Refine
Year of publication
- 2023 (256) (remove)
Institute
- Fachbereich Gestaltung (95)
- Fachbereich Medizintechnik und Technomathematik (38)
- Fachbereich Elektrotechnik und Informationstechnik (29)
- ECSM European Center for Sustainable Mobility (23)
- Fachbereich Luft- und Raumfahrttechnik (23)
- Fachbereich Wirtschaftswissenschaften (21)
- Fachbereich Chemie und Biotechnologie (17)
- Fachbereich Energietechnik (14)
- INB - Institut für Nano- und Biotechnologien (12)
- Fachbereich Maschinenbau und Mechatronik (10)
Document Type
- Bachelor Thesis (93)
- Article (76)
- Conference Proceeding (36)
- Part of a Book (23)
- Book (11)
- Patent (3)
- Habilitation (2)
- Master's Thesis (2)
- Preprint (2)
- Talk (2)
Keywords
- Corporate Design (6)
- Editorial (6)
- Illustration (6)
- Typografie (6)
- Nachhaltigkeit (5)
- Produktdesign (5)
- Fotografie (4)
- Publikation (4)
- Design (3)
- Erscheinungsbild (3)
- Information extraction (3)
- Kinder (3)
- Künstliche Intelligenz (3)
- Museum (3)
- Natural language processing (3)
- nachhaltig (3)
- Animation (2)
- Architektur (2)
- Associated liquids (2)
- Bacillaceae (2)
- Biotechnological application (2)
- CFD (2)
- Datenvisualisierung (2)
- Diversity Management (2)
- Editorial Design (2)
- Engineering Habitus (2)
- Familie (2)
- Future Skills (2)
- Graphic Novel (2)
- Industriedesign (2)
- Informationsdesign (2)
- Inklusion (2)
- Interdisciplinarity (2)
- Kampagne (2)
- Keramik (2)
- Kommunikation (2)
- Kommunikationsdesign (2)
- Lernen (2)
- Licht (2)
- Magazin (2)
- Medienkompetenz (2)
- Modular (2)
- Musik (2)
- Organizational Culture (2)
- Power plants (2)
- Print (2)
- Redesign (2)
- Sammlung (2)
- Sport (2)
- Subtilases (2)
- Subtilisin (2)
- Sustainability (2)
- additive manufacturing (2)
- factory planning (2)
- interaktiv (2)
- manufacturing flexibility (2)
- ultrasound (2)
- (Poly)saccharides (1)
- (R)- or (S)- gamma-valerolactone (1)
- 197m/gHg (1)
- 2D (1)
- 3D Scan (1)
- 4-hydroxy valeric acid (1)
- 60er Jahre (1)
- Abenteuer (1)
- Abgelegene Gebiete (1)
- Abstrahierung (1)
- Abstrakt (1)
- Abwechslung (1)
- Academia (1)
- Active learning (1)
- Acyl-amino acids (1)
- Aeroelasticity (1)
- Agent-based simulation (1)
- Agile development (1)
- Algen (1)
- Aloe vera (1)
- Alternative Konsumoption (1)
- Aminoacylase (1)
- Amtliche Mitteilungen (1)
- Analoge und Digitale Welt (1)
- Anammox (1)
- Android (1)
- Angststörungen (1)
- Anomaly detection (1)
- Antennen (1)
- Anti-Bias (1)
- Antibias (1)
- Arbeitsbekleidung (1)
- Architectural design (1)
- Asymptotic relative efficiency (1)
- Atmen (1)
- Aufklärung (1)
- Aufklärungskampagne (1)
- Ausstellungsdesign (1)
- Ausstellungskonzept (1)
- Automation (1)
- Automobil (1)
- Automotive safety approach (1)
- Autonomy (1)
- BMW (1)
- Bachelor (1)
- Bacillus atrophaeus spores (1)
- Bacterial cellulose (1)
- Bahn (1)
- Bahnfahrt (1)
- Bambus (1)
- Barock (1)
- Benin Bronzen (1)
- Benutzerfreundlich (1)
- Berlin (1)
- Best practice sharing (1)
- Bewegtbild (1)
- Bewegung (1)
- Bioabsorbable (1)
