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Bacterial cell appendix formation supports cell-cell interaction, cell adhesion and cell movement. Additionally, in bioelectrochemical systems (BES), cell appendages have been shown to participate in extracellular electron transfer. In this work, the cell appendix formation of Clostridium acetobutylicum in biofilms of a BES are imaged and compared with conventional biofilms. Under all observed conditions, the cells possess filamentous appendages with a higher number and density in the BES. Differences in the amount of extracellular polymeric substance in the biofilms of the electrodes lead to the conclusion that the cathode can be used as electron donor and the anode as electron acceptor by C. acetobutylicum. When using conductive atomic force microscopy, a current response of about 15 nA is found for the cell appendages from the BES. This is the first report of conductivity for clostridial cell appendices and represents the basis for further studies on their role for biofilm formation and electron transfer.
Das „Recht auf Vergessenwerden“ unter Geltung der DSGVO: Anwendungsbereich und Rechtmäßigkeit
(2019)
Diversity is increasingly being addressed as an innovation-promoting factor. For this reason, companies and institutions tackle the integration of a diversity management approach that enables a heterogenic perspective on innovation development. However, system-theoretical frameworks state that the implementation of diversity measures that are not tailored to the needs of the organization often leads to a rejection or reactivity with regard to the management approach. In this context, especially organizations, which are characterized by a specific hierarchical structure, a dominant habitus or specialist culture, must face the challenge of realizing a sustainable change of the corporate culture that sets the basis for implementing diversity management approaches. The presented research project focuses on analyzing the situation in a huge scientific collaborative project - so called Cluster of Excellence (CoE) - with the aim to implement a diversity - and innovation management strategy. Considering the influencing determinants, the CoE is characterized by its embeddedness in the scientific system, a complex organizational structure, and a high fluctuation rate. The paper presents a systemic approach of reflecting these factors in order to develop a diversity- and innovation management strategy. In this frame, the results of a quantitative survey of CoE employees and derived mindset-types are presented. The results show a need for taking different mindset-types into account, to be able to develop a tailored management strategy. The aim of the project is to give recommendations for developing a sustainable management concept that promotes both diversity and innovation by drawing on the persisting mindsets of organization members while reflecting top down as well as bottom up factors of implementation processes as well as the psychology of change. This paper addresses all who are concerned with the management of human resources in innovation processes and are striving for a cultural change within the framework of complex organizations.
The results of a statistical investigation of 42 fixed-wing, small to medium sized (20 kg−1000 kg) reconnaissance unmanned air vehicles (UAVs) are presented. Regression analyses are used to identify correlations of the most relevant geometry dimensions with the UAV’s maximum take-off mass. The findings allow an empirical based geometry-build up for a complete unmanned aircraft by referring to its take-off mass only. This provides a bridge between very early design stages (initial sizing) and the later determination of shapes and dimensions. The correlations might be integrated into a UAV sizing environment and allow designers to implement more sophisticated drag and weight estimation methods in this process. Additional information on correlation factors for a rough drag estimation methodology indicate how this technique can significantly enhance the accuracy of early design iterations.
Wind loads have great impact on many engineering structures. Wind storms often cause irreparable damage to the buildings which are exposed to it. Along with the earthquakes, wind represents one of the most common environmental load on structures and is relevant for limit state design. Modern wind codes indicate calculation procedures allowing engineers to deal with structural systems, which are susceptible to conduct wind-excited oscillations. In the codes approximate formulas for wind buffeting are specified which relate the dynamic problem to rather abstract parameter functions. The complete theory behind is not visible in order to simplify the applicability of the procedures. This chapter derives the underlying basic relations of the spectral method for wind buffeting and explains the main important applications of it in order to elucidate part of the theoretical background of computations after the new codes. The stochasticity of the wind processes is addressed, and the analysis of analytical as well as measurement based power spectra is outlined. Short MATLAB codes are added to the Appendix 3 which carry out the computation of a single sided auto-spectrum from a statistically stationary, discrete stochastic process. Two examples are presented.
