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In positron emission tomography improving time, energy and spatial detector resolutions and using Compton kinematics introduces the possibility to reconstruct a radioactivity distribution image from scatter coincidences, thereby enhancing image quality. The number of single scattered coincidences alone is in the same order of magnitude as true coincidences. In this work, a compact Compton camera module based on monolithic scintillation material is investigated as a detector ring module. The detector interactions are simulated with Monte Carlo package GATE. The scattering angle inside the tissue is derived from the energy of the scattered photon, which results in a set of possible scattering trajectories or broken line of response. The Compton kinematics collimation reduces the number of solutions. Additionally, the time of flight information helps localize the position of the annihilation. One of the questions of this investigation is related to how the energy, spatial and temporal resolutions help confine the possible annihilation volume. A comparison of currently technically feasible detector resolutions (under laboratory conditions) demonstrates the influence on this annihilation volume and shows that energy and coincidence time resolution have a significant impact. An enhancement of the latter from 400 ps to 100 ps leads to a smaller annihilation volume of around 50%, while a change of the energy resolution in the absorber layer from 12% to 4.5% results in a reduction of 60%. The inclusion of single tissue-scattered data has the potential to increase the sensitivity of a scanner by a factor of 2 to 3 times. The concept can be further optimized and extended for multiple scatter coincidences and subsequently validated by a reconstruction algorithm.
Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential.
Aneurysmal subarachnoid hemorrhage (aSAH) is associated with early and delayed brain injury due to several underlying and interrelated processes, which include inflammation, oxidative stress, endothelial, and neuronal apoptosis. Treatment with melatonin, a cytoprotective neurohormone with anti-inflammatory, anti-oxidant and anti-apoptotic effects, has been shown to attenuate early brain injury (EBI) and to prevent delayed cerebral vasospasm in experimental aSAH models. Less is known about the role of endogenous melatonin for aSAH outcome and how its production is altered by the pathophysiological cascades initiated during EBI. In the present observational study, we analyzed changes in melatonin levels during the first three weeks after aSAH.
Cardiopulmonary bypass (CPB) is a standard technique for cardiac surgery, but comes with the risk of severe neurological complications (e.g. stroke) caused by embolisms and/or reduced cerebral perfusion. We report on an aortic cannula prototype design (optiCAN) with helical outflow and jet-splitting dispersion tip that could reduce the risk of embolic events and restores cerebral perfusion to 97.5% of physiological flow during CPB in vivo, whereas a commercial curved-tip cannula yields 74.6%. In further in vitro comparison, pressure loss and hemolysis parameters of optiCAN remain unaffected. Results are reproducibly confirmed in silico for an exemplary human aortic anatomy via computational fluid dynamics (CFD) simulations. Based on CFD simulations, we firstly show that optiCAN design improves aortic root washout, which reduces the risk of thromboembolism. Secondly, we identify regions of the aortic intima with increased risk of plaque release by correlating areas of enhanced plaque growth and high wall shear stresses (WSS). From this we propose another easy-to-manufacture cannula design (opti2CAN) that decreases areas burdened by high WSS, while preserving physiological cerebral flow and favorable hemodynamics. With this novel cannula design, we propose a cannulation option to reduce neurological complications and the prevalence of stroke in high-risk patients after CPB.
Biologically sensitive field-effect devices (BioFEDs) advantageously combine the electronic field-effect functionality with the (bio)chemical receptor’s recognition ability for (bio)chemical sensing. In this review, basic and widely applied device concepts of silicon-based BioFEDs (ion-sensitive field-effect transistor, silicon nanowire transistor, electrolyte-insulator-semiconductor capacitor, light-addressable potentiometric sensor) are presented and recent progress (from 2019 to early 2021) is discussed. One of the main advantages of BioFEDs is the label-free sensing principle enabling to detect a large variety of biomolecules and bioparticles by their intrinsic charge. The review encompasses applications of BioFEDs for the label-free electrical detection of clinically relevant protein biomarkers, deoxyribonucleic acid molecules and viruses, enzyme-substrate reactions as well as recording of the cell acidification rate (as an indicator of cellular metabolism) and the extracellular potential.