- Bioenergiefassaden (1)
- Blade element method (1)
- Blindenstock (1)
- Blog (1)
- Blütenkelch (1)
- Bookazine (1)
- Bragg peak (1)
- Brake set-up (1)
- Braking curves (1)
- Branding (1)
- Brands (1)
- Broad pH spectrum (1)
- Broschüre (1)
- Building Automation (1)
- Business Process Intelligence (1)
- CO2 (1)
- CO2 emission reduction targets (1)
- CPQ (1)
- CRISPR/Cas9 (1)
- Capacitive field-effect sensor (1)
- Carbon Dioxide (1)
- Carbon sources (1)
- Cellulose nanostructure (1)
- Change (1)
- Chaperone co-expression (1)
- Charging station (1)
- Chiralidon-R (1)
- Chiralidon-S (1)
- Chondroitin sulfate (1)
- Clustering (1)
- Cognitive assistance system (1)
- Collagen fibrils (1)
- Competitiveness (1)
- Computerspiel (1)
- Conductive Boundary Condition (1)
- Connected Automated Vehicle (1)
- Connective tissues (1)
- Control (1)
- Corporatedesign (1)
- Cost function (1)
- Cost-effectiveness (1)
- Cramér-von-Mises test (1)
- Crashworthiness (1)
- Cross border adjustment mechanism (1)
- Culture media (1)
- Cyclotron production (1)
- DPA (dipicolinic acid) (1)
- Daniele Ganser (1)
- Datasets (1)
- Datenschutzgrundverordnung (1)
- Decision theory (1)
- Deep learning (1)
- Depressionen (1)
- Design Thinking (1)
- Dienstplanung (1)
- Dietary supplements (1)
- Digital (1)
- Digital leadership (1)
- Digital transformation (1)
- Digital triage (1)
- Digital twin (1)
- Digitales Lernen (1)
- Diskurs (1)
- Diskussionskarten (1)
- Distinktion (1)
- District data model (1)
- District energy planning platform (1)
- Dokumentarfilm (1)
- Dokumentarfotografie (1)
- Dokumentation (1)
- Drag estimation (1)
- Driver assistance system (1)
- Driving cycle recognition (1)
- Dänisch (1)
- E-Mobility (1)
- ECMS (1)
- EMS (1)
- Earthquake (1)
- Editorail Design (1)
- Editorial-Design (1)
- Education (1)
- Effizienz (1)
- Einkaufen (1)
- Eisenerz (1)
- Eishockey (1)
- Electrocardiography (1)
- Electrochemistry (1)
- Electronic vehicle (1)
- Elektrotechnik (1)
- Elicit (1)
- Eltern (1)
- Emotionen (1)
- Endometriose (1)
- Endothelial dysfunction (1)
- Energiemanagement (1)
- Energy Disaggregation (1)
- Energy management strategies (1)
- Energy market design (1)
- Energy storage (1)
- Energy system planning (1)
- Energy-intensive industry (1)
- Enma (1)
- Entdecken (1)
- Enterprise information systems (1)
- Erkunden (1)
- Erneuerbare Energien (1)
- Erweiterbar (1)
- Experimentalfilm (1)
- Experimente (1)
- Experteninterviews (1)
- Expertise (1)
- Extracellular matrix (ECM) (1)
- FH Aachen (1)
- Fahrzeug (1)
- Familienkasse (1)
- Fan-Kultur (1)
- Fans (1)
- Farbe (1)
- Farbwechsel (1)
- Fassadenverkleidung (1)
- Fault approximation (1)
- Fault detection (1)
- Feldsimulation (1)
- Fenster (1)
- Finite element method (1)
- Finland (1)
- Fliesen (1)
- Floor prices (1)
- Flut (1)
- Flächennutzung (1)
- Formel 1 (1)
- Fotoinstallation (1)
- Frau (1)
- Freight rail (1)
- Freiheit (1)
- Full-vehicle crash test (1)
- Future skills (1)
- Fußball (1)
- Fußballtrikot (1)
- Ga-68 (1)
- Gamification (1)
- Gaming Maus (1)
- Gaming Produkte (1)
