Article
Refine
Year of publication
Institute
- Fachbereich Medizintechnik und Technomathematik (1585) (remove)
Document Type
- Article (1585) (remove)
Keywords
- Einspielen <Werkstoff> (7)
- FEM (4)
- Finite-Elemente-Methode (4)
- LAPS (4)
- CellDrum (3)
- Label-free detection (3)
- biosensors (3)
- hydrogen peroxide (3)
- impedance spectroscopy (3)
- shakedown analysis (3)
- Bacillus atrophaeus (2)
- Bauingenieurwesen (2)
- Biosolubilization (2)
- Boundary integral equations (2)
- CAD (2)
- Capacitive field-effect sensor (2)
- Coal (2)
- Conductive boundary condition (2)
- Einspielanalyse (2)
- Empirical process (2)
- Field-effect sensor (2)
- Goodness-of-fit test (2)
- Independence test (2)
- Light-addressable potentiometric sensor (2)
- Lipopolysaccharide (2)
- Paired sample (2)
- Parametric bootstrap (2)
- Raman spectroscopy (2)
- Shakedown analysis (2)
- Stiffness (2)
- Traglastanalyse (2)
- Transmission eigenvalues (2)
- capacitive field-effect sensors (2)
- carbonized rice husk (2)
- civil engineering (2)
- constructive alignment (2)
- damage (2)
- examination (2)
- field-effect sensor (2)
- frequency mixing magnetic detection (2)
- likelihood ratio test (2)
- limit analysis (2)
- locomotion (2)
- long-term retention (2)
- multimodal (2)
- muscle fascicle behavior (2)
- not identically distributed (2)
- practical learning (2)
- shakedown (2)
- tobacco mosaic virus (TMV) (2)
- ultrasound (2)
- ultrasound imaging (2)
- (Bio)degradation (1)
- AI ethics (1)
- Acceleration (1)
- Accessibility (1)
- Achilles tendon (1)
- Adaptive control (1)
- Afterload (1)
- Ageing (1)
- Air purification (1)
- AlterG (1)
- Alternating plasticity (1)
- Alzheimer's disease (1)
- Analysis (1)
- Analytischer Zulaessigkeitsnachweis (1)
- Anastomotic leakage (1)
- Anatomy (1)
- Annulus Fibrosus (1)
- Architectural design (1)
- Architectural gear ratio (1)
- Architektur (1)
- Arthosetherapie (1)
- Assistive technology (1)
- Asymptotic efficiency (1)
- Aufschlagversuch (1)
- Autolysis (1)
- Automatic control (1)
- Axialbelastung (1)
- Axially cracked pipe (1)
- Bacillus atrophaeus spores (1)
- Bacillus sp (1)
- Bacterial cellulose (1)
- Balance (1)
- Basis Reduktion (1)
- Basis reduction (1)
- Bicharakteristikenverfahren (1)
- Bioabsorbable (1)
- Biobeneficiation (1)
- Biocomposites (1)
- Biomechanical simulation (1)
- Bioreaktor (1)
- Blutzellenlagerung (1)
- Bone quality and biomechanics (1)
- Booster Station (1)
- Bootstrap (1)
- Bootstrapping (1)
- Boundary integral equations, (1)
- Brownian Pillow (1)
- CNOT (1)
- Calorimetric gas sensor (1)
- Capacitive field-effect (1)
- Capacitive model (1)
- Carbon sources (1)
- Cardiac myocytes (1)
- Cardiac tissue (1)
- Categorial variable (1)
- Cell permeability (1)
- Cellular force (1)
- Cellulose nanostructure (1)
- Cement infiltration (1)
- Cementoblast (1)
- Censored data (1)
- Chemical images (1)
- Chemical imaging sensor (1)
- Chemical sensor (1)
- Circular Dichroism (1)
- Clusterion (1)
- Co-managed care (1)
- Collective risk model (1)
- Competitiveness (1)
- Complex System (1)
- Complex-valued eigenvalues (1)
- Compliance (1)
