Article
Refine
Author
- Selmer, Thorsten (49)
- Bongaerts, Johannes (46)
- Biselli, Manfred (45)
- Scheer, Nico (34)
- Schöning, Michael Josef (32)
- Tippkötter, Nils (30)
- Mang, Thomas (27)
- Scherer, Ulrich W. (27)
- Seibler, Jost (26)
- Siegert, Petra (26)
- Baumann, Marcus (22)
- Paulßen, Elisabeth (22)
- Ulber, Roland (21)
- Maurer, Karl-Heinz (17)
- Wolf, C. Roland (17)
- Öhlschläger, Peter (17)
- Prielmeier, Franz (16)
- Elbers, Gereon (15)
- Monakhova, Yulia (15)
- Wagner, Torsten (15)
- Rode, Anja (13)
- Berndt, Heinz (12)
- Keusgen, Michael (11)
- Kotter, Michael (11)
- Hojdis, Nils (10)
- Pohl, Martina (10)
- Evers, Stefan (9)
- Hoehr, Cornelia (9)
- Poghossian, Arshak (9)
- Abram, Ulrich (8)
- Lang, E. W. (8)
- Lüdemann, H.-D. (8)
- Wandrey, Christian (8)
- Kapelyukh, Yury (7)
- Kricheldorf, Hans R. (7)
- Wandrey, C. (7)
- Wubbolts, Marcel (7)
- Albrecht, Dirk (6)
- Bode, Jürgen (6)
- Brüning, Jens C. (6)
- Campos-Ortega, José A. (6)
- Hecker, Michael (6)
- Henderson, Colin J. (6)
- Jeromin, Günter Erich (6)
- Kratz, J. V. (6)
- Molinnus, Denise (6)
- Pilas, Johanna (6)
- Schiffels, Johannes (6)
- Schnitzler, Thomas (6)
- Van der Pol, Jens J. (6)
- Voigt, Birgit (6)
- Born, C. (5)
- Bott, Michael (5)
- Brüchle, W. (5)
- Buckel, Wolfgang (5)
- Bäcker, Matthias (5)
- Gäggeler, H. W. (5)
- Karimi-Varzaneh, Hossein Ali (5)
- Krämer, Marco (5)
- Lauth, Jakob (5)
- Merschenz-Quack, Angelika (5)
- Muschallik, Lukas (5)
- Müller, Michael (5)
- Osen, Wolfram (5)
- Ross, Jillian (5)
- Schulze, Margit (5)
- Schwenk, Frieder (5)
- Schädel, M. (5)
- Thömmes, J. (5)
- Unden, Gottfried (5)
- Yoshinobu, Tatsuo (5)
- Al-Kaidy, Huschyar (4)
- Bovenberg, Roel (4)
- Daniel, Rolf (4)
- Demir, Ayhan S. (4)
- Diehl, Bernd W. K. (4)
- Diehl, Bernd W.K. (4)
- Engel, Mareike (4)
- Falkenberg, Fabian (4)
- Feuerriegel, Uwe (4)
- Hager, Jonathan (4)
- Hentschke, Reinhard (4)
- Holtmann, Dirk (4)
- Höcker, Hartwig (4)
- Kolz, J. (4)
- Krafft, Simone (4)
- Lehmann, G. (4)
- Liesegang, Heiko (4)
- Muffler, Kai (4)
- Müller, Ulrike (4)
- Raeven, Leon (4)
- Raue, Markus (4)
- Riekert, L. (4)
- Riekert, Lothar (4)
- Schmidt, Bernhard (4)
- Schweder, Thomas (4)
- Schübeler, Dirk (4)
- Sohling, Ulrich (4)
- Speedy, R. J. (4)
- Srivastava, Alok (4)
- Stanley, Lesley A. (4)
- Suck, Kirstin (4)
- Takors, Ralf (4)
- Temiz Artmann, Aysegül (4)
- Zimmermann, H. P. (4)
- Adels, Klaudia (3)
- Aletsee, Ludwig (3)
- Alvarez, Gerardo (3)
- Andrei, Paula I. (3)
- Artmann, Gerhard (3)
- Becher, Dörte (3)
- Breuer, Lars (3)
- Burger, René (3)
- Christmann, K. (3)
- Do, Xuan Tung (3)
- Dünnwald, Thomas (3)
- Elcombe, Clifford R. (3)
- Everaers, Ralf (3)
- Figura, Kurt von (3)
- Fleck, Franz (3)
- Frahm, Jens (3)
- Gober, M. K. (3)
- Greguric, Ivan (3)
- Grötzinger, Joachim (3)
- Haeger, Gerrit (3)
- Hellmuth, Hendrik (3)
- Hilbert, U. (3)
- Hoffstadt, Kevin (3)
- Iding, Hans (3)
- Jablonski, Melanie (3)
- Jost, D. T. (3)
- Jürgen, Britta (3)
- Keusgen, M. (3)
- Kuperjans, Isabel (3)
- Küter-Luks, Birgit (3)
- Lalk, Michael (3)
- Lassonczyk, Beate (3)
- Mclaughlin, Lesley A. (3)
- Meinhardt, Friedhelm (3)
- Mootz, D. (3)
- Nagatomo, Yasushi (3)
- Noll, T. (3)
- Noll, Thomas (3)
- O'Connell, Timothy (3)
- Pierik, Antonio J. (3)
- Pinkenburg, Olaf (3)
- Radkowitsch, H. (3)
- Remme, S. (3)
- Ruf, Friedrich (3)
- Rumpf, Jessica (3)
- Schaffer, Paul (3)
- Schmidt, S. (3)
- Schroeter, Rebecca (3)
- Six, S. (3)
- Sprenger, G. (3)
- Svaneborg, Carsten (3)
- Türler, A. (3)
- Unden, G. (3)
- Wagner, Patrick (3)
- Wege, Christina (3)
- Zang, Werner (3)
- Aggarwal, Pranav (2)
- Bauer, Bernhard L. (2)
- Baumann, Martin (2)
- Becker, S. (2)
- Benard, Francois (2)
- Bertalanffy, Helmut (2)
- Beuger, Vincent (2)
- Bial, J. (2)
- Biel, Markus (2)
- Birner-Gruenberger, R. (2)
- Blaser, Martin (2)
- Braband, Henrik (2)
- Braeuning, Albert (2)
- Buckley, Ken (2)
- Buechel, Sandra (2)
- Burmistrova, Natalia A. (2)
- Bélanger-Champagne, Camille (2)
- Büchs, Jochen (2)
- Canzoneri, Michele (2)
- Capitain, Charlotte (2)
- Celler, Anna (2)
- Cheenakula, Dheeraja (2)
- Chen, Liangfu (2)
- Chibout, Salah-Dine (2)
- Chu, Xiaoyan (2)
