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Expertensystem-Projekte. Entwicklungsmethodik, Organisation und Management / Kurbel, K., Pietsch, W.
(1989)
A Portable Implementation of Index Sequential Input-Output [Part 1] / Kurbel, Karl; Pietsch, W.
(1986)
A Portable Implementation of Index Sequential Input-Output [Part 2] / Kurbel, Karl; Pietsch, W.
(1986)
Für die Erstellung von Maschinenbelegungsplanen wurden im Operations Research aufwendige Optimierungsverfahren konzipiert und entsprechende Programme entwickelt. Maschinenbelegungsprobleme sind klassische Vertreter der Klasse der np-vollständigen Probleme, also sichere Kandidaten für kombinatorische Explosion der Lösungsalternativen. Deshalb ist der Einsatz konventioneller Planungssysteme wegen der hohen Rechneranforderungen der gängigen Verfahren an die Hardware oft nicht praktikabel.
Knowledge Management
(2001)
In this paper, methods of sample preparation for potentiometric measurement of phenylalanine are presented. Basing on the spectrophotometric measurements of phenylalanine, the concentrations of reagents of the enzymatic reaction (10 mM L-Phe, 0,4 mM NAD+, 2U L-PheDH) were determined. Then, the absorption spectrum of the reaction product, NADH, was monitored (maximum peak at 340 nm). The results obtained by the spectrophotometric method were compared with the results obtained by the colourimetry, using pH indicators. The above-mentioned two methods will be used as references for potentiometric measurements of phenylalanine concentration.
In this paper, methods of surface modification of different supports, i.e. glass and polymeric beads for enzyme immobilisation are described. The developed method of enzyme immobilisation is based on Schiff’s base formation between the amino groups on the enzyme surface and the aldehyde groups on the chemically modified surface of the supports. The surface of silicon modified by APTS and GOPS with immobilised enzyme was characterised by atomic force microscopy (AFM), time-of-flight secondary ion mass spectroscopy (ToF-SIMS) and infrared spectroscopy (FTIR). The supports with immobilised enzyme (urease) were also tested in combination with microreactors fabricated in silicon and Perspex, operating in a flow-through system. For microreactors filled with urease immobilised on glass beads (Sigma) and on polymeric beads (PAN), a very high and stable signal (pH change) was obtained. The developed method of urease immobilisation can be stated to be very effective.
An enzyme-based multi-parameter biosensor is developed for monitoring the concentration of formate, d-lactate, and l-lactate in biological samples. The sensor is based on the specific dehydrogenation by an oxidized β-nicotinamide adenine dinucleotide (NAD+)-dependent dehydrogenase (formate dehydrogenase, d-lactic dehydrogenase, and l-lactic dehydrogenase, respectively) in combination with a diaphorase from Clostridium kluyveri (EC 1.8.1.4). The enzymes are immobilized on a platinum working electrode by cross-linking with glutaraldehyde (GA). The principle of the determination scheme in case of l-lactate is as follows: l-lactic dehydrogenase (l-LDH) converts l-lactate into pyruvate by reaction with NAD+. In the presence of hexacyanoferrate(III), the resulting reduced β-nicotinamide adenine dinucleotide (NADH) is then regenerated enzymatically by diaphorase. The electrochemical detection is based on the current generated by oxidation of hexacyanoferrate(II) at an applied potential of +0.3 V vs. an Ag/AgCl reference electrode. The biosensor will be electrochemically characterized in terms of linear working range and sensitivity. Additionally, the successful practical application of the sensor is demonstrated in an extract from maize silage.
Multi-analyte biosensors may offer the opportunity to perform cost-effective and rapid analysis with reduced sample volume, as compared to electrochemical biosensing of each analyte individually. This work describes the development of an enzyme-based biosensor system for multi-parametric determination of four different organic acids. The biosensor array comprises five working electrodes for simultaneous sensing of ethanol, formate, d-lactate, and l-lactate, and an integrated counter electrode. Storage stability of the biosensor was evaluated under different conditions (stored at +4 °C in buffer solution and dry at −21 °C, +4 °C, and room temperature) over a period of 140 days. After repeated and regular application, the individual sensing electrodes exhibited the best stability when stored at −21 °C. Furthermore, measurements in silage samples (maize and sugarcane silage) were conducted with the portable biosensor system. Comparison with a conventional photometric technique demonstrated successful employment for rapid monitoring of complex media.
