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Enzyme-catalyzed reactions have been designed to mimic various Boolean logic gates in the general framework of unconventional biomolecular computing. While some of the logic gates, particularly OR, AND, are easy to realize with biocatalytic reactions and have been reported in numerous publications, some other, like NXOR, are very challenging and have not been realized yet with enzyme reactions. The paper reports on a novel approach to mimicking the NXOR logic gate using the bell-shaped enzyme activity dependent on pH values. Shifting pH from the optimum value to the acidic or basic values by using acid or base inputs (meaning 1,0 and 0,1 inputs) inhibits the enzyme reaction, while keeping the optimum pH (assuming 0,0 and 1,1 input combinations) preserves a high enzyme activity. The challenging part of the present approach is the selection of an enzyme with a well-demonstrated bell-shape activity dependence on the pH value. While many enzymes can satisfy this condition, we selected pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase as this enzyme has the optimum pH center-located on the pH scale allowing the enzyme activity change by the acidic and basic pH shift from the optimum value corresponding to the highest activity. The present NXOR gate is added to the biomolecular “toolbox” as a new example of Boolean logic gates based on enzyme reactions.
Monitoring the cellular metabolism of bacteria in (bio)fermentation processes is crucial to control and steer them, and to prevent undesired disturbances linked to metabolically inactive microorganisms. In this context, cell-based biosensors can play an important role to improve the quality and increase the yield of such processes. This work describes the simultaneous analysis of the metabolic behavior of three different types of bacteria by means of a differential light-addressable potentiometric sensor (LAPS) set-up. The study includes Lactobacillus brevis, Corynebacterium glutamicum, and Escherichia coli, which are often applied in fermentation processes in bioreactors. Differential measurements were carried out to compensate undesirable influences such as sensor signal drift, and pH value variation during the measurements. Furthermore, calibration curves of the cellular metabolism were established as a function of the glucose concentration or cell number variation with all three model microorganisms. In this context, simultaneous (bio)sensing with the multi-organism LAPS-based set-up can open new possibilities for a cost-effective, rapid detection of the extracellular acidification of bacteria on a single sensor chip. It can be applied to evaluate the metabolic response of bacteria populations in a (bio)fermentation process, for instance, in the biogas fermentation process.
Complexity for heterogeneous classes: teaching embedded systems using an open project approach
(2019)
Entwicklung einer Qualitätssicherung für das Laserstrahlschweißen im Vakuum mittels Bildverarbeitung
(2019)
Speicher statt Kohle. Integration thermischer Stromspeicher in vorhandene Kraftwerksstandorte
(2019)
A new in vitro tool to investigate cardiac contractility under physiological mechanical conditions
(2019)
Übungsaufgaben und Berechnungen für den Baubetrieb: Klausurvorbereitung mit ausführlichen Lösungen
(2019)
Übungsaufgaben und Berechnungen für den Baubetrieb: Klausurvorbereitung mit ausführlichen Lösungen
(2019)
The increasing complexity of Advanced Driver Assistance Systems (ADAS) presents a challenging task to validate safe and reliable performance of these systems under varied conditions. The test and validation of ADAS/AD with real test drives, although important, involves huge costs and time. Simulation tools provide an alternative with the added advantage of reproducibility but often use ideal sensors, which do not reflect real sensor output accurately. This paper presents a new validation methodology using fault injection, as recommended by the ISO 26262 standard, to test software and system robustness. In our work, we investigated and developed a tool capable of inserting faults at different software and system levels to verify its robustness. The scope of this paper is to cover the fault injection test for the Visteon’s DriveCore™ system, a centralized domain controller for Autonomous driving which is sensor agnostic and SoC agnostic. With this new approach, the validation of safety monitoring functionality and its behavior can be tested using real-world data instead of synthetic data from simulation tools resulting in having better confidence in system performance before proceeding with in-vehicle testing.
Themen
(2019)
Hydrogen peroxide (H2O2) is a typical surface sterilization agent for packaging materials used in the pharmaceutical, food and beverage industries. We use the finite-elements method to analyze the conceptual design of an in-line thermal evaporation unit to produce a heated gas mixture of air and evaporated H2O2 solution. For the numerical model, the required phase-transition variables of pure H2O2 solution and of the aerosol mixture are acquired from vapor-liquid equilibrium (VLE) diagrams derived from vapor-pressure formulations. This work combines homogeneous single-phase turbulent flow with heat-transfer physics to describe the operation of the evaporation unit. We introduce the apparent heat-capacity concept to approximate the non-isothermal phase-transition process of the H2O2-containing aerosol. Empirical and analytical functions are defined to represent the temperature- and pressure-dependent material properties of the aqueous H2O2 solution, the aerosol and the gas mixture. To validate the numerical model, the simulation results are compared to experimental data on the heating power required to produce the gas mixture. This shows good agreement with the deviations below 10%. Experimental observations on the formation of deposits due to the evaporation of stabilized H2O2 solution fits the prediction made from simulation results.
Dimensionen 1-2019: Magazin der FH Aachen University of Applied Sciences - Wir sind FH Aachen!
(2019)
Inhaltsverzeichnis:
6 Wir sind FH!
8 Steigen Sie ein : Wir nehmen Sie mit auf eine Reise der Roboter und Maschinen
18 Grenzenlose Förderung : Das Stipendienprogramm geht in das zehnte Jahr
20 Marias neue Kleider : Wissenschaftler unterstützen die Domschatzkammer
24 Die Sprengstoffschnüffler : Fliegerbomben im Erdreich: Neues Verfahren auf Basis der Neutronenaktivierungsanalyse
26 Geschafft! : Erster marokkanischer Elektrotechnikstudent macht seinen Doppelabschluss an der FH Aachen
28 Maßgeschneidert : Dr. Denise Milinnus vom INB entwickelt digitale Biosensoren für die personalisierte Medizin
32 Auf Höhenflügen : Tobias Barth macht außergewöhnliche Luftaufnahmen
36 Über alle Berge : Talentscouting eröffnet neue Wege
38 Der etwas andere Reiseführer : FH-Studentinnen entwerfen Stadtplan für junge Menschen
42 Warum kommt mein Zug zu spät? : FH-Experten im Interview über Probleme und Lösungen der Schiene
48 Der Alina-Weg : Alina Richter promoviert bei der Volkswaren-Konzernforschung
51 Selbst ist die Frau : Die 31-jährige Meral Dural studiert erfolgreich Elektrotechnik am FH-Campus Jülich
52 An der Schnittstelle : INFORM-Professur für angewandte Mathematik und Informatik
53 Kopfnuss
54 Einmal scannen bitte : Forschungsprojekt am MASKOR-Institut wird vom Bund gefördert
56 Inspiriert vom Tier- und Pflanzenmeer : FH-Absolventin Lara Bispinck gewinnt "Future Impact Maker"
60 Schmusekurs mit dem Tiger : FH Aachen führt Kooperationsverbund mit taiwanesischen Hochschulen an
62 Impressum