- Couttet, Philippe (2)
- Dallas, Shannon (2)
- Delaittre, Guillaume (2)
- Deppe, Veronika Maria (2)
- Dierks, Thomas (2)
- Druckenmüller, Katharina (2)
- Duwe, Anna-Maria (2)
- Dürst, Matthias (2)
- Eckert, Alexander (2)
- Eisenkrätzer, Detlef (2)
- Eiteljoerg, I. (2)
- Elskens, M. (2)
- Faust, Nicole (2)
- Ferguson, Simon (2)
- Fiering, Steven (2)
- Gerigk, M. (2)
- Gradinger, R. (2)
- Grenet, Olivier (2)
- Groebel, Simone (2)
- Groth, Ulrich (2)
- Gruber, K. (2)
- Hampel, Brigitte (2)
- Handtke, Stefan (2)
- Hanemaayer, Victoire (2)
- Hans, Stefan (2)
- Harms, Hauke (2)
- Haulena, Friedhelm (2)
- Henderson, Colin James (2)
- Herfurth, C. (2)
- Hetzel, Marc (2)
- Hirschwald, W. (2)
- Hoelderich, W. (2)
- Horsburgh, Brian C. (2)
- Hou, Xinchi (2)
- Huhn, Thomas (2)
- Hör, G. (2)
- Iber, Michaela (2)
- Ingendoh, Arnd (2)
- Jaeger, Karl-Erich (2)
- Jahnke, J. (2)
- Jakob, Felix (2)
- Jelinek, N. (2)
- Jennemann, Richard (2)
- Joksch, B. (2)
- Jonkers, Jos (2)
- Jonté, J. Michael (2)
- Jossek, Ralf (2)
- Kalbe, Jochen (2)
- Karl, W. (2)
- Kauselmann, Gunther (2)
- Kern, Heidrun (2)
- Kipp, Carina Ronja (2)
- Klose, W. (2)
- Koch, Linda (2)
- Kragl, U. (2)
- Krauss, Manuel (2)
- Kremer, K. (2)
- Krumbe, Christoph (2)
- Krüger, Götz (2)
- Kunta, Jeevan (2)
- Kuropka, Rolf (2)
- Könner, A. Christine (2)
- Kühn, Ralf (2)
- Laplanche, Loic (2)
- Le, Van So (2)
- Lempiäinen, Harri (2)
- Lengkeek, Nigel A. (2)
- Leurs, Ulrike (2)
- Lin, De (2)
- Lindner, Simon (2)
- Lintz, Hans-Günther (2)
- Luisier, Raphaëlle (2)
- Lüllau, E. (2)
- MacLeod, Alastair Kenneth (2)
- Manea, Marilena (2)
- Martinez, Ronny (2)
- Martins, J. (2)
- Meehan, Richard R. (2)
- Mesch, K. (2)
- Methling, Karen (2)
- Meyer-Stork, L. Sebastian (2)
- Mezler, Mario (2)
- Moggs, Jonathan G. (2)
- Mostacci, Domiziano (2)
- Moulin, Pierre (2)
- Mues genannt Koers, Lucas (2)
- Müller, Arne (2)
- Niedermeier, Jana (2)
- Niehaves, Sandra (2)
- Nikolausz, Marcell (2)
- Nokihara, Kiyoshi (2)
- Orban, Erika (2)
- Pang, Jodie (2)
- Pellegrini, Paul A. (2)
- Penner, Crystal (2)
- Plum, Leona (2)
- Quetting, Michael (2)
- Rehahn, Matthias (2)
- Remler, P. (2)
- Ribitsch, D. (2)
- Riedl, Iris (2)
- Riley, R. J. (2)
- Roth, Jasmine (2)
- Runstadler, P. W. (2)
- Röhlen, Desiree (2)
- Schelden, Maximilian (2)
- Schirawski, J. (2)
- Schmitz, Dominik (2)
- Schneider, Felix (2)
- Schreiter, K. (2)
- Schröder, B. (2)
- Schwab, H. (2)
- Schwaneberg, Ulrich (2)
- Schwarz, Michael (2)
- Seifarth, Volker (2)
- Semeneh, M. (2)
- Sieker, Tim (2)
- Singh, Virendra (2)
- Soboleva, Polina M. (2)
- Solomun, T. (2)
- Sprenger, Georg A. (2)
- Stahlberg, R. (2)
- Stiefelmaier, Judith (2)
- Takenaga, Shoko (2)
- Thiel, Alexander (2)
- Thoelen, R. (2)
- Thomson, John P. (2)
- Trinczek, Michael (2)
- Tüg, Helmut (2)
- Usherovich, Samuel (2)
- Volland, Sonja (2)
- Wagenblast, G. (2)
- Wagner, P. (2)
- Walther, Andreas (2)
- Wehr, R. (2)
- Weiner, Ron (2)
- Welden, Melanie (2)
- Werner, Frederik (2)
- Wick, Markus (2)
- Wiegand, Sandra (2)
- Wieland, S. (2)
- Wientjens, Ellen (2)
- Wiesen, Sebastian (2)
- Wilson, E. M. (2)
- Wilson, Ian D. (2)
- Wolf, Roland C. (2)
- Wollny, Steffen (2)
- Wunderlich, F. Thomas (2)
- Yabut, Jocelyn (2)
- Zeisler, Stefan (2)
- Zevnik, Branko (2)
- Abbasi, Mozhdeh (1)
- Abetz, C. (1)
- Abetz, V. (1)
- Abouabdillah, Aziz (1)
- Aboudrare, Abdellah (1)
- Aboulnaga, El-Hussiny A. A. (1)
- Aboulnaga, Elhussiny A. (1)
- Abulnaga, El-Hussiny (1)
- Achebach, Stephanie (1)
- Adam, Michael J. (1)
- Adler, Thure (1)
- Aggarwal, Prerna (1)
- Akpinar, Hale (1)
- Al-Khasawneh, Kafa (1)
- Al-Momani, Lóay (1)
- Alaily, F. (1)
- Alami, Raouf (1)
- Alber, Jens (1)
- Alberto, Roger (1)
- Albertz, Michael (1)
- Albracht, Kirsten (1)
- Alenina, Natalia (1)
- Aliotta, M. (1)
- Alkemade, J. (1)
- Alloza, Leonor (1)
- Almajhdi, Fahad N. (1)
- Ammann, Markus (1)
- Anastassiadis, Konstantinos (1)
- Andonian, Clara (1)
- Andreas, Susanne (1)
- Andrei-Selmer, Luminita-Cornelia (1)
- Ansorge, Marion (1)
- Ansorge-Schumacher, Marion (1)
- Arciszewski, Pawel (1)
- Armbruster, P. (1)
- Arndt, Patrick (1)
- Ashcroft, Frances M. (1)
- Atmane, Ilyas (1)