- Compression (1)
- Computational biomechanics (1)
- Concomitant (1)
- Conductive Boundary Condition (1)
- Conservation laws (1)
- Constitutive model (1)
- Contractile tension (1)
- Contractility (1)
- Convex optimization (1)
- Cost-effectiveness (1)
- Coverage probability (1)
- Cramér-von-Mises statistic (1)
- Cramér-von-Mises test (1)
- Cross border adjustment mechanism (1)
- Crámer–von-Mises distance (1)
- Culture media (1)
- C–V method (1)
- DNA biosensor (1)
- DNA hybridization (1)
- DPA (dipicolinic acid) (1)
- Damage mechanics theory (1)
- Decomposition (1)
- Deep Learning (1)
- Deformation (1)
- Dehydrogenase (1)
- Design-by-analysis (1)
- Diaphorase (1)
- Dimensional splitting (1)
- Disc Degeneration (1)
- Discontinuous fractures (1)
- Discrete Optimization (1)
- Distorsion des oberen Sprunggelenks (1)
- Druckbeanspruchung (1)
- Druckbehälter (1)
- Druckbelastung (1)
- Druckgeräte (1)
- Drug simulation (1)
- E-Mobility (1)
- E. coli detection (1)
- EIS capacitive sensor (1)
- ELISA (1)
- ES-FEM (1)
- Easy read (1)
- Eigenvalue trajectories (1)
- Einspiel-Analyse (1)
- Einspiel-Kriterium (1)
- Einspielen (1)
- Elastizität (1)
- Elderly (1)
- Electrolyte–insulator–semiconductor (1)
- Electromagnetism (1)
- Electromechanical modeling (1)
- Elektroenzephalographie (1)
- Elemental (1)
- End-to-end colorectal anastomosis (1)
- Endothelial cells (1)
- Endothelial dysfunction (1)
- Energy-intensive industry (1)
- Enterprise information systems (1)
- Entropy solution (1)
- Environmental impact (1)
- Enzymatic biosensor (1)
- Enzyme coverage (1)
- Enzyme logic gate (1)
- Enzyme-linked immunosorbent assay (1)
- Epithel (1)
- Equivalence test (1)
- Esophageal Doppler monitor (1)
- Experiment (1)
- Exponential Euler scheme, (1)
- Exponential time differencing (1)
- External knee adduction moments (1)
- FS-FEM (1)
- Fall prevention (1)
- Fault approximation (1)
- Fault detection (1)
- Fehlerstellen (1)
- Fibroblast (1)
- Field effect (1)
- Field-effect biosensor (1)
- Finite difference methods (1)
- Finite element analysis (1)
- Finite element modelling (1)
- Fließgrenze (1)
- Floor prices (1)
- Force (1)
- Forces (1)
- Fracture configuration (1)
- Fracture simulation (1)
- Freeze–thaw process (1)
- Frequency adaption (1)
- Frequency mixing magnetic detection (1)
- Functional Delta Method (1)
- Fußball (1)
- Gamma distribution (1)
- Geriatric (1)
- German (1)
- Glaucoma (1)
- Global and local collapse (1)
- Gold nanoparticles (1)
- Gonarthrose (1)
- Goodness-of-fit tests for uniformity (1)
- Grenzwertberechnung (1)
- Ground-level falls (1)
- H2 (1)
- Hadamard differentiability (1)
- Haemodialysis (1)
- Handbike (1)
- Harnleiter (1)
- Heart tissue culture (1)
- Helmholtz equation (1)
- Hemoglobin structure (1)
- Heterostructure (1)
- Higher-order codes (1)
- Hip fractures (1)
- Hodgkin–Huxley models (1)
- Hoeffding-Blum-Kiefer-Rosenblatt independence test (1)
- Homogenization (1)
- Hotelling’s T² test (1)
- Human-Computer interaction (1)
- Hydrogen peroxide (1)
- Hydrogenotrophic methanogens (1)
- Hämoglobin (1)
- Hämoglobinstruktur (1)
- Image Reconstruction (1)
