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Is part of the Bibliography
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In this paper, carbon nanotubes (CNTs) were incorporated in penicillinase-phospholipid Langmuir and Langmuir–Blodgett (LB) films to enhance the enzyme catalytic properties. Adsorption of the penicillinase and CNTs at dimyristoylphosphatidic acid (DMPA) monolayers at the air–water interface was investigated by surface pressure–area isotherms, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to solid supports through the LB technique, forming mixed DMPA-CNTs-PEN films, which were investigated by quartz crystal microbalance, vibrational spectroscopy, and atomic force microscopy. Enzyme activity was studied with UV–vis spectroscopy and the feasibility of the supramolecular device nanostructured as ultrathin films were essayed in a capacitive electrolyte–insulator–semiconductor (EIS) sensor device. The presence of CNTs in the enzyme–lipid LB film not only tuned the catalytic activity of penicillinase but also helped conserve its enzyme activity after weeks, showing increased values of activity. Viability as penicillin sensor was demonstrated with capacitance/voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results may be related not only to the nanostructured system provided by the film, but also to the synergism between the compounds on the active layer, leading to a surface morphology that allowed a fast analyte diffusion because of an adequate molecular accommodation, which also preserved the penicillinase activity. This work therefore demonstrates the feasibility of employing LB films composed of lipids, CNTs, and enzymes as EIS devices for biosensing applications.
Momentan finden in vielen Branchen umfassende Veränderungen von Märkten und Wertschöpfungsketten statt, welche auch als Digitale Transformation bezeichnet werden. In diesem Zusammenhang wird das Internet der Dinge (Internet of Things, IoT) als ein wichtiger technischer Enabler der Veränderungen angesehen. Primäre Ziele des IoT sind die Steuerung physischer Gegen-stände aus der Distanz und das Erfassen von Informationen aus dem Umfeld dieser Gegenstände. Welche neuen Geschäfts-bzw. Partnermodelle entstehen durch die gemeinsame Nutzung von IoT-Daten und Big-Data-Technologien und welcher qualitative Mehrwert wird dadurch geschaffen? Als Antwort wird in diesem Beitrag ein Bewertungsrahmen zur qualitativen Wertschöpfungsanalyse von IoT vorgeschlagen. Anhand dieses Bewertungsrahmens wird ein Anwendungsfall untersucht, der in anonymisierter Form an konkrete Praxisprojekte angelehnt ist. Konkret wird ein Anwendungsfall betrachtet, der eine Abfallwirtschaft 2.0 basierend auf dem Einsatz von IoT vorschlägt. Aus den Untersuchungsergebnissen gehen beispielsweise Erkenntnisse hervor, wie Geschäftsmodelle auf Basis eines unentgeltlichen Informationsaustauschs durch IoT gestaltet werden können.
Primäre Ziele des Internets der Dinge sind die Steuerung physischer Gegenstände aus der Distanz und das Erfassen von Informationen aus dem Umfeld dieser Gegenstände. Dazu werden Hardwarekomponenten in Gegenstände des täglichen Lebens und die Umwelt integriert. Mithilfe von Informations- und Kommunikationstechnologien entsteht hieraus das Internet der Dinge (Internet of Things, IoT). Vor einem Jahr wurde mit Narrowband Internet of Things (NB-IoT) eine Technologie die es ermöglicht, Hardwarekomponenten energieeffizient und unmittelbar über das Mobilfunknetz zu vernetzen. Gegenstände werden dadurch über große Reichweiten eigenständig kommunikationsfähig. Das IoT steht mit NB-IoT vor einem gestiegenen Nutzenpotenzial, da eine zunehmende Anzahl miteinander verbundener Gegenstände und der Austausch größerer Datenmengen realisierbar sind. Damit sind aus wirtschaftlicher Sicht neue, innovative Anwendungsfälle des IoT möglich, die auch bereits in der Praxis diskutiert werden. In diesem Beitrag wird anhand eines konkreten Anwendungsfalls untersucht, welche neuen Geschäfts- bzw. Partnermodelle durch die gemeinsame Nutzung von NB-IoT-Daten und Big Data-Technologien entstehen und welcher qualitative Mehrwert für die an einem Anwendungsfall beteiligten Stakeholder geschaffen wird. Dazu wird – einem konstruktionsorientierten Forschungsansatz folgend – ein Bewertungsrahmen zur qualitativen Wertschöpfungsanalyse von NB-IoT entwickelt, der u.a. auf der Schablone nach Cockburn und dem Business Model Canvas basiert. Anhand dieses Bewertungsrahmens wird ein Anwendungsfall untersucht, der in anonymisierter Form an konkrete Praxisprojekte angelehnt ist. Konkret wird ein Anwendungsfall betrachtet, der einen Fahrradverleih 2.0 basierend auf dem Einsatz von NB-IoT vorschlägt. Aus den Untersuchungsergebnissen gehen beispielsweise Erkenntnisse hervor, wie Geschäftsmodelle auf
Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.
Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM−1 (L-malate biosensor) and 0.4 μA mM−1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0–10.0 mM with a sensitivity of 0.09 μA mM−1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates.
Analysis Of Base Isolated Liquid Storage Tanks With 3D Fsi-Analysis As Well As Simplified Approaches
(2017)
Tanks are preferably designed, for cost-saving reasons, as circular, cylindrical, thin-walled shells. In case of seismic excitation, these constructions are highly vulnerable to stability failures. An earthquake-resistant design of rigidly supported tanks for high seismic loading demands, however, uneconomic wall thicknesses. A cost-effective alternative can be provided by base isolation systems. In this paper, a simplified seismic design procedure for base isolated tanks is introduced, by appropriately modifying the standard mechanical model for flexible, rigidly supported tanks. The non-linear behavior of conventional base isolation systems becomes an integral part of a proposed simplified process, which enables
the assessment of the reduced hydrodynamic forces acting on the tank walls and the corresponding stress distribution. The impulsive and convective actions of the liquid are taken into account. The validity of this approach is evaluated by
employing a non-linear fluid-structure interaction algorithm of finite element method. Special focus is placed on the boundary conditions imposed from the base isolation and the resulting hydrodynamic pressures. Both horizontal and vertical
component of ground motion are considered in order to study the principal effects of the base isolation on the pressure distribution of the tank walls. The induced rocking effects associated with elastomeric bearings are discussed. The results
manifest that base isolated tanks can be designed for seismic loads by means of the proposed procedure with sufficient accuracy, allowing to dispense with numerically expensive techniques.