- Au, M. (1)
- Baarends, Willy M. (1)
- Bacher, Michael (1)
- Bachiri, Najib (1)
- Bader, Michael (1)
- Badesso, Brian (1)
- Baer, Alexandra (1)
- Bahrenberg, Gregor (1)
- Baier, M. (1)
- Baitzel, Catherina (1)
- Balakrishnan, Karthikeyan (1)
- Balimane, Praveen (1)
- Ballemans, L. (1)
- Baltensperger, Urs (1)
- Balthasar, Nina (1)
- Baranyai, Zsuzsa (1)
- Barbazán, Paula (1)
- Bart, Hans-Jörg (1)
- Bartsch, J. (1)
- Bartz, Alexander (1)
- Barve, Avantika (1)
- Bauch, Melanie (1)
- Baumann, M. (1)
- Bayer, Hendrik (1)
- Becht, Alexander (1)
- Beck-Sickinger, Annette G. (1)
- Becker, C. (1)
- Beckers, Mario (1)
- Begemann, Jens (1)
- Beging, Stefan (1)
- Behner, T. (1)
- Beier, Reinhold (1)
- Belgardt, Bengt F. (1)
- Beloqui, Ana (1)
- Benham, C. (1)
- Berg, G. (1)
- Berg, Joost H. van den (1)
- Bergmann, Martin (1)
- Bergs, Michel (1)
- Betsch, Matthias (1)
- Bilban, Martin (1)
- Blader, Patrick (1)
- Bleisteiner, Monika (1)
- Block, Franziska (1)
- Blümich, B. (1)
- Bochert, Ulrich K. (1)
- Bode, J. (1)
- Boggetti, Barbara (1)
- Bolognani, Federico (1)
- Bonatelli, Maria (1)
- Booij, A. S. (1)
- Borgmeier, Claudia (1)
- Bork, M. (1)
- Bosch, L. (1)
- Bott, L. (1)
- Bouabid, Rachid (1)
- Bouhassira, Eric E. (1)
- Boulikas, T. (1)
- Bourioug, Mohamed (1)
- Bouwman, Peter (1)
- Bower, Conrad C. (1)
- Brabant, Georg (1)
- Brandini, F. (1)
- Brandini, Frederico (1)
- Brandt, Jens van den (1)
- Brasa, Sarah (1)
- Braun, Heiko (1)
- Braun, Thomas (1)
- Bremer, Erhard (1)
- Breuer, L. (1)
- Brock, Matthias (1)
- Brocke, Rainer (1)
- Bruhn, H. (1)
- Bruno, C. G. (1)
- Brönneke, Hella S. (1)
- Brückner, Benjamin (1)
- Brügger, M. (1)
- Brüser, Thomas (1)
- Buchholz, Heinrich (1)
- Buck, Manfred (1)
- Buckel, W. (1)
- Budianto, Arif (1)
- Bujnicki, R. (1)
- Bujnicki, Robert (1)
- Burdakov, Denis (1)
- Busch, Diana (1)
- Busch, Dirk H. (1)
- Böhmig, Georg A. (1)
- Böttger, Thomas (1)
- Büchs, J. (1)
- Bühl, Michael (1)
- Büllesbach, Erika E. (1)
- Caldeira, Sandra (1)
- Calzada-Wack, Julia (1)
- Capitain, C. (1)
- Cappellen, Wiggert A. van (1)
- Carballo, Rosa (1)
- Casanova, F. (1)
- Casotti, R. (1)
- Castillo, J. (1)
- Cehreli, Ruksan (1)
- Cereghini, Silvia (1)
- Cesari, Francesca (1)
- Chandra, Amita (1)
- Chasseigneaux, Stephanie (1)
- Chayeb, Hamid (1)
- Chen, Ruijiu (1)
- Chitnis, Ajay B. (1)
- Chowdhury, Nilanjan Pal (1)
- Christoph, Thomas (1)
- Cirpus, Irina (1)
- Claßen, Melanie (1)
- Clegg, William (1)
- Coppari, Roberto (1)
- Cornelissen-Steijger, Paulien (1)
- Corvinus, Florian M. (1)
- Cronin, Neil J. (1)
- Croué, Jean-Philippe (1)
- Cwienczek, Marcel (1)
- Dahl, Christiane (1)
- Dahmen, Markus (1)
- Danho, Waleed (1)
- Darley, Dan J. (1)
- Darley, Daniel (1)
- Davinson, T. (1)
- De Gooijer, Cornelis D. (1)
- Declèves, Xavier (1)
- Deflon, Victor M. (1)
- Degering, Christian (1)
- Dehairs, F. (1)
- Dell, Kerstin (1)
- Delle, L. (1)
- Dellmann, Sophia Florence (1)
- Demmer, Julius K. (1)
- Denkova, A.G. (1)
- Denkova, Antonia G. (1)
- Denzler, Hans-Jörg (1)
- Deterding, A. (1)
- Dhiman, Shashi K. (1)
- DiLoreto, Karen (1)
- Dickel, T. (1)
- Dickie, A. P. (1)
- Dickie, A.P. (1)
- Diehl, Bernd (1)
- Diehl, Bernd W. (1)
- Diehm, Ralf (1)
- Dierks, T. (1)
- Dietrich, Sascha (1)
- Digel, Ilya (1)
- Dillmann, Iris (1)
- Dimitrova, Darina (1)
- Ding, Xinxin (1)
- Dinter, Andre (1)
- Dmytriev, D. (1)
- Dodel, Richard (1)
- Dong, Lihua (1)
- Dreisbach, C. (1)
- Drost, Rinske (1)
- Dubost, Valerie (1)
- Dubost, Valérie (1)
- Dunker, R. (1)
- Dursun, Gözde (1)
- Dutta, Suryendu (1)
- Duwe, Anna (1)
- Dünkelmann, Pascal (1)
- E-Refai, Ahmed (1)
- Eberhardt, R. (1)
- Eberhardt, Rolf (1)
- Ebert, Klaus H. (1)
- Eck, J. (1)
- Ederer, Hanns J. (1)
- Eggert, Thorsten (1)
- Ehrenreich, Armin (1)
- Eisen, Andrew (1)
- El Bergui, Omnia (1)
- El Hatka, Hicham (1)
- El Moussaoui, Noureddine (1)
- Ellinger-Ziegelbauer, Heidrung (1)
- Engels, Ralf (1)
- Englberger, Werner (1)
- Englert, Christoph (1)
- Engudar, Gokce (1)
- Epple, Matthias (1)
- Erbacher, P. (1)
- Erbay, E. (1)
- Erdmann, Volker A. (1)
- Ermler, Ulrich (1)
- Esposito, Irene (1)
- Esser, Simon (1)
- Evers, Raymond (1)