- Impedance spectroscopy (1)
- Implicit methods (1)
- Incomplete data (1)
- Induced pluripotent stem cells (1)
- Information extraction (1)
- Inotropic compounds (1)
- Integrated empirical distribution (survival) function (1)
- Interior Neumann eigenvalues (1)
- Interior transmission eigenvalues (1)
- Interior transmission problem (1)
- Intervertebral Disc (1)
- Intradiscal Pressure (1)
- Inverse Scattering (1)
- Inverse dynamic problem (1)
- Inverse kinematic problem (1)
- Inverse scattering (1)
- Inverse scattering problem (1)
- Inverse spectral problem (1)
- Ion channels (1)
- Iterative learning control (1)
- Kinetic energy (1)
- Kniegelenkarthrose (1)
- Knochen (1)
- Knochenbildung (1)
- Knochenchirugie (1)
- Knochendichte (1)
- Kohlenstofffaser (1)
- LPS (1)
- Lab-on-Chip (1)
- Langevin theory (1)
- Large language models (1)
- Layer-by-layer adsorption (1)
- LbL films (1)
- Light-addressable Potentiometric Sensor (1)
- Limit analysis (1)
- Liver (1)
- Long COVID (1)
- Luftreiniger (1)
- MBST (1)
- MCDA (1)
- MOS (1)
- Machine learning (1)
- Magnetic nanoparticles (1)
- Manipulated variables (1)
- Marginal homogeneity test (1)
- Master stamp (1)
- Materialermüdung (1)
- Matrix exponential (1)
- Mechanotransduction (1)
- Medusomyces gisevi (1)
- Metascintillator (1)
- Methane (1)
- Methanogenesis (1)
- Microcirculation (1)
- Micromagnetic simulation (1)
- Microorganisms (1)
- Mild cognitive impairment (1)
- Mobility (1)
- Mobility tests (1)
- Mobility transition (1)
- Model-driven software engineering (1)
- Monotone methods (1)
- Multi-criteria decision analysis (1)
- Multi-dimensional partial differential equations (1)
- Multi-sample problem (1)
- Multianalyte detection (1)
- Multicell (1)
- Multiple TOF kernels (1)
- Multiplexing (1)
- Muscle (1)
- Muscle Fascicle (1)
- Muscle Force (1)
- Musculoskeletal model (1)
- Musculoskeletal system (1)
- Myocardial infarction and cardiac death (1)
- NONOate (1)
- Natural fibres (1)
- Natural language processing (1)
- Negative impedance convertor (1)
- Neural Network (1)
- Nitric Oxide (1)
- Nitric Oxide Donor (1)
- Non-parallel fissures (1)
- Nonequilibrium dynamics (1)
- Nonlinear Dynamics (1)
- Nonlinear PDEs (1)
- Nonlinear eigenvalue problems (1)
- Nucleus Pulposus (1)
- Numerical inversion of Laplace transforms (1)
- Numerical linear algebra (1)
- Numerics (1)
- O2 plasma (1)
- Ocular blood flow (1)
- Organic light-emitting diode display (1)
- Organkultur (1)
- Osteoporose (1)
- Osteoporosis (1)
- Parabolic SPDEs (1)
- Paralympic sport (1)
- Penicillin (1)
- Permeability (1)
- Permeabilität (1)
- Peroxidase (1)
- Pflanzenphysiologie (1)
- Pflanzenscanner (1)
- Pflanzenstress (1)
- Pharmacology (1)
- Photolithographic mimics (1)
- Physiology (1)
- Plant virus (1)
- Plasmacluster ion technology (1)
- Plastizität (1)
- Poly(allylamine hydrochloride) (1)
- Poly(d,l-lacticacid) (1)
- Polyimide (1)
- Polylactide acid (1)
- Polymer-matrix composites (1)
- Post-COVID-19 syndrome (1)
- Potential theory (1)
- Preference assessment (1)
- Pressure loaded crack-face (1)
- Prevention (1)
- Product-integration (1)