- Gefahr (1)
- Gehirn (1)
- Gemüse (1)
- Generative Gestaltung (1)
- Generatives Design (1)
- Geometrisch (1)
- Geriatric (1)
- Germany (1)
- Gerüche (1)
- Gesellschaftskritik (1)
- Gesteine (1)
- Gesundheit (1)
- Gesundheitsförderung (1)
- GewohnheitDerHaltung (1)
- Glas (1)
- Glucosamine (1)
- Gold nanoparticle (AuNP) (1)
- Gold nanoparticles (1)
- Good News Fokus (1)
- Grabstaetten (1)
- Grafikdesign (1)
- Griechisch (1)
- Grotesk (1)
- Guide Tube (1)
- Habitate (1)
- Halotolerant protease (1)
- Haltung (1)
- Haltungsschwäche (1)
- Handwerk (1)
- Hardcase (1)
- Haushaltsgerät (1)
- Hebamme (1)
- Heimat (1)
- High-field NMR (1)
- Hindernisse (1)
- Hip fractures (1)
- Historie (1)
- Hochfrequenztechnik (1)
- Hochwasserkatastrophe (1)
- Holzverbindungen (1)
- Home Assistant (1)
- Home Automation Platform (1)
- Human factors (1)
- Human-centered work design (1)
- Human-robot collaboration (1)
- ITFS (1)
- Ice melting probe (1)
- Ice penetration (1)
- Icy moons (1)
- Identifikation (1)
- Inclusion bodies (1)
- Incomplete data (1)
- Informationsfluss (1)
- Inklusiv (1)
- Innovation (1)
- Instagram store (1)
- Installation (1)
- Interaktive Gestaltung (1)
- Interculturality (1)
- Interessen (1)
- Interview (1)
- Intuitiv (1)
- Inverse Scattering (1)
- Inverse scattering problem (1)
- Iran (1)
- J.R.R Tolkien (1)
- Japan (1)
- Juli21 (1)
- KI (1)
- KI Kunst (1)
- Key competences (1)
- Kind (1)
- Kindererziehung (1)
- Kinderfahrrad (1)
- Kindheit (1)
- Klassische Musik (1)
- Klassizismus (1)
- Klettern (1)
- Klimakrise (1)
- Kochen (1)
- Konkurrenz (1)
- Konservierung (1)
- Kontaktabbruch (1)
- Konzerthaus (1)
- Kooperation (1)
- Krankheit (1)
- Kreativer Bildungsweg (1)
- Kreativität (1)
- Krebs (1)
- Krise (1)
- Kulturgut (1)
- Kunst (1)
- Kunstsammlung (1)
- Kurzfilme (1)
- Küche (1)
- Künstliche Intelligenz (KI) (1)
- Label-free detection (1)
- Labyfrinth weirs (1)
- Lactobacillus rhamnosus GG (1)
- Lampe (1)
- Landwirt (1)
- Landwirtschaft (1)
- Large Eddy Simulation (1)
- Latentes Wasser (1)
- Latvia (1)
- LbL films (1)
- Leaderboard (1)
- Leben (1)
- Lebensmittel (1)
- Leichen (1)
- Leitfaden (1)
- Lesesessel (1)
- Letraset (1)
- Leuchte (1)
- Levulinic acid (1)
- Lichtkunst (1)
- Lichtkunst Museum (1)
- Linkshändigkeit (1)
- Livestream (1)
- Local path planning (1)
- Lokal (1)
- Long COVID (1)
- Luftreiniger (1)
- Luxury (1)
- MCDA (1)
- Machine Learning (1)
- Mainstream (1)
- Marginal homogeneity (1)
- Market modeling (1)
- Mars (1)
- Masonry partition walls (1)
- Mechanical stability (1)
- Medical radionuclide production (1)
- Medien (1)
- Medienjournalist (1)
- Medienscouts (1)
- Medizindesign (1)
- Medusomyces gisevi (1)
- Meere (1)
- Meitner-Auger-electron (MAE) (1)
- Menschen (1)
- Mental Health (1)
- Metal contaminants (1)
- Microfluidic solvent extraction (1)
- Micromix (1)
- Mineral (1)
- Mineralien (1)
- Minimalismus (1)
- Minimum Risk Manoeuvre (1)
- Minor chemistry (1)
- Mittelalter (1)
- Mobil (1)
- Mobility transition (1)
- Mobilität (1)
- Model-driven software engineering (1)
