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The use of transgenic animal models has transformed our knowledge of complex biochemical pathways in vivo. It has allowed disease processes to be modelled and used in the development of new disease prevention and treatment strategies. They can also be used to define cell- and tissue-specific pathways of gene regulation. A further major application is in the area of preclinical development where such models can be used to define pathways of chemical toxicity, and the pathways that regulate drug disposition. One major application of this approach is the humanisation of mice for the proteins that control drug metabolism and disposition. Such models can have numerous applications in the development of drugs and in their more sophisticated use in the clinic.
Production of Y-86 and other radiometals for research purposes using a solution target system
(2015)
Lepautre
(2015)
The understanding that optimized components do not automatically lead to energy-efficient systems sets the attention from the single component on the entire technical system. At TU Darmstadt, a new field of research named Technical Operations Research (TOR) has its origin. It combines mathematical and technical know-how for the optimal design of technical systems. We illustrate our optimization approach in a case study for the design of a ventilation system with the ambition to minimize the energy consumption for a temporal distribution of diverse load demands. By combining scaling laws with our optimization methods we find the optimal combination of fans and show the advantage of the use of multiple fans.
Booster stations can fulfill a varying pressure demand with high energy-efficiency, because individual pumps can be deactivated at smaller loads. Although this is a seemingly simple approach, it is not easy to decide precisely when to activate or deactivate pumps. Contemporary activation controls derive the switching points from the current volume flow through the system. However, it is not measured directly for various reasons. Instead, the controller estimates the flow based on other system properties. This causes further uncertainty for the switching decision. In this paper, we present a method to find a robust, yet energy-efficient activation strategy.
The conference center darmstadtium in Darmstadt is a prominent example of energy efficient buildings. Its heating system consists of different source and consumer circuits connected by a Zortström reservoir. Our goal was to reduce the energy costs of the system as much as possible. Therefore, we analyzed its supply circuits. The first step towards optimization is a complete examination of the system: 1) Compilation of an object list for the system, 2) collection of the characteristic curves of the components, and 3) measurement of the load profiles of the heat and volume-flow demand. Instead of modifying the system manually and testing the solution by simulation, the second step was the creation of a global optimization program. The objective was to minimize the total energy costs for one year. We compare two different topologies and show opportunities for significant savings.
Cheap does not imply cost-effective -- this is rule number one of zeitgeisty system design. The initial investment accounts only for a small portion of the lifecycle costs of a technical system. In fluid systems, about ninety percent of the total costs are caused by other factors like power consumption and maintenance. With modern optimization methods, it is already possible to plan an optimal technical system considering multiple objectives. In this paper, we focus on an often neglected contribution to the lifecycle costs: downtime costs due to spontaneous failures. Consequently, availability becomes an issue.
Inhalt
07 Der Stoff, aus dem die Träume sind | Modedesigner, Fotograf, Künstler : der FH-Absolvent Hans W. Krämer
12 Wurzeln, die tief zurückreichen | Die Handwerker- und Kunstgewerbeschule Aachen
18 Eine einmalige Chance | Der japanische Gastwissenschaftler Prof. Dr. Ko-ichiro Miyamoto forscht ein Jahr lang am Campus Jülich
22 Pionierarbeit auf leisen Sohlen | Vier junge Marokkanerinnen sind die ersten Absolventinnen des internationalen Studiengangs Angewandte Chemie
26 Gute Hacker - Böse Hacker| FH Aachen bietet Kurse zum ethischen Hacken an
28 Eiffelturm meets Kartenhaus | Architekturstudierende entwickeln ausgefuchstes Stecksystem für temporäre Architektur
32 Dom in 3-D | Fachbereich Bauingenieurwesen vermisst das Aachener Welterbe
36 "Müssen Behinderte denn Auto fahren?!" | FH-Absolventinnen gründen Fahrschule für Menschen mit Handicap
40 Im Innern des "Blutenden Gletschers" | Fünf Wochen lang lebten und arbeiteten FH-Ingenieure in der größten Eiswüste der Erde
46 Das ist mein Zuhause | Nach über 40 Jahren verlässt Prof. Dr. Horst Heinrichs die FH Aachen
50 Die Qual der Wahl | Mit dem "Guten Studienstart" ins Ingenieurstudium
52 Fachtutorenschulung an der FH Aachen
55 Zusammen wachsen | Neue Schnittstelle: Erste Studierende machen ihren Master in Energiewirtschafts-Informatik
56 Pro8 geht in die achte Runde | Studierende stellen sich Herausforderungen aus der Industrie
58 Auf die Messe, fertig, los! | Alumnus Moritz Christ gibt der Euregio Wirtschaftsschau ein neues Gesicht
61 Unsere EM wird 75: Die FH wünscht alles Gute!
61 Herzlichen Glückwunsch! Alt-Rektor Prof. Buchkremer wird 75
62 FH Aachen kooperiert mit Ford | Hannover Messe: FH präsentiert drei Projekte | FH Aachen ausgezeichnet : Zertifikat 2014 Vielfalt gestalten in NRW
63 Impressum
Manufacturing Process Simulation for the Prediction of Tool-Part-Interaction and Ply Wrinkling
(2015)
We introduce a new way to measure the forecast effort that analysts devote to their earnings forecasts by measuring the analyst's general effort for all covered firms. While the commonly applied effort measure is based on analyst behaviour for one firm, our measure considers analyst behaviour for all covered firms. Our general effort measure captures additional information about analyst effort and thus can identify accurate forecasts. We emphasise the importance of investigating analyst behaviour in a larger context and argue that analysts who generally devote substantial forecast effort are also likely to devote substantial effort to a specific firm, even if this effort might not be captured by a firm-specific measure. Empirical results reveal that analysts who devote higher general forecast effort issue more accurate forecasts. Additional investigations show that analysts' career prospects improve with higher general forecast effort. Our measure improves on existing methods as it has higher explanatory power regarding differences in forecast accuracy than the commonly applied effort measure. Additionally, it can address research questions that cannot be examined with a firm-specific measure. It provides a simple but comprehensive way to identify accurate analysts.