Eigenkapitalkosten sind eine wesentliche Determinante bei der Wertbestimmung von Unternehmen und Unternehmensteilen. Die Eigenkapitalkosten werden regelmäßig mittels des CAPM bestimmt. Für sog. konzerninterne Routinefunktionen mit geringem Risiko stellt diese Bestimmung mittels CAPM ein Problem dar, da börsennotierte Peergroups für eine zuverlässige Bestimmung des Beta-Faktors meist nicht identifizierbar sind. Damit ergeben sich bei Bewertungen von Routineunternehmen Unsicherheiten und Konfliktpotenzial in steuerlichen Betriebsprüfungen. Dieser Beitrag gibt einen Überblick der in der Praxis genutzten Ansätze und stellt eine theoretische Fundierung zur Bestimmung der Eigenkapitalkosten von konzerninternen Routinefunktionen vor. Dabei wird verdeutlicht, dass Eigenkapitalkosten von konzerninternen Routinefunktionen nicht denen des Gesamtkonzerns entsprechen und Praktikeransätze eine grundsätzliche Berechtigung besitzen.
Simone de Beauvoir veröffentlichte 1949 ihr Werk ‚Das andere Geschlecht‘, in welchem sie die subjektiven und objektiven Einschränkungen, Belastungen und die Abhängigkeiten vom Mann darlegt, denen Frauen schon seit tausenden Jahren ausgesetzt waren und sind. Aber wie ist das heute? Sind diese Aussagen überhaupt noch aktuell bzw. relevant? Innerhalb der Publikation werden Kernthesen aber auch Textausschnitte aus ihrem Werk aufgeführt sowie aktuelle Artikel, die sich mit der derzeitigen Lage befassen. Durch das gestalterische Konzept innerhalb der Publikation, haben die Lesenden die Möglichkeit, sich konkret mit genau den Themen zu befassen, die jeweils dem persönlichen Interesse entsprechen. Die Publikation dient als Erinnerung und als Nachschlagewerk, um immer wieder lesen können, welche Kämpfe hinsichtlich der Gleichstellung der Geschlechter bereits gekämpft wurden und welche noch gekämpft werden müssen.
Wald im Wandel
(2021)
Die Arbeit „Wald im Wandel“ beschäftigt sich mit dem derzeitigen Zustand des Waldes in Deutschland und seiner kulturhistorischen Bedeutung. Im dazugehörigen Kurzfilm sieht man Aufnahmen der menschlichen Einflussnahme auf den Wald. Diese wurden mit „waldromantischen“ Motiven umgestaltet.
Die Kraft „waldromantischer“ Bilder ist so überzeugend, dass hieraus Überlegungen zu einer klimapolitischen Kampagne entstanden sind. Diese sind auf einer Informations-Webpage mit dem Titel „Projekt: Wald im Wandel“ nachzulesen.
Die Arbeit schlägt eine Brücke vom kulturhistorischen Symbol „deutscher Wald“ hin zur Gegenwart - und dem Wald in Deutschland als einem potenziellen klimapolitischen Symbol.
In einer Mischklasse, bestehend aus sehenden und nicht-sehenden Kindern, welche nicht schriftlich oder spielerisch miteinander kommunizieren können, gehen einige soziale Aspekte und Lernübungen verloren. Partnerarbeiten und das gegenseitige Kontrollieren der Richtigkeit, beispielsweise bei der Anwendung von Satzzeichen, sind Möglichkeiten, welche die Kinder ohne ein gemeinsames Material nicht wahrnehmen können. Diese Arbeit ermöglicht ein gemeinsames Arbeiten aller Kinder durch dasselbe Material. Hierfür dienen dreidimensionale Objekte, welche im STL-Dateiformat zur Verfügung stehen. Es eignet sich für schriftliche und geografische Arbeiten. Des Weiteren ist ein Memory-Spiel enthalten, welches ebenso von sehenden und nicht-sehenden Kinder gespielt werden kann. Diese STLs können weltweit verschickt werden, sodass diese beliebig mit einem 3D-Drucker gedruckt werden können.
