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In comparison to single-analyte devices, multiplexed systems for a multianalyte detection offer a reduced assay time and sample volume, low cost, and high throughput. Herein, a multiplexing platform for an automated quasi-simultaneous characterization of multiple (up to 16) capacitive field-effect sensors by the capacitive–voltage (C–V) and the constant-capacitance (ConCap) mode is presented. The sensors are mounted in a newly designed multicell arrangement with one common reference electrode and are electrically connected to the impedance analyzer via the base station. A Python script for the automated characterization of the sensors executes the user-defined measurement protocol. The developed multiplexing system is tested for pH measurements and the label-free detection of ligand-stabilized, charged gold nanoparticles.
In this work, the bioabsorbable materials, namely fibroin, polylactide acid (PLA), magnesium and magnesium oxide are investigated for their application as transient, resistive temperature detectors (RTD). For this purpose, a thin-film magnesium-based meander-like electrode is deposited onto a flexible, bioabsorbable substrate (fibroin or PLA) and encapsulated (passivated) by additional magnesium oxide layers on top and below the magnesium-based electrode. The morphology of different layered RTDs is analyzed by scanning electron microscopy. The sensor performance and lifetime of the RTD is characterized both under ambient atmospheric conditions between 30°C and 43°C, and wet tissue-like conditions with a constant temperature regime of 37°C. The latter triggers the degradation process of the magnesium-based layers. The 3-layers RTDs on a PLA substrate could achieve a lifetime of 8.5 h. These sensors also show the best sensor performance under ambient atmospheric conditions with a mean sensitivity of 0.48 Ω/°C ± 0.01 Ω/°C.
Background
Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices.
Methods
This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare & Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results.
Results
With a 10% fracture risk reduction, model A costs between $8,850 and $46,940 per quality-adjusted life-year ($/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side’s prophylaxis, the patient’s age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between $11,000/QALY and $74,000/QALY, which is below the defined willingness to pay threshold.
Conclusion
Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks.
Companies often build their businesses based on product information and therefore try to automate the process of information extraction (IE). Since the information source is usually heterogeneous and non-standardized, classic extract, transform, load techniques reach their limits. Hence, companies must implement the newest findings from research to tackle the challenges of process automation. They require a flexible and robust system that is extendable and ensures the optimal processing of the different document types. This paper provides a distributed microservice architecture pattern that enables the automated generation of IE pipelines. Since their optimal design is individual for each input document, the system ensures the ad-hoc generation of pipelines depending on specific document characteristics at runtime. Furthermore, it introduces the automated quality determination of each available pipeline and controls the integration of new microservices based on their impact on the business value. The introduced system enables fast prototyping of the newest approaches from research and supports companies in automating their IE processes. Based on the automated quality determination, it ensures that the generated pipelines always meet defined business requirements when they come into productive use.
Obstacle avoidance is critical for unmanned aerial vehicles (UAVs) operating autonomously. Obstacle avoidance algorithms either rely on global environment data or local sensor data. Local path planners react to unforeseen objects and plan purely on local sensor information. Similarly, animals need to find feasible paths based on local information about their surroundings. Therefore, their behavior is a valuable source of inspiration for path planning. Bumblebees tend to fly vertically over far-away obstacles and horizontally around close ones, implying two zones for different flight strategies depending on the distance to obstacles. This work enhances the local path planner 3DVFH* with this bio-inspired strategy. The algorithm alters the goal-driven function of the 3DVFH* to climb-preferring if obstacles are far away. Prior experiments with bumblebees led to two definitions of flight zone limits depending on the distance to obstacles, leading to two algorithm variants. Both variants reduce the probability of not reaching the goal of a 3DVFH* implementation in Matlab/Simulink. The best variant, 3DVFH*b-b, reduces this probability from 70.7 to 18.6% in city-like worlds using a strong vertical evasion strategy. Energy consumption is higher, and flight paths are longer compared to the algorithm version with pronounced horizontal evasion tendency. A parameter study analyzes the effect of different weighting factors in the cost function. The best parameter combination shows a failure probability of 6.9% in city-like worlds and reduces energy consumption by 28%. Our findings demonstrate the potential of bio-inspired approaches for improving the performance of local path planning algorithms for UAV.
In this work, the effects of carbon sources and culture media on the production and structural properties of bacterial cellulose (BC) synthesized by Medusomyces gisevii have been studied. The culture medium was composed of different initial concentrations of glucose or sucrose dissolved in 0.4% extract of plain green tea. Parameters of the culture media (titratable acidity, substrate conversion degree etc.) were monitored daily for 20 days of cultivation. The BC pellicles produced on different carbon sources were characterized in terms of biomass yield, crystallinity and morphology by field emission scanning electron microscopy (FE-SEM), atomic force microscopy and X-ray diffraction. Our results showed that Medusomyces gisevii had higher BC yields in media with sugar concentrations close to 10 g L−1 after a 18–20 days incubation period. Glucose in general lead to a higher BC yield (173 g L−1) compared to sucrose (163.5 g L−1). The BC crystallinity degree and surface roughness were higher in the samples synthetized from sucrose. Obtained FE-SEM micrographs show that the BC pellicles synthesized in the sucrose media contained densely packed tangles of cellulose fibrils whereas the BC produced in the glucose media displayed rather linear geometry of the BC fibrils without noticeable aggregates.