Kyphoplasty of Osteoporotic Fractured Vertebrae: A Finite Element Analysis about Two Types of Cement
(2019)
Masonry infill walls are commonly used in reinforced concrete (RC) frame structures, also in seismically active areas, although they often experience serious damage during earthquakes. One of the main reasons for their poor behaviour is the connection to the frame, which is usually constructed using mortar. This paper describes the novel solution for infill/frame connection based on application of elastomeric material between them. The system called INODIS (Innovative Decoupled Infill System) has the aim to postpone the activation of infill in in-plane direction and at the same time to provide sufficient out-of-plane support. First, experimental tests on infilled frame specimens are presented and the comparison of the results between traditionally infilled frames and infilled frames with the INODIS system are given. The results are then used for calibration and validation of numerical model, which can be further employed for investigating the influence of some material parameters on the behaviour of infilled frames with the INODIS system.
Thermal and Optical Study on the Frequency Dependence of an Atmospheric Microwave Argon Plasma Jet
(2019)
In diesem Paper wird die Entwicklung und Evaluation eines grafischen Regeleditors für das Erstellen von „Smart Living Environments“-Services vorgestellt. Dafür werden zunächst die Deduktion und Implementierung des grafischen Regeleditors erläutert. Anschließend wird eine Probandenstudie vorgestellt, in welcher der Mehrwert bezogen auf die Aspekte Zeit, Fehleranfälligkeit und Gebrauchstauglichkeit festgestellt wird.
Soziale Netzwerke sind aus dem Alltag nicht wegzudenken. Es vergeht keine Sekunde, in der nicht abertausende Status-Updates, Kommentare und Nachrichten rund um den Globus versendet werden. Die Stellung als Informations- und Kommunikationsmedium macht die Betreiber solcher Plattformen - zahlreichen Skandalen zum Trotz - zu den Internetgiganten unserer Zeit. Insoweit ist es nicht verwunderlich, dass die Datenschutz-Grundverordnung (DSGVO) auch und gerade mit dem Ziel angetreten ist, soziale Netzwerke zu regulieren.
Die datenschutzrechtliche Diskussion fokussierte sich vor allem auf die Betreiber von sozialen Netzwerken. Unter welchen Umständen welches Recht auf wen Anwendung findet, wer für welche Tätigkeiten verantwortlich ist, und unter welchen Bedingungen eine Verarbeitung rechtmäßig ist, wurde bislang nur pauschal beantwortet. Bei Web 2.0-Plattformen wirkt jedoch eine Vielzahl von Beteiligten zusammen, bei denen Art der Verarbeitung, verfolgte Zwecke und mögliche Rechtsgrundlagen divergieren. Dies macht eine sorgfältige Differenzierung notwendig. Das vorliegende Werk analysiert die Handlungen von Netzwerkbetreibern, Fansite-Betreibern und Nutzern in sozialen Netzwerken und zeigt gleichermaßen Voraussetzungen wie praxistaugliche Lösungen für eine datenschutzkonforme Datenverarbeitung in Hinblick auf alle Beteiligten unter der DSGVO auf.
Schwerpunkte sind die Anwendbarkeit der DSGVO, der Umfang der Verantwortlichkeit der einzelnen Akteure und die Rechtmäßigkeit der Verarbeitung. Daneben werden auch jene Besonderheiten der DSGVO, die spezifische Relevanz für soziale Netzwerke entfalten, ausführlich behandelt. Hierzu zählt etwa das Haushaltsprivileg, die Verarbeitung "sensibler" Daten, das Kopplungsverbot, das Recht auf Datenübertragbarkeit, Privacy by Default oder das vielzitierte "Recht auf Vergessenwerden".
Schalung und Gerüste
(2019)
Die grundsätzliche Planung von Schalungsaufgaben wird heute in der Regel im Rahmen der Arbeitsvorbereitung von den entsprechenden Stabsabteilungen oder als Serviceleistung von den Schalungsherstellern mit Anwendung von spezieller Software und den technischen Unterlagen für die jeweiligen Schalungsgeräte durchgeführt. Diese Programme und technischen Unterlagen stehen in der Regel auch den Mitarbeitern in der Bauleitung zur Verfügung, werden dort aber eher seltener genutzt. Zur Anwendung auf der Baustelle stellen die Schalungshersteller neben den technischen Unterlagen Bemessungstabellen zur Verfügung, welche die Auswahl und Dimensionierung einzelner Schalungen wesentlich erleichtern.
