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Year of publication
Document Type
- Article (454)
- Conference Proceeding (23)
- Part of a Book (18)
- Patent (17)
- Book (9)
- Preprint (1)
Language
- English (522) (remove)
Has Fulltext
- no (522) (remove)
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- Heparin (3)
- Chemometrics (2)
- IR spectroscopy (2)
- NMR spectroscopy (2)
- Principal component analysis (2)
- Standardization (2)
- (R)- or (S)- gamma-valerolactone (1)
- 4-hydroxy valeric acid (1)
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- Biorefinery (1)
- Biorefinery definitions (1)
- Bladder (1)
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- CRISPR/Cas9 (1)
- Chimeric liver-humanized mice (1)
Institute
- Fachbereich Chemie und Biotechnologie (522) (remove)
Jochen Kalbe
; Rolf Kuropka
; L. Sebastian Meyer-Stork
; S. L. Lauter
; Hartwig Höcker
; Heinz Berndt
Harri Lempiäinen
; Philippe Couttet
; Federico Bolognani
; Arne Müller
; Valérie Dubost
; Raphaëlle Luisier
; Alberto del Rio-Espinola
; Veronique Vitry
; Elif B. Unterberger
; John P. Thomson
; Fridolin Treindl
; Ute Metzger
; Clemens Wrzodek
; Florian Hahne
; Tulipan Zollinger
; Sarah Brasa
; Magdalena Kalteis
; Magali Marcellin
; Fanny Giudicelli
; Albert Braeuning
; Laurent Morawiec
; Natasa Zamurovic
; Ulrich Längle
; Nico Scheer
; Dirk Schübeler
; Jay Goodman
; Salah-Dine Chibout
; Jennifer Marlowe
; Dietlinde Theil
; David J. Heard
; Olivier Grenet
; Andreas Zell
; Markus F. Templin
; Richard R. Meehan
; Roland C. Wolf
; Clifford R. Elcombe
; Michael Schwarz
; Pierre Moulin
; Rémi Terranova
; Jonathan G. Moggs
The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of gene expression. Here, we have investigated the temporal sequence of molecular and pathological perturbations at early stages of phenobarbital (PB) mediated liver tumor promotion in vivo. Molecular profiling (mRNA, microRNA [miRNA], DNA methylation, and proteins) of mouse liver during 13 weeks of PB treatment revealed progressive increases in hepatic expression of long noncoding RNAs and miRNAs originating from the Dlk1-Dio3 imprinted gene cluster, a locus that has recently been associated with stem cell pluripotency in mice and various neoplasms in humans. PB induction of the Dlk1-Dio3 cluster noncoding RNA (ncRNA) Meg3 was localized to glutamine synthetase-positive hypertrophic perivenous hepatocytes, sug- gesting a role for β-catenin signaling in the dysregulation of Dlk1-Dio3 ncRNAs. The carcinogenic relevance of Dlk1-Dio3 locus ncRNA induction was further supported by in vivo genetic dependence on constitutive androstane receptor and β-catenin pathways. Our data identify Dlk1-Dio3 ncRNAs as novel candidate early biomarkers for mouse liver tumor promotion and provide new opportunities for assessing the carcinogenic potential of novel compounds.
Lars Breuer
; Markus Raue
; M. Strobel
; Thomas Mang
; Michael Josef Schöning
; R. Thoelen
; Torsten Wagner
Abstractauthoren Graphene oxide (GO) nanoparticles were incorporated in temperature-sensitive Poly(N-isopropylacrylamide) (PNIPAAm) hydrogels. The nanoparticles increase the light absorption and convert light energy into heat efficiently. Thus, the hydrogels with GO can be stimulated spatially resolved by illumination as it was demonstrated by IR thermography. The temporal progression of the temperature maximum was detected for different concentrations of GO within the polymer network. Furthermore, the compatibility of PNIPAAm hydrogels with GO and cell cultures was investigated. For this purpose, culture medium was incubated with hydrogels containing GO and the viability and morphology of chinese hamster ovary (CHO) cells was examined after several days of culturing in presence of this medium.
Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism
(2019)
Yasuhiro Kazuki
; Kaoru Kobayashi
; Masumi Hirabayashi
; Satoshi Abe
; Naoyo Kajitani
; Kanoko Kazuki
; Shoko Takehara
; Masato Takiguchi
; Daisuke Satoh
; Jiro Kuze
; Tetsushi Sakuma
; Takehito Kaneko
; Tomoji Mashimo
; Minori Osamura
; Mari Hashimoto
; Riko Wakatsuki
; Rika Hirashima
; Ryoichi Fujiwara
; Tsuneo Deguchi
; Atsushi Kurihara
; Yasuko Tsukazaki
; Naoto Senda
; Takashi Yamamoto
; Nico Scheer
; Mitsuo Oshimura
Mark Whitehead
; Peter Öhlschläger
; Fahad N. Almajhdi
; Leonor Alloza
; Pablo Marzábal
; Ann E. Meyers
; Inga I. Hitzeroth
; Edward P. Rybicki
Jillian Ross
; Simon M. Plummer
; Anja Rode
; Nico Scheer
; Conrad C. Bower
; Ortwin Vogel
; Colin J. Henderson
; C. Roland Wolf
; Clifford R. Elcombe
Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to human health is unclear. The xenoreceptors, constitutive androstane receptors (CARs), and pregnane X receptor (PXR) play key roles in these processes. Novel “humanized” and knockout models for both receptors were developed to investigate potential species differences in hepatomegaly. The effects of PB (80 mg/kg/4 days) and chlordane (10 mg/kg/4 days) were investigated in double humanized PXR and CAR (huPXR/huCAR), double knockout PXR and CAR (PXRKO/CARKO), and wild-type (WT) C57BL/6J mice. In WT mice, both compounds caused increased liver weight, hepatocellular hypertrophy, and cell proliferation. Both compounds caused alterations to a number of cell cycle genes consistent with induction of cell proliferation in WT mice. However, these gene expression changes did not occur in PXRKO/CARKO or huPXR/huCAR mice. Liver hypertrophy without hyperplasia was demonstrated in the huPXR/huCAR animals in response to both compounds. Induction of the CAR and PXR target genes, Cyp2b10 and Cyp3a11, was observed in both WT and huPXR/huCAR mouse lines following treatment with PB or chlordane. In the PXRKO/CARKO mice, neither liver growth nor induction of Cyp2b10 and Cyp3a11 was seen following PB or chlordane treatment, indicating that these effects are CAR/PXR dependent. These data suggest that the human receptors are able to support the chemically induced hypertrophic responses but not the hyperplastic (cell proliferation) responses. At this time, we cannot be certain that hCAR and hPXR when expressed in the mouse can function exactly as the genes do when they are expressed in human cells. However, all parameters investigated to date suggest that much of their functionality is maintained.
Birgit Voigt
; Dirk Albrecht
; Susanne Sievers
; Dörte Becher
; Johannes Bongaerts
; Stefan Evers
; Thomas Schweder
; Karl-Heinz Maurer
; Michael Hecker
Clostridium propionicum is the only organism known to ferment β-alanine, a constituent of coenzyme A (CoA) and the phosphopantetheinyl prosthetic group of holo-acyl carrier protein. The first step in the fermentation is a CoA-transfer to β-alanine. Subsequently, the resulting β-alanyl-CoA is deaminated by the enzyme β-alanyl-CoA:ammonia lyase (Acl) to reversibly form ammonia and acrylyl-CoA. We have determined the crystal structure of Acl in its apo-form at a resolution of 0.97 Å as well as in complex with CoA at a resolution of 1.59 Å. The structures reveal that the enyzme belongs to a superfamily of proteins exhibiting a so called “hot dog fold” which is characterized by a five-stranded antiparallel β-sheet with a long α-helix packed against it. The functional unit of all “hot dog fold” proteins is a homodimer containing two equivalent substrate binding sites which are established by the dimer interface. In the case of Acl, three functional dimers combine to a homohexamer strongly resembling the homohexamer formed by YciA-like acyl-CoA thioesterases. Here, we propose an enzymatic mechanism based on the crystal structure of the Acl·CoA complex and molecular docking. Proteins 2014; 82:2041–2053. © 2014 Wiley Periodicals, Inc.