- Faath, Stefan (1)
- Fagroud, Mustapha (1)
- Fedotova, Elena S. (1)
- Fekete, Csaba (1)
- Feliks, Mikolaj (1)
- Feng, Yong-Qing (1)
- Fischer, David (1)
- Fischer, Rainer (1)
- Flaig, Sascha T. (1)
- Foerstel, D. H. (1)
- Forouzan, Dara (1)
- Forstner, Oliver (1)
- Frahm, J. (1)
- Franke, Dirk (1)
- Frech, Moritz (1)
- Freire-Fernández, D. (1)
- Freudl, Roland (1)
- Freyschmidt, Eva-Jasmin (1)
- Friedrich, Andrea (1)
- Friedrich, Peter (1)
- Friedrich, W. (1)
- Friesel, Jürgen (1)
- Frink, C. (1)
- Fuchs, Helmut (1)
- Föhles, Joseph (1)
- Förster, Arnold (1)
- Gabor, E. (1)
- Gabriel, B. (1)
- Gailus-Durner, Valérie (1)
- Galgens, Jochem (1)
- Ganpo-Nkwenkwa, E. (1)
- Garske, U. (1)
- Gebeshuber, Christoph A. (1)
- Geier, Ethan G. (1)
- Geissel, H. (1)
- Geissler, Miriam (1)
- Gelissen, Melanie (1)
- Gemünde, Andre (1)
- Gensior, A. (1)
- Georgopanos, P. (1)
- Gerlach, J. (1)
- Ghod, Mumin M. (1)
- Ghosch, S. (1)
- Gieselmann, Volkmar (1)
- Gissmann, Lutz (1)
- Giudicelli, Fanny (1)
- Glaser, Stefan (1)
- Gleitz, M. (1)
- Glorius, J. (1)
- Glöggler, S. (1)
- Goebel, H. [u.a.] (1)
- Goetze, Sandra (1)
- Goeyens, L. (1)
- Goga, N. (1)
- Gokarn, Ravi R. (1)
- Gomez, Raquel (1)
- Gomez-Zepeda, David (1)
- Gonzalez, Laura Osorio (1)
- Goodman, Jay (1)
- Goodman, S. D. (1)
- Gottrup, Marcus (1)
- Goubeaud, Marcel (1)
- Goßmann, Matthias (1)
- Grankin, Alina (1)
- Grasl-Kraupp, Bettina (1)
- Grefen, Dana (1)
- Greger, M. (1)
- Gregorich, K. E. (1)
- Greiner, Lasse (1)
- Griffin, Christopher J. (1)
- Grisenti, R. (1)
- Groettrup, Marcus (1)
- Grogg, A. (1)
- Grondal, Christoph (1)
- Grootegoed, J. Anton (1)
- Grosse, J. O. (1)
- Grosse, Joachim O. (1)
- Grossmann, Matthias (1)
- Groth, Anne (1)
- Groudine, Mark (1)
- Grömping, Markus (1)
- Gröne, Hermann-Josef (1)
- Grützke, Martin (1)
- Guebitz, G. M. (1)
- Guenther, Klaus (1)
- Gulden, Hanneke van der (1)
- Gumberidze, Alexandre (1)
- Guo, Jiaqi (1)
- Guo, Yuanyuan (1)
- Gyngell, M. L. (1)
- Gäb, Martina (1)
- Gätgens, J. (1)
- Göbel, K. (1)
- Günther, Klaus (1)
- Haanen, J. B. A. G. (1)
- Haanen, John B. (1)
- Haettner, Emma (1)
- Hafidi, Youssef (1)
- Hagenbach, Adelheid (1)
- Hagmann, Siegbert (1)
- Hahne, Florian (1)
- Halbach, Thorsten (1)
- Hallmann, Armin (1)
- Hambach, B. (1)
- Hammon, U. (1)
- Hammon, Ulrich (1)
- Handge, U. A. (1)
- Hanicke, W. (1)
- Hannig, M. (1)
- Hans, Marcus (1)
- Hara, Hisanori (1)
- Harish, Ajay B. (1)
- Harrington, Ross W. (1)
- Hartkopf-Fröder, Christoph (1)
- Hasegawa, Maki (1)
- Haumaitre, Cécile (1)
- Hayward, Michael D. (1)
- He, Handan (1)
- Heard, David J. (1)
- Heeren, Joerg (1)
- Heering, J. (1)
- Heider, Johann (1)
- Heijden, Ingrid van der (1)
- Heil, M. (1)
- Heilmann, Marcel (1)
- Heimann, Cornelia (1)
- Heimbach, Tycho (1)
- Heine, A. (1)
- Heinze, D. (1)
- Heinze, Daniel (1)
- Heinzle, Elmar (1)
- Hemmerling, H.-J. (1)
- Hemmerling, Hans-Jörg (1)
- Hendo, Karsten (1)
- Hengsbach, Jan-Niklas (1)
- Henken, F. E. (1)
- Hennek, Thomas (1)
- Herfurth, Cornelia (1)
- Hering, T. (1)
- Hering, Thomas (1)
- Hermann, Gloria (1)
- Herold, Marco J. (1)
- Herrera, Cony N. (1)
- Herrmann, G. (1)
- Herrmanns, Karolin (1)
- Hertel, Robert (1)
- Heschel, I. (1)
- Heumann, S. (1)
- Heß, R. (1)
- Heßberger, F. P. (1)
- Hijum, Sacha A. F. T. van (1)
- Hillenbrand, P.-M. (1)
- Hirche, H.-J. (1)
- Hirsch, E. (1)
- Hitzeroth, Inga I. (1)
- Hodenius, M. A. J. (1)
- Hoeijmakers, Jan H. J. (1)
- Hoepfner, Sandra (1)
- Hoffmann, Alexander (1)
- Hoffmann, Katharina (1)
- Hoffmann, Tamara (1)
- Hoft, Carolin (1)
- Hogervorst, Frank B. L. (1)
- Holighaus, G. (1)
- Holzgrabe, Ulrike (1)
- Hooijberg, E. (1)
- Horvath, Tamas L. (1)
- Hough, Lindsay B. (1)
- Howell, Nicholas R. (1)
- Hrabe de Angelis, Martin (1)
- Hruschka, Steffen M. (1)
- Hubberten, D.N. (1)
- Huck, Christina (1)
- Hummel, Helga (1)
- Hummel, Joana (1)
- Hunger, K. (1)
- Huster, Manuel (1)
- Huth, A. (1)
- Hörstermann, D. (1)
- Höxter, Maria (1)
- Iber, M. (1)
- Ignatova, Ludmila (1)
- Ihme, B. (1)
- Iken, Heiko (1)
- Immel, Timo (1)
- Immel, Timo A. (1)
- Inagaki, Akiko (1)
- Infantino, Angelo (1)
- Irlenbusch, Sigrid (1)
- Ittobane, Najim (1)