Die nachfolgend aufgeführten Beispiele aus dem Bereich Schalung und Gerüste beschreiben Aufgaben, die im Baustellenbetrieb auf die Bauleitung zu kommen können und auch ohne Unterstützung einer Stabsabteilung gelöst werden können.
Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism
(2019)
Kombination quantitativer und qualitativer Methoden zur Untersuchung der Studieneingangsphase
(2019)
In competition with other modes of transport, rail freight transport is looking for solutions to become more attractive. Short-term success can be achieved through the data-driven optimization of operations and maintenance as well as the application of novel strategies such as prescriptive maintenance. After introducing the concept of prescriptive maintenance, this paper aims to prove that vehicle-focused applications of this approach indeed have the potential to increase attractiveness. However, even greater advantages can be activated if data from the horizontal network of the vehicle is available. Drawing on the state of the art in research and technology in the field of cyber-physical systems (CPS) as well as digital twins and shadows, our work serves to design a system of systems for the horizontal interconnection of a rail vehicle and to conceptualize a draft for a digital twin of a locomotive.
Application of Low NOx Micro-mix Hydrogen Combustion to 2MW Class Industrial Gas Turbine Combustor
(2019)
Heating efficiency of magnetic nanoparticles decreases with gradual immobilization in hydrogels
(2019)
Monitoring the cellular metabolism of bacteria in (bio)fermentation processes is crucial to control and steer them, and to prevent undesired disturbances linked to metabolically inactive microorganisms. In this context, cell-based biosensors can play an important role to improve the quality and increase the yield of such processes. This work describes the simultaneous analysis of the metabolic behavior of three different types of bacteria by means of a differential light-addressable potentiometric sensor (LAPS) set-up. The study includes Lactobacillus brevis, Corynebacterium glutamicum, and Escherichia coli, which are often applied in fermentation processes in bioreactors. Differential measurements were carried out to compensate undesirable influences such as sensor signal drift, and pH value variation during the measurements. Furthermore, calibration curves of the cellular metabolism were established as a function of the glucose concentration or cell number variation with all three model microorganisms. In this context, simultaneous (bio)sensing with the multi-organism LAPS-based set-up can open new possibilities for a cost-effective, rapid detection of the extracellular acidification of bacteria on a single sensor chip. It can be applied to evaluate the metabolic response of bacteria populations in a (bio)fermentation process, for instance, in the biogas fermentation process.
Enzyme-catalyzed reactions have been designed to mimic various Boolean logic gates in the general framework of unconventional biomolecular computing. While some of the logic gates, particularly OR, AND, are easy to realize with biocatalytic reactions and have been reported in numerous publications, some other, like NXOR, are very challenging and have not been realized yet with enzyme reactions. The paper reports on a novel approach to mimicking the NXOR logic gate using the bell-shaped enzyme activity dependent on pH values. Shifting pH from the optimum value to the acidic or basic values by using acid or base inputs (meaning 1,0 and 0,1 inputs) inhibits the enzyme reaction, while keeping the optimum pH (assuming 0,0 and 1,1 input combinations) preserves a high enzyme activity. The challenging part of the present approach is the selection of an enzyme with a well-demonstrated bell-shape activity dependence on the pH value. While many enzymes can satisfy this condition, we selected pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase as this enzyme has the optimum pH center-located on the pH scale allowing the enzyme activity change by the acidic and basic pH shift from the optimum value corresponding to the highest activity. The present NXOR gate is added to the biomolecular “toolbox” as a new example of Boolean logic gates based on enzyme reactions.
Sabbioneta: Atlas
(2019)
Rapid Tooling
(2019)
MedicVR : Acceleration and Enhancement Techniques for Direct Volume Rendering in Virtual Reality
(2019)
Forschendes Lernen ist dazu geeignet, epistemische Neugier – definiert als Freude an neuen Erkenntnissen - anzuregen und zu befriedigen. Neben der Selbstwirksamkeit zeigt sich die Neugier als relevant für den Studienerfolg. Allerdings ist bisher nicht geklärt, in welcher Beziehung diese beiden Konstrukte zueinanderstehen.
