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Sleep spindles are neurophysiological phenomena that appear to be linked to memory formation and other functions of the central nervous system, and that can be observed in electroencephalographic recordings (EEG) during sleep. Manually identified spindle annotations in EEG recordings suffer from substantial intra- and inter-rater variability, even if raters have been highly trained, which reduces the reliability of spindle measures as a research and diagnostic tool. The Massive Online Data Annotation (MODA) project has recently addressed this problem by forming a consensus from multiple such rating experts, thus providing a corpus of spindle annotations of enhanced quality. Based on this dataset, we present a U-Net-type deep neural network model to automatically detect sleep spindles. Our model’s performance exceeds that of the state-of-the-art detector and of most experts in the MODA dataset. We observed improved detection accuracy in subjects of all ages, including older individuals whose spindles are particularly challenging to detect reliably. Our results underline the potential of automated methods to do repetitive cumbersome tasks with super-human performance.
Wo einst fast lückenlos Laubwälder wuchsen, steht heute nur noch ein Drittel der ursprünglichen Waldfläche. Echte Urwälder gibt es hier schon lange nicht mehr: Die Rede ist vom deutschen Wald.
Unsere Welt ist im Wandel. Auch in unseren heimischen Wäldern lassen sich die Einflüsse von Mensch und Klimawandel auf die Biodiversität beobachten.
Die illustrierte Publikation „Adapt or die“ lädt mit mehr als 80 großformatigen Artenportraits, Habitat-Kartierungen und gestalteten Themenklappenseiten zur Auseinandersetzung mit dem Wandel unserer heimischen Wälder ein. Dabei sensibilisiert sie für einen bewussteren Umgang mit Umwelt und Natur. Erweiterungen durch Augmented Reality bieten vereinzelt neben dem Printprodukt aktualisierbare Prognosen, digital und ressourcenschonend.
Das komplexe Ökosystem des Waldes reagiert empfindlich auf Veränderungen: Wer sich nicht anpassen kann, wird verschwinden.
aco : eine digitale Anwendung zur Verbesserung der Lebensqualität
von Neurodermitis-Patient:innen
(2022)
Neurodermitis hat in den letzten Jahrzehnten deutlich zugenommen. Etwa 10 bis 15 Prozent der Kinder und 2,5 bis 3,5 Prozent der Erwachsenen sind davon betroffen. Für sie stellen Auswirkungen der Hautkrankheit auf Körper und Psyche eine enorme Einschränkung der Lebensqualität dar.
Die App „aco“ möchte Neurodermitis-Patient:Innen dabei unterstützen, ihre Behandlung selbst in die Hand zu nehmen. Eine ganzheitliche Therapie umfasst eben nicht nur Fachpersonen, sondern auch Patient:Innen selbst. Durch eine regelmäßige Dokumentation ermöglicht die Anwendung eine aktive Auseinandersetzung mit der Krankheit. Triggerfaktoren werden ausgewertet und es wird Wissen über Behandlungsmöglichkeiten vermittelt. Zudem wird ein Austausch ermöglicht, der emotionale und praktische Unterstützung bieten soll. Damit möchte „aco“ Betroffenen eine Möglichkeit geben, das Ruder selbst in die Hand zu nehmen und leistet damit einen wichtigen Beitrag zur Therapie von Neurodermitis.
The fourth industrial revolution presents a multitude of challenges for industries, one of which being the increased flexibility required of manufacturing lines as a result of increased consumer demand for individualised products. One solution to tackle this challenge is the digital twin, more specifically the standardised model of a digital twin also known as the asset administration shell. The standardisation of an industry wide communications tool is a critical step in enabling inter-company operations. This paper discusses the current state of asset administration shells, the frameworks used to host them and their problems that need to be addressed. To tackle these issues, we propose an event-based server capable of drastically reducing response times between assets and asset administration shells and a multi-agent system used for the orchestration and deployment of the shells in the field.
