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Miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge favor the semiconductor field-effect platform as one of the most attractive approaches for the development of label-free DNA chips. In this work, a capacitive field-effect EIS (electrolyte–insulator–semiconductor) sensor covered with a layer-by-layer prepared, positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)) was used for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization. The negatively charged probe single-stranded DNA (ssDNA) molecules were electrostatically adsorbed onto the positively charged PAH layer, resulting in a preferentially flat orientation of the ssDNA molecules within the Debye length, thus yielding a reduced charge-screening effect and a higher sensor signal. Each sensor-surface modification step (PAH adsorption, probe ssDNA immobilization, hybridization with complementary target DNA (cDNA), reducing an unspecific adsorption by a blocking agent, incubation with noncomplementary DNA (ncDNA) solution) was monitored by means of capacitance–voltage and constant-capacitance measurements. In addition, the surface morphology of the PAH layer was studied by atomic force microscopy and contact-angle measurements. High hybridization signals of 34 and 43 mV were recorded in low-ionic strength solutions of 10 and 1 mM, respectively. In contrast, a small signal of 4 mV was recorded in the case of unspecific adsorption of fully mismatched ncDNA. The density of probe ssDNA and dsDNA molecules as well as the hybridization efficiency was estimated using the experimentally measured DNA immobilization and hybridization signals and a simplified double-layer capacitor model. The results of field-effect experiments were supported by fluorescence measurements, verifying the DNA-immobilization and hybridization event.
Capacitive field-effect electrolyte-insulator-semiconductor sensors consisting of an Al-p-Si-SiO2 structure have been used for the electrical detection of unlabelled single- and double-stranded DNA (dsDNA) molecules by their intrinsic charge. A simple functionalization protocol based on the layer-by-layer (LbL) technique was used to prepare a weak polyelectrolyte/probe-DNA bilayer, followed by the hybridization with complementary target DNA molecules. Due to the flat orientation of the LbL-adsorbed DNA molecules, a high sensor signal has been achieved. In addition, direct label-free detection of in-solution hybridized dsDNA molecules has been studied.
Light-stimulated hydrogel actuators with incorporated graphene oxide for microfluidic applications
(2015)
Poly(N-isopropylacrylamide) (PNIPAAm) hydrogel films with incorporated graphene oxide (GO) were developed and tested as light-stimulated actuators. GO dispersions were synthesized via Hummers method and characterized toward their optical properties and photothermal energy conversion. The hydrogels were prepared by means of photopolymerization. In addition, the influence of GO within the hydrogel network on the lower critical solution temperature (LCST) was investigated by differential scanning calorimetry (DSC). The optical absorbance and the response to illumination were determined as a function of GO concentration for thin hydrogel films. A proof of principle for the stimulation with light was performed.
The Scarab Project
(2015)
Urban Search and Rescue (USAR) is an active research
field in the robotics community. Despite recent advances
for many open research questions, these kind of systems are
not widely used in real rescue missions. One reason is that such
systems are complex and not (yet) very reliable; another is that
one has to be an robotic expert to run such a system. Moreover,
available rescue robots are very expensive and the benefits of
using them are still limited.
In this paper, we present the Scarab robot, an alternative
design for a USAR robot. The robot is light weight, humanpackable
and its primary purpose is that of extending the
rescuer’s capability to sense the disaster site. The idea is that a
responder throws the robot to a certain spot. The robot survives
the impact with the ground and relays sensor data such as
camera images or thermal images to the responder’s hand-held
control unit from which the robot can be remotely controlled.
