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Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7
(2011)
Raum 02103 - eine Hommage
(2011)
Raum 02103. Ein Ort - tausende von Ideen, Geschichten und Träumen. die Bibliothek des Fachbereichs Design der FH Aachen. Eine scheinbar starre Gestalt und doch in ständigem Wandel. Menschen kommen und gehen; Dinge sind in Bewegung. Ein stiller Fluss von Veränderung, wie in einer eigenständigen Welt. Was macht diesen Ort aus? Was können Zahlen über ihn verraten? Und was befindet sich unter seiner strukturierten Oberfläche? Mit besonderem Blick auf das oft Unbemerkte, ist meine Arbeit eine Hommage an den „Raum 02103“ - an alles was ich dort bereits entdecken durfte und was noch zu entdecken ist.
Reasoning with Qualitative Positional Information for Domestic Domains in the Situation Calculus
(2011)
Objective
To investigate the feasibility of 7T MR imaging of the kidneys utilising a custom-built 8-channel transmit/receive radiofrequency body coil.
Methods
In vivo unenhanced MR was performed in 8 healthy volunteers on a 7T whole-body MR system. After B0 shimming the following sequences were obtained: 1) 2D and 3D spoiled gradient-echo sequences (FLASH, VIBE), 2) T1-weighted 2D in and opposed phase 3) True-FISP imaging and 4) a T2-weighted turbo spin echo (TSE) sequence. Visual evaluation of the overall image quality was performed by two radiologists.
Results
Renal MRI at 7T was feasible in all eight subjects. Best image quality was found using T1-weighted gradient echo MRI, providing high anatomical details and excellent conspicuity of the non-enhanced vasculature. With successful shimming, B1 signal voids could be effectively reduced and/or shifted out of the region of interest in most sequence types. However, T2-weighted TSE imaging remained challenging and strongly impaired because of signal heterogeneities in three volunteers.
Conclusion
The results demonstrate the feasibility and diagnostic potential of dedicated 7T renal imaging. Further optimisation of imaging sequences and dedicated RF coil concepts are expected to improve the acquisition quality and ultimately provide high clinical diagnostic value.