The increasing complexity of Advanced Driver Assistance Systems (ADAS) presents a challenging task to validate safe and reliable performance of these systems under varied conditions. The test and validation of ADAS/AD with real test drives, although important, involves huge costs and time. Simulation tools provide an alternative with the added advantage of reproducibility but often use ideal sensors, which do not reflect real sensor output accurately. This paper presents a new validation methodology using fault injection, as recommended by the ISO 26262 standard, to test software and system robustness. In our work, we investigated and developed a tool capable of inserting faults at different software and system levels to verify its robustness. The scope of this paper is to cover the fault injection test for the Visteon’s DriveCore™ system, a centralized domain controller for Autonomous driving which is sensor agnostic and SoC agnostic. With this new approach, the validation of safety monitoring functionality and its behavior can be tested using real-world data instead of synthetic data from simulation tools resulting in having better confidence in system performance before proceeding with in-vehicle testing.
Complexity for heterogeneous classes: teaching embedded systems using an open project approach
(2019)
Entwicklung einer Qualitätssicherung für das Laserstrahlschweißen im Vakuum mittels Bildverarbeitung
(2019)
Praxistransfer in der tertiären Bildungsforschung: Modelle, Gelingensbedingungen und Nachhaltigkeit
(2019)
Water suppliers are faced with the great challenge of achieving high-quality and, at the same time, low-cost water supply. In practice, the focus is set on the most beneficial maintenance measures and/or capacity adaptations of existing water distribution systems (WDS). Since climatic and demographic influences will pose further challenges in the future, the resilience enhancement of WDS, i.e. the enhancement of their capability to withstand and recover from disturbances, has been in particular focus recently. To assess the resilience of WDS, metrics based on graph theory have been proposed. In this study, a promising approach is applied to assess the resilience of the WDS for a district in a major German City. The conducted analysis provides insight into the process of actively influencing the
resilience of WDS
The paper industry is the industry with the third highest energy consumption in the European Union. Using recycled paper instead of fresh fibers for papermaking is less energy consuming and saves resources. However, adhesive contaminants in recycled paper are particularly problematic since they reduce the quality of the resulting paper-product. To remove as many contaminants and at the same time obtain as many valuable fibres as possible, fine screening systems, consisting of multiple interconnected pressure screens, are used. Choosing the best configuration is a non-trivial task: The screens can be interconnected in several ways, and suitable screen designs as well as operational parameters have to be selected. Additionally, one has to face conflicting objectives. In this paper, we present an approach for the multi-criteria optimization of pressure screen systems based on Mixed-Integer Nonlinear Programming. We specifically focus on a clear representation of the trade-off between different objectives.
The initial idea of Robotic Process Automation (RPA) is the automation of business processes through the presentation layer of existing application systems. For this simple emulation of user input and output by software robots, no changes of the systems and architecture is required. However, considering strategic aspects of aligning business and technology on an enterprise level as well as the growing capabilities of RPA driven by artificial intelligence, interrelations between RPA and Enterprise Architecture (EA) become visible and pose new questions. In this paper we discuss the relationship between RPA and EA in terms of perspectives and implications. As workin- progress we focus on identifying new questions and research opportunities related to RPA and EA.