Antibias training is increasingly demanded and practiced in academia and industry to increase employees’ sensitivity to discrimination, racism, and diversity. Under the heading of “Diversity Management,” antibias trainings are mainly offered as one-off workshops intending to raise awareness of unconscious biases, create a diversity-affirming corporate culture, promote awareness of the potential of
diversity, and ultimately enable the reflection of diversity in development processes. However, coming from childhood education, research and scientific articles on the sustainable effectiveness of antibias in adulthood, especially in academia, are very scarce. In order to fill this research gap, the article aims to explore how sustainable the effects of individual antibias trainings on participants’ behavior are. In order to investigate this, participant observation in a qualitative pre–post setting was conducted, analyzing antibias training in an academic context. Two observers actively participated in the training sessions and documented the activities and reflection processes of the participants. Overall, the results question the effectiveness of single antibias trainings and show that a target-group adaptive approach is mandatory owing to the background of the approach in early childhood education. Therefore, antibias work needs to be adapted to the target group’s needs and realities of life. Furthermore, the study reveals that single antibias trainings must be embedded in a holistic diversity management approach to stimulate sustainable reflection processes among the target group. This article is one of the first to scientifically evaluate antibias training effectiveness, especially in engineering sciences and the university context.
Throughout the last decade, and particularly in 2022, water scarcity has become a critical concern in Morocco and other Mediterranean countries. The lack of rainfall during spring was worsened by a succession of heat waves during the summer. To address this drought, innovative solutions, including the use of new technologies such as hydrogels, will be essential to transform agriculture. This paper presents the findings of a study that evaluated the impact of hydrogel application on onion (Allium cepa) cultivation in Meknes, Morocco. The treatments investigated in this study comprised two different types of hydrogel-based soil additives (Arbovit® polyacrylate and Huminsorb® polyacrylate), applied at two rates (30 and 20 kg/ha), and irrigated at two levels of water supply (100% and 50% of daily crop evapotranspiration; ETc). Two control treatments were included, without hydrogel application and with both water amounts. The experiment was conducted in an open field using a completely randomized design. The results indicated a significant impact of both hydrogel-type dose and water dose on onion plant growth, as evidenced by various vegetation parameters. Among the hydrogels tested, Huminsorb® Polyacrylate produced the most favorable outcomes, with treatment T9 (100%, HP, 30 kg/ha) yielding 70.55 t/ha; this represented an increase of 11 t/ha as compared to the 100% ETc treatment without hydrogel application. Moreover, the combination of hydrogel application with 50% ETc water stress showed promising results, with treatment T4 (HP, 30 kg, 50%) producing almost the same yield as the 100% ETc treatment without hydrogel while saving 208 mm of water.
In today's ultra-connected world, the significance of audio-visual documentation is rapidly growing. Technological advancements have made it more accessible to obtain powerful and compact audio-visual equipment, thereby reducing the dependency on a larger team for the documentation process. This has favoured the development of what is known as backpack journalism.
This project meets an unmet market need and presents an opportunity for innovative product development. It focuses on backpack journalists working in remote and challenging conditions with unpredictable transportation and working conditions. The proposed backpack design addresses both transport and working setups. Offering a robust and waterproof yet overall lightweight construction for easy equipment carrying, while also providing an extension of the workspace for essential gear.
Pendelleuchte aus Glas
(2023)
Glas ist seit jeher ein faszinierender Werkstoff. Es findet Anwendung in zahlreichen Gebieten und bietet als Material für Leuchten eine besondere Eleganz. Die Pendelleuchte „Calice di fiori“ vereint handwerkliche Kunstfertigkeit und komfortables Design. Sie ist aus mundgeblasenem Glas gefertigt und verleiht durch ihre Färbung eine kraftvolle und dynamische Atmosphäre im Raum. Das besondere Merkmal der Pendelleuchte ist eine Öffnung, die eine einfache und intuitive Montage erleichtert. Die Pendelleuchte ist mit energieeffizienten LEDs ausgestattet und lässt sich mit einem Smart-Home-System bedienen. Die Lichtintensität und Lichtfarbe können den individuellen Bedürfnissen angepasst werden. „Calice di fiori“ mit schnell abnehmbarem Leuchtenschirm fügt sich in modern eingerichtete Räume ein und bringt einen Hauch Blütenflair mit sich.
Der heutige Alltag vieler Menschen ist durch längere Sitz-Einheiten gekennzeichnet, während die körperliche Bewegung vernachlässigt wird. Diese Entwicklung kann einen negativen Einfluss auf die Haltung von Personen und ihre Gesundheit haben. In diesem Fall ist eine korrekte Haltung nicht nur für die körperliche, sondern auch für die psychische Gesundheit von großer Relevanz. Die Bachelorarbeit „LittleHabit“ ermöglicht es, dass bei Kindern die Bewegung nach langen Sitz-Einheiten durch gezieltes Training zur Gewohnheit wird. Hierbei wird zwischen dem Zuhause- und dem Schulbereich differenziert. Zu Hause soll das Kind beim Erledigen der Hausaufgaben durch Animationen und Lichtsignale dazu motiviert werden, Bewegungspausen einzulegen. In der Schule soll dieses Vorhaben in reduzierter Form aufgegriffen und mithilfe von Licht- und Farbsignalen umgesetzt werden. Darüber hinaus fördert es die intrinsische Motivation, sodass Kinder aus eigenem Antrieb ein Interesse dafür entwickeln, sich nach langen Sitz-Einheiten zu bewegen. LittleHabit setzt einen Baustein für die Entwicklung einer gesunden Sitz-Haltung und zielt darauf ab, Haltungsschwächen zu verhindern.
„ALIGN“ ist ein smartes Möbelsystem, das den individuellen Lebensstil und die Werte der heutigen Gesellschaft widerspiegelt. Es bietet ausreichend Stauraum und ermöglicht es, Objekte gezielt in Szene zu setzen oder in den Hintergrund zu rücken. Das vielseitige System passt sich an unterschiedliche Raum- und Nutzungsszenarien an. Es ermöglicht die individuelle Gestaltung des Wohnraums nach persönlichen Vorlieben und hilft, den Herausforderungen des modernen Lebens gerecht zu werden. „ALIGN“ – eine passende Lösung für jedes Problem.