DO or DIE: Leistungssport
(2021)
Es ist dieser eine Moment, der über Versagen oder Erfolg entscheidet. Dieser Augenblick, der so unfassbar wichtig ist und dennoch nicht mal eine Sekunde dauert. Als Leistungssportler bereitet man sich immer und immer wieder auf diesen einen Moment vor. Wie unterscheidet sich dieser Moment in verschiedenen Sportarten? Gibt es ihn überhaupt in jeder Sportart?
Das Projekt „Do or Die“ fokussiert sich auf entscheidende und wichtige Situationen in unterschiedlichen Sportarten und zeigt dabei die Facetten und Vielseitigkeit des Leistungssports auf. In einem besonderen Konzept wird der Fokus auf genau diese Momente gelegt und greift den Aspekt des Scheiterns und Erfolgs auf. Es wird untersucht, wie sichtbar diese Augenblicke nach außen hin sind oder inwiefern entscheidende Momente auch nur im Kopf stattfinden und durch Emotionen zu erkennen sind.
Neuerfindung der Ligaturen
(2021)
Gegenstand des Projekts ist, Ligaturen als erweiterte Mittel der Informationsübertragung einzusetzen.
Ligaturen als zusätzliches Instrument sollen die visuelle Komponente des Textes unterstützen, ihm die gewisse Frische einhauchen und ihn hiermit insgesamt sichtbarer, origineller und moderner machen. Der Einsatzbereich erstreckt sich hierbei in die verschiedensten Bereiche hin über Design und Werbung, als auch im Handel oder in sozialen Bereichen.
Hierbei kann eine große Anzahl an Wörtern neue Formen annehmen und mithin an neuem Leben und Bedeutung gewinnen, was sicherlich die allgemeinen Sprachmittel bereichern wird.
Auf einer historischen Basis und mit Hilfe der Dekonstruktion wurden neue Formen der Ligaturen geschaffen — seltsame, kontroverse, auffällige und einzigartige.
Die heutige, vielfältige kinetische Typografie hat eine lange Entwicklung durchgemacht. Die Darstellung dieser in einer zeitlichen Reihenfolge vermittelt ein Verständnis über Ursprung und Evolution. Die Publikation stellt die historische, analoge sowie die moderne, digitale Entwicklung dar. Dabei wird die Verbindung und der Einfluss der damaligen Gestaltung in der heutigen Umsetzung beleuchtet.
Die Plakatreihe erklärt drei Anwendungsmöglichkeiten der kinetischen Typografie. Hierbei werden teils reale Objekte nachgestellt, um die Wiedererkennung dieser im Alltag zu fördern. Gemeinsam zeigen die Plakate und die Publikation ein breites Spektrum der kinetischen Typografie und fördern das Verständnis dieser digitalen Umsetzung von Schrift in bewegter Form.
In the study, the process chain of additive manufacturing by means of powder bed fusion will be presented based on the material glass. In order to reliably process components additively, new concepts with different solutions were developed and investigated.
Compared to established metallic materials, the properties of glass materials differ significantly. Therefore, the process control was adapted to the material glass in the investigations. With extensive parameter studies based on various glass powders such as borosilicate glass and quartz glass, scientifically proven results on powder bed fusion of glass are presented. Based on the determination of the particle properties with different methods, extensive investigations are made regarding the melting behavior of glass by means of laser beams. Furthermore, the experimental setup was steadily expanded. In addition to the integration of coaxial temperature measurement and regulation, preheating of the building platform is of major importance. This offers the possibility to perform 3D printing at the transformation temperatures of the glass materials. To improve the component’s properties, the influence of a subsequent heat treatment was also investigated.