Im Rahmen der Digitalisierung ist die zunehmende Automatisierung von bisher manuellen Prozessschritten ein Aspekt, der massive Auswirkungen auf die zukünftige Arbeitswelt haben wird. In diesem Kontext werden an den Einsatz von Softwarerobotern zur Prozessautomatisierung hohe Erwartungen geknüpft. Bei den Implementierungsansätzen wird die Diskussion aktuell insbesondere durch Robotic Process Automation (RPA) und Chatbots geprägt. Beide Ansätze verfolgen das gemeinsame Ziel einer 1:1-Automatisierung von menschlichen Handlungen und dadurch ein direktes Ersetzen von Mitarbeitern durch Maschinen. Bei RPA werden Prozesse durch Softwareroboter erlernt und automatisiert ausgeführt. Dabei emulieren RPA-Roboter die Eingaben auf der bestehenden Präsentationsschicht, so dass keine Änderungen an vorhandenen Anwendungssystemen notwendig sind. Am Markt werden bereits unterschiedliche RPA-Lösungen als Softwareprodukte angeboten. Durch Chatbots werden Ein- und Ausgaben von Anwendungssystemen über natürliche Sprache realisiert. Dadurch ist die Automatisierung von unternehmensexterner Kommunikation (z. B. mit Kunden) aber auch von unternehmensinternen Assistenztätigkeiten möglich. Der Beitrag diskutiert die Auswirkungen von Softwarerobotern auf die Arbeitswelt anhand von Anwendungsbeispielen und erläutert die unternehmensindividuelle Entscheidung über den Einsatz von Softwarerobotern anhand von Effektivitäts- und Effizienzzielen.
In der Diskussion über die Digitalisierung der Forschung spielt die Frage nach der optimalen IT-Unterstützung für Forschende eine wichtige Rolle. Forschende können heute an ihren Hochschulen bzw. Wissenschaftseinrichtungen auf ein breites Angebot interner IT-Dienstleistungen zurückgreifen, das auch kooperative IT-Dienste umfasst, die von mehreren Institutionen in Zusammenarbeit bereitgestellt werden. Außerhalb der eigenen Organisation und des weiteren Verbunds hat sich im Internet zudem ein breites externes Angebot an innovativen, häufig kostenlos nutzbaren Onlinediensten entwickelt. Neben horizontalen Onlinediensten, die sich prinzipiell an jeden Internetnutzer richten (bspw. Dropbox, Twitter, WhatsApp), nimmt auch die Zahl von vertikalen Diensten für wissenschaftliche bzw. Forschungszwecke immer weiter zu (bspw. GoogleScholar, ResearchGate, figshare). Für Forschende eröffnen sich damit vielfältige neue Möglichkeiten, ihren individuellen Forschungsprozess durch digitale Werkzeuge zu verbessern. Aufgrund rechtlicher, technischer und personeller Restriktionen können jedoch interne Dienstleister bei der Identifizierung, Auswahl und Nutzung externer Onlinedienste nur wenig Unterstützung leisten. Aus einer serviceorientierten Perspektive stehen Forschende zunehmend vor dem Problem, wie sich heterogene IT-Dienste interner und externer Anbieter in den eigenen Forschungsprozess integrieren lassen. Als Lösungsansatz skizziert das Kapitel das Konzept eines persönlichen Forschungsinformationssystems
nach Gesichtspunkten eines digitalen Servicesystems.
Information technologies, such as big data analytics, cloud computing,
cyber physical systems, robotic process automation, and the internet of things, provide a sustainable impetus for the structural development of business sectors as well as the digitalization of markets, enterprises, and processes. Within the consulting industry, the proliferation of these technologies opened up the new segment of digital transformation, which focuses on setting up, controlling, and implementing projects for enterprises from a broad range of sectors. These recent developments raise the question, which requirements evolve for IT consultants as important success factors of those digital transformation projects. Therefore, this empirical contribution provides indications regarding the qualifications and competences necessary for IT consultants in the era of digital transformation from a labor market perspective. On the one hand, this knowledge base is interesting for the academic education of consultants, since it supports a market-oriented design of adequate training measures. On the other hand, insights into the competence requirements for consultants are considered relevant for skill and talent management processes in consulting practice. Assuming that consulting companies pursue a strategic human resource management approach, labor market information may also be useful to discover strategic behavioral patterns.
Due to the high number of customer contacts, fault clearances, installations, and product provisioning per year, the automation level of operational processes has a significant impact on financial results, quality, and customer experience. Therefore, the telecommunications operator Deutsche Telekom (DT) has defined a digital strategy with the objectives of zero complexity and zero complaint, one touch, agility in service, and disruptive thinking. In this context, Robotic Process Automation (RPA) was identified as an enabling technology to formulate and realize DT’s digital strategy through automation of rule-based, routine, and predictable tasks in combination with structured and stable data.
Embedded Systems für IoT
(2019)