In addition to the technical content, modern courses at university should also teach professional skills to enhance the competencies of students towards their future work. The competency driven approach including technical as well as professional skills makes it necessary to find a suitable way for the integration into the corresponding module in a scalable and flexible manner. Agile development, for example, is essential for the development of modern systems and applications and makes use of dedicated professional skills of the team members, like structured group dynamics and communication, to enable the fast and reliable development. This paper presents an easy to integrate and flexible approach to integrate Scrum, an agile development method, into the lab of an existing module. Due to the different role models of Scrum the students have an individual learning success, gain valuable insight into modern system development and strengthen their communication and organization skills. The approach is implemented and evaluated in the module Vehicle Systems, but it can be transferred easily to other technical courses as well. The evaluation of the implementation considers feedback of all stakeholders, students, supervisor and lecturers, and monitors the observations during project lifetime.
Durch das WEMoG (Gesetz v. 16.10.2020, BGBl. I 2187) hat der Gesetzgeber die Regelung des § 20 WEG eingeführt. Demnach ist auch für bauliche Veränderungen an Räumen und Flächen, die einem Sondernutzungsrecht unterliegen, die Zustimmung der Gemeinschaft notwendig. Der BGH hat nun mit Urt. v. 17.3.2023 –V ZR 140/22, MDR 2023, 619 deutlich gemacht, dass bei Fehlen eines entsprechenden Beschlusses, die bauliche Veränderung durch einen einzelnen Wohnungseigentümer nicht vorgenommen werden darf, sondern eine rechtswidrige Eigentumsbeeinträchtigung darstellt. Der folgende Beitrag nimmt die Entscheidung zum Anlass, um die neue Rechtslage durch § 20 WEG eingehend zu erläutern. Gleichzeitig werden die Folgen der aktuellen Entscheidung näher dargestellt.
Melting probes are a proven tool for the exploration of thick ice layers and clean sampling of subglacial water on Earth. Their compact size and ease of operation also make them a key technology for the future exploration of icy moons in our Solar System, most prominently Europa and Enceladus. For both mission planning and hardware engineering, metrics such as efficiency and expected performance in terms of achievable speed, power requirements, and necessary heating power have to be known.
Theoretical studies aim at describing thermal losses on the one hand, while laboratory experiments and field tests allow an empirical investigation of the true performance on the other hand. To investigate the practical value of a performance model for the operational performance in extraterrestrial environments, we first contrast measured data from terrestrial field tests on temperate and polythermal glaciers with results from basic heat loss models and a melt trajectory model. For this purpose, we propose conventions for the determination of two different efficiencies that can be applied to both measured data and models. One definition of efficiency is related to the melting head only, while the other definition considers the melting probe as a whole. We also present methods to combine several sources of heat loss for probes with a circular cross-section, and to translate the geometry of probes with a non-circular cross-section to analyse them in the same way. The models were selected in a way that minimizes the need to make assumptions about unknown parameters of the probe or the ice environment.
The results indicate that currently used models do not yet reliably reproduce the performance of a probe under realistic conditions. Melting velocities and efficiencies are constantly overestimated by 15 to 50 % in the models, but qualitatively agree with the field test data. Hence, losses are observed, that are not yet covered and quantified by the available loss models. We find that the deviation increases with decreasing ice temperature. We suspect that this mismatch is mainly due to the too restrictive idealization of the probe model and the fact that the probe was not operated in an efficiency-optimized manner during the field tests. With respect to space mission engineering, we find that performance and efficiency models must be used with caution in unknown ice environments, as various ice parameters have a significant effect on the melting process. Some of these are difficult to estimate from afar.
Manufacturing companies across multiple industries face an increasingly dynamic and unpredictable environment. This development can be seen on both the market and supply side. To respond to these challenges, manufacturing companies must implement smart manufacturing systems and become more flexible and agile. The flexibility in operational planning regarding the scheduling and sequencing of customer orders needs to be increased and new structures must be implemented in manufacturing systems’ fundamental design as they constitute much of the operational flexibility available. To this end, smart and more flexible solutions for production planning and control (PPC) are developed. However, scheduling or sequencing is often only considered isolated in a predefined stable environment. Moreover, their orientation on the fundamental logic of the existing IT solutions and their applicability in a dynamic environment is limited. This paper presents a conceptual model for a task-based description logic that can be applied to factory planning, technology planning, and operational control. By using service-oriented architectures, the goal is to generate smart manufacturing systems. The logic is designed to allow for easy and automated maintenance. It is compatible with the existing resource and process allocation logic across operational and strategic factory and production planning.
Traditional vulcanization mold manufacturing is complex, costly, and under pressure due to shorter product lifecycles and diverse variations. Additive manufacturing using Fused Filament Fabrication and high-performance polymers like PEEK offer a promising future in this industry. This study assesses the compressive strength of various infill structures (honeycomb, grid, triangle, cubic, and gyroid) when considering two distinct build directions (Z, XY) to enhance PEEK’s economic and resource efficiency in rapid tooling. A comparison with PETG samples shows the behavior of the infill strategies. Additionally, a proof of concept illustrates the application of a PEEK mold in vulcanization. A peak compressive strength of 135.6 MPa was attained in specimens that were 100% solid and subjected to thermal post-treatment. This corresponds to a 20% strength improvement in the Z direction. In terms of time and mechanical properties, the anisotropic grid and isotropic cubic infill have emerged for use in rapid tooling. Furthermore, the study highlights that reducing the layer thickness from 0.15 mm to 0.1 mm can result in a 15% strength increase. The study unveils the successful utilization of a room-temperature FFF-printed PEEK mold in vulcanization injection molding. The parameters and infill strategies identified in this research enable the resource-efficient FFF printing of PEEK without compromising its strength properties. Using PEEK in rapid tooling allows a cost reduction of up to 70% in tool production.
