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A methodology for assessment, seismic verification and strengthening of existing masonry buildings is presented in this paper. The verification is performed using a calculation model calibrated with the results from ambient vibration measurements. The calibrated model serves as an input for a deformation-based verification procedure based on the Capacity Spectrum Method (CSM). The bearing capacity of the building is calculated from experimental capacity curves of the individual walls idealized with bilinear elastic-perfectly plastic curves. The experimental capacity curves were obtained from in-plane cyclic loading tests on unreinforced and strengthened masonry walls with reinforced concrete jackets. The seismic action is compared with the load-bearing capacity of the building considering non-linear material behavior with its post-peak capacity. The application of the CSM to masonry buildings and the influence of a traditional strengthening method are demonstrated on the example of a public school building in Skopje, Macedonia.