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Kyphoplasty of Osteoporotic Fractured Vertebrae: A Finite Element Analysis about Two Types of Cement
(2019)
Meyer, Carolin ; Gaalen, Kerstin van ; Leschinger, Tim ; Scheyerer, Max J. ; Neiss, Wolfram F. ; Staat, Manfred ; Müller, Lars P. ; Wegmann, Kilian
Baader, Fabian ; Keller, Denis ; Lehmann, Raphael ; Gerber, Lukas ; Reiswich, Martin ; Dachwald, Bernd ; Förstner, Roger
Albanna, Walid ; Lüke, Jan Niklas ; Schubert, Gerrit Alexander ; Dibué-Adjei, Maxine ; Kotliar, Konstantin ; Hescheler, Jürgen ; Clusmann, Hans ; Steiger, Hans-Jakob ; Hänggi, Daniel ; Kamp, Marcel A. ; Schneider, Toni ; Neumaier, Felix
Attar, Mandana Hossein Zadeh ; Merk, Hans F. ; Kotliar, Konstantin ; Wurpts, Gerda ; Röseler, Stefani ; Moll-Slodowy, Silke ; Plange, Johann ; Baron, Jens Malte ; Balakirski, Galina
Werkhausen, Amelie ; Cronin, Neil J. ; Albracht, Kirsten ; Bojsen-Møller, Jens ; Seynnes, Olivier R.
Ermolaev, AP ; Erichev, VP ; Antonov, AA ; Grigoryan, GL ; Kotliar, Konstantin ; Levitsky, YV ; Hderi, K ; Mazurova, YV
Capri, Miriam ; Morsiani, Cristina ; Santoro, Aurelia ; Moriggi, Manuela ; Conte, Maria ; Martucci, Morena ; Bellavista, Elena ; Fabbri, Cristina ; Giampieri, Enrico ; Albracht, Kirsten ; Flück, Martin ; Ruoss, Severin ; Brocca, Lorenza ; Canepari, Monica ; Longa, Emanuela ; Giulio, Irene Di ; Bottinelli, Roberto ; Cerretelli, Paolo ; Salvioli, Stefano ; Gelfi, Cecilia ; Franceschi, Claudio ; Narici, Marco ; Rittweger, Jörn
Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application
(2019)
Kopp, Alexander ; Schmeets, Ralf ; Gosau, Martin ; Friedrich, Reinhard E. ; Fuest, Sandra ; Behbahani, Mehdi ; Barbeck, Mike ; Rutkowski, Rico ; Burg, Simon ; Kluwe, Lan ; Henningsen, Anders
Ketelhut, Maike ; Kolditz, Melanie ; Göll, Fabian ; Braunstein, Bjoern ; Albracht, Kirsten ; Abel, Dirk
Neuromuscular strength training of the leg extensor muscles plays an important role in the rehabilitation and prevention of age and wealth related diseases. In this paper, we focus on the design and implementation of a Cartesian admittance control scheme for isotonic training, i.e. leg extension and flexion against a predefined weight. For preliminary testing and validation of the designed algorithm an experimental research and development platform consisting of an
industrial robot and a force plate mounted at its end-effector has been used. Linear, diagonal and arbitrary two-dimensional motion trajectories with different weights for the leg extension and flexion part are applied. The proposed algorithm is easily adaptable to trajectories consisting of arbitrary six-dimensional poses and allows the implementation of individualized trajectories.
Effective training requires high muscle forces potentially leading to training-induced injuries. Thus, continuous monitoring and controlling of the loadings applied to the musculoskeletal system along the motion trajectory is required. In this paper, a norm-optimal iterative learning control algorithm for the robot-assisted training is developed. The algorithm aims at minimizing the external knee joint moment, which is commonly used to quantify the loading of the medial compartment. To estimate the external knee joint moment, a musculoskeletal lower extremity model is implemented in OpenSim and coupled with a model of an industrial robot and a force plate mounted at its end-effector. The algorithm is tested in simulation for patients with varus, normal and valgus alignment of the knee. The results show that the algorithm is able to minimize the external knee joint moment in all three cases and converges after less than seven iterations.