Eine Sensorvorrichtung (10;110;210;310;410) zur Erfassung eines Magnetfelds, mit einer Wiegand-Sensoreinheit (12;112;212) umfassend: • - mindestens zwei Wiegand-Drähte (20) und • - eine Spulenanordnung (22;122;222), die die mindestens zwei Wiegand-Drähte (20) radial umschließt und die • • • ein Sensorelement (26;126;226) und • • ein Triggerelement (28;128;228), durch das ein Triggermagnetfeld erzeugbar ist, bildet, ist bekannt. Um ein magnetbasiertes Sensorsystem (300;400) zur Erfassung einer Bewegung eines beweglichen Objekts (301;401) zu ermöglichen, das ohne externe Energieversorgung zuverlässig sowie energieeffizient arbeitet und kostengünstig hergestellt werden kann, ist bei der erfindungsgemäßen Sensorvorrichtung (10;110;210;310;410) eine Wiegand-Triggereinheit (14;14a) vorhanden, umfassend: • - einen Wiegand-Draht (30) und • - eine Trigger-Sensorspule (32), die den Wiegand-Draht (30) radial umschließt, wobei ein erstes Ende der Trigger-Sensorspule (32) der Wiegand-Triggereinheit (14;14a) mit einem ersten Ende des Triggerelements (28;128;228) der Wiegand-Sensoreinheit (12;112;212) elektrisch verbunden ist und ein zweites Ende der Trigger-Sensorspule (32) der Wiegand-Triggereinheit (14;14a) mit einem zweiten Ende des Triggerelements (28;128;228) der Wiegand-Sensoreinheit (12;112;212) elektrisch verbunden ist. Auf diese Weise verstärkt ein in der Trigger-Sensorspule (32) erzeugter Impuls das Gesamtmagnetfeld, das auf die Wiegand-Drähte (20) in der Sensoreinheit einwirkt, derart, dass die Triggefeldstärke aller Wiegand-Drähte (20) überschritten wird und diese im wesentlichen zeitgleich auslösen.
Achieving the 17 Sustainable Development Goals (SDGs) set by the United Nations (UN) in 2015 requires global collaboration between different stakeholders. Industry, and in particular engineers who shape industrial developments, have a special role to play as they are confronted with the responsibility to holistically reflect sustainability in industrial processes. This means that, in addition to the technical specifications, engineers must also question the effects of their own actions on an ecological, economic and social level in order to ensure sustainable action and contribute to the achievement of the SDGs. However, this requires competencies that enable engineers to apply all three pillars of sustainability to their own field of activity and to understand the global impact of industrial processes. In this context, it is relevant to understand how industry already reflects sustainability and to identify competences needed for sustainable development.
Damit Sie auch in den immer häufiger werdenden Onlineveranstaltungen als Moderator gut bestehen, sollten Sie wissen, was bei der Onlinemoderation im Besonderen zu beachten ist.
In diesem dritten Teil der Beitragsserie erfahren Sie, warum online anders als offline ist. Die technischen Möglichkeiten werden vorgestellt und auch wie diese zu nutzen sind. Schließlich erhalten Sie Tipps, die Sie beim Sprechen online beachten sollten.
Damit Sie auch in den immer häufiger werdenden Onlineveranstaltungen als Moderator gut bestehen, sollten Sie wissen, was bei der Onlinemoderation im Besonderen zu beachten ist.
In diesem dritten Teil der Beitragsserie erfahren Sie, warum online anders als offline ist. Die technischen Möglichkeiten werden vorgestellt und auch wie diese zu nutzen sind. Schließlich erhalten Sie Tipps, die Sie beim Sprechen online beachten sollten.
This book is based on a multimedia course for biological and chemical engineers, which is designed to trigger students' curiosity and initiative. A solid basic knowledge of thermodynamics and kinetics is necessary for understanding many technical, chemical, and biological processes.
The one-semester basic lecture course was divided into 12 workshops (chapters). Each chapter covers a practically relevant area of physical chemistry and contains the following didactic elements that make this book particularly exciting and understandable:
- Links to Videos at the start of each chapter as preparation for the workshop
- Key terms (in bold) for further research of your own
- Comprehension questions and calculation exercises with solutions as learning checks
- Key illustrations as simple, easy-to-replicate blackboard pictures
Humorous cartoons for each workshop (by Faelis) additionally lighten up the text and facilitate the learning process as a mnemonic. To round out the book, the appendix includes a summary of the most popular experiments in basic physical chemistry courses, as well as suggestions for designing workshops with exhibits, experiments, and "questions of the day."
Suitable for students minoring in chemistry; chemistry majors are sure to find this slimmed-down, didactically valuable book helpful as well. The book is excellent for self-study.
In times of social climate protection movements, such as Fridays for Future, the priorities of society, industry and higher education are currently changing. The consideration of sustainability challenges is increasing. In the context of sustainable development, social skills are crucial to achieving the United Nations Sustainable Development Goals (SDGs). In particular, the impact that educational activities have on people, communities and society is therefore coming to the fore. Research has shown that people with high levels of social competence are better able to manage stressful situations, maintain positive relationships and communicate effectively. They are also associated with better academic performance and career success. However, especially in engineering programs, the social pillar is underrepresented compared to the environmental and economic pillars.
In response to these changes, higher education institutions should be more aware of their social impact - from individual forms of teaching to entire modules and degree programs. To specifically determine the potential for improvement and derive resulting change for further development, we present an initial framework for social impact measurement by transferring already established approaches from the business sector to the education sector. To demonstrate the applicability, we measure the key competencies taught in undergraduate engineering programs in Germany.