- Modernität (1)
- Modularität (1)
- Modulbau (1)
- Monster (1)
- Motivation (1)
- Mpc (1)
- Multi-criteria decision analysis (1)
- Multi-objective optimization (1)
- Multicell (1)
- Multimedia (1)
- Multiplexing (1)
- Multirotor UAS (1)
- Mutter (1)
- Männlichkeit (1)
- Nachhaltig (1)
- Nahrung (1)
- Narzissmus (1)
- Natur (1)
- Natural Language Processing (1)
- Natural language understanding (1)
- Navigation (1)
- Neue Arbeitsweise (1)
- Neugestaltung (1)
- Neural networks (1)
- Nitrogen removal (1)
- Nozzle (1)
- Obstacle avoidance (1)
- Ocean worlds (1)
- Office (1)
- Online-Radikalisierung (1)
- Onlinehandel (1)
- Onlinepräsenz (1)
- Open Educational Resources (OER) (1)
- Open Source (1)
- OpenEMS (1)
- Operational Design Domain (1)
- Operations (1)
- Optimierung (1)
- Organic acids (1)
- Out-of-plane capacity (1)
- Ozean (1)
- PLS (1)
- Paired sample (1)
- Parking (1)
- Partial nitritation (1)
- Path planning (1)
- Path-following (1)
- Pendelleuchte (1)
- Pendelnde (1)
- Performance (1)
- Personality (1)
- Perspektive (1)
- Pflanzenteile (1)
- Philipp Hübl (1)
- Physical chemistry (1)
- Physical chemistry basics (1)
- Physical chemistry starters (1)
- Pix2Pix (1)
- Pizza (1)
- Plakat (1)
- Plasmatechnik (1)
- Politik (1)
- Polster (1)
- Polylactide acid (1)
- Polysaccharides (1)
- Portalrahmen (1)
- Portrait (1)
- Positives Feedback (1)
- Post-COVID-19 syndrome (1)
- Predictive battery discharge (1)
- Preference assessment (1)
- Prevention (1)
- Privacy (1)
- Process Model Extraction (1)
- Process optimization (1)
- Produkt Design (1)
- Produktion (1)
- Profile extraction (1)
- Propeller (1)
- Propeller elasticity (1)
- Prophylaxis (1)
- Prototype (1)
- Prozessauswahl (1)
- Prozessautomatisierung (1)
- Prozessverbesserung (1)
- Prävention (1)
- Prüfungsordnung (1)
- Psychologie (1)
- Psychotherapie (1)
- Quality control (1)
- Quelle-Fertighaus (1)
- Query learning (1)
- RWTH Aachen (1)
- Rabbit Hole (1)
- Raman spectroscopy (1)
- Raumatmosphäre (1)
- Regalsystem (1)
- Regie (1)
- Regionalization (1)
- Rehabilitaion (1)
- Relation classification (1)
- Renewable energy integration (1)
- Reproducible research (1)
- Reservation system (1)
- Resistive temperature detector (1)
- Responsibility (1)
- Ressourcenschonung (1)
- Restaurierung (1)
- Revolution (1)
- Riten (1)
- Rivalität (1)
- Robotic Process Automation (1)
- Rotary encoder (1)
- Rotring (1)
- Router (1)
- Roverandom (1)
- Rucksack (1)
- Ruhe (1)
- Rückgabe (1)
- Rüster (1)
- SOA (1)
- Sachbuch (1)
- Schadensersatz (1)
- Schattenseite (1)
- Schauspiel (1)
- Schauspielhaus (1)
- Schein (1)
- Schichtarbeit (1)
- Schlafstörungen (1)
- Schlepper (1)
- Schlüter (1)
- Schraffur (1)
- Schriftvarianten (1)
- Schönheit (1)
- Seamlessconnection (1)
- Seepferdchen (1)
- Sehbehinderung (1)
- Selbstzensur (1)
- Selektionskriterien (1)
- Sendungskonzeption (1)
- Sensors comparison (1)
- Serie (1)
- Sharing (1)
- Shiba Inu (1)
- Shunting (1)
- Siebdruck (1)
- Siegerland (1)
- Silk fibroin (1)
- Simulation (1)
- Skandinavien (1)
