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Betrifft Design : von historischen Zukunftsperspektiven zu gegenwärtigen Vergangenheitssehnsüchten
(2019)
Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich).
The method of fundamental solutions is applied to the approximate computation of interior transmission eigenvalues for a special class of inhomogeneous media in two dimensions. We give a short approximation analysis accompanied with numerical results that clearly prove practical convenience of our alternative approach.
Hypertension describes the pathological increase of blood pressure, which is most commonly associated with the increase of vascular wall stiffness [1]. Referring to the “Deutsche Bluthochdruck Liga” this pathology shows a growing trend in our aging society. In order to find novel pharmacological and probably personalized treatments, we want to present a functional approach to study biomechanical properties of a human aortic vascular model.
In this method review we will give an overview of recent studies which were carried out with the CellDrum technology [2] and underline the added value to already existing standard procedures known from the field of physiology.
Herein described CellDrum technology is a system to measure functional mechanical properties of cell monolayers and thin tissue constructs in-vitro. Additionally, the CellDrum enables to elucidate the mechanical response of cells to pharmacological drugs, toxins and vasoactive agents. Due to its highly flexible polymer support, cells can also be mechanically stimulated by steady and cyclic biaxial stretching.
Clearance of blood components and fluid drainage play a crucial role in subarachnoid hemorrhage (SAH) and post hemorrhagic hydrocephalus (PHH). With the involvement of interstitial fluid (ISF) and cerebrospinal fluid (CSF), two pathways for the clearance of fluid and solutes in the brain are proposed. Starting at the level of capillaries, flow of ISF follows along the basement membranes in the walls of cerebral arteries out of the parenchyma to drain into the lymphatics and CSF [1]–[3]. Conversely, it is shown that CSF enters the parenchyma between glial and pial basement membranes of penetrating arteries [4]–[6]. Nevertheless, the involved structures and the contribution of either flow pathway to fluid balance between the subarachnoid space and interstitial space remains controversial. Low frequency oscillations in vascular tone are referred to as vasomotion and corresponding vasomotion waves are modeled as the driving force for flow of ISF out of the parenchyma [7]. Retinal vessel analysis (RVA) allows non-invasive measurement of retinal vessel vasomotion with respect to diameter changes [8]. Thus, the aim of the study is to investigate vasomotion in RVA signals of SAH and PHH patients.
Übungsaufgaben und Berechnungen für den Baubetrieb: Klausurvorbereitung mit ausführlichen Lösungen
(2019)
Übungsaufgaben und Berechnungen für den Baubetrieb: Klausurvorbereitung mit ausführlichen Lösungen
(2019)
Design and Development of a Novel Self-Igniting Microwave Plasma Jet for Industrial Applications
(2019)
Betriebsorganisation
(2019)
Obwohl es eine Vielzahl von Einführungskonzepten für ITSM gibt, hat sich bisher keines dieser Konzepte auf breiter Linie durchgesetzt. Das gilt in erhöhtem Maße für ITSM-Einführungskonzepte für KMU, wohl nicht zuletzt aufgrund der Tatsache, dass der Mehrwert von ITSM für KMU aufgrund der geringeren Größe der IT-Organisationen nur entsprechend schwieriger generiert werden kann.
Mit diesem Beitrag wird ein Einführungskonzept für ITSM in KMU systematisch hergeleitet. Dafür wurden zunächst die Treiber und Barrieren von ITSM untersucht, um daraus ein umfassendes Wirkmodell zu entwickeln. Da mit diesem Wirkungsmodell die Einflussfaktoren auf den Erfolg von ITSM in KMU deutlich werden, konnte auf dieser Basis ein Einführungskonzept abgeleitet werden, welches insbesondere die positiven Effekte unterstützt bzw.
verstärkt.