The aim is to prepare the students for success in the modern world of work and their future contribution to sustainable development. Additionally, the university can include the results in its sustainability report. Our method can be applied to different teaching methods and enables their comparison.
Amino acid-based surfactants are valuable compounds for cosmetic formulations. The chemical synthesis of acyl-amino acids is conventionally performed by the Schotten-Baumann reaction using fatty acyl chlorides, but aminoacylases have also been investigated for use in biocatalytic synthesis with free fatty acids. Aminoacylases and their properties are diverse; they belong to different peptidase families and show differences in substrate specificity and biocatalytic potential. Bacterial aminoacylases capable of synthesis have been isolated from Burkholderia, Mycolicibacterium, and Streptomyces. Although several proteases and peptidases from S. griseus have been described, no aminoacylases from this species have been identified yet. In this study, we investigated two novel enzymes produced by S. griseus DSM 40236ᵀ . We identified and cloned the respective genes and recombinantly expressed an α-aminoacylase (EC 3.5.1.14), designated SgAA, and an ε-lysine acylase (EC 3.5.1.17), designated SgELA, in S. lividans TK23. The purified aminoacylase SgAA was biochemically characterized, focusing on its hydrolytic activity to determine temperature- and pH optima and stabilities. The aminoacylase could hydrolyze various acetyl-amino acids at the Nα -position with a broad specificity regarding the sidechain. Substrates with longer acyl chains, like lauroyl-amino acids, were hydrolyzed to a lesser extent. Purified aminoacylase SgELA specific for the hydrolysis of Nε -acetyl-L-lysine was unstable and lost its enzymatic activity upon storage for a longer period but could initially be characterized. The pH optimum of SgELA was pH 8.0. While synthesis of acyl-amino acids was not observed with SgELA, SgAA catalyzed the synthesis of lauroyl-methionine.
Social Media - Segen oder Fluch? : Eine Aufklärungskampagne zu Auswirkungen von Social Media Nutzung
(2023)
Das Projekt „Social Media – Segen oder Fluch“ beschäftigt sich mit negativen Auswirkungen, die die Nutzung Sozialer Medien haben kann. Soziale Medien werden heutzutage ständig und von fast jedem genutzt, vor allem von Jugendlichen und jungen Erwachsenen. Vielen ist aber nicht bewusst, dass sich die Nutzung negativ auf sie und ihre Gesundheit auswirken kann. Eine Kampagne soll daran etwas ändern. Soziale Medien bzw. der Content, der die Nutzer:innen negativ beeinflusst, ist wie ein Monster, vor dem sich die Nutzer:innen in acht nehmen müssen. Angesprochen werden hauptsächlich 12-29-jährige, die Soziale Medien nutzen. Die Kampagne soll durch verschiedene Maßnahmen wie Plakatwerbung und Posts auf Social Media Kanälen, den negativen Auswirkungen von Social Media Nutzung entgegenwirken. Sie soll über die Auswirkungen aufklären und zu einem bewussteren Umgang mit Sozialen Netzwerken anregen.
§ 1 | Geltungsbereich der Prüfungsordnung
§ 2 | Ziel des Studiums, Zweck der Prüfung, Abschlussgrad
§ 3 | Beginn, Dauer, Umfang und Gliederung des Studiums
§ 4 | Zugang zum Studium, Praktikum
§ 5 | Prüfungsausschuss
§ 6 | Studien- und Prüfungselemente
§ 7 | Zulassung zu den Prüfungen
§ 8 | Durchführung von Prüfungen
§ 9 | Verbesserungsversuch
§ 10 | Anrechnung von Studienzeiten, Studien- und Prüfungsleistungen
§ 11 | Praxissemester
§ 12 | Mobilitätssemester (Auslandssemester)
§ 13 | Bachelorprojekt§ 14 | Gesamtnote, Zeugnis, Bachelorurkunde
§ 15 | Inkrafttreten, Veröffentlichung
Anlage 1 | Studienplan Kernstudium
Anlage 2 | Allgemeine Kompetenzen
Der Uni-Cup ist ein Amateur Eishockey Turnier der RWTH Aachen. Es treten Studierende und Professor:innen gegeneinander an. Ausgetragen wurde das Turnier vor etwa 2.500 Zuschauern in der 100,5 Arena am Tivoli. Um das Event einer breiteren Masse zugänglich zu machen, wurde dort im Rahmen der Bachelorarbeit erstmals eine Live Übertragung produziert. Das Ziel dabei war es, eine möglichst professionelle und unterhaltsame Show zu kreieren.
In der heutigen digitalisierten und individualisierten Welt spielt das Theater weiterhin eine bedeutende Rolle als kulturelle Institution und als Ort des künstlerischen Ausdrucks. Dabei ist einer der wichtigsten Aspekte die Bewegung. Sie findet auf der Bühne in jeglicher Form statt – Tanz, Gestik, Mimik, die Schritte der Schauspieler:innen, Sprünge, Armbewegungen. All diese unterschiedlichen Arten von Bewegung sind ausschlaggebend für die Wirkung der Texte und Stücke. Für das neue Erscheinungsbild des Düsseldorfer Schauspielhauses wurde dieser Bewegungsaspekt in ein spannendes, modernes und übersichtliches Corporate Design übersetzt. Das Ergebnis: Sonderzeichen, die „Bewegung“ aufgreifen und entsprechend „verformt“ wurden. Durch ihr verändertes Aussehen spiegeln sie diese Bewegung abstrahiert wider und führen abwechslungsreich durch die verschiedenen Medien.