- Jackson, Tim (1)
- Jacobi, M. (1)
- Jaenisch, Rudolf (1)
- Janke, Heinz Peter (1)
- Janoschek, Ruth (1)
- Jeitner, C. (1)
- Jelinek, Nanni (1)
- Jessen, Holly (1)
- Joksch, Burkhard (1)
- Jomaa, Ahlem (1)
- Jordan, Sabine D. (1)
- Joseph, R. (1)
- Jungk, Juliane (1)
- Jurado, B. (1)
- Jäger, E. (1)
- Kahlcke, Nils (1)
- Kahn, C. Ronald (1)
- Kahnt, Jörg (1)
- Kain, Renate (1)
- Kalteis, Magdalena (1)
- Kampeis, Percy (1)
- Kappel, Sven (1)
- Kappler-Tanudyaya, Nathalie (1)
- Karimi-Varnaneh, Hossein Ali (1)
- Kashkar, Hamid (1)
- Kassmi, Khalil (1)
- Katsifis, Andrew G. (1)
- Kattner, G. (1)
- Kaufmann, Andreas M. (1)
- Kaufmann, R. (1)
- Kayser, Peter (1)
- Kehler, Jonathan (1)
- Kenyon, George L. (1)
- Kerjaschki, Dontscho (1)
- Ketterer, Lothar (1)
- Kiesewetter, André (1)
- Kim, Ceol-Hee (1)
- Kim, Jihoe (1)
- Kirschbaum, M. (1)
- Kistaubayeva, Aida (1)
- Klatte, Stephanie (1)
- Kleinridders, Andre (1)
- Klijn, Christiaan N. (1)
- Klingenspor, Martin (1)
- Kloock, Joachim P. (1)
- Klose, Holger (1)
- Klostermeyer, Henning (1)
- Klyushnichenko, Vadim (1)
- Knecht, Rainald (1)
- Kneen, Malea M. (1)
- Knippschild, Uwe (1)
- Koch, Sabine (1)
- Kohn, Sophie (1)
- Kolter-Jung, Doris (1)
- Kong, Shushu (1)
- Konow, Christopher (1)
- Kornauth, Christoph (1)
- Kornfeld, Jan-Wilhelm (1)
- Kotnik, Katarina (1)
- Kovacs, J. (1)
- Kozak, Stefan (1)
- Kozhuharov, Christophor (1)
- Kranert, W. T. (1)
- Kranz, Andrea (1)
- Kratz, F. (1)
- Krauss, N. (1)
- Kreft, Bertolt (1)
- Kremer, Susanne (1)
- Kreutzer, A. (1)
- Kroll, Stephen (1)
- Krone, Wilhelm (1)
- Krueger, Rolf (1)
- Krueger, Sylvia (1)
- Krämer, Andrea (1)
- Krüger, Markus (1)
- Krüger, Peter (1)
- Kuhne, Stefan (1)
- Kula, M.-R. (1)
- Kulikov, I. (1)
- Kumar, G. (1)
- Kumar, Vivekanantha (1)
- Kurreck, Jens (1)
- Kurunci-Csacsko, Elisabeth (1)
- Kurutsch, Anja (1)
- Kuthan, Kai (1)
- Kuwada, John Y. (1)
- Kögel, Babette (1)
- Kückmann, Theresa (1)
- Küppers, Tobias (1)
- Lacayo, Jorge (1)
- Lammers, Tom (1)
- Lancelot, C. (1)
- Lange, H. R. (1)
- Lange, J. (1)
- Lange, M. (1)
- Langer, Christoph (1)
- Langer, Oliver (1)
- Langsdorf, Alexander (1)
- Lara, R.J. (1)
- Lawson, Nathan D. (1)
- Le, Dao (1)
- Leber, R. (1)
- Leboulch, Philippe (1)
- Leckenby, Guy (1)
- Lederer-Woods, C. (1)
- Lee, Chris Jaeil (1)
- Lee, Dongtao N. (1)
- Leitner, W. (1)
- Leitner, Walter (1)
- Lengkeek, Nigel (1)
- Lenzen, Sigurd (1)
- Lestinsky, M. (1)
- Li, D. X. (1)
- Li, Wenkui (1)
- Liebl, Wolfgang (1)
- Liese, Andreas (1)
- Lin, Wen (1)
- Linden, Gottfried (1)
- Lingen, Bettina (1)
- Linnemann, J. (1)
- Lisdat, Fred (1)
- Lisinski, Susanne (1)
- Litvinov, S. A. (1)
- Litvinov, Yu A. (1)
- Liu, Z. (1)
- Lobe, Melanie (1)
- Lohuizen, Maarten van (1)
- Lorbach, Volker (1)
- Lorenz, B. A. (1)
- Lorenz, E. (1)
- Loss, Peter (1)
- Loveland, Kate L. (1)
- Lowis, Carsten (1)
- Lubitz, Sandra (1)
- Lukatela, G. (1)
- Längle, Ulrich (1)
- Löher, Bastian (1)
- Lüdemann, H. D. (1)
- Ma, Xiaosong (1)
- Maass, Karin (1)
- Maaß, D. (1)
- Machnik, Marc (1)
- Maggakis-Kelemen, C. (1)
- Maier, G. (1)
- Mak, Tak W. (1)
- Mamaril-Fishman, Donna (1)
- Mandawe, John (1)
- Mann, Ulrich (1)
- Marcellin, Magali (1)
- Mariano, K. (1)
- Markert, Bernd (1)
- Marlowe, Jennifer (1)
- Marquard, Andrea (1)
- Marquardt, Andreas (1)
- Marsh, J. (1)
- Martinez, Javier (1)
- Martins, Berta M. (1)
- Marz, Martin (1)
- Marzábal, Pablo (1)
- Matoni, Georg (1)
- Matthess, Yves (1)
- Maul, F. D. (1)
- Maurer, Jan (1)
- May, Alexander (1)
- Mayer, Jan (1)
- McEwan, Jillian (1)
- McLeish, Michael J. (1)
- McNeil, S. W. (1)
- Mclaren, Aileen W. (1)
- Medlin, L. K. (1)
- Meier, Rahel (1)
- Meissner, Petra (1)
- Meißner, P. (1)
- Menet, Marie-Claude (1)
- Menz, Esther Babette (1)
- Merboldt, K. D. (1)
- Merboldt, K.-D. (1)
- Merkwirth, Carsten (1)
- Merseburg, Johannes (1)
- Methner, F.-J. (1)
- Metzger, Ute (1)
- Meyer, Hanna (1)
- Meyer, Jan (1)
- Meyer, Lina (1)
- Meyers, Ann E. (1)
- Mezo, Gabor (1)
- Miao, Qing (1)
- Michalak, Ewa Malgorzata (1)
- Michel, Nico (1)
- Miech, Claudia (1)
- Mielke, C. (1)
- Milow, Barbara (1)
- Miyamoto, Ko-ichiro (1)
- Moeller, Marcus J. (1)
