Conference Proceeding
Refine
Year of publication
Institute
- Fachbereich Medizintechnik und Technomathematik (210) (remove)
Language
- English (210) (remove)
Document Type
- Conference Proceeding (210) (remove)
Keywords
- Biosensor (25)
- CAD (7)
- Finite-Elemente-Methode (7)
- civil engineering (7)
- Bauingenieurwesen (6)
- Clusterion (4)
- Limit analysis (4)
- Natural language processing (4)
- Air purification (3)
- Einspielen <Werkstoff> (3)
- Hämoglobin (3)
- Luftreiniger (3)
- Plasmacluster ion technology (3)
- Raumluft (3)
- Shakedown analysis (3)
- Sonde (3)
- shakedown analysis (3)
- Bruchmechanik (2)
- Clustering (2)
- Eisschicht (2)
- Erythrozyt (2)
- FEM (2)
- Information extraction (2)
- Kohlenstofffaser (2)
- Lipopolysaccharide (2)
- Shakedown (2)
- Stickstoffmonoxid (2)
- biosensor (2)
- celldrum technology (2)
- limit analysis (2)
- lipopolysaccharides (2)
- nitric oxide gas (2)
- 3-nitrofluoranthene (1)
- Active learning (1)
- Adsorption (1)
- Agent-based simulation (1)
- Analytischer Zulaessigkeitsnachweis (1)
- Anastomose (1)
- Anastomosis (1)
- Autofluoreszenzverfahren (1)
- BTEX compounds (1)
- Bakterien (1)
- Bio-Sensors (1)
- Biomechanics (1)
- Biomechanik (1)
- Biomedizinische Technik (1)
- Biophoton (1)
- Biosensorik (1)
- Blitzschutz (1)
- CAD ; (1)
- CO (1)
- Chance constrained programming (1)
- Cloud Computing (1)
- Cloud Service Broker (1)
- Conducing polymer (1)
- Dattel (1)
- Deep learning (1)
- Dekontamination (1)
- ECT (1)
- EEG (1)
- EPN (1)
- Einspiel-Analyse (1)
- Einspielanalyse (1)
- Elastodynamik (1)
- Elektrodynamik (1)
- Endothelzelle (1)
- Energy market design (1)
- Evolution of damage (1)
- Exact Ilyushin yield surface (1)
- Extension fracture (1)
- Extension strain criterion (1)
- Festkörper (1)
- Fibroblast (1)
- Finite element method (1)
- First Order Reliabiblity Method (1)
- First-order reliability method (1)
- Fluorescence (1)
- Force (1)
- GaAs hot electron injector (1)
- Gas sensor (1)
- Grid Computing (1)
- Gunn diode (1)
- Heavy metal detection (1)
- High throughput experimentation (1)
- Hotplate (1)
- Hydrodynamik (1)
- Hydrogel (1)
- Hydrogen sensor (1)
- I3S 2005 (1)
- ISFET (1)
- Impedance Spectroscopy (1)
- Information Extraction (1)
- International Symposium on Sensor Science (1)
- Iterative learning control (1)
- Knee (1)
- Körpertemperatur (1)
- LED chip (1)
- Level sensor (1)
- Lichtstreuungsbasierte Instrumente (1)
- Load modeling (1)
- MEMS (1)
- Machine learning (1)
- Main sensitivity (1)
- Market modeling (1)
- Mechanische Beanspruchung (1)
- Microreactors (1)
- Mohr–Coulomb criterion (1)
- Multi-dimensional wave propagation (1)
- Nano Materials (1)
- Nanomaterial (1)
- Nanoparticles (1)
- Nanopartikel (1)
- Nanostructuring (1)
- Nanotechnologie (1)
- Nanotechnology ; Microelectronics ; Biosensors ; Superconductor ; MEMS (1)
- Natriumhypochlorit (1)
- Natural Language Processing (1)
- Natural language understanding (1)
- Nichtlineare Gleichung (1)
- Nichtlineare Optimierung (1)
- Nichtlineare Welle (1)
- Organophosphorus (1)
- Ostazine Orange (1)
- PFM (1)
- Pflanzenphysiologie (1)
- Pflanzenscanner (1)
- Phenylalanine determination (1)
- Potentiometry (1)
- Process model (1)
- Profile Extraction (1)
- Profile extraction (1)
- Proteine (1)
- Pseudomonas putida (1)
- Quartz crystal nanobalance (QCN) (1)
- Quartz micro balances (1)
- Query learning (1)
- Random variable (1)
- Ratcheting (1)
- Reaction-diffusion (1)
- Relation classification (1)
- Reliability of structures (1)
- Reproducible research (1)
- Sensitivity (1)
- Sepsis (1)
- Sleep EEG (1)
- Solid amalgam electrodes (1)
- Stochastic programming (1)
- Supraleiter (1)
- Technische Mechanik (1)
- Text Mining (1)
- Text mining (1)
- Tin oxide (1)
