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The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 %. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days.
We investigate interaction networks that we derive from multivariate time series with methods frequently employed in diverse scientific fields such as biology, quantitative finance, physics, earth and climate sciences, and the neurosciences. Mimicking experimental situations, we generate time series with finite length and varying frequency content but from independent stochastic processes. Using the correlation coefficient and the maximum cross-correlation, we estimate interdependencies between these time series. With clustering coefficient and average shortest path length, we observe unweighted interaction networks, derived via thresholding the values of interdependence, to possess non-trivial topologies as compared to Erdös-Rényi networks, which would indicate small-world characteristics. These topologies reflect the mostly unavoidable finiteness of the data, which limits the reliability of typically used estimators of signal interdependence. We propose random networks that are tailored to the way interaction networks are derived from empirical data. Through an exemplary investigation of multichannel electroencephalographic recordings of epileptic seizures – known for their complex spatial and temporal dynamics – we show that such random networks help to distinguish network properties of interdependence structures related to seizure dynamics from those spuriously induced by the applied methods of analysis.
Understanding Additive Manufacturing : Rapid Prototyping - Rapid Tooling - Rapid Manufacturing
(2011)
The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.
Theoretische und experimentelle Untersuchung des spaltungsinduzierten Versagens von TRC Prüfkörpern
(2011)
The proposed Den Haag Zuidwest district heating system of the city of The Hague consists of a deep doublet in a Jurassic sandstone layer that is designed for a production temperature of 75 °C and a reinjection temperature of 40 °C at a flow rate of 150 m3 h−1. The prediction of reservoir temperature and production behavior is crucial for success of the proposed geothermal doublet. This work presents the results of a study of the important geothermal and geohydrological issues for the doublet design. In the first phase of the study, the influences of the three-dimensional (3D) structures of anticlines and synclines on the temperature field were examined. A comprehensive petrophysical investigation was performed to build a large scale 3D-model of the reservoir. Several bottomhole temperatures (BHTs), as well as petrophysical logs were used to calibrate the model using thermal conductivity measurements on 50 samples from boreholes in different lithological units in the study area. Profiles and cross sections extracted from the calculated temperature field were used to study the temperature in the surrounding areas of the planned doublet. In the second phase of the project, a detailed 3D numerical reservoir model was set up, with the aim of predicting the evolution of the producer and injector temperatures, and the extent of the cooled area around the injector. The temperature model from the first phase provided the boundary conditions for the reservoir model. Hydraulic parameters for the target horizons, such as porosity and permeability, were taken from data available from the nearby exploration wells. The simulation results are encouraging as no significant thermal breakthrough is predicted. For the originally planned location of the producer, the extracted water temperature is predicted to be around 79 °C, with an almost negligible cooling in the first 50 years of production. When the producer is located shallower parts of the reservoir, the yield water temperatures is lower, starting at ≈76 °C and decreasing to ≈74 °C after 50 years of operation. This comparatively larger decrease in temperature with time is caused by the structural feature of the reservoir, namely a higher dip causes the cooler water to easily move downward. In view of the poor reservoir data, the reservoir simulation model is constructed to allow iterative updates using data assimilation during planned drilling, testing, and production phases. Measurements during an 8 h pumping test carried out in late 2010 suggest that a flow rate of 150 m3 h−1 is achievable. Fluid temperatures of 76.5 °C were measured, which is very close to the predicted value.
Speicheroptimierung
(2011)
In dieser Lektion wurden beginnend mit der Darstellung des fundamentalen Wandels
des Gasmarktes die daraus folgenden Implikationen für die Einsatzweise von
Gasspeichern abgeleitet. Anschließend wurden zwei Bewertungs- und Steuerungsverfahren für einen Gasspeicher an den beiden Marktstufen Termin- und Spotmarkt methodisch vorgestellt und anhand von Beispielrechnungen illustriert.