- Progressive plastic deformation (1)
- Prophylaxis (1)
- Proximal humerus fracture (1)
- Psychiatrische Biomarker (1)
- Pulsations (1)
- Pump System (1)
- Quartz crystal microbalance (1)
- RVA (1)
- Ratchetting (1)
- Raumluft (1)
- Reaction-diffusion systems (1)
- Real distinct pole (1)
- Real-time monitoring (1)
- Recombinant activated protein C (1)
- Red blood cell storage (1)
- Regionalization (1)
- Rehabilitation Technology and Prosthetics (1)
- Rehabilitation engineering (1)
- Resampling test (1)
- Resistive temperature detector (1)
- Resolvent Operator (1)
- Resonance-mode measurement (1)
- Retinal vessel analysis (1)
- Retinal vessels (1)
- Robotic rehabilitation (1)
- Rohr (1)
- Rohrbruch (1)
- Rotator cuff (1)
- Running (1)
- S-FEM (1)
- ScaLAPACK (1)
- Schienbeinschoner (1)
- Schlafspindeldetektion (1)
- Schwammknochen (1)
- Semi-parametric random censorship model (1)
- Septic cardiomyopathy (1)
- Shakedown (1)
- Shakedown criterion (1)
- Silk fibroin (1)
- Simulation (1)
- Simultaneous determination (1)
- Skeletal muscle (1)
- Small Aral Sea (1)
- Sn₃O₄ (1)
- Software and systems modeling (1)
- Source term (1)
- Spleen (1)
- Sprunggelenkorthesen (1)
- Stahl (1)
- Steel industry (1)
- Sterilisation process (1)
- Stress concentrations (1)
- Strukturanalyse (1)
- SunRav BookEditor (1)
- Surface imprinted polymer (1)
- Surfactants (1)
- Surgical Navigation and Robotics (1)
- Surgical staplers (1)
- Survival analysis (1)
- TMV adsorption (1)
- TOF PET (1)
- Ta₂O₅ gate (1)
- Technical Operations Research (TOR) (1)
- Temperaturabhängigkeit (1)
- Tendon Rupture (1)
- Tendon properties (1)
- Tendons (1)
- Tension (1)
- Tinetti test (1)
- Tissue Engineering (1)
- Tobacco mosaic virus (TMV) (1)
- Traglast (1)
- Transmission Eigenvalues (1)
- Ultrasound (1)
- Uniaxial compression test (1)
- Vapnik–Čhervonenkis class (1)
- Variable height stapler design (1)
- Vascular response (1)
- Vasomotions (1)
- Velocity (1)
- Vertebroplastie (1)
- Vertebroplasty (1)
- Viscous flow (1)
- Viskose Strömung (1)
- Viskosität (1)
- Visual field asymmetry (1)
- Volterra integral equation (1)
- Volume of confidence regions (1)
- Volume status (1)
- Wolff's Law (1)
- Wolffsches Gesetz (1)
- Wundheilung (1)
- XOR (1)
- Zeta potential (1)
- Zug-Druck Belastung (1)
- acetoin (1)
- acetoin reductase (1)
- achilles tendon (1)
- actin cytoskeleton (1)
- adipose-derived stromal cells (ASCs) (1)
- adsorption (1)
- agility (1)
- alcoholic beverages (1)
- allocation (1)
- alternierend Verformbarkeit (1)
- amperometric biosensors (1)
- anaesthetic complications (1)
- anisotropy (1)
- ankle braces (1)
- ankle sprain (1)
- annealing (1)
- aortic perfusion (1)
- aquaculture (1)
- architecture (1)
- aromatic amines (1)
- arthrosis therapy (1)
- artificial olfactory image (1)
- asymptotic relative efficiency (1)
- atomic layer deposition (1)
- barium strontium titanate (1)
- biaxial tensile experiment (1)
- bicharacteristics (1)
- bioburdens (1)
- biocompatible (1)
- biocompatible materials (1)
- biodegradabl (1)
- biodegradable electronic devices (1)
- biomechanics (1)
- biopotential electrodes (1)