- Mojsen-Moeller, Jens (1)
- Molina, R. (1)
- Molina, Roberto (1)
- Moll, Fabian (1)
- Monzon, Magaly (1)
- Morawiec, Laurent (1)
- Moret, J.L.T.M. (1)
- Morgenroth, T. (1)
- Mori, Marcelo A. (1)
- Moriggl, Richard (1)
- Muntel, Jan (1)
- Musina, Kristina T. (1)
- Mußmann, Nina (1)
- Möhring, Sophie (1)
- Möller, Martin (1)
- Mühlsiepen, Heinz (1)
- Müller, Bettina (1)
- Müller, Janina (1)
- Müller, Joachim (1)
- Müller, Michael A. (1)
- Müller-Renno, C.M. (1)
- Müller-Renno, Christine (1)
- Münstermann, Felix (1)
- Münzberg, Heike (1)
- Müschen, S. (1)
- Nacerddine, Karim (1)
- Nachtrodt, Frederik (1)
- Naithani, V. K (1)
- Naithani, Vinod K. (1)
- Nalwalk, Julia W. (1)
- Nehls, Jenny (1)
- Nehlsen, Kristina (1)
- Netz, Daili Jacqueline Aguilar (1)
- Neuner, Andreas (1)
- Ngyugen, Hung Huy (1)
- Nicholls, Hayley T. (1)
- Niedermeyer, Angela (1)
- Nieger, Martin (1)
- Niehaus, F. (1)
- Nikolaev, Lev (1)
- Nitsche, Adam (1)
- Noack, Udo (1)
- Noor, Johan A.E. (1)
- Nordheim, Alfred (1)
- Nork, Jasmina (1)
- Näser, Ulrike (1)
- Oehlenschläger, Katharina (1)
- Oertel, Dan (1)
- Ohbo, Kazu (1)
- Ojovan, Michael I. (1)
- Olkkonen, Vesa M. (1)
- Ommen, J.R. van (1)
- Ooms, Marja (1)
- Oosterhuis, K. (1)
- Oosterhuis, Koen (1)
- Orf, Sonja (1)
- Orth, Carina (1)
- Oswald, Stefan (1)
- Pasteur, Aline (1)
- Pawlitzky, Inka (1)
- Peiler, Tanja (1)
- Pellegrini, Paul (1)
- Pereira, Tony (1)
- Pes, Michaela (1)
- Peter, Karin (1)
- Petridis, N. (1)
- Pettrak, Jürgen (1)
- Pfeffer, Hans-Ulrich (1)
- Pham, Van N. (1)
- Pibernat, Jerome (1)
- Picard, Frank (1)
- Pierre, Esaie (1)
- Pieterse, Mark (1)
- Pietersen, Alexandra (1)
- Plummer, Simon M. (1)
- Pogrebnjak, Alexander (1)
- Pohl, Regula (1)
- Polen, T. (1)
- Popescu, C. (1)
- Popova, Elena (1)
- Popp, U. (1)
- Portela-Klein, Theresa (1)
- Poth, Sebastian (1)
- Prasad, Bhagwat (1)
- Prasetyanti, Pramudita (1)
- Prevost, David (1)
- Prinz, Florian (1)
- Prissok, F. (1)
- Probst, Johanna (1)
- Psaltis, Athanasios (1)
- Pude, Ralf (1)
- Puls, Michael (1)
- Putzer, Harald (1)
- Raab, Monika (1)
- Rachinger, Michael (1)
- Radchenko, V. (1)
- Rahba, Jade (1)
- Rajewsky, Klaus (1)
- Rakowski, D. (1)
- Rath, S. (1)
- Rathkolb, Birgit (1)
- Ratke, Lorenz (1)
- Raupp, Sebastian M. (1)
- Rechmann, Hanrik (1)
- Recker, Carla (1)
- Recker, Inga (1)
- Recksiek, Michael (1)
- Redemann, Nora (1)
- Regestein, Lars (1)
- Reichardt, Holger M. (1)
- Reifarth, R. (1)
- Reinecke, Diana (1)
- Reiss, Martina (1)
- Rennekampff, Verena (1)
- Rettner, Cornelius (1)
- Reugels, Alexander M. (1)
- Reuter, K. (1)
- Riesner, Detlev (1)
- Rio-Espinola, Alberto del (1)
- Ritterbecks, S. (1)
- Robb, Lorraine (1)
- Rodenas, J. (1)
- Rodenbrock, Anja (1)
- Rodriguez-Hermida, Sabina (1)
- Roellig, Daniela (1)
- Rohde, M. (1)
- Roikaew, W. (1)
- Roikaew, Wipa (1)
- Rolef, G. (1)
- Romuli, Sebastian (1)
- Roosen, C. (1)
- Roosen, Christoph (1)
- Rosman, Jan (1)
- Ross-Jones, J. (1)
- Ross-Jones, Jesse (1)
- Rother, Eva (1)
- Rousseau, V. (1)
- Rudolph, Tobias (1)
- Ruth, Thomas (1)
- Ruth, Thomas J. (1)
- Rutledge, Douglas N. (1)
- Rybicki, Edward P. (1)
- Rädle, M. (1)
- Röhl, Thomas (1)
- Rösch, C. (1)
- Saalwächter, Kay (1)
- Sagol, Ozgul (1)
- Sakshaug, E. (1)
- Salpati, Laurent (1)
- Salphati, Laurent (1)
- Sanhaji, Mourad (1)
- Sanjari, Shahab (1)
- Santana, H. H. S. (1)
- Sasaki, André N. (1)
- Sauter, Sybille L. (1)
- Savitskaya, Irina (1)
- Schaap, K. S. (1)
- Schabel, Wilhelm (1)
- Scharfer, Philip (1)
- Scheele, Sandra (1)
- Scheidenberger, C. (1)
- Scheidt, Annette (1)
- Scheja, Ludger (1)
- Schenk, Frieder (1)
- Scheper, Thomas (1)
- Scherbichler, Nina (1)
- Schiedermeier, Maximilian (1)
- Schiene, Klaus (1)
- Schimpf, E. (1)
- Schinkel, Alfred H. (1)
- Schlake, Thomas (1)
- Schlegel, Christin (1)
- Schlüter, Rabea (1)
- Schmich, Peter (1)
- Schmid, Georg (1)
- Schmidt, Aaron C. (1)
- Schmidt, Sebastian (1)
- Schmitt, Heike (1)
- Schmitt, Marcel (1)
- Schmitz, M. (1)
- Schmitz, Sandra (1)
- Schmitz-Rode, T. (1)
- Schmoll, H.-J. (1)
- Schneeweiss, F. (1)
- Schneider, Benno (1)
- Schollmayer, Curd (1)
- Schoor, Michael (1)
- Schröder, Bernd (1)
