Refine
Year of publication
Document Type
- Article (3149)
- Conference Proceeding (1016)
- Part of a Book (184)
- Book (144)
- Doctoral Thesis (30)
- Patent (25)
- Other (9)
- Report (9)
- Preprint (4)
- Poster (3)
- Talk (3)
- Master's Thesis (2)
- Working Paper (2)
- Bachelor Thesis (1)
- Contribution to a Periodical (1)
- Habilitation (1)
Language
- English (4583) (remove)
Has Fulltext
- no (4583) (remove)
Keywords
- Gamification (6)
- avalanche (6)
- Earthquake (5)
- Enterprise Architecture (5)
- MINLP (5)
- solar sail (5)
- Diversity Management (4)
- Energy storage (4)
- Engineering optimization (4)
- LAPS (4)
- Natural language processing (4)
- Papierkunst (4)
- Power plants (4)
- Seismic design (4)
- field-effect sensor (4)
- frequency mixing magnetic detection (4)
- hydrogen (4)
- metal structure (4)
- snow (4)
- steel (4)
Institute
- Fachbereich Medizintechnik und Technomathematik (1545)
- Fachbereich Elektrotechnik und Informationstechnik (686)
- IfB - Institut für Bioengineering (560)
- Fachbereich Energietechnik (552)
- INB - Institut für Nano- und Biotechnologien (532)
- Fachbereich Chemie und Biotechnologie (522)
- Fachbereich Luft- und Raumfahrttechnik (463)
- Fachbereich Maschinenbau und Mechatronik (261)
- Fachbereich Wirtschaftswissenschaften (196)
- Solar-Institut Jülich (160)
- Fachbereich Bauingenieurwesen (146)
- ECSM European Center for Sustainable Mobility (75)
- MASKOR Institut für Mobile Autonome Systeme und Kognitive Robotik (62)
- Fachbereich Gestaltung (24)
- Nowum-Energy (24)
- Institut fuer Angewandte Polymerchemie (23)
- Sonstiges (21)
- Fachbereich Architektur (20)
- Freshman Institute (18)
- Kommission für Forschung und Entwicklung (18)
Bacillus pumilus reveals a remarkably high resistance to hydrogen peroxide provoked oxidative stress
(2014)
Bacillus pumilus is characterized by a higher oxidative stress resistance than other comparable industrially relevant Bacilli such as B. subtilis or B. licheniformis. In this study the response of B. pumilus to oxidative stress was investigated during a treatment with high concentrations of hydrogen peroxide at the proteome, transcriptome and metabolome level. Genes/proteins belonging to regulons, which are known to have important functions in the oxidative stress response of other organisms, were found to be upregulated, such as the Fur, Spx, SOS or CtsR regulon. Strikingly, parts of the fundamental PerR regulon responding to peroxide stress in B. subtilis are not encoded in the B. pumilus genome. Thus, B. pumilus misses the catalase KatA, the DNA-protection protein MrgA or the alkyl hydroperoxide reductase AhpCF. Data of this study suggests that the catalase KatX2 takes over the function of the missing KatA in the oxidative stress response of B. pumilus. The genome-wide expression analysis revealed an induction of bacillithiol (Cys-GlcN-malate, BSH) relevant genes. An analysis of the intracellular metabolites detected high intracellular levels of this protective metabolite, which indicates the importance of bacillithiol in the peroxide stress resistance of B. pumilus.