- Slab deflection (1)
- Smart Building (1)
- Smart-Home (1)
- Smarthome (1)
- Smartwatch (1)
- Sn₃O₄ (1)
- Social Media Kampagne (1)
- Social impact measurement (1)
- Society (1)
- Software (1)
- Software and systems modeling (1)
- Software development (1)
- Software testing (1)
- Softwareentwicklung (1)
- Solarenergie (1)
- Sonderausstellung (1)
- Sonderzeichen (1)
- Soziale Medien (1)
- Sozialer Wohnungsbau (1)
- Sozialleistungen (1)
- Spectroscopy (1)
- Spezies (1)
- Spiele (1)
- Stadt Aachen (1)
- Stahlkonstruktion (1)
- Start-up (1)
- Starterkit (1)
- Steckverbindung (1)
- Steel industry (1)
- Storytelling (1)
- Streptomyces griseus (1)
- Streptomyces lividans (1)
- Stress (1)
- Stress testing (1)
- Stuhl (1)
- Stuttgart (1)
- Suction (1)
- Sustainable engineering education (1)
- TICTOP (1)
- Tanz (1)
- Tapered ends (1)
- Targeted radionuclide therapy (TRT) (1)
- Tauchboot (1)
- Teamwork (1)
- Technologie (1)
- Telefonat (1)
- Text Mining (1)
- Text mining (1)
- Theater (1)
- Therapeutensuche (1)
- Therapieplatzsuche (1)
- Thermodynamics as minor (1)
- Tiere (1)
- Time-series synchronization (1)
- Tochter (1)
- Tod (1)
- Toolbar (1)
- Traktor (1)
- Transdisciplinarity (1)
- Transformative Competencies (1)
- Transiton of Control (1)
- Transkulturen (1)
- Transmission Eigenvalues (1)
- Triage-app (1)
- Trickfilm-Festival (1)
- Trikot (1)
- Trustworthy artificial intelligence (1)
- UAV (1)
- UI (1)
- UI Design (1)
- UI/UX-Design (1)
- UX (1)
- UX Design (1)
- UX-Design (1)
- Unterstützung (1)
- Unterwasserwelt (1)
- Urbane Gestaltung (1)
- Urbanisierung (1)
- Usability (1)
- Utilization improvement (1)
- V2X (1)
- Variable Schriften (1)
- Vater (1)
- Verschwörungstheorien (1)
- Verwesung (1)
- Vibrio natriegens (1)
- Virtuelles Wasser (1)
- Visuelle Gestaltung (1)
- Voltfang (1)
- Volumes of confidence regions (1)
- Wallrafmuseum (1)
- Wandverkleidung (1)
- Waschmaschine (1)
- Wasserknappheit (1)
- Wastewater (1)
- Wattenmeer (1)
- Wearable electronic device (1)
- Weiterentwicklung (1)
- Werkstatt (1)
- Werkzeuge (1)
- WiLMo (1)
- Wiegand sensor (1)
- Wifi (1)
- Wind milling (1)
- Wind tunnel experiments (1)
- Windkraft (1)
- Wirtschaftsinformatik (1)
- Wissensvermittlung (1)
- Work-Life-Balance (1)
- Workaholic (1)
- Wortmarke (1)
- Zeit (1)
- Zen (1)
- Zensur (1)
- Zoo (1)
- Zug (1)
- active learning (1)
- adaptive systems (1)
- aircraft engine (1)
- allocation (1)
- amperometric biosensors (1)
- analog (1)
- anammox (1)
- artificial intelligence (1)
- aspergillus (1)
- assistance system (1)
- audiovisuell (1)
- auswechseln (1)
- bacterial cellulose (1)
- bio-methane (1)
- biocompatible (1)
- biodegradabl (1)
- biofilms (1)
- biological dosimeter (1)
- biomechanics (1)
- biosensor (1)
- bubble column (1)
- central symmetry test (1)
- children (1)
- climate change (1)
- combustion (1)
- compression behavior (1)
- conceptual design (1)
- conditional excess distribution (1)
- conditional expectation principle (1)
- confidence interval (1)
- connective tissue (1)
- covariance principle (1)