- Schröder, Wolfgang (1)
- Schulcz, Akos (1)
- Schumacher, Katharina (1)
- Schumacher, Ton N. (1)
- Schusser, Sebastian (1)
- Schwab, Lukas (1)
- Schwarz, E. (1)
- Schwarzer, Klemens (1)
- Schweighöfer, Philip V. (1)
- Schübeler, D. (1)
- Schürmann, Melanie (1)
- Schütz, J. (1)
- Scott, Richard (1)
- Sehr, Peter (1)
- Severins, Robin (1)
- Seynnes, Olivier R. (1)
- Sguazzin, M. (1)
- Shanabrough, Marya (1)
- Shepherd, Rachael K. (1)
- Shima, Seigo (1)
- Shin, Myung K. (1)
- Sidhu, Ragandeep Singh (1)
- Sierig, Ralph (1)
- Sievers, Susanne (1)
- Simic, Damir (1)
- Singh, Arjun (1)
- Singh, Tejvir (1)
- Singh, Vivendra (1)
- Singla, M. L. (1)
- Singla, Madan L. (1)
- Sleddens-Linkels, Esther (1)
- Sloboshanin, S. (1)
- Smith, Walker O. (1)
- Snaith, Mike (1)
- Snezhkov, Evgeney (1)
- Soars, Matthew G. (1)
- Sommerlade, Hans-Jörg (1)
- Sorich, Maren (1)
- Spelthahn, Heiko (1)
- Spies, Elmar (1)
- Spiess, Elmar (1)
- Spillmann, Uwe (1)
- Spohn, U. (1)
- Spohn, Uwe (1)
- Späte, Anne-Katrin (1)
- Stadtmüller, Ralf (1)
- Stanley, Lesley (1)
- Staubes, Regina (1)
- Steck, M. (1)
- Steenbergen, R. D. M. (1)
- Steffen, Victoria (1)
- Steinberg, Thorsten (1)
- Steinmetz, Hans-Jürgen (1)
- Steinwachs, S. (1)
- Stellberg, Michael (1)
- Stewart, A. Francis (1)
- Stoffel, Markus (1)
- Strebhardt, Klaus (1)
- Streu, Sandra (1)
- Strittmatter, Axel (1)
- Strobel, M. (1)
- Stöhlker, T. (1)
- Stückmann, Henning (1)
- Sumper, Manfred (1)
- Surzhykov, A. (1)
- Suzuki, Akira (1)
- Swartz, J. A. (1)
- Sänger, Nicole (1)
- Tahara, Harunobu (1)
- Talbi, Sofian (1)
- Talipova, Aizhan (1)
- Tanger, Ellen (1)
- Tauber, Stefanie (1)
- Tejeda, Miguel (1)
- Templin, Markus F. (1)
- Ternes, D. (1)
- Terranova, Remi (1)
- Terranova, Rémi (1)
- Terwesten, F. (1)
- Teumer, T. (1)
- Thamer, Wiebke (1)
- Theil, Diethilde (1)
- Theil, Dietlinde (1)
- Theis, K. (1)
- Thoelen, Ronald (1)
- Thomas, D. (1)
- Thomas, D.N. (1)
- Thömmes, Jörg (1)
- Tietsch, Wolfgang (1)
- Tillmann, Urban (1)
- Tim, Sieker (1)
- Tix, Julian (1)
- Todiras, Mihail (1)
- Toebes, Mireille (1)
- Tomasberger, T. (1)
- Trachtmann, Natalie (1)
- Tran, Quang Hon (1)
- Trapp, Svenja (1)
- Trautmann, S. (1)
- Treindl, Fridolin (1)
- Trimm, D. L. (1)
- Tu, Ran (1)
- Turek, Monika (1)
- Turek, Thomas (1)
- Turgut, Hatice (1)
- Törnqvist, H. (1)
- Ullmann, Matthias G. (1)
- Umanskaya, N. (1)
- Unadkat, Jashvant D. (1)
- Unterberger, Elif B. (1)
- Upcraft, T.M. (1)
- Vahidpour, Farnoosh (1)
- Vardag, T. (1)
- Varga, L. (1)
- Vaulot, D. (1)
- Veltkamp, T. C. (1)
- Vescovi, Diego (1)
- Vintersten, Kristina (1)
- Vitobello, Antonio (1)
- Vitry, Veronique (1)
- Vlad, Dorina (1)
- Vogel, Ortwin (1)
- Vogt, Merly C. (1)
- Vogt, Thomas F. (1)
- Voigt, B. (1)
- Volkmar, Marianne (1)
- Voß, Leonie (1)
- Vry, Jean de (1)
- Vuong, Lam Giang (1)
- Vázquez-López, Ezequiel M. (1)
- Völkering, Georg (1)
- Wackwitz, B. (1)
- Wagner, Michaela (1)
- Wagner, Patrick Hermann (1)
- Wagner, Sebastian (1)
- Waller, Mark P. (1)
- Walz, Anna-Lena (1)
- Wambach, M. (1)
- Wanek, Thomas (1)
- Wang, J. (1)
- Wang, Ren-Qi (1)
- Wang, Shijun (1)
- Wardoyo, Arinto Y.P. (1)
- Warren, J.T. (1)
- Wassenaar, Evelyne (1)
- Weichold, O. (1)
- Weichold, Oliver (1)
- Weick, H. (1)
- Weidner, Uwe (1)
- Weigand, M. (1)
- Weinstein, Brant M. (1)
- Weizäcker, Elisabeth von (1)
- Welden, Rene (1)
- Welsch, Volker (1)
- Wendisch, V. F. (1)
- Wendlandt, Tim (1)
- Werkhausen, Amelie (1)
- Westerman, Karen A. (1)
- Wetzel, Katharina (1)
- Weyland, F. (1)
- Weyland, Friedrich (1)
- Whitehead, Mark (1)
- Wiebel, Franziska F. (1)
- Wiechert, Wolfgang (1)
- Wielbalck, Swantje (1)
- Wilfried, Reichardt (1)
- Wilhelm, Manfred (1)
- Willanzheimer, Angela (1)
- Willenberg, H. (1)
- Willenberg, Holger S. (1)
- Willmes, Diana M. (1)
- Wilming, Anja (1)
- Wilson, C. E. (1)
- Wilson, Claire E. (1)
- Wilson, David L. (1)
- Wilson, I. D. (1)
- Winckler, Silvia (1)
- Winkelmann, Gunda (1)
- Winkelmann, Silke (1)
- Wissenbach, U. (1)
- Witte, Karin (1)
- Wolf, Anna M. (1)
- Wolf, Charles Roland (1)
- Wolf, Eckhard (1)
- Wolterbeek, H.T. (1)
- Woods, P. (1)
- Woznyj, M. (1)
- Wriggers, Peter (1)
- Wright, Jayne (1)