- biosensor (1)
- bone density (1)
- bone structure (1)
- bootstrap (1)
- burst pressure (1)
- burst tests (1)
- calorimetric gas sensor (1)
- calorimetric gas sensor;hydrogen peroxide;wireless sensor system (1)
- cancellous bone (1)
- capacitive electrolyte–insulator–semiconductor sensors (1)
- capacitive field-effect sensor (1)
- carbon electrodes (1)
- cardiomyocyte biomechanics (1)
- catalytic metal (1)
- cell aerosolization (1)
- cell atomization (1)
- central symmetry test (1)
- cerebral small vessel disease (1)
- chance constrained programming (1)
- chemical sensor (1)
- chip-based sensor setup (1)
- cognitive impairment (1)
- community dwelling (1)
- complete block symmetry (1)
- computational fluid dynamics analysis (1)
- conditional excess distribution (1)
- conditional expectation principle (1)
- confidence interval (1)
- connective tissue (1)
- constitutive modeling (1)
- contactless conductivity sensor (1)
- correlation (1)
- coupled Néel–Brownian relaxation dynamics (1)
- covariance principle (1)
- dental trauma (1)
- dialysis (1)
- difficult airway (1)
- direct method (1)
- distance learning (1)
- distorted element (1)
- double-lumen tube intubation (1)
- drop jump (1)
- e-books (1)
- e-issues (1)
- ecological structure (1)
- eigensolvers (1)
- elastic scattering (1)
- elastic solids (1)
- electrical conductivity of liquids (1)
- electrolyte-insulator semiconductor sensor (EIS) (1)
- electromyography (1)
- electronic nose (1)
- encapsulation materials (1)
- endoluminal (1)
- endospores (1)
- energy absorption (1)
- energy dissipation (1)
- enzymatic (bio)degradation (1)
- enzymatic biosensor (1)
- enzyme cascade (1)
- epithelization (1)
- exchangeability test (1)
- extracorporeal membrane oxygenation (1)
- fatigue analyses (1)
- fatty acid (1)
- fibroin (1)
- fibulare Bandruptur (1)
- field-effect structure (1)
- flaw (1)
- force generation (1)
- forecast (1)
- forehead EEG (1)
- fortschreitende plastische Deformation (1)
- frequency mixing (1)
- functional data (1)
- gait (1)
- gas sensor (1)
- glucose (1)
- glucose oxidase (GOx) (1)
- gonarthrosis (1)
- goodness-of-fit test (1)
- graphene oxide (1)
- healthy aging (1)
- heavy metals (1)
- hiPS cardiomyocytes (1)
- high-intensity exercise (1)
- high-k material (1)
- horseradish peroxidase (HRP) (1)
- huge dimensional data (1)
- human dermal fibroblasts (1)
- humic acid (1)
- hydroxylation (1)
- hyper-gravity (1)
- hyperelastic (1)
- hypo-gravity (1)
- immobilization (1)
- in-ear EEG (1)
- in-situ monitoring (1)
- independence test (1)
- intraclass correlation coefficient (1)
- key performance indicators (1)
- konvexe Optimierung (1)
- lable-free detection (1)
- large language models (1)
- layer-by-layer technique (1)
- light-addressable potentiometric sensor (1)
- light-addressing technologies (1)
- lignite (1)
- limit load (1)
- lipopolysaccharide (1)
- lipopolysaccharides (1)
- load limit (1)
- magnetic actuation (1)
- magnetic beads (1)
- magnetic biosensing (1)
- magnetic nanoparticles (1)
- magnetic relaxation (1)
- magnetic sandwich immunoassay (1)
- magnetic sensing (1)
- magnetic separation (1)