- deficit irrigation (1)
- distribution grid simulation (1)
- e-mobility (1)
- eVTOL development (1)
- eVTOL safety (1)
- electromyography (1)
- emission index (1)
- encapsulation materials (1)
- energy efficiency (1)
- entrepreneurship education (1)
- entspannen (1)
- enzyme cascade (1)
- exchangeability test (1)
- fibroin (1)
- field-effect sensor (1)
- filamentous fungi (1)
- forecast (1)
- fuel cell vehicle (1)
- fused filament fabrication (1)
- gamification (1)
- gendern (1)
- genome engineering (1)
- glucose oxidase (GOx) (1)
- goodness-of-fit test (1)
- heavy metals (1)
- horseradish peroxidase (HRP) (1)
- hydrogel (1)
- hydrogen (1)
- immobilization (1)
- independence test (1)
- industrial design (1)
- infill strategy (1)
- intelligent control (1)
- intelligent energy management (1)
- klimakrise (1)
- klimawandel (1)
- lab work (1)
- locomotion (1)
- machine learning (1)
- mainstream deammonification (1)
- manufacturing (1)
- manufacturing data model (1)
- methanation (1)
- mix flexibility (1)
- modular (1)
- nachhaltiges Bauen (1)
- nanobelts (1)
- neutrons (1)
- niedlich (1)
- nitric oxides (1)
- nitrogen elimination (1)
- not identically distributed (1)
- onion (1)
- optical fibers (1)
- optical sensor setup (1)
- optical trapping (1)
- optimization system (1)
- overload (1)
- physiology (1)
- plug flow reactor (1)
- polyetheretherketone (PEEK) (1)
- portfolio risk (1)
- power-to-gas (1)
- prebiotic (1)
- production planning and control (1)
- professional skills (1)
- proton therapy (1)
- protons (1)
- purchase factor (1)
- qNMR (1)
- random effects (1)
- rapid tooling (1)
- recombinant expression (1)
- recyclebar (1)
- relative dosimetry (1)
- reparierbar (1)
- retinal microvasculature (1)
- schlafen (1)
- service-oriented architectures (1)
- shopping behavior (1)
- smart-charging (1)
- sterilization (1)
- stretch-shortening cycle (1)
- structural equation model (1)
- technology planning (1)
- tobacco mosaic virus (TMV) (1)
- turnip vein clearing virus (TVCV) (1)
- volume flexibility (1)
- wastewater (1)
- water economy (1)
- yield (1)
- α-aminoacylase (1)
- ε-lysine acylase (1)
Zugriffsart
- weltweit (97)
- campus (48)
- bezahl (30)
- fachbereichsweit (FB4) (12)
Stand 01.01.2022 sind in Deutschland 618.460 elektrisch angetriebene KFZ zugelassen. Insgesamt sind derzeit 48.540.878 KFZ zugelassen, was einer Elektromobilitätsquote von ca. 1,2 % entspricht. Derzeit werden Elektromobile über Ladestationen oder Steckdosen mit dem Stromnetz verbunden und üblicherweise mit der vollen Ladekapazität des Anschlusses aufgeladen, bis das Batteriemanagementsystem des Fahrzeugs abhängig vom Ladezustand der Batterie die Ladeleistung reduziert.
Zeit spielt in unser aller Leben eine allgegenwärtige Rolle. Sie ist immer da, war schon immer da und nimmt ihren Lauf, ganz egal was wir tun. Aber was macht die Zeit und was hat sie für einen Einfluss auf uns? Ist sie unsere ständige Begleiterin oder unsere »Gegnerin«? Wie unterschiedlich wir auf Zeit blicken können, was sie bewirkt und wie unser Umgang mit