- Wrzodek, Clemens (1)
- Wulfhorst, Helene (1)
- Wunderlich, H. (1)
- Wunderlich, Hartmut (1)
- Xian, Mo (1)
- Xing, Y. (1)
- Yamaguchi, Taiyo (1)
- Yang, Hua (1)
- Yazici, Y. (1)
- Yazici, Yasemen (1)
- Yegen, Eda (1)
- Yu, Lihua (1)
- Yuan, Juping (1)
- Zahn, H. (1)
- Zamurovic, Natasa (1)
- Zauner, Stefan (1)
- Zell, Andreas (1)
- Zeng, Steffen (1)
- Zhang, Jin (1)
- Zhang, Xiaolin (1)
- Zhantlessova, Sirina (1)
- Zhou, Bei (1)
- Ziegler, C. (1)
- Ziegler, Christiane (1)
- Zientz, Evelyn (1)
- Zollinger, Tulipan (1)
- Zoor, Annegreth (1)
- Zoschke, Sascha (1)
- Zou, Huibin (1)
- [u.a.] (1)
- de Blois, E. (1)
- de Kruijff, Robin M. (1)
- van Waterschoot, Robert A.B. (1)
Year of publication
Institute
- Fachbereich Chemie und Biotechnologie (472) (remove)
Language
- English (472) (remove)
Document Type
- Article (472) (remove)
Keywords
- Heparin (3)
- Bacillaceae (2)
- Biotechnological application (2)
- Butanol (2)
- Chemometrics (2)
- IR spectroscopy (2)
- NMR spectroscopy (2)
- Principal component analysis (2)
- Standardization (2)
- Subtilases (2)
Voigt, Birgit ; Albrecht, Dirk ; Sievers, Susanne ; Becher, Dörte ; Bongaerts, Johannes ; Evers, Stefan ; Schweder, Thomas ; Maurer, Karl-Heinz ; Hecker, Michael
Takenaga, Shoko ; Schneider, Benno ; Erbay, E. ; Biselli, Manfred ; Schnitzler, Thomas ; Schöning, Michael Josef ; Wagner, Torsten
A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.
Immel, Timo ; Grützke, Martin ; Späte, Anne-Katrin ; Groth, Ulrich ; Öhlschläger, Peter ; Huhn, Thomas
Chelate stabilization of a titanium(IV)–salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.
Henken, F. E. ; Oosterhuis, K. ; Öhlschläger, Peter ; Bosch, L. ; Hooijberg, E. ; Haanen, J. B. A. G. ; Steenbergen, R. D. M.
Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of ‘gene-shuffled’ (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies.
Wiegand, Sandra ; Voigt, Birgit ; Albrecht, Dirk ; Bongaerts, Johannes ; Evers, Stefan ; Hecker, Michael ; Daniel, Rolf ; Liesegang, Heiko
Efficient FACS selection procedure for cells undergoing Flp-mediated site-specific conversions
(1998)
Transcription-promoting genomic sites in mammalia: their elucidation and architectural principles
(1998)
Bode, J. ; Bartsch, J. ; Boulikas, T. ; Iber, M. ; Mielke, C. ; Schübeler, D. ; Seibler, Jost ; Benham, C.
Feng, Yong-Qing ; Seibler, Jost ; Alami, Raouf ; Eisen, Andrew ; Westerman, Karen A. ; Leboulch, Philippe ; Fiering, Steven ; Bouhassira, Eric E.
The transgeneticist's toolbox: novel methods for the targeted modification of eukaryotic genomes
(2000)
Bode, Jürgen ; Schlake, Thomas ; Iber, Michaela ; Schübeler, Dirk ; Seibler, Jost ; Snezhkov, Evgeney ; Nikolaev, Lev
Cesari, Francesca ; Rennekampff, Verena ; Vintersten, Kristina ; Vuong, Lam Giang ; Seibler, Jost ; Bode, Jürgen ; Wiebel, Franziska F. ; Nordheim, Alfred
Goetze, Sandra ; Baer, Alexandra ; Winkelmann, Silke ; Nehlsen, Kristina ; Seibler, Jost ; Maass, Karin ; Bode, Jürgen
Seibler, Jost ; Zevnik, Branko ; Küter-Luks, Birgit ; Andreas, Susanne ; Kern, Heidrun ; Hennek, Thomas ; Rode, Anja ; Heimann, Cornelia ; Faust, Nicole ; Kauselmann, Gunther ; Schoor, Michael ; Jaenisch, Rudolf ; Rajewsky, Klaus ; Kühn, Ralf ; Schwenk, Frieder
Seibler, Jost ; Küter-Luks, Birgit ; Kern, Heidrun ; Streu, Sandra ; Plum, Leona ; Maurer, Jan ; Kühn, Ralf ; Brüning, Jens C. ; Schwenk, Frieder
Plum, Leona ; Ma, Xiaosong ; Hampel, Brigitte ; Balthasar, Nina ; Coppari, Roberto ; Münzberg, Heike ; Shanabrough, Marya ; Burdakov, Denis ; Rother, Eva ; Janoschek, Ruth ; Alber, Jens ; Belgardt, Bengt F. ; Koch, Linda ; Seibler, Jost ; Schenk, Frieder ; Fekete, Csaba ; Suzuki, Akira ; Mak, Tak W. ; Krone, Wilhelm ; Horvath, Tamas L. ; Ashcroft, Frances M. ; Brüning, Jens C.
Seibler, Jost ; Kleinridders, Andre ; Küter-Luks, Birgit ; Niehaves, Sandra ; Brüning, Jens C. ; Schwenk, Frieder
Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice
(2008)
Christoph, Thomas ; Bahrenberg, Gregor ; Vry, Jean de ; Englberger, Werner ; Erdmann, Volker A. ; Frech, Moritz ; Kögel, Babette ; Röhl, Thomas ; Schiene, Klaus ; Schröder, Wolfgang ; Seibler, Jost ; Kurreck, Jens