Inhaltsverzeichnis - Bachelorarbeiten
1. Testamentsgestaltung bei Patchworkfamilien – Lösungsansätze für typische
Praxisprobleme unter Berücksichtigung der Interessenlagen der Parteien
- Ronja Bundrock 4 - 58
2. Die Haftung des AG-Vorstands gegenüber der Gesellschaft in unterneh-
mensinternen und -externen Krisen
- Nico Kremers 59 - 122
3. The Relationship of the Ex-Ante Uncertainty about the Value of a Stock
and its IPO Underpricing – An Analysis of the German Market
- Lennard Pankok 123 - 179
4. Attractiveness Bias in Venture Capital – An Analysis of Investor Decision
Making in “Die Höhle der Löwen”
- Theresa Maria Weisheit 180 - 242
Inhaltsverzeichnis – Masterarbeiten
Erhöhung der Energieautarkie in der Backbranche – Anwendung von bidi-
rektionalem Laden und dessen Auswirkungen auf die Geschäftsprozesse
und Informationssysteme
- Jasper Spoede 243 - 355
Inhaltsverzeichnis - Bachelorarbeiten
1. The impact of the EU non-financial reporting directive on sustainability reporting practices of DAX 30 companies
- Lene Christin Blöcker 4 - 29
2. Kurzarbeit als Krisenbewältigungsinstrument – Die arbeitsrechtlichen Voraussetzungen für die wirksame Einführung von Kurzarbeit
- Julia Esser 30 - 87
3. Die virtuelle Hauptversammlung der Aktiengesellschaft – Notlösung während der Corona-Pandemie oder dauerhafte Alternative?
- Pauline Hengstebeck 88 - 152
4. Die psychische Gesundheit am Arbeitsplatz – Aktuelle Problematik, Ursachenforschung, Folgen, rechtliche Rahmenbedingungen und geeignete Präventionsmaßnahmen aus Arbeitgebersicht
- Carolin Venrath 153 - 224
Inhaltsverzeichnis – Masterarbeiten
The influence of religion on the representation of women in politics
- Eva Scholtes 225 - 345
This study reviews the practice of brake tests in freight railways, which is time consuming and not suitable to detect certain failure types. Public incident reports are analysed to derive a reasonable brake test hardware and communication architecture, which aims to provide automatic brake tests at lower cost than current solutions. The proposed solutions relies exclusively on brake pipe and brake cylinder pressure sensors, a brake release position switch as well as radio communication via standard protocols. The approach is embedded in the Wagon 4.0 concept, which is a holistic approach to a smart freight wagon. The reduction of manual processes yields a strong incentive due to high savings in manual
labour and increased productivity.
Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here.
On the basis of bivariate data, assumed to be observations of independent copies of a random vector (S,N), we consider testing the hypothesis that the distribution of (S,N) belongs to the parametric class of distributions that arise with the compound Poisson exponential model. Typically, this model is used in stochastic hydrology, with N as the number of raindays, and S as total rainfall amount during a certain time period, or in actuarial science, with N as the number of losses, and S as total loss expenditure during a certain time period. The compound Poisson exponential model is characterized in the way that a specific transform associated with the distribution of (S,N) satisfies a certain differential equation. Mimicking the function part of this equation by substituting the empirical counterparts of the transform we obtain an expression the weighted integral of the square of which is used as test statistic. We deal with two variants of the latter, one of which being invariant under scale transformations of the S-part by fixed positive constants. Critical values are obtained by using a parametric bootstrap procedure. The asymptotic behavior of the tests is discussed. A simulation study demonstrates the performance of the tests in the finite sample case. The procedure is applied to rainfall data and to an actuarial dataset. A multivariate extension is also discussed.
A generalized shear-lag theory for fibres with variable radius is developed to analyse elastic fibre/matrix stress transfer. The theory accounts for the reinforcement of biological composites, such as soft tissue and bone tissue, as well as for the reinforcement of technical composite materials, such as fibre-reinforced polymers (FRP). The original shear-lag theory proposed by Cox in 1952 is generalized for fibres with variable radius and with symmetric and asymmetric ends. Analytical solutions are derived for the distribution of axial and interfacial shear stress in cylindrical and elliptical fibres, as well as conical and paraboloidal fibres with asymmetric ends. Additionally, the distribution of axial and interfacial shear stress for conical and paraboloidal fibres with symmetric ends are numerically predicted. The results are compared with solutions from axisymmetric finite element models. A parameter study is performed, to investigate the suitability of alternative fibre geometries for use in FRP.