Weithin leuchtend – tief unter der Erde strahlend: Das »Zentrum für internationale Lichtkunst« in Unna ist ein »Unikat« unter den Kunstmuseen weltweit, da das Museum das Einzige ist, welches sich ausschließlich der zeitgenössischen Lichtkunst widmet. Seit 2001 erstreckt sich die Sammlung von 21 dauerhaften Werken in einem großzügigen Kellergewölbe. Viele der Lichtinstallationen wurden eigens für die Räumlichkeiten konzipiert und sind sowohl in ihrem technischen, als auch ästhetischen und perspektivischen Auftritt unverwechselbar.
Die Zielsetzung des Projektes ist es, ein systematisches und einheitliches Erscheinungsbild, welches crossmedial eingesetzt werden kann, zu erarbeiten. Des Weiteren soll die Thematik Lichtkunst in dem Corporate Design aufgegriffen und widergespiegelt werden, sodass die Berührungspunkte des Publikums spannungsvoll und einprägend aufgenommen werden.
Boys will be boys
(2023)
"boys will be boys" erkundet bestehende Meinungen zum Thema Männlichkeit und versucht Alternativen zu finden: Wege, die Männlichkeit gehen und Richtungen, in die sich Männlichkeit verändern kann. Auf 236 Seiten wird das Thema von so vielen Seiten wie irgendwie möglich beleuchtet. Es gibt sowohl sehr persönliche, subjektive Beschäftigung mit dem Thema als auch eine objektive, wissenschaftliche Herangehensweise. Das Buch ist vor allem mit typografischen Elementen gestaltet worden, wobei in Inhalt und Typografie viel Wert auf Niedrigschwelligkeit gelegt wurde. Außen ist ein partieller Relieflack aufgetragen worden, innen hat das Buch bedrucktes Vorsatzpapier. Ziel des Projektes war es, Männlichkeit und die verschiedenen Meinungen dazu möglichst verständlich wiedergeben zu können, um so einen Dialog zum Thema anzuregen.
Entwicklung eines neuen Erscheinungsbildes für das Wallraf-Richartz-Museum und Fondation Carboud
(2023)
Das Wallraf-Richartz-Museum & Fondation Corboud besitzt eine der wichtigsten europäischen Kunstsammlungen vom Mittelalter bis zum 19. Jahrhundert. Durch das Zusammenspiel von Forschung und Vermittlung der Kunst- und Epochengeschichte trägt das Museum maßgeblich zum Erhalt des kulturellen Erbes und dem Meinungsaustausch über die Vergangenheit, Gegenwart und die Zukunft bei. Im Fokus des neuen Erscheinungsbildes steht die an den kulturellen und historischen Kontext angepasste Szenografie des Museums. Die beeindruckend verzierten Bilderrahmen der gezeigten Kunstepochen werden abstrahiert und durch einen typografischen Rahmen neu interpretiert. Das entwickelte Headline-Prinzip wird durch eine sehr zurückhaltende Gestaltung ergänzt, was der Thematik und den gezeigten Meisterwerken Raum zum Wirken verleiht.
Die Bachelorarbeit beschäftigte sich mit der Integration von künstlicher Intelligenz (KI) in softwarebasierte Lösungen und hatte das Ziel, ein prototypisches Lösungsmodell zu entwickeln. Dabei wurde das User-Experience-Designverfahren angewendet, um eine neue innovative Arbeitsweise zu schaffen, die KI-gestützte Produktentwicklungsprozesse umfasst.
Hippocampus
(2023)
Hippocampus – Eine Publikation über das Erscheinungsbild und Verhaltensweisen von Seepferdchen, ihre Lebensräume, Bedrohungen und die Schutzmaßnahmen. Seepferdchen gehören zu den wenigen Fischarten, die allgemein bekannt sind. In den meisten Fällen werden Seepferdchen einfach als »süß« beschrieben. Doch Seepferdchen haben weit mehr zu bieten als ihr märchenhaftes Aussehen. Diese Publikation setzt sich mit kuriosen Erkenntnissen, aktuellen Forschungsergebnissen und Mythen rund um Seepferdchen auseinander und dient als Einstieg in die Thematik.
Fahrzeugstruktur
(2023)
Um sowohl Treibhausgas-Emissionen zu verringern als auch Kraftstoffressourcen zu schonen, wird zunehmend an einer Transformation konventionell angetriebener Kraftfahrzeuge hin zu elektrifizierten Antriebskonzepten gearbeitet. Basierend auf herkömmlichen Fahrzeugen mit Verbrennungsmotor wurde eine Vielzahl neuer Antriebssysteme mit verschiedenem Elektrifizierungsgrad entwickelt. Mitte der 1990er-Jahre kamen erste Fahrzeuge mit einem Hybridantrieb auf den Markt. Die Kombination aus Verbrennungs- und Elektromotor erlaubt eine Verbrauchsreduktion und Bremsenergierückgewinnung sowie lokal emissionsfreies Fahren.
This paper introduces an inexpensive Wiegand-sensor-based rotary encoder that avoids rotating magnets and is suitable for electrical-drive applications. So far, Wiegand-sensor-based encoders usually include a magnetic pole wheel with rotating permanent magnets. These encoders combine the disadvantages of an increased magnet demand and a limited maximal speed due to the centripetal force acting on the rotating magnets. The proposed approach reduces the total demand of permanent magnets drastically. Moreover, the rotating part is manufacturable from a single piece of steel, which makes it very robust and cheap. This work presents the theoretical operating principle of the proposed approach and validates its benefits on a hardware prototype. The presented proof-of-concept prototype achieves a mechanical resolution of 4.5 ° by using only 4 permanent magnets, 2Wiegand sensors and a rotating steel gear wheel with 20 teeth.