Abfallwirtschaft
(2015)
Abfallwirtschaft
(2015)
Data-driven prediction and prevention of extreme events in a spatially extended excitable system
(2015)
Let X₁,…,Xₙ be independent and identically distributed random variables with distribution F. Assuming that there are measurable functions f:R²→R and g:R²→R characterizing a family F of distributions on the Borel sets of R in the way that the random variables f(X₁,X₂),g(X₁,X₂) are independent, if and only if F∈F, we propose to treat the testing problem H:F∈F,K:F∉F by applying a consistent nonparametric independence test to the bivariate sample variables (f(Xᵢ,Xⱼ),g(Xᵢ,Xⱼ)),1⩽i,j⩽n,i≠j. A parametric bootstrap procedure needed to get critical values is shown to work. The consistency of the test is discussed. The power performance of the procedure is compared with that of the classical tests of Kolmogorov–Smirnov and Cramér–von Mises in the special cases where F is the family of gamma distributions or the family of inverse Gaussian distributions.
A multi-functional device applying for the safe maintenance at high-altitude on wind turbines
(2015)
Cheap does not imply cost-effective -- this is rule number one of zeitgeisty system design. The initial investment accounts only for a small portion of the lifecycle costs of a technical system. In fluid systems, about ninety percent of the total costs are caused by other factors like power consumption and maintenance. With modern optimization methods, it is already possible to plan an optimal technical system considering multiple objectives. In this paper, we focus on an often neglected contribution to the lifecycle costs: downtime costs due to spontaneous failures. Consequently, availability becomes an issue.
Simulation model for the transient process behaviour of solar aluminium recycling in a rotary kiln
(2015)
For several thousand years, biotechnology and its associated technical processes have had a great impact on the development of mankind. Based on empirical methods, in particular for the production of foodstuffs and daily commodities, these disciplines have become one of the most innovative future issues. Due to the increasing detailed understanding of cellular processes, production strains can now be optimized. In combination with modern bioprocesses, a variety of bulk and fine chemicals as well as pharmaceuticals can be produced efficiently. In this article, some of the current trends in biotechnology are discussed.
Inhalt
07 Der Stoff, aus dem die Träume sind | Modedesigner, Fotograf, Künstler : der FH-Absolvent Hans W. Krämer
12 Wurzeln, die tief zurückreichen | Die Handwerker- und Kunstgewerbeschule Aachen
18 Eine einmalige Chance | Der japanische Gastwissenschaftler Prof. Dr. Ko-ichiro Miyamoto forscht ein Jahr lang am Campus Jülich
22 Pionierarbeit auf leisen Sohlen | Vier junge Marokkanerinnen sind die ersten Absolventinnen des internationalen Studiengangs Angewandte Chemie
26 Gute Hacker - Böse Hacker| FH Aachen bietet Kurse zum ethischen Hacken an
28 Eiffelturm meets Kartenhaus | Architekturstudierende entwickeln ausgefuchstes Stecksystem für temporäre Architektur
32 Dom in 3-D | Fachbereich Bauingenieurwesen vermisst das Aachener Welterbe
36 "Müssen Behinderte denn Auto fahren?!" | FH-Absolventinnen gründen Fahrschule für Menschen mit Handicap
40 Im Innern des "Blutenden Gletschers" | Fünf Wochen lang lebten und arbeiteten FH-Ingenieure in der größten Eiswüste der Erde
46 Das ist mein Zuhause | Nach über 40 Jahren verlässt Prof. Dr. Horst Heinrichs die FH Aachen
50 Die Qual der Wahl | Mit dem "Guten Studienstart" ins Ingenieurstudium
52 Fachtutorenschulung an der FH Aachen
55 Zusammen wachsen | Neue Schnittstelle: Erste Studierende machen ihren Master in Energiewirtschafts-Informatik
56 Pro8 geht in die achte Runde | Studierende stellen sich Herausforderungen aus der Industrie
58 Auf die Messe, fertig, los! | Alumnus Moritz Christ gibt der Euregio Wirtschaftsschau ein neues Gesicht
61 Unsere EM wird 75: Die FH wünscht alles Gute!
61 Herzlichen Glückwunsch! Alt-Rektor Prof. Buchkremer wird 75
62 FH Aachen kooperiert mit Ford | Hannover Messe: FH präsentiert drei Projekte | FH Aachen ausgezeichnet : Zertifikat 2014 Vielfalt gestalten in NRW
63 Impressum