The experience gained was incorporated into a new experimental system, which allows a much better exploration of the 3D printing of glass. Currently, studies are being conducted to improve surface texture, building accuracy, and geometrical capabilities using three-dimensional specimen.
The contribution shows the development of research in the field of 3D printing of glass, gives an insight into the machine and process engineering as well as an outlook on the possibilities and applications.
A new formulation to calculate the shakedown limit load of Kirchhoff plates under stochastic conditions of strength is developed. Direct structural reliability design by chance con-strained programming is based on the prescribed failure probabilities, which is an effective approach of stochastic programming if it can be formulated as an equivalent deterministic optimization problem. We restrict uncertainty to strength, the loading is still deterministic. A new formulation is derived in case of random strength with lognormal distribution. Upper bound and lower bound shakedown load factors are calculated simultaneously by a dual algorithm.
Project work and inter disciplinarity are integral parts of today's engineering work. It is therefore important to incorporate these aspects into the curriculum of academic studies of engineering. At the faculty of Electrical Engineering and Information Technology an interdisciplinary project is part of the bachelor program to address these topics. Since the summer term 2020 most courses changed to online mode during the Covid-19 crisis including the interdisciplinary projects. This online mode introduces additional challenges to the execution of the projects, both for the students as well as for the lecture. The challenges, but also the risks and chances of this kind of project courses are subject of this paper, based on five different interdisciplinary projects
During the Covid-19 pandemic, vocational colleges, universities of applied science and technical universities often had to cancel laboratory sessions requiring students’ attendance. These above of all are of decisive importance in order to give learners an understanding of theory through practical work.This paper is a contribution to the implementation of distance learning for laboratory work applicable for several upper secondary educational facilities. Its aim is to provide a paradigm for hybrid teaching to analyze and control a non-linear system depicted by a tank model. For this reason, we redesign a full series of laboratory sessions on the basis of various challenges. Thus, it is suitable to serve different reference levels of the European Qualifications Framework (EQF).We present problem-based learning through online platforms to compensate the lack of a laboratory learning environment. With a task deduced from their future profession, we give students the opportunity to develop own solutions in self-defined time intervals. A requirements specification provides the framework conditions in terms of time and content for students having to deal with the challenges of the project in a self-organized manner with regard to inhomogeneous previous knowledge. If the concept of Complete Action is introduced in classes before, they will automatically apply it while executing the project.The goal is to combine students’ scientific understanding with a procedural knowledge. We suggest a series of remote laboratory sessions that combine a problem formulation from the subject area of Measurement, Control and Automation Technology with a project assignment that is common in industry by providing extracts from a requirements specification.
Die »tape foundry« ist eine interdisziplinäre Distributionsplattform für studentische Schriften, die Studierende auf dem großen Type-Design Markt neu platziert und einen Raum zur Entfaltung gibt. Besonders durch Instagram ist die heutige Type-Designszene größer denn je und viele Entwürfe gehen in der Maße unter. Um diesem Phänomen entgegenzuwirken wurde die »tape foundry« ins Leben gerufen. Sie versucht mit der Kombination aus Fotografie, Type Design und der Funktion als Kassettenlabel neue interdisziplinäre Wege zu gehen, um sich von der klassischen Ästhetik abzusetzen. Die Webseite stellt sich bewusst gegen gängige UX/UI Standards und setzt auf neue Nutzungsprinzipien kombiniert mit einer lauten kontrastreichen Bildwelt.
Die Applikation „Slot“ ist eine lehrbegleitende Kommunikations- und Kooperationsplattform, die eine zeitgemäße Lehre, Studienorganisation und Präsentation zulässt.