Blottner, Dieter ; Hastermann, Maria ; Muckelt, Paul ; Albracht, Kirsten ; Schoenrock, Britt ; Salanova, Michele ; Warner, Martin ; Gunga, Hans-Christian ; Stokes, Maria
The MYOTONES experiment is the first to monitor changes in the basic biomechanical properties (tone, elasticity and stiffness) of the resting human myofascial system due to microgravity with a oninvasive, portable device on board the ISS. The MyotonPRO device applies several brief mechanical stimuli to the surface of the skin, and the natural oscillation signals of the tissue beneath are detected and computed by the MyotonPRO. Thus, an objective, quick and easy determination of the state of the underlying tissue is possible.
Two preflight, four inflight and four post flight measurements were performed on a male astronaut using the same 10 measurement points (MP) for each session. MPs were located on the plantar fascia, Achilles tendon, M. soleus, M. gastrocnemius, M. multifidus, M. splenius capitis, M. deltoideus anterior, M. rectus femoris, infrapatellar tendon, M. tibialis anterior. Subcutaneous tissues thickness above the MPs was measured using ultrasound imaging. Magnetic resonance images (MRI) of lower limb muscles and functional tests were also performed pre- and postflight.
Our first measurements on board the ISS confirmed increased tone and stiffness of the lumbar multifidus muscle, an important trunk stabilizer, dysfunction of which is known to be associated with back pain. Furthermore, reduced tone and stiffness of Achilles tendon and plantar fascia were observed inflight vs. preflight, confirming previous findings from terrestrial analog studies and parabolic
flights. Unexpectedly, the deltoid showed negative inflight changes in tone and stiffness, and increased elasticity, suggesting a potential risk of muscle atrophy in longer spaceflight that should be addressed by adequate inflight countermeasure protocols. Most values from limb and back MPS showed deflected patterns (in either directions) from inflight shortly after the re-entry phase on the landing day and one week later. Most parameter values then normalized to baseline after 3 weeks likely due to 1G re-adaptation and possible outcome of the reconditioning protocol. No major changes in subcutaneous tissues thickness above the MPs were found inflight vs preflight, suggesting no bias (i.e., fluid shift, extreme tissue thickening or loss). Pre- and postflight MRI and functional tests showed negligible changes in calf muscle size, power and force, which is likely due to training effects from current inflight exercise protocols.
The MYOTONES experiment is currently ongoing to collect data from further crew members. The potential impact of this research is to better understand the effects of microgravity and countermeasures over the time course of an ISS mission cycle. This will enable exercise countermeasures to be tailored
Training-induced increase in Achilles tendon stiffness affects tendon strain pattern during running
(2019)
Werkhausen, Amelie ; Cronin, Neil J. ; Albracht, Kirsten ; Paulsen, Gøran ; Larsen, Askild V. ; Bojsen-Møller, Jens ; Seynnes, Olivier R.
Background
During the stance phase of running, the elasticity of the Achilles tendon enables the utilisation of elastic energy and allows beneficial contractile conditions for the triceps surae muscles. However, the effect of changes in tendon mechanical properties induced by chronic loading is still poorly understood. We tested the hypothesis that a training-induced increase in Achilles tendon stiffness would result in reduced tendon strain during the stance phase of running, which would reduce fascicle strains in the triceps surae muscles, particularly in the mono-articular soleus.
Methods
Eleven subjects were assigned to a training group performing isometric singleleg plantarflexion contractions three times per week for ten weeks, and another ten subjects formed a control group. Before and after the training period, Achilles tendon stiffness was estimated, and muscle-tendon mechanics were assessed during running at preferred speed using ultrasonography, kinematics and kinetics.
Results
Achilles tendon stiffness increased by 18% (P <0:01) in the training group, but the associated reduction in strain seen during isometric contractions was not statistically significant. Tendon elongation during the stance phase of running was similar after training, but tendon recoil was reduced by 30% (P <0:01), while estimated tendon force remained unchanged. Neither gastrocnemius medialis nor soleus fascicle shortening during stance was affected by training.
Discussion
These results show that a training-induced increase in Achilles tendon
stiffness altered tendon behaviour during running. Despite training-induced changes in tendon mechanical properties and recoil behaviour, the data suggest that fascicle shortening patterns were preserved for the running speed that we examined. The asymmetrical changes in tendon strain patterns supports the notion that simple inseries models do not fully explain the mechanical output of the muscle-tendon unit during a complex task like running.