Das Verfahren zur Bewertung und Steuerung im Terminmarkt stellt ein sehr
robustes und methodisch einfaches Verfahren dar. Hierbei wird die Saisonalität
der Forwardkurve bzw. deren Veränderungen arbitragefrei mithilfe des Speichers
ausgenutzt. Dieses Verfahren kann nicht den gesamten Zeitwert des Speichers
ausweisen. Es zieht in jedem Zeitpunkt nur die aktuellen Informationen der Forwardkurve zur Entscheidung heran. Es bildet aber keine bedingte Erwartung über
zukünftige Erträge und deren Beeinflussung durch die aktuelle Speicherfahrweise,
um hieraus eine optimale Entscheidung zu formulieren.
Bei der Bewertung gegenüber dem Spotmarkt mithilfe der Least-Squares-Monte-
Carlo-Simulation wird in einer stochastischen Optimierung dagegen der volle Zeitwert des Speichers und damit der gesamte Zusatznutzen der Flexibilität ermittelt. Hierdurch leiten sich auch wesentlich andere Hedging-Empfehlungen als im ersten Verfahren ab, um diesen zu sichern. Der Einsatz der beiden Verfahren im Alltag zur Bewirtschaftung des Speichers hängt insbesondere vom Know-how, den Speicherparametern und der Risikobereitschaft des Handels ab. Beide Strategien liefern hierzu Hedging-Empfehlungen ab, mit welchem der zugrunde liegende Wert gesichert werden kann. Risikoaverse Händler, die einen Großteil des inneren Wertes sichern wollen, könnten im Terminmarkt einen Großteil des Speichers mithilfe des „Intrinsic Rolling“-Verfahrens bewirtschaften. Sie würden hierdurch den saisonalen Spread in der Forwardkurve rollierend sichern. Gleichzeitig kann ein kleinerer Anteil mithilfe der stochastischen Optimierung und den damit verbundenen Ausübungsgrenzen gegenüber dem Spotmarkt bewirtschaftet werden.
In einem liquiden vollständigen Markt wird eine Steuerung des Speichers allein
gegenüber den vorhandenen Marktstufen vorgenommen und der Wert für alle
Marktteilnehmer objektiv messbar. Für den Fall, dass der Markt illiquide ist und
hierdurch z. B. eine Kundenlast nicht allein am Termin- und Spotmarkt jederzeit
gedeckt werden kann, erscheint es notwendig, den Speicher im Kontext einer Portfoliooptimierung zu bewerten. Dies wird in der nächsten Lektion vorgenommen.
Hierbei ist aber zu beachten, dass der Speicher dadurch eine individualisierte Wertkomponente erhält, die von der konkreten Ausgestaltung des jeweiligen Portfolios abhängt.
Digital elevation models (DEMs), represent the three-dimensional terrain and are the basic input for numerical snow avalanche dynamics simulations. DEMs can be acquired using topographic maps or remote-sensing technologies, such as photogrammetry or lidar. Depending on the acquisition technique, different spatial resolutions and qualities are achieved. However, there is a lack of studies that investigate the sensitivity of snow avalanche simulation algorithms to the quality and resolution of DEMs. Here, we perform calculations using the numerical avalance dynamics model RAMMS, varying the quality and spatial resolution of the underlying DEMs, while holding the simulation parameters constant. We study both channelized and open-terrain avalanche tracks with variable roughness. To quantify the variance of these simulations, we use well-documented large-scale avalanche events from Davos, Switzerland (winter 2007/08), and from our large-scale avalanche test site, Valĺee de la Sionne (winter 2005/06). We find that the DEM resolution and quality is critical for modeled flow paths, run-out distances, deposits, velocities and impact pressures. Although a spatial resolution of ~25 m is sufficient for large-scale avalanche modeling, the DEM datasets must be checked carefully for anomalies and artifacts before using them for dynamics calculations.
Objective
To investigate the feasibility of 7T MR imaging of the kidneys utilising a custom-built 8-channel transmit/receive radiofrequency body coil.
Methods
In vivo unenhanced MR was performed in 8 healthy volunteers on a 7T whole-body MR system. After B0 shimming the following sequences were obtained: 1) 2D and 3D spoiled gradient-echo sequences (FLASH, VIBE), 2) T1-weighted 2D in and opposed phase 3) True-FISP imaging and 4) a T2-weighted turbo spin echo (TSE) sequence. Visual evaluation of the overall image quality was performed by two radiologists.