The immobilization of NAD+-dependent dehydrogenases, in combination with a diaphorase, enables the facile development of multiparametric sensing devices. In this work, an amperometric biosensor array for simultaneous determination of ethanol, formate, d- and l-lactate is presented. Enzyme immobilization on platinum thin-film electrodes was realized by chemical cross-linking with glutaraldehyde. The optimization of the sensor performance was investigated with regard to enzyme loading, glutaraldehyde concentration, pH, cofactor concentration and temperature. Under optimal working conditions (potassium phosphate buffer with pH 7.5, 2.5 mmol L-1 NAD+, 2.0 mmol L-1 ferricyanide, 25 °C and 0.4% glutaraldehyde) the linear working range and sensitivity of the four sensor elements was improved. Simultaneous and cross-talk free measurements of four different metabolic parameters were performed successfully. The reliable analytical performance of the biosensor array was demonstrated by application in a clarified sample of inoculum sludge. Thereby, a promising approach for on-site monitoring of fermentation processes is provided.
Optimierte Schnittmuster in Kleinunternehmen : Konzept zur Branchenverschiebung in der Modeindustrie
(2024)
Die vorliegende Arbeit widmet sich Herangehensweisen, die dem Fast-Fashion-Phänomen – einem Trend in der Bekleidungsindustrie, der sich durch immer schnellere Produktion, kürzere Produktlebenszyklen und kostengünstigere Massenproduktion auszeichnet, entgegenstehen. Die alternative Herangehensweise orientiert sich am Berufsbild des Maßschneiders. Ein Lasercutter, der für den Arbeitsalltag von Kleinunternehmen in der Kleidungsbranche optimiert ist, übernimmt das Ausschneiden von Schnittmustern auf Stoffen. Dies ermöglicht Unternehmen in der digitalisierten Welt konkurrenzfähig zu bleiben, ohne große Aufrüstungsarbeiten.
Regardless of size or destination, synthetic biology starts with com-parably small information units, which need to be combined and properly arranged in order to achieve a certain goal. This may be the de novo synthesis of individual genes from oligonucleotides, a shuffling of protein domains in order to create novel biocatalysts, the assembly of multiple enzyme encoding genes in metabolic pathway design, or strain development at the production stage. The CoLibry concept has been designed in order to close the gap between recombinant production of individual genes and genome editing.
Attitude and Orbital Dynamics Modeling for an Uncontrolled Solar-Sail Experiment in Low-Earth Orbit
(2015)
Gossamer-1 is the first project of the three-step Gossamer roadmap, the purpose of which is to develop, prove and demonstrate that solar-sail technology is a safe and reliable propulsion technique for long-lasting and high-energy missions. This paper firstly presents the structural analysis performed on the sail to understand its elastic behavior. The results are then used in attitude and orbital simulations. The model considers the main forces and torques that a satellite experiences in low-Earth orbit coupled with the sail deformation. Doing the simulations for varying initial conditions in attitude and rotation rate, the results show initial states to avoid and maximum rotation rates reached for correct and faulty deployment of the sail. Lastly comparisons with the classic flat sail model are carried out to test the hypothesis that the elastic behavior does play a role in the attitude and orbital behavior of the sail
Die Marktübersicht „Unterschiedliche Entwicklungsansätze von Multiplattform-Anwendungen“ richtet sich an IT-Dienstleister, Entwickler und IT-Abteilungen von Unternehmen, die Multiplattform Anwendungen entwickeln. In dieser Marktübersicht werden verschiedene Entwicklungsansätze beschrieben und ihre jeweiligen Vor- und Nachteile aufgezeigt.
Die Erfindung betrifft einen elektromagnetischen Aktuator zur Betätigung eines Stellgliedes (7) mit wenigstens einem gesteuert bestrombaren Elektromagneten (1, 2) und einem mit dem Stellglied (7) in Wirkverbindung stehenden Anker (5), der bei Bestromung des Elektromagneten (1, 2) gegen die Kraft wenigstens einer an einem Gehäuse (12) abgestützten Rückstellfeder (10) an der Polfläche (3, 4) des Elektromagneten (1, 2) zur Anlage kommt, und daß zumindest der Anker (5) über eine sphärische Gelenkanordnung (11) auf der Rückstellfeder (10) abgestützt ist.