochschuldidaktik und Evaluation (74)
- MASKOR Institut für Mobile Autonome Systeme und Kognitive Robotik (71)
- Nowum-Energy (70)
- Institut fuer Angewandte Polymerchemie (32)
- Sonstiges (24)
NMR standardization approach that uses the 2H integral of deuterated solvent for quantitative multinuclear analysis of pharmaceuticals is described. As a proof of principle, the existing NMR procedure for the analysis of heparin products according to US Pharmacopeia monograph is extended to the determination of Na+ and Cl- content in this matrix. Quantification is performed based on the ratio of a 23Na (35Cl) NMR integral and 2H NMR signal of deuterated solvent, D2O, acquired using the specific spectrometer hardware. As an alternative, the possibility of 133Cs standardization using the addition of Cs2CO3 stock solution is shown. Validation characteristics (linearity, repeatability, sensitivity) are evaluated. A holistic NMR profiling of heparin products can now also be used for the quantitative determination of inorganic compounds in a single analytical run using a single sample. In general, the new standardization methodology provides an appealing alternative for the NMR screening of inorganic and organic components in pharmaceutical products.
Although several successful applications of benchtop nuclear magnetic resonance (NMR) spectroscopy in quantitative mixture analysis exist, the possibility of calibration transfer remains mostly unexplored, especially between high- and low-field NMR. This study investigates for the first time the calibration transfer of partial least squares regressions [weight average molecular weight (Mw) of lignin] between high-field (600 MHz) NMR and benchtop NMR devices (43 and 60 MHz). For the transfer, piecewise direct standardization, calibration transfer based on canonical correlation analysis, and transfer via the extreme learning machine auto-encoder method are employed. Despite the immense resolution difference between high-field and low-field NMR instruments, the results demonstrate that the calibration transfer from high- to low-field is feasible in the case of a physical property, namely, the molecular weight, achieving validation errors close to the original calibration (down to only 1.2 times higher root mean square errors). These results introduce new perspectives for applications of benchtop NMR, in which existing calibrations from expensive high-field instruments can be transferred to cheaper benchtop instruments to economize.
The continuing growth of scientific publications raises the question how research processes can be digitalized and thus realized more productively. Especially in information technology fields, research practice is characterized by a rapidly growing volume of publications. For the search process various information systems exist. However, the analysis of the published content is still a highly manual task. Therefore, we propose a text analytics system that allows a fully digitalized analysis of literature sources. We have realized a prototype by using EBSCO Discovery Service in combination with IBM Watson Explorer and demonstrated the results in real-life research projects. Potential addressees are research institutions, consulting firms, and decision-makers in politics and business practice.
The initial idea of Robotic Process Automation (RPA) is the automation of business processes through the presentation layer of existing application systems. For this simple emulation of user input and output by software robots, no changes of the systems and architecture is required. However, considering strategic aspects of aligning business and technology on an enterprise level as well as the growing capabilities of RPA driven by artificial intelligence, interrelations between RPA and Enterprise Architecture (EA) become visible and pose new questions. In this paper we discuss the relationship between RPA and EA in terms of perspectives and implications. As workin- progress we focus on identifying new questions and research opportunities related to RPA and EA.
The initial idea of Robotic Process Automation (RPA) is the automation of business processes through a simple emulation of user input and output by software robots. Hence, it can be assumed that no changes of the used software systems and existing Enterprise Architecture (EA) is
required. In this short, practical paper we discuss this assumption based on a real-life implementation project. We show that a successful RPA implementation might require architectural work during analysis, implementation, and migration. As practical paper we focus on exemplary lessons-learned and new questions related to RPA and EA.
Digital twins enable the modeling and simulation of real-world entities
(objects, processes or systems), resulting in improvements in the associated value
chains. The emerging field of quantum computing holds tremendous promise for
evolving this virtualization towards Quantum (Digital) Twins (QDT) and
ultimately Quantum Twins (QT). The quantum (digital) twin concept is not a
contradiction in terms - but instead describes a hybrid approach that can be
implemented using the technologies available today by combining classical
computing and digital twin concepts with quantum processing. This paper
presents the status quo of research and practice on quantum (digital) twins. It also
discuses their potential to create competitive advantage through real-time
simulation of highly complex, interconnected entities that helps companies better
address changes in their environment and differentiate their products and
services.
Das Gesundheitswesen ist konfrontiert mit steigenden Kosten und einer immer schwieriger werdenden Personalsituation. Zeitgleich versprechen moderne Sprachsteuerungssysteme Prozesse in Arztpraxen und Krankenhäusern zu verschlanken und Vorgänge zu beschleunigen. Dennoch wird derzeit der Einsatz von Sprachsteuerungssystemen in Arztpraxen oder Krankenhäusern nur selten beobachtet, was auch an den besonders strengen Datenschutzauflagen der Datenschutzgrundverordnung (DSGVO) liegt. Darüber hinaus wirft die niedrige Nutzungsrate die Frage nach den konkreten Anforderungen und ihrer Umsetzbarkeit auf, was durch den vorliegenden Beitrag adressiert wird, indem die Ergebnisse von Interviews mit acht medizinischen Fachexperten ausgewertet werden. Ergänzend wird die technische Umsetzbarkeit einzelner Anforderungen mit unterschiedlichen Cloud-Anbietern erprobt.
We study the possibility to fabricate an arbitrary phase mask in a one-step laser-writing process inside the volume of an optical glass substrate. We derive the phase mask from a Gerchberg–Saxton-type algorithm as an array and create each individual phase shift using a refractive index modification of variable axial length. We realize the variable axial length by superimposing refractive index modifications induced by an ultra-short pulsed laser at different focusing depth. Each single modification is created by applying 1000 pulses with 15 μJ pulse energy at 100 kHz to a fixed spot of 25 μm diameter and the focus is then shifted axially in steps of 10 μm. With several proof-of-principle examples, we show the feasibility of our method. In particular, we identify the induced refractive index change to about a value of Δn=1.5⋅10−3. We also determine our current limitations by calculating the overlap in the form of a scalar product and we discuss possible future improvements.