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The purpose of this study was to investigate whether sprint performance is related to lower leg musculoskeletal geometry within a homogeneous group of highly trained 100-m sprinters. Using a cluster analysis, eighteen male sprinters were divided into two groups based on their personal best (fast: N = 11, 10.30 ± 0.07 s; slow: N = 7, 10.70 ± 0.08 s). Calf muscular fascicle arrangement and Achilles tendon moment arms (calculated by the gradient of tendon excursion versus ankle joint angle) were analyzed for each athlete using ultrasonography. Achilles tendon moment arm, foot and ankle skeletal geometry, fascicle arrangement as well as the ratio of fascicle length to Achilles tendon moment arm showed no significant (p > 0.05) correlation with sprint performance, nor were there any differences in the analyzed musculoskeletal parameters between the fast and slow sprinter group. Our findings provide evidence that differences in sprint ability in world-class athletes are not a result of differences in the geometrical design of the lower leg even when considering both skeletal and muscular components.
Durch die Kombination von Oligonukleotid-Liganden (Aptameren) hoher Bindungsaffinitäten
mit hochselektiv abtrennbaren magnetisierbaren Mikropartikeln
wird eine einstufige Separation von Zielmolekülen aus mikrobiologischen
Produktionsansätzen möglich. Die Aptamere werden hierfür reversibel
auf den Partikeloberflächen gebunden und für die spezifische Isolierung von
Bioprodukten eingesetzt. Die Abtrennung der beladenen Partikel erfolgt
durch einen neuen Rotor-Stator-Separator mit Hochgradient-Magnetfeld.
Market changes have forced telecommunication companies to transform their business. Increased competition, short innovation cycles, changed usage patterns, increased customer expectations and cost reduction are the main drivers. Our objective is to analyze to what extend transformation projects have improved the orientation towards the end-customers. Therefore, we selected 38 real-life case studies that are dealing with customer orientation. Our analysis is based on a telecommunication-specific framework that aligns strategy, business processes and information systems. The result of our analysis shows the following: transformation projects that aim to improve the customer orientation are combined with clear goals on costs and revenue of the enterprise. These projects are usually directly linked to the customer touch points, but also to the development and provisioning of products. Furthermore, the analysis shows that customer orientation is not the sole trigger for transformation. There is no one-fits-all solution; rather, improved customer orientation needs aligned changes of business processes as well as information systems related to different parts of the company.
Meiotic functions of RAD18
(2011)
Der Erfolg eines Softwarenentwicklungsprojektes insbesondere eines Systemintegrationsprojektes wird mit der Erfüllung des „Teufelsdreiecks“, „In-Time“, „In-Budget“, „In-Quality“ gemessen. Hierzu ist die Kenntnis der Software- und Prozessqualität essenziell, um die Einhaltung der Qualitätskriterien festzustellen, aber auch, um eine Vorhersage hinsichtlich Termin- und Budgettreue zu treffen. Zu diesem Zweck wurde in der T-Systems Systems Integration ein System aus verschiedenen Key Performance Indikatoren entworfen und in der Organisation implementiert, das genau das leistet und die Kriterien für CMMI Level 3 erfüllt.
Modification and testing of an engine and fuel control system for a hydrogen fuelled gas turbine
(2011)
Möglichkeiten und Grenzen der Anwendbarkeit statisch nichtlinearer Verfahren nach DIN EN 1998-1
(2011)
The development and analysis of three waveguides for the exposure of small biological in vitro samples to mobile communication signals at 900 MHz (GSM, Global System for Mobile Communications), 1.8 GHz (GSM), and 2 GHz (UMTS, Universal Mobile Telecommunications System) is presented. The waveguides were based on a fin-line concept and the chamber containing the samples bathed in extracellular solution was placed onto two fins with a slot in between, where the exposure field concentrates. Measures were taken to allow for patch clamp recordings during radiofrequency (RF) exposure. The necessary power for the achievement of the maximum desired specific absorption rate (SAR) of 20 W/kg (average over the mass of the solution) was approximately Pin = 50 mW, Pin = 19 mW, and Pin = 18 mW for the 900 MHz, 1800 MHz, and 2 GHz devices, respectively. At 20 W/kg, a slight RF-induced temperature elevation in the solution of no more than 0.3 °C was detected, while no thermal offsets due to the electromagnetic exposure could be detected at the lower SAR settings (2, 0.2, and 0.02 W/kg). A deviation of 10% from the intended solution volume yielded a calculated SAR deviation of 8% from the desired value. A maximum ±10% variation in the local SAR could occur when the position of the patch clamp electrode was altered within the area where the cells to be investigated were located.
Numerical and experimental investigation of tensile behavior of laser beam welded TRIP700 steel
(2011)
The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
One-chip integrated dual amperometric/field-effect sensor for the detection of dissolved hydrogen
(2011)
Purpose:
At 1.5 T, real-time MRI of joint movement has been shown to be feasible. However, 7 T, provides higher SNR and thus an improved potential for parallel imaging acceleration. The purpose of this work was to build an open, U-shaped eight-channel transmit/receive microstrip coil for 7 T MRI to enable high-resolution and real-time imaging of the moving ankle joint.
Methods:
A U-shaped eight-channel transmit/receive array for the human ankle was built.urn:x-wiley:00942405:mp3399:equation:mp3399-math-0001-parameters and urn:x-wiley:00942405:mp3399:equation:mp3399-math-0002-factor were measured. SAR calculations of different ankle postures were performed to ensure patient safety. Inhomogeneities in the transmit field consequent to the open design were compensated for by the use of static RF shimming. High-resolution and real-time imaging was performed in human volunteers.
Results:
The presented array showed good performance with regard to patient comfort and image quality. High acceleration factors of up to 4 are feasible without visible acceleration artifacts. Reasonable image homogeneity was achieved with RF shimming.
Conclusions:
Open, noncylindrical designs for transmit/receive coils are practical at 7 T and real-time imaging of the moving joint is feasible with the presented coil design.