With the prevalence of glucosamine- and chondroitin-containing dietary supplements for people with osteoarthritis in the marketplace, it is important to have an accurate and reproducible analytical method for the quantitation of these compounds in finished products. NMR spectroscopic method based both on low- (80 MHz) and high- (500–600 MHz) field NMR instrumentation was established, compared and validated for the determination of chondroitin sulfate and glucosamine in dietary supplements. The proposed method was applied for analysis of 20 different dietary supplements. In the majority of cases, quantification results obtained on the low-field NMR spectrometer are similar to those obtained with high-field 500–600 MHz NMR devices. Validation results in terms of accuracy, precision, reproducibility, limit of detection and recovery demonstrated that the developed method is fit for purpose for the marketed products. The NMR method was extended to the analysis of methylsulfonylmethane, adulterant maltodextrin, acetate and inorganic ions. Low-field NMR can be a quicker and cheaper alternative to more expensive high-field NMR measurements for quality control of the investigated dietary supplements. High-field NMR instrumentation can be more favorable for samples with complex composition due to better resolution, simultaneously giving the possibility of analysis of inorganic species such as potassium and chloride.
Die kulturgeschichtlichen Stationen des Spielens vom Beginn der Industrialisierung bis zur Jahrtausendwende werden sowohl aus dem Blickwinkel der Designgeschichte als auch aus dem der Game Studies betrachtet. Die Bandbreite der Themen reicht von der Bauhaus-Wurfpuppe bis zur Barbie, vom Japonismus bis zur Pixelgrafik, von der grafischen Raumillusion zu 3D-Umgebungen und Interaktionsgestaltung, vom Brettspiel bis zum Kriegsspielzeug, von den Utopien der beginnenden Neuzeit bis zu merkantilen Absichten digitaler Spielkonzepte.
Das vorliegende Buch dient als Grundlage für die Bachelor- und Master-Ausbildung von Studierenden im Fachgebiet Strömungslehre und Aerodynamik. Im hier behandelten Teilbereich der inkompressiblen Profile und Tragflügelaerodynamik werden schwerpunktmäßig die folgenden Themen besprochen:
- Profilaerodynamik
- Tragflügelaerodynamik
- Flugzeugpolare
- Methoden zur Flugbereichserweiterung
- Schwebeschub und Schwebeleistung
- Propellerblattaerodynamik
- Numerische Methoden zur Tragflügelberechnung
AI-based systems are nearing ubiquity not only in everyday low-stakes activities but also in medical procedures. To protect patients and physicians alike, explainability requirements have been proposed for the operation of AI-based decision support systems (AI-DSS), which adds hurdles to the productive use of AI in clinical contexts. This raises two questions: Who decides these requirements? And how should access to AI-DSS be provided to communities that reject these standards (particularly when such communities are expert-scarce)? This chapter investigates a dilemma that emerges from the implementation of global AI governance. While rejecting global AI governance limits the ability to help communities in need, global AI governance risks undermining and subjecting health-insecure communities to the force of the neo-colonial world order. For this, this chapter first surveys the current landscape of AI governance and introduces the approach of relational egalitarianism as key to (global health) justice. To discuss the two horns of the referred dilemma, the core power imbalances faced by health-insecure collectives (HICs) are examined. The chapter argues that only strong demands of a dual strategy towards health-secure collectives can both remedy the immediate needs of HICs and enable them to become healthcare independent.
Due to the decarbonization of the energy sector, the electric distribution grids are undergoing a major transformation, which is expected to increase the load on the operating resources due to new electrical loads and distributed energy resources. Therefore, grid operators need to gradually move to active grid management in order to ensure safe and reliable grid operation. However, this requires knowledge of key grid variables, such as node voltages, which is why the mass integration of measurement technology (smart meters) is necessary. Another problem is the fact that a large part of the topology of the distribution grids is not sufficiently digitized and models are partly faulty, which means that active grid operation management today has to be carried out largely blindly. It is therefore part of current research to develop methods for determining unknown grid topologies based on measurement data. In this paper, different clustering algorithms are presented and their performance of topology detection of low voltage grids is compared. Furthermore, the influence of measurement uncertainties is investigated in the form of a sensitivity analysis.
Autonomous agents require rich environment models for fulfilling their missions. High-definition maps are a well-established map format which allows for representing semantic information besides the usual geometric information of the environment. These are, for instance, road shapes, road markings, traffic signs or barriers. The geometric resolution of HD maps can be as precise as of centimetre level. In this paper, we report on our approach of using HD maps as a map representation for autonomous load-haul-dump vehicles in open-pit mining operations. As the mine undergoes constant change, we also need to constantly update the map. Therefore, we follow a lifelong mapping approach for updating the HD maps based on camera-based object detection and GPS data. We show our mapping algorithm based on the Lanelet 2 map format and show our integration with the navigation stack of the Robot Operating System. We present experimental results on our lifelong mapping approach from a real open-pit mine.
Coupé Nr. 13
(2023)
Coupé Nr. 13 ist eine kurze Animation über ein Zugcoupé mit 6 individuellen Passagieren und den 5 Stufen der Kommunikationsentwicklung zwischen ihnen. Die Passagiere des "Coupé Nummer 13" werden zu ihrem wahren Ich, wenn sie sich gegenseitig die Kofferklappen öffnen. Doch dieses Offen-Sein ist gar nicht so einfach. Es fühlt sich anfangs verletzlich an, psychologisch nackt und meist ängstlich. Aber diese Verletzlichkeit ist aus psychologischer Sicht der Schlüssel zu engen Beziehungen. Wahre Verbundenheit entsteht nur, wenn man den Weg zur Schattenseite des anderen findet – indem man sie so sieht und annimmt, wie sie wirklich sind. In der Tat bewundern und respektieren wir meistens die Verletzlichkeit anderer Menschen. Wir sehen sie in der Regel als ein Zeichen von Stärke und Mut – nicht von Schwäche.