- magnetic tweezers (1)
- magnetophoretic velocity (1)
- mechanical buffer (1)
- metagenomics (1)
- metal-oxide-semiconductor structure (1)
- metathesis (1)
- method of fundamental solutions (1)
- microbial diversity (1)
- microfluidics (1)
- micromagnetic simulation (1)
- multi-functional material (1)
- multinomial distribution (1)
- multiparametric immunoassays (1)
- multivariate normal distribution (1)
- muscle mechanics (1)
- nanobelts (1)
- nanomaterials (1)
- nanostructured carbonized plant parts (1)
- nanostrukturierte carbonisierte Pflanzenteile (1)
- naphtols (1)
- non-simplex S-FEM elements (1)
- novel photoexcitation method (1)
- optical sensor setup (1)
- optical spore trapping (1)
- optical trapping (1)
- organosilanes (1)
- overload (1)
- pH sensors (1)
- parabolic flight (1)
- penicillin (1)
- penicillinase (1)
- performance analysis (1)
- performance testing (1)
- phenols (1)
- photoelectrochemistry (1)
- physiology (1)
- pipes (1)
- plant scanner (1)
- plant stress (1)
- plant virus detection (1)
- plug-based microfluidic device (1)
- poly(d, l-lactic acid) (1)
- polyamide (1)
- polyaniline (1)
- polyester (1)
- portfolio risk (1)
- prevention (1)
- psychosocial (1)
- random effects (1)
- random effects meta-regression model (1)
- ratchetting (1)
- rehabilitation (1)
- reliability analysis (1)
- reliability of structures (1)
- renewable resources (1)
- retinal microvasculature (1)
- retinal vessels (1)
- running (1)
- rupture of the fibular ligament (1)
- sEMG (1)
- sarcomere operating length (1)
- scanned light pulse technique (1)
- semantic role labeling (1)
- separable Hilbert space (1)
- series elastic element behavior (1)
- shakedown analyses (1)
- shotgun sequencing (1)
- shoulder (1)
- silanization (1)
- simulation (1)
- smooth muscle contraction (1)
- softs (1)
- spatial resolution (1)
- speaker attribution (1)
- sprint start (1)
- standard error of measurement (1)
- sterilisation (1)
- sterility tests (1)
- sterilization (1)
- sterilization conditions (1)
- sterilization efficacy (1)
- sterilization methods (1)
- stiffness (1)
- stochastic programming (1)
- strain energy function (1)
- stretch reflex (1)
- stretch-shortening cycle (1)
- superparamagnetic bead (1)
- superparamagnetic nanoparticles (1)
- surface functionalization (1)
- surface modification (1)
- survival (1)
- temperature (1)
- tendon rupture (1)
- tension–torsion loading (1)
- test-retest reliability (1)
- thermal ratcheting (1)
- thermometry (1)
- tilted constant illumination (1)
- titanium dioxide photoanode (1)
- tri-lineage differentiation (1)
- turnip vein clearing virus (TVCV) (1)
- twin-fluid atomizer (1)
- ultrasonography (1)
- ultrathin gate insulators (1)
- uniformly most powerful invariant test (1)
- unloading (1)
- validation methods (1)
- vessels (1)
- videolaryngoscopy (1)
- virgin passive (1)
- viscoelasticity (1)
- visualization (1)
- walking (1)
- walking gait (1)
- wound healing (1)
- yield stress (1)
- · Psychiatrische Erkrankungen/Diagnostik (1)
A Classical Reformulation of Finite-Dimensional Quantum Mechanics. Hellwig, K.-E.; Stulpe, W.