- Tobacco mosaic virus (1)
- Traglast (1)
- Traglastanalyse (1)
- Training (1)
- Trustworthy artificial intelligence (1)
- UML (1)
- Unified Modeling Language (1)
- Wafer (1)
- Wasserbrücke (1)
- Wasserstoffperoxid (1)
- Wellen (1)
- Workflow (1)
- Workflow Orchestration (1)
- acetoin (1)
- activated nanostructured carbon (1)
- aktivierte nanostrukturierte Kohlenstofffaser (1)
- ammonia gas sensors (1)
- amperometric sensor (1)
- antimony doped tin oxide (1)
- autofluorescence-based detection system (1)
- biopotential electrodes (1)
- capacitive field-effect biosensor (1)
- capillary micro-droplet cell (1)
- carcinogens (1)
- catalytic decomposition (1)
- chemical reduction method (1)
- contractile tension (1)
- cross sensitivity (1)
- cytosolic water diffusion (1)
- date palm tree (1)
- design-by-analysis (1)
- doped metal oxide (1)
- doped silicon (1)
- doping (1)
- electrical capacitance tomography (1)
- electro-migration (1)
- electronic noses dendronized polymers inverted mesa technology (1)
- enzymatic methods (1)
- enzyme immobilisation (1)
- enzyme immobilization (1)
- fenitrothion (1)
- finite element analysis (1)
- fluidic (1)
- gas sensor (1)
- gas sensor array (1)
- heater metallisation (1)
- hemoglobin (1)
- hemoglobin dynamics (1)
- high-temperature stability (1)
- humidity (1)
- hydrogel (1)
- hydrogen peroxide (1)
- image sensor (1)
- imaging (1)
- impedance spectroscopy (1)
- ion-selective electrodes (1)
- kontraktile Spannung (1)
- lab-on-a-chip (1)
- lab-on-chip (1)
- layer expansion (1)
- lenslet array (1)
- light scattering analysis (1)
- lightning flash (1)
- limit and shakedown analysis (1)
- limit load (1)
- linear kinematic hardening (1)
- lower bound theorem (1)
- magnetic particles (1)
- material shakedown (1)
- matrix method (1)
- mechanical waves (1)
- metal oxide (1)
- microreactor (1)
- microwave generation (1)
- modeling biosensor (1)
- modelling (1)
- modified electrode (1)
- multi-interface measurement (1)
- nanostructured carbonized plant parts (1)
- nanostrukturierte carbonisierte Pflanzenteile (1)
- nitrogen oxides (1)
- nonlinear kinematic hardening (1)
- nonlinear optimization (1)
- nonlinear solids (1)
- nonlinear tensor constitutive equation (1)
- organic PVC membranes (1)
- pH-based biosensing (1)
- pattern-size reduction (1)
- plant scanner (1)
- plasma generated ions (1)
- polymer composites (1)
- porous Pt electrode (1)
- principal component (1)
- probabilistic fracture mechanics (1)
- protein (1)
- quantum charging (1)
- ratchetting (1)
- reliability (1)
- rhAPC (1)
- screen-printing (1)
- second-order reliability method (1)
- self-aligned patterning (1)
- sensing properties (1)
- sensors (1)
- shakedown (1)
- sterilisation (1)
- subsurface ice research (1)
- subsurface probe (1)
- surface modification (1)
- swift heavy ions (1)
- thick-film technology (1)
- thin-film microsensors (1)
- voltammetry (1)
- wafer-level testing (1)
- water bridge phenomenon (1)
Smoothed Finite Element Methods for Nonlinear Solid Mechanics Problems: 2D and 3D Case Studies
(2016)
The Smoothed Finite Element Method (SFEM) is presented as an edge-based and a facebased techniques for 2D and 3D boundary value problems, respectively. SFEMs avoid shortcomings of the standard Finite Element Method (FEM) with lower order elements such as overly stiff behavior, poor stress solution, and locking effects. Based on the idea of averaging spatially the standard strain field of the FEM over so-called smoothing domains SFEM calculates the stiffness matrix for the same number of degrees of freedom (DOFs) as those of the FEM. However, the SFEMs significantly improve accuracy and convergence even for distorted meshes and/or nearly incompressible materials.