Das Fußballtrikot – Arbeitsbekleidung, Identifikationsmerkmal, Distinktionsmerkmal? Was ist das Fußballtrikot, was sind seine identitätsstiftenden Merkmale und welche Gestaltungsparameter prägen sein heutiges Aussehen? In dieser Publikation wird die Geschichte des Trikots ebenso wie die äußeren Einflüsse auf sein heutiges Erscheinungsbild dokumentiert und analysiert. Die Publikation definiert die verschiedenen Gestaltungsparameter, erläutert diese und ordnet sie ein. Ebenso wird ein Einblick in den kreativen Gestaltungsprozess von Fußballtrikots gewährt. Das Ziel dieser Publikation besteht darin, das Erscheinungsbild von Trikots zu verstehen und eine kritische Reflexion darüber zu ermöglichen, wie das Fußballtrikot individuell definiert wird.
"News Flow" Nachrichten- und Informationsprozesse im digitalen Wandel. In der digitalen Welt sind wir von Informationen aus unterschiedlichen Medien umgeben. Die ständige Verfügbarkeit führt zu Überforderung und Orientierungslosigkeit. Junge Menschen bevorzugen Streaming und Social Media gegenüber traditionellen Nachrichten. Angesichts globaler Krisen und Desinformation sind innovative Lösungen wichtig, um den Informationsfluss zu verbessern. "News Flow" ist eine digitale Anwendung für Alternativen des Nachrichtenkonsums. Sie berücksichtigt individuelle Bedürfnisse und nutzt moderne Technologien. Durch die visuelle Vermittlung wird das Interesse an Nachrichten gesteigert und junge Zielgruppen angesprochen. Diese Arbeit stellt sich den Herausforderungen des digitalen Wandels im Nachrichtenbereich und eröffnet eine neue Perspektive auf den Nachrichtenkonsum.
„Keine Schmerzen in der Regel“ : Aufklärungskampagne zur Früherkennung der Krankheit Endometriose
(2023)
Jede zehnte Frau hat Endometriose. Hierbei entstehen Zysten und Entzündungen, welche sich beispielsweise an den Eierstöcken ansiedeln können. Wie kann es also sein, dass so viele noch nie was von dieser Erkrankung gehört haben? Mit der online Aufklärungskampagne „ Keine Schmerzen in der Regel“ soll sich das ändern. In vielen Fällen werden Beschwerden der Endometriose fälschlicherweise als normale Menstruationsbeschwerden abgetan. Die Differenzierung zwischen normal und nicht normal misslingt. Die Aufmerksamkeit von Mädchen und Frauen, die sich in den nicht normalen Aspekten wiederfinden, soll erregt werden. Dafür werden vier Symptome visualisiert und gegenübergestellt. Zusätzlich bietet ein Schnellcheck weitere Informationen. Diese Kampagne soll dem Problem der Unbekanntheit von Endometriose entgegenwirken und ein gesellschaftliches Bewusstsein für sie schaffen.
Anti-bias trainings are increasingly demanded and practiced in academia and industry to increase employees’ sensitivity to discrimination, racism, and diversity. Under the heading of “Diversity Management”, anti-bias trainings are mainly offered as one-off workshops intending to raise awareness of unconscious biases, create a diversity-affirming corporate culture, awake awareness of the potential of diversity, and ultimately enable the reflection of diversity in development processes. However, coming from childhood education, research and scientific articles on the sustainable effectiveness of anti-bias in adulthood, especially in academia, are very scarce. In order to fill this research gap, the paper explores how sustainable the effects of individual anti-bias trainings on the behavior of participants are. In order to investigate this, participant observation in a qualitative pre-post setting was conducted, analyzing anti-bias trainings in an academic context. Two observers actively participated in the training sessions and documented the activities and reflection processes of the participants. Overall, the results question the effectiveness of single anti-bias trainings and show that a target-group adaptive approach is mandatory due to the background of the approach in early childhood education. Therefore, it can be concluded that anti-bias work needs to be adapted to the target group’s needs and reality of life. Furthermore, the study reveals that single anti-bias trainings must be embedded in a holistic diversity management approach to stimulate sustainable reflection processes among the target group. This paper is one of the first to scientifically evaluate anti-bias training effectiveness, especially in engineering sciences and the university context.
Sustainability is playing an increasingly important role. Not least due to the definition of the sustainable development goals (SDGs) in the framework of the agenda 2030 by the United Nations (UN) in 2015 (United Nations, n.d.), it has become clear that the cooperation of different actors is needed to achieve the defined 17 goals. Industry, as a global actor, has a special role to play in this. In the course of sustainable production processes and chains, the industry is confronted with the responsibility of reflecting on the consequences of its own trade on an ecological, economic, and also social level and deriving measures that, according to the definition of sustainability (Hauff, 1987), will also enable future generations to satisfy their needs. While the ecological pillar of sustainability is already being addressed by different industrial initiatives (Deloitte, 2021), it is questionable to what extent the economic and, above all, the social pillars of sustainability also play a decisive role. Accordingly, it is questionable to what extent sustainability in its triad of social, ecological, and economic aspects is taken into account holistically at all, and thus to what extent the industry contributes to achieving the 17 goals defined by the UN.
This paper presents a qualitative study that explores these questions. Interviewing 31 representatives from the manufacturing industry in Germany, results indicate a Paradox of Sustainable Production expressed by a theoretical reflection of the need for focusing on people in production processes on the one hand and a lack of addressing the social pillar of sustainability in concepts on the other hand. However, while it is a troublesome finding given the striking need for sustainable development (The-Sustainable-Development-Goals-Report-2022; Kropp 2019; von Hauff 2021; Roy and Singh 2017), the paradox directly lays out a path of resolving it. This is because, given its nature, we can see that we could resolve it via the implementation of strong educational efforts trying to help the respective people of the manufacturing industry to understand the holistic and interdependent character of sustainable development (The-Sustainable-Development-Goals-Report-2022).