Slot dient dabei nicht nur als Hilfestellung für Lehrende und Lernende, sondern ermöglicht auch die vollständige Durchführung von effizientem Unterricht. Den Lernenden soll maximale Kontrolle zur Erarbeitung ihres Wissens und Übersichtlichkeit in der Kommunikation geboten werden. Um für die unterschiedlichen Nutzergruppen ein benutzerfreundliches System zu schaffen, steht eine breitgefächerte Funktionsauswahl zur Verfügung: Videochat, Messenger, VR-Raum, Whiteboard, Aufgabenübersicht, Datenabgabe, Kalender, Profil und ToDo-List. Die Nutzungsmöglichkeiten können individuell auf die unterschiedlichen Nutzergruppen und deren entsprechenden Bedürfnissen angepasst werden.
Dual frequency magnetic excitation of magnetic nanoparticles (MNP) enables enhanced biosensing applications. This was studied from an experimental and theoretical perspective: nonlinear sum-frequency components of MNP exposed to dual-frequency magnetic excitation were measured as a function of static magnetic offset field. The Langevin model in thermodynamic equilibrium was fitted to the experimental data to derive parameters of the lognormal core size distribution. These parameters were subsequently used as inputs for micromagnetic Monte-Carlo (MC)-simulations. From the hysteresis loops obtained from MC-simulations, sum-frequency components were numerically demodulated and compared with both experiment and Langevin model predictions. From the latter, we derived that approximately 90% of the frequency mixing magnetic response signal is generated by the largest 10% of MNP. We therefore suggest that small particles do not contribute to the frequency mixing signal, which is supported by MC-simulation results. Both theoretical approaches describe the experimental signal shapes well, but with notable differences between experiment and micromagnetic simulations. These deviations could result from Brownian relaxations which are, albeit experimentally inhibited, included in MC-simulation, or (yet unconsidered) cluster-effects of MNP, or inaccurately derived input for MC-simulations, because the largest particles dominate the experimental signal but concurrently do not fulfill the precondition of thermodynamic equilibrium required by Langevin theory.
Der vorliegende Beitrag stellt den seismischen Nachweis von Mauerwerksbauten in Deutschland auf Grundlage der DIN EN 1998‐1/NA vor, wobei auch die wesentlichen Änderungen zu der Norm DIN 4149 vergleichend erläutert werden. Vorgestellt werden die Definition der Erdbebeneinwirkung, das seismische Verhalten von Mauerwerksbauten und die Erläuterung der Rechenverfahren. Darauf aufbauend wird die Anwendung an drei Praxisbeispielen demonstriert.
The recent advances in microbiology have shed light on understanding the role of vitamins beyond the nutritional range. Vitamins are critical in contributing to healthy biodiversity and maintaining the proper function of gut microbiota. The sharing of vitamins among bacterial populations promotes stability in community composition and diversity; however, this balance becomes disturbed in various pathologies. Here, we overview and analyze the ability of different vitamins to selectively and specifically induce changes in the intestinal microbial community. Some schemes and regularities become visible, which may provide new insights and avenues for therapeutic management and functional optimization of the gut microbiota.
This paper introduces a new maritime search and rescue system based on S-band illumination harmonic radar (HR). Passive and active tags have been developed and tested while attached to life jackets and a small boat. In this demonstration test carried out on the Baltic Sea, the system was able to detect and range the active tags up to a distance of 5800 m using an illumination signal transmit-power of 100 W. Special attention is given to the development, performance, and conceptual differences between passive and active tags used in the system. Guidelines for achieving a high HR dynamic range, including a system components description, are given and a comparison with other HR systems is performed. System integration with a commercial maritime X-band navigation radar is shown to demonstrate a solution for rapid search and rescue response and quick localization.
The Robot Operating System (ROS) is the current de-facto standard in robot middlewares. The steadily increasing size of the user base results in a greater demand for training as well. User groups range from students in academia to industry professionals with a broad spectrum of developers in between. To deliver high quality training and education to any of these audiences, educators need to tailor individual curricula for any such training. In this paper, we present an approach to ease compiling curricula for ROS trainings based on a taxonomy of the teaching contents. The instructor can select a set of dedicated learning units and the system will automatically compile the teaching material based on the dependencies of the units selected and a set of parameters for a particular training. We walk through an example training to illustrate our work.