Numerical results of the SFEMs for a cardiac tissue membrane (thin plate inflation) and an artery (tension of 3D tube) show clearly their advantageous properties in improving accuracy particularly for the distorted meshes and avoiding shear locking effects.
The human arm consists of the humerus (upper arm), the medial ulna and the lateral radius (forearm). The joint between the humerus and the ulna is called humeroulnar joint and the joint between the humerus and the radius is called humeroradial joint. Lateral and medial collateral ligaments stabilize the elbow. Statistically, 2.5 out of 10,000 people suffer from radial head fractures [1]. In these fractures the cartilage is often affected. Caused by the injured cartilage, degenerative diseases like posttraumatic arthrosis may occur. The resulting pain and reduced range of motion have an impact on the patient’s quality of life. Until now, there has not been a treatment which allows typical loads in daily life activities and offers good long-term results. A new surgical approach was developed with the motivation to reduce the progress of the posttraumatic arthrosis. Here, the radius is shortened by 3 mm in the proximal part [2]. By this means, the load of the radius is intended to be reduced due to a load shift to the ulna. Since the radius is the most important stabilizer of the elbow it has to be confirmed that the stability is not affected. In the first test (Fig. 1 left), pressure distributions within the humeroulnar and humeroradial joints a native and a shortened radius were measured using resistive pressure sensors (I5076 and I5027, Tekscan, USA). The humerus was loaded axially in a tension testing machine (Z010, Zwick Roell, Germany) in 50 N steps up to 400 N. From the humerus the load is transmitted through both the radius and the ulna into the hand which is fixed on the ground. In the second test (Fig. 1 right), the joint stability was investigated using a digital image correlation system to measure the displacement of the ulna. Here, the humerus is fixed with a desired flexion angle and the unconstrained forearm lies on the ground. A rope connects the load actuator with a hook fixed in the ulna. A guide roller is used so that the rope pulls the ulna horizontally when a tensile load is applied. This creates a moment about the elbow joint with a maximum value of 7.5 Nm. Measurements were performed with varying flexion angles (0°, 30°, 60°, 90°, 120°). For both tests and each measurement, seven specimens were used. Student ́s t-test was employed to determine whether the mean values of the measurements in native specimen and operated specimens differ significantly.
The structure of the female pelvic floor (PF) is an inter-related system of bony pelvis,muscles, pelvic organs, fascias, ligaments, and nerves with multiple functions. Mechanically, thepelvic organ support system are of two types: (I) supporting system of the levator ani (LA) muscle,and (II) the suspension system of the endopelvic fascia condensation [1], [2]. Significantdenervation injury to the pelvic musculature, depolimerization of the collagen fibrils of the softvaginal hammock, cervical ring and ligaments during pregnancy and vaginal delivery weakens thenormal functions of the pelvic floor. Pelvic organ prolapse, incontinence, sexual dysfunction aresome of the dysfunctions which increases progressively with age and menopause due toweakened support system according to the Integral theory [3]. An improved 3D finite elementmodel of the female pelvic floor as shown in Fig. 1 is constructed that: (I) considers the realisticsupport of the organs to the pelvic side walls, (II) employs the improvement of our previous FEmodel [4], [5] along with the patient based geometries, (III) incorporates the realistic anatomy andboundary conditions of the endopelvic (pubocervical and rectovaginal) fascia, and (IV) considersvarying stiffness of the endopelvic fascia in the craniocaudal direction [3]. Several computationsare carried out on the presented computational model with healthy and damaged supportingtissues, and comparisons are made to understand the physiopathology of the female PF disorders.