An improved and convenient ninhydrin assay for aminoacylase activity measurements was developed using the commercial EZ Nin™ reagent. Alternative reagents from literature were also evaluated and compared. The addition of DMSO to the reagent enhanced the solubility of Ruhemann's purple (RP). Furthermore, we found that the use of a basic, aqueous buffer enhances stability of RP. An acidic protocol for the quantification of lysine was developed by addition of glacial acetic acid. The assay allows for parallel processing in a 96-well format with measurements microtiter plates.
[NON]HUMAN
(2022)
"[NON]HUMAN“ ist ein 3D-animierter Kurzfilm, der in einer Zombieapokalypse spielt und sich mit dem Thema der Menschlichkeit befasst. Welche Taten können gerechtfertigt werden und welche nicht? Die Handlungsmöglichkeiten der Menschen im Zuge des Ausbruchs eines neuen Virus werfen viele moralische Fragen auf, mit denen zwischen den Zeilen gerungen wird. Denn in diesem Film bestimmen sie Leben und Tod.
Das Ziel dieser Arbeit war es, eine simple Geschichte spannend zu erzählen, indem das Publikum durch eindrucksstarke Bilder gefesselt wird. Dabei eröffnen 3D-Animationen neue Möglichkeiten, die insbesondere in den Aufnahmen der zerstörten Stadt zur Geltung kommen. Diese Arbeit zeigt spielerisch, wie sich mit etwas technischem Know-How auch ohne großem Budget hochwertige Filme drehen lässt, indem man das Potential smart ausschöpft.
The recent amendment to the Ethernet physical layer known as the IEEE 802.3cg specification, allows to connect devices up to a distance of one kilometer and delivers a maximum of 60 watts of power over a twisted pair of wires. This new standard, also known as 10BASE-TIL, promises to overcome the limits of current physical layers used for field devices and bring them a step closer to Ethernet-based applications. The main advantage of 10BASE- TIL is that it can deliver power and data over the same line over a long distance, where traditional solutions (e.g., CAN, IO-Link, HART) fall short and cannot match its 10 Mbps bandwidth. Due to its recentness, IOBASE- TIL is still not integrated into field devices and it has been less than two years since silicon manufacturers released the first Ethernet-PHY chips. In this paper, we present a design proposal on how field devices could be integrated into a IOBASE-TIL smart switch that allows plug-and-play connectivity for sensors and actuators and is compliant with the Industry 4.0 vision. Instead of presenting a new field-level protocol for this work, we have decided to adopt the IO-Link specification which already includes a plug-and-play approach with features such as diagnosis and device configuration. The main objective of this work is to explore how field devices could be integrated into 10BASE-TIL Ethernet, its adaption with a well-known protocol, and its integration with Industry 4.0 technologies.
"I Was Here!"
(2022)
Die Menschheit erlebt aktuell Zeiten drastischen Wandels. Deswegen könnte es wohltun, einen Blick in die Vergangenheit zu werfen und sich darauf zu besinnen, wo die Menschen herkommen, wer sie waren und was seitdem bereits erreicht wurde.
In dieser Grafiknovelle wird ein kleiner Steinzeitjunge namens Muami begleitet, der vor 35.000 Jahren die Vergänglichkeit des Lebens kennenlernt. Im Verlauf des folgenden Jahres erfindet er die Selbstverewigung in der Höhlenmalerei.
Mit seiner Figur soll aufgezeigt werden, dass die frühen Europäer eben keine primitiven Halbaffen, sondern intelligente und außerdem zutiefst kreative Menschen waren. Trotz ihrer rauen Umwelt waren ihre Sorgen und Freuden den unseren gar nicht so unähnlich. „I Was Here!“ ist ein Versuch, ein authentisches Porträt jener Menschen zu schaffen und dabei ihrer Welt, ihrem Leben und ihrer Kunst gerecht zu werden.