Most drugs are no longer produced in their own countries by the pharmaceutical companies, but by contract manufacturers or at manufacturing sites in countries that can produce more cheaply. This not only makes it difficult to trace them back but also leaves room for criminal organizations to fake them unnoticed. For these reasons, it is becoming increasingly difficult to determine the exact origin of drugs. The goal of this work was to investigate how exactly this is possible by using different spectroscopic methods like nuclear magnetic resonance and near- and mid-infrared spectroscopy in combination with multivariate data analysis. As an example, 56 out of 64 different paracetamol preparations, collected from 19 countries around the world, were chosen to investigate whether it is possible to determine the pharmaceutical company, manufacturing site, or country of origin. By means of suitable pre-processing of the spectra and the different information contained in each method, principal component analysis was able to evaluate manufacturing relationships between individual companies and to differentiate between production sites or formulations. Linear discriminant analysis showed different results depending on the spectral method and purpose. For all spectroscopic methods, it was found that the classification of the preparations to their manufacturer achieves better results than the classification to their pharmaceutical company. The best results were obtained with nuclear magnetic resonance and near-infrared data, with 94.6%/99.6% and 98.7/100% of the spectra of the preparations correctly assigned to their pharmaceutical company or manufacturer.
How different diversity factors affect the perception of first-year requirements in higher education
(2021)
In the light of growing university entry rates, higher education institutions not only serve larger numbers of students, but also seek to meet first-year students’ ever more diverse needs. Yet to inform universities how to support the transition to higher education, research only offers limited insights. Current studies tend to either focus on the individual factors that affect student success or they highlight students’ social background and their educational biography in order to examine the achievement of selected, non-traditional groups of students. Both lines of research appear to lack integration and often fail to take organisational diversity into account, such as different types of higher education institutions or degree programmes. For a more comprehensive understanding of student diversity, the present study includes individual, social and organisational factors. To gain insights into their role for the transition to higher education, we examine how the different factors affect the students’ perception of the formal and informal requirements of the first year as more or less difficult to cope with. As the perceived requirements result from both the characteristics of the students and the institutional context, they allow to investigate transition at the interface of the micro and the meso level of higher education. Latent profile analyses revealed that there are no profiles with complex patterns of perception of the first-year requirements, but the identified groups rather differ in the overall level of perceived challenges. Moreover, SEM indicates that the differences in the perception largely depend on the individual factors self-efficacy and volition.
Stretch-shortening type actions are characterized by lengthening of the pre-activated muscle-tendon unit (MTU) in the eccentric phase immediately followed by muscle shortening. Under 1 g, pre-activity before and muscle activity after ground contact, scale muscle stiffness, which is crucial for the recoil properties of the MTU in the subsequent push-off. This study aimed to examine the neuro-mechanical coupling of the stretch-shortening cycle in response to gravity levels ranging from 0.1 to 2 g. During parabolic flights, 17 subjects performed drop jumps while electromyography (EMG) of the lower limb muscles was combined with ultrasound images of the gastrocnemius medialis, 2D kinematics and kinetics to depict changes in energy management and performance. Neuro-mechanical coupling in 1 g was characterized by high magnitudes of pre-activity and eccentric muscle activity allowing an isometric muscle behavior during ground contact. EMG during pre-activity and the concentric phase systematically increased from 0.1 to 1 g. Below 1 g the EMG in the eccentric phase was diminished, leading to muscle lengthening and reduced MTU stretches. Kinetic energy at take-off and performance were decreased compared to 1 g. Above 1 g, reduced EMG in the eccentric phase was accompanied by large MTU and muscle stretch, increased joint flexion amplitudes, energy loss and reduced performance. The energy outcome function established by linear mixed model reveals that the central nervous system regulates the extensor muscles phase- and load-specifically. In conclusion, neuro-mechanical coupling appears to be optimized in 1 g. Below 1 g, the energy outcome is compromised by reduced muscle stiffness. Above 1 g, loading progressively induces muscle lengthening, thus facilitating energy dissipation.