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Animal experiments and preliminary results in humans have indicated alterations of hippocampal muscarinic acetylcholine receptors (mAChR) in temporal lobe epilepsy. Patients with temporal lobe epilepsy often present with a reduction in hippocampal volume. The aim of this study was to investigate the influence of hippocampal atrophy on the quantification of mAChR with single photon emission tomography (SPET) in patients with temporal lobe epilepsy. Cerebral uptake of the muscarinic cholinergic antagonist [123I]4-iododexetimide (IDex) was investigated by SPET in patients suffering from temporal lobe epilepsy of unilateral (n=6) or predominantly unilateral (n=1) onset. Regions of interest were drawn on co-registered magnetic resonance images. Hippocampal volume was determined in these regions and was used to correct the SPET results for partial volume effects. A ratio of hippocampal IDex binding on the affected side to that on the unaffected side was used to detect changes in muscarinic cholinergic receptor density. Before partial volume correction a decrease in hippocampal IDex binding on the focus side was found in each patient. After partial volume no convincing differences remained. Our results indicate that the reduction in hippocampal IDex binding in patients with epilepsy is due to a decrease in hippocampal volume rather than to a decrease in receptor concentration.
HSP III Koordinatenmessgerät
(1997)
The technology programme “Reduction of aerodynamic drag (RaWid)” for high speed aerodynamics at Daimler-Benz Aerospace Airbus is sponsered by the German ministry for education, research and technology since July 1, 1995. Connected to this industrial programme are the cooperation programmes “MEGAFLOW” under leadership of the DLR and “Transition” by the DFG, and several contributions by DLR and universities.
The programme is oriented towards technologies required for a MEGALINER which gains momentum by the ambitious plans for a new large Airbus A3XX.
In the first year new technological steps were undertaken in theory, design and experiment. Some critical steps were verified by wing designs checked in wind tunnel tests.