Jan Thimo, Grundmann ; Bauer, Waldemar ; Biele, Jens ; Boden, Ralf ; Ceriotti, Matteo ; Cordero, Federico ; Dachwald, Bernd ; Dumont, Etienne ; Grimm, Christian D. ; Hercik, David
Grundmann, Jan Thimo ; Bauer, Waldemar ; Boden, Ralf Christian ; Ceriotti, Matteo ; Cordero, Federico ; Dachwald, Bernd ; Dumont, Etienne ; Grimm, Christian D. ; Hercik, D. ; Herique, A. ; Ho, Tra-Mi ; Jahnke, Rico ; Kofman, Wlodek ; Lange, Caroline ; Lichtenheldt, Roy ; McInnes, Colin R. ; Mikschl, Tobias ; Montenegro, Sergio ; Moore, Iain ; Pelivan, Ivanka ; Peloni, Alessandro ; Plettenmeier, Dirk ; Quantius, Dominik ; Reershemius, Siebo ; Renger, Thomas ; Riemann, Johannes ; Rogez, Yves ; Ruffer, Michael ; Sasaki, Kaname ; Schmitz, Nicole ; Seboldt, Wolfgang ; Seefeldt, Patric ; Spietz, Peter ; Spröwitz, Tom ; Sznajder, Maciej ; Toth, Norbert ; Viavattene, Giulia ; Wejmo, Elisabet ; Wolff, Friederike ; Ziach, Christian
In parallel to the evolution of the Planetary Defense Conference, the exploration of small solar system bodies has advanced from fast fly-bys on the sidelines of missions to the planets to the implementation of dedicated sample-return and in-situ analysis missions. Spacecraft of all sizes have landed, touch-and-go sampled, been gently beached, or impacted at hypervelocity on asteroid and comet surfaces. More have flown by close enough to image their surfaces in detail or sample their immediate environment, often as part of an extended or re-purposed mission. And finally, full-scale planetary defense experiment missions are in the making. Highly efficient low-thrust propulsion is increasingly applied beyond commercial use also in mainstream and flagship science missions, in combination with gravity assist propulsion. Another development in the same years is the growth of small spacecraft solutions, not in size but in numbers and individual capabilities. The on-going NASA OSIRIS-REx and JAXA HAYABUSA2 missions exemplify the trend as well as the upcoming NEA SCOUT mission or the landers MINERVA-II and MASCOT recently deployed on Ryugu. We outline likely as well as possible and efficient routes of continuation of all these developments towards a propellant-less and highly efficient class of spacecraft for small solar system body exploration: small spacecraft solar sails designed for carefree handling and equipped with carried landers and application modules, for all asteroid user communities –planetary science, planetary defence, and in-situ resource utilization. This projection builds on the experience gained in the development of deployable membrane structures leading up to the successful ground deployment test of a (20 m)² solar sail at DLR Cologne and in the 20 years since. It draws on the background of extensive trajectory optimization studies, the qualified technology of the DLR GOSSAMER-1 deployment demonstrator, and the MASCOT asteroid lander. These enable ‘now-term’ as well as near-term hardware solutions, and thus responsive fast-paced development. Mission types directly applicable to planetary defense include: single and Multiple NEA Rendezvous ((M)NR) for mitigation precursor, target monitoring and deflection follow-up tasks; sail-propelled head-on retrograde kinetic impactors (RKI) for mitigation; and deployable membrane based methods to modify the asteroid’s properties or interact with it. The DLR-ESTEC GOSSAMER Roadmap initiated studies of missions uniquely feasible with solar sails such as Displaced L1 (DL1) space weather advance warning and monitoring and Solar Polar Orbiter (SPO) delivery which demonstrate the capability of near-term solar sails to achieve NEA rendezvous in any kind of orbit, from Earth-coorbital to extremely inclined and even retrograde orbits. For those mission types using separable payloads, such as SPO, (M)NR and RKI, design concepts can be derived from the separable Boom Sail Deployment Units characteristic of DLR GOSSAMER solar sail technology, nanolanders like MASCOT, or microlanders like the JAXA-DLR Jupiter Trojan Asteroid Lander for the OKEANOS mission which can shuttle from the sail to the asteroids visited and enable multiple NEA sample-return missions. These are an ideal match for solar sails in micro-spacecraft format whose launch configurations are compatible with ESPA and ASAP secondary payload platforms.
Lyons, W. Berry ; Mikucki, Jill A. ; German, Laura A. ; Welch, Kathleen A. ; Welch, Susan A. ; Gardener, Christopher B. ; Tulaczyk, Slawek M. ; Pettit, Erin C. ; Kowalski, Julia ; Dachwald, Bernd