Results
Renal MRI at 7T was feasible in all eight subjects. Best image quality was found using T1-weighted gradient echo MRI, providing high anatomical details and excellent conspicuity of the non-enhanced vasculature. With successful shimming, B1 signal voids could be effectively reduced and/or shifted out of the region of interest in most sequence types. However, T2-weighted TSE imaging remained challenging and strongly impaired because of signal heterogeneities in three volunteers.
Conclusion
The results demonstrate the feasibility and diagnostic potential of dedicated 7T renal imaging. Further optimisation of imaging sequences and dedicated RF coil concepts are expected to improve the acquisition quality and ultimately provide high clinical diagnostic value.
Reasoning with Qualitative Positional Information for Domestic Domains in the Situation Calculus
(2011)
Raum 02103 - eine Hommage
(2011)
Raum 02103. Ein Ort - tausende von Ideen, Geschichten und Träumen. die Bibliothek des Fachbereichs Design der FH Aachen. Eine scheinbar starre Gestalt und doch in ständigem Wandel. Menschen kommen und gehen; Dinge sind in Bewegung. Ein stiller Fluss von Veränderung, wie in einer eigenständigen Welt. Was macht diesen Ort aus? Was können Zahlen über ihn verraten? Und was befindet sich unter seiner strukturierten Oberfläche? Mit besonderem Blick auf das oft Unbemerkte, ist meine Arbeit eine Hommage an den „Raum 02103“ - an alles was ich dort bereits entdecken durfte und was noch zu entdecken ist.
Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7
(2011)
Purpose:
At 1.5 T, real-time MRI of joint movement has been shown to be feasible. However, 7 T, provides higher SNR and thus an improved potential for parallel imaging acceleration. The purpose of this work was to build an open, U-shaped eight-channel transmit/receive microstrip coil for 7 T MRI to enable high-resolution and real-time imaging of the moving ankle joint.
Methods:
A U-shaped eight-channel transmit/receive array for the human ankle was built.urn:x-wiley:00942405:mp3399:equation:mp3399-math-0001-parameters and urn:x-wiley:00942405:mp3399:equation:mp3399-math-0002-factor were measured. SAR calculations of different ankle postures were performed to ensure patient safety. Inhomogeneities in the transmit field consequent to the open design were compensated for by the use of static RF shimming. High-resolution and real-time imaging was performed in human volunteers.
Results:
The presented array showed good performance with regard to patient comfort and image quality. High acceleration factors of up to 4 are feasible without visible acceleration artifacts. Reasonable image homogeneity was achieved with RF shimming.
Conclusions:
Open, noncylindrical designs for transmit/receive coils are practical at 7 T and real-time imaging of the moving joint is feasible with the presented coil design.
One-chip integrated dual amperometric/field-effect sensor for the detection of dissolved hydrogen
(2011)
The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Numerical and experimental investigation of tensile behavior of laser beam welded TRIP700 steel
(2011)
The development and analysis of three waveguides for the exposure of small biological in vitro samples to mobile communication signals at 900 MHz (GSM, Global System for Mobile Communications), 1.8 GHz (GSM), and 2 GHz (UMTS, Universal Mobile Telecommunications System) is presented. The waveguides were based on a fin-line concept and the chamber containing the samples bathed in extracellular solution was placed onto two fins with a slot in between, where the exposure field concentrates. Measures were taken to allow for patch clamp recordings during radiofrequency (RF) exposure. The necessary power for the achievement of the maximum desired specific absorption rate (SAR) of 20 W/kg (average over the mass of the solution) was approximately Pin = 50 mW, Pin = 19 mW, and Pin = 18 mW for the 900 MHz, 1800 MHz, and 2 GHz devices, respectively. At 20 W/kg, a slight RF-induced temperature elevation in the solution of no more than 0.3 °C was detected, while no thermal offsets due to the electromagnetic exposure could be detected at the lower SAR settings (2, 0.2, and 0.02 W/kg). A deviation of 10% from the intended solution volume yielded a calculated SAR deviation of 8% from the desired value. A maximum ±10% variation in the local SAR could occur when the position of the patch clamp electrode was altered within the area where the cells to be investigated were located.
Möglichkeiten und Grenzen der Anwendbarkeit statisch nichtlinearer Verfahren nach DIN EN 1998-1
(2011)