(1993)
A Formulation of Quantum Stochastic Processes and Some of its Properties. Hellwig, K.-E.; Stulpe, W.
(1983)
Altered gastrocnemius contractile behavior in former achilles tendon rupture patients during walking
(2022)
Achilles tendon rupture (ATR) remains associated with functional limitations years after injury. Architectural remodeling of the gastrocnemius medialis (GM) muscle is typically observed in the affected leg and may compensate force deficits caused by a longer tendon. Yet patients seem to retain functional limitations during—low-force—walking gait. To explore the potential limits imposed by the remodeled GM muscle-tendon unit (MTU) on walking gait, we examined the contractile behavior of muscle fascicles during the stance phase. In a cross-sectional design, we studied nine former patients (males; age: 45 ± 9 years; height: 180 ± 7 cm; weight: 83 ± 6 kg) with a history of complete unilateral ATR, approximately 4 years post-surgery. Using ultrasonography, GM tendon morphology, muscle architecture at rest, and fascicular behavior were assessed during walking at 1.5 m⋅s–1 on a treadmill. Walking patterns were recorded with a motion capture system. The unaffected leg served as control. Lower limbs kinematics were largely similar between legs during walking. Typical features of ATR-related MTU remodeling were observed during the stance sub-phases corresponding to series elastic element (SEE) lengthening (energy storage) and SEE shortening (energy release), with shorter GM fascicles (36 and 36%, respectively) and greater pennation angles (8° and 12°, respectively). However, relative to the optimal fascicle length for force production, fascicles operated at comparable length in both legs. Similarly, when expressed relative to optimal fascicle length, fascicle contraction velocity was not different between sides, except at the time-point of peak series elastic element (SEE) length, where it was 39 ± 49% lower in the affected leg. Concomitantly, fascicles rotation during contraction was greater in the affected leg during the whole stance-phase, and architectural gear ratios (AGR) was larger during SEE lengthening. Under the present testing conditions, former ATR patients had recovered a relatively symmetrical walking gait pattern. Differences in seen AGR seem to accommodate the profound changes in MTU architecture, limiting the required fascicle shortening velocity. Overall, the contractile behavior of the GM fascicles does not restrict length- or velocity-dependent force potentials during this locomotor task.
Achilles tendon rupture (ATR) patients have persistent functional deficits in the triceps surae muscle–tendon unit (MTU). The complex remodeling of the MTU accompanying these deficits remains poorly understood. The purpose of the present study was to associate in vivo and in silico data to investigate the relations between changes inMTU properties and strength deficits inATR patients. Methods: Elevenmale subjects who had undergone surgical repair of complete unilateral ATR were examined 4.6 ± 2.0 (mean ± SD) yr after rupture. Gastrocnemius medialis (GM) tendon stiffness, morphology, and muscle architecture were determined using ultrasonography. The force–length relation of the plantar flexor muscles was assessed at five ankle joint angles. In addition, simulations (OpenSim) of the GM MTU force–length properties were performed with various iterations of MTU properties found between the unaffected and the affected side. Results: The affected side of the patients displayed a longer, larger, and stiffer GM tendon (13% ± 10%, 105% ± 28%, and 54% ± 24%, respectively) compared with the unaffected side. The GM muscle fascicles of the affected side were shorter (32% ± 12%) and with greater pennation angles (31% ± 26%). A mean deficit in plantarflexion moment of 31% ± 10% was measured. Simulations indicate that pairing an intact muscle with a longer tendon shifts the optimal angular range of peak force outside physiological angular ranges, whereas the shorter muscle fascicles and tendon stiffening seen in the affected side decrease this shift, albeit incompletely. Conclusions: These results suggest that the substantial changes in MTU properties found in ATR patients may partly result from compensatory remodeling, although this process appears insufficient to fully restore muscle function.
A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.