Label-free sensing of biomolecules by their intrinsic molecular charge using field-effect devices
(2015)
Light-stimulated hydrogel actuators with incorporated graphene oxide for microfluidic applications
(2015)
Heavy metal detection with semiconductor devices based on PLD-prepared chalcogenide glass thin films
(2007)
DNA-hybridization detection using light-addressable potentiometric sensor modified with gold layer
(2014)
Multi-parameter detection for supporting monitoring and control of biogas processes in agriculture
(2014)
A 3D finite element model of the female pelvic floor for the reconstruction of urinary incontinence
(2014)
Design and implementation aspects of a 3D reconstruction algorithm for the Jülich TierPET system
(1997)
An application of a scanning light-addressable potentiometric sensor for label-free DNA detection
(2013)
Effectiveness of the edge-based smoothed finite element method applied to soft biological tissues
(2012)
The interest in PET detectors with monolithic block scintillators is growing. In order to obtain high spatial resolutions dedicated positioning algorithms are required. But even an ideal algorithm can only deliver information which is provided by the detector. In this simulation study we investigated the light distribution on one surface of cuboid LSO scintillators of different size. Scintillators with a large aspect ratio (small footprint and large height) showed significant position information only for a minimum interaction depth of the gamma particle. The results allow a quantitative estimate for a useful aspect ratio.
An increasing number of applications target their executions on specific hardware like general purpose Graphics Processing Units. Some Cloud Computing providers offer this specific hardware so that organizations can rent such resources. However, outsourcing the whole application to the Cloud causes avoidable costs if only some parts of the application benefit from the specific expensive hardware. A partial execution of applications in the Cloud is a tradeoff between costs and efficiency. This paper addresses the demand for a consistent framework that allows for a mixture of on- and off-premise calculations by migrating only specific parts to a Cloud. It uses the concept of workflows to present how individual workflow tasks can be migrated to the Cloud whereas the remaining tasks are executed on-premise.
Recently, the SHARP Corporation, Japan, has developed the world’s first "Plasma Cluster Ions (PCI)" air purification technology using plasma discharge to generate cluster ions. The new plasma cluster device releases positive and negative ions into the air, which are able to decompose and deactivate harmful airborne substances by chemical reactions. Because cluster ions consist of positive and negative ions that normally exist in the natural world, they are completely harmless and safe to humans. The amount of ozone generated by cluster ions is less than 0.01 ppm, which is significantly less than the 0.05-ppm standard for industrial operations and consumer electronics. This amount, thus, has no harming effects whatsoever on the human body. But particular properties and chemical processes in PCI treatment are still under study. It has been shown that PCI in most cases show strongly pronounced irreversible killing effects in respect of airborne microflora due to free-radical induced reactions and can be considered as a potent technology to disinfect both home, medical and industrial appliances.
Summary and Conclusions PCIs were clearly effective in terms of their antibacterial effects with the strains tested. This efficacy increased with the time the bacteries were exposed to PCIs. The bactericidal action has proved to be irreversible. PCIs were significantly less effective in shadowed areas. PCI exposure caused multiple protein damages as observed in SDS PAGE studies. There was no single but multiple molecular mechanism causing the bacterial death.
Recently, SHARP corporation has developed the world’s first “Plasma Cluster Ions (PCI)” air purification technology, which uses plasma discharge to generate cluster ions. The new plasma cluster device releases into the air positive and negative ions, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. A lot of phenomenological tests of the PCI air purification technology on microbial cells have been conducted. And, in most cases, it has been shown that PCI demonstrate strongly pronounced killing effect. Although, the particular mechanisms of PCI action are still not evident. We studied variations in resistance to PCI among gram-positive airborne microorganisms, as well as some dose-dependent, spatial, cultural and biochemical properties of PCI action in respect of Staphylococcus spp, Enterococcus spp, Micrococcus spp.
Recently, SHARP corporation has developed the world’s first "Plasma Cluster Ions® (PCI)" air purification technology, which uses plasma discharge to generate cluster ions. The new Plasma Cluster Device releases positive and negative ions into the air, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. In the past, phenomenological tests on the efficacy of the PCI air purification technology on microbial cells have been conducted. In most cases, it has been shown that PCI demonstrated strongly pronounced killing effects on microorganisms. However, the particular mechanisms of PCI action still have to be uncovered.
Mechanical stimulation of the cells resulted in evident changes in the cell morphology, protein composition and gene expression. Microscopically, additional formation of stress fibers accompanied by cell re-arrangements in a monolayer was observed. Also, significant activation of p53 gene was revealed as compared to control. Interestingly, the use of CellTech membrane coating induced cell death after mechanical stress had been applied. Such an effect was not detected when fibronectin had been used as an adhesion substrate.
The sorption of LPS toxic shock by nanoparticles on base of carbonized vegetable raw materials
(2008)
Immobilization of lactobacillus on high temperature carbonizated vegetable raw material (rice husk, grape stones) increases their physiological activity and the quantity of the antibacterial metabolits, that consequently lead to increase of the antagonistic activity of lactobacillus. It is implies that the use of the nanosorbents for the attachment of the probiotical microorganisms are highly perspective for decision the important problems, such as the probiotical preparations delivery to the right address and their attachment to intestines mucosa with the following detoxication of gastro-intestinal tract and the normalization of it’s microecology. Besides that, thus, the received carbonizated nanoparticles have peculiar properties – ability to sorption of LPS toxical shock and, hence, to the detoxication of LPS.
A melting probe equipped with autofluorescence-based detection system combined with a light scattering unit, and, optionally, with a microarray chip would be ideally suited to probe icy environments like Europa’s ice layer as well as the polar ice layers of Earth and Mars for recent and extinct live.
As a deduction from these results, we can conclude that proteins mainly in vitro, denaturate totally at a temperature between 57°C -62°C, and they also affected by NO and different ions types. In which mainly, NO cause earlier protein denaturation, which means that, NO has a destabilizing effect on proteins, and also different ions will alter the protein denaturation in which, some ions will cause earlier protein denaturation while others not.
The absence of a general method for endotoxin removal from liquid interfaces gives an opportunity to find new methods and materials to overcome this gap. Activated nanostructured carbon is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study is to find the adsorption rates for a carboneous material produced at different temperatures, as well as to reveal possible differences between the performance of the material for each of the adsorbates used during the study (hemoglobin, serum albumin and lipopolysaccharide, LPS).
One of interesting but not well known water properties is related to appearance of highly ordered structures in response to strong electrical field. In 1893 Sir William Armstrong placed a cotton thread between two wine glasses filled with chemically pure water. When high DC voltage was applied between the glasses, a connection consisting of water formed, producing a "water bridge"
We present the novel concept of a combined drilling and melting probe for subsurface ice research. This probe, named “IceMole”, is currently developed, built, and tested at the FH Aachen University of Applied Sciences’ Astronautical Laboratory. Here, we describe its first prototype design and report the results of its field tests on the Swiss Morteratsch glacier. Although the IceMole design is currently adapted to terrestrial glaciers and ice shields, it may later be modified for the subsurface in-situ investigation of extraterrestrial ice, e.g., on Mars, Europa, and Enceladus. If life exists on those bodies, it may be present in the ice (as life can also be found in the deep ice of Earth).
Tests with palm tree leaves have just started yet and scan data are in the process to be analyzed. The final goal of future project for palm tree gender and species recognition will be to develop optical scanning technology to be applied to date palm tree leaves for in–situ screening purposes. Depending on the software used and the particular requirements of the users the technology potentially shall be able to identify palm tree diseases, palm tree gender, and species of young date palm trees by scanning leaves.
Proceedings of the 2nd Humboldt Kolleg, Hammamet, Tunisia Organizer: Alexander von Humboldt Stiftung, Germany. pdf 184 p. Welcome Address Dear Participants, Welcome to the 2nd Humboldt Kolleg in “Nanoscale Science and Technology” (NS&T’12) in Tunisia, sponsored by the "Alexander von Humboldt" foundation. The NS&T’12 multidisciplinary scientific program includes seven "hot" topics dealing with "Nanoscale Science and Technology" covering basic and application-oriented research as well as industrial (market) aspects: - Molecular Biophyics, Spectroscopy Techniques, Imaging Microscopy - Nanomaterials Synthesis for Medicine and Bio-chemical Sensors - Nanostructures, Semiconductors, Photonics and Nanodevices - New Technologies in Market Industry - Environment, Electro-chemistry, Bio-polymers and Fuel Cells - Nanomaterials, Photovoltaic, Modelling, Quantum Physics - Microelectronics, Sensors Networks and Embedded Systems We are deeply indebted to all members of the Scientific Committee and General Chairs for joint Sessions and to all speakers and chairmen, who have dedicated invaluable time and efforts for the realization of this event. On behalf of the Organizing Committee, we are cordially inviting you to join the conference and hope that your stay will be fruitful, rewarding and enjoyable. Prof. Dr. Michael J. Schöning, Prof. Dr. Adnane Abdelghani
Summary: This paper presents a methodology to study and understand the mechanics of stapled anastomotic behaviors by combining empirical experimentation and finite element analysis. Performance of stapled anastomosis is studied in terms of leakage and numerical results which are compared to in vitro experiments performed on fresh porcine tissue. Results suggest that leaks occur between the tissue and staple legs penetrating through the tissue.
In: Proc. of the 11th Intl. Conf. on Computing in Civil and Building Engineering (ICCCBE-XI) ed. Hugues Rivard, Montreal, Canada, Seite 1-12, ACSE (CD-ROM), 2006 Currently, the conceptual design phase is not adequately supported by any CAD tool. Neither the support while elaborating conceptual sketches, nor the automatic proof of correctness with respect to effective restrictions is currently provided by any commercial tool. To enable domain experts to store the common as well as their personal domain knowledge, we develop a visual language for knowledge formalization. In this paper, a major extension to the already existing concepts is introduced. The possibility to define rule dependencies extends the expressiveness of the knowledge definition language and contributes to the usability of our approach.
Proc. of the 2005 ASCE Intl. Conf. on Computing in Civil Engineering (ICCC 2005) eds. L. Soibelman und F. Pena-Mora, Seite 1-14, ASCE (CD-ROM), Cancun, Mexico, 2005 Current CAD tools are not able to support the fundamental conceptual design phase, and none of them provides consistency analyses of sketches produced by architects. To give architects a greater support at the conceptual design phase, we develop a CAD tool for conceptual design and a knowledge specification tool allowing the definition of conceptually relevant knowledge. The knowledge is specific to one class of buildings and can be reused. Based on a dynamic knowledge model, different types of design rules formalize the knowledge in a graph-based realization. An expressive visual language provides a user-friendly, human readable representation. Finally, consistency analyses enable conceptual designs to be checked against this defined knowledge. In this paper we concentrate on the knowledge specification part of our project.
In: Computer Aided Architectural Design Futures 2005 2005, Part 4, 207-216, DOI: http://dx.doi.org/10.1007/1-4020-3698-1_19 The conceptual design at the beginning of the building construction process is essential for the success of a building project. Even if some CAD tools allow elaborating conceptual sketches, they rather focus on the shape of the building elements and not on their functionality. We introduce semantic roomobjects and roomlinks, by way of example to the CAD tool ArchiCAD. These extensions provide a basis for specifying the organisation and functionality of a building and free architects being forced to directly produce detailed constructive sketches. Furthermore, we introduce consistency analyses of the conceptual sketch, based on an ontology containing conceptual relevant knowledge, specific to one class of buildings.
IASSE-2004 - 13th International Conference on Intelligent and Adaptive Systems and Software Engineering eds. W. Dosch, N. Debnath, pp. 245-250, ISCA, Cary, NC, 1-3 July 2004, Nice, France We introduce a UML-based model for conceptual design support in civil engineering. Therefore, we identify required extensions to standard UML. Class diagrams are used for elaborating building typespecific knowledge: Object diagrams, implicitly contained in the architect’s sketch, are validated against the defined knowledge. To enable the use of industrial, domain-specific tools, we provide an integrated conceptual design extension. The developed tool support is based on graph rewriting. With our approach architects are enabled to deal with semantic objects during early design phase, assisted by incremental consistency checks.
In: Net-distributed Co-operation : Xth International Conference on Computing in Civil and Building Engineering, Weimar, June 02 - 04, 2004 ; proceedings / [ed. by Karl Beuke ...] . - Weimar: Bauhaus-Univ. Weimar 2004. - 1. Aufl. . Seite 1-14 ISBN 3-86068-213-X International Conference on Computing in Civil and Building Engineering <10, 2004, Weimar> Summary In our project, we develop new tools for the conceptual design phase. During conceptual design, the coarse functionality and organization of a building is more important than a detailed worked out construction. We identify two roles, first the knowledge engineer who is responsible for knowledge definition and maintenance; second the architect who elaborates the conceptual de-sign. The tool for the knowledge engineer is based on graph technology, it is specified using PROGRES and the UPGRADE framework. The tools for the architect are integrated to the in-dustrial CAD tool ArchiCAD. Consistency between knowledge and conceptual design is en-sured by the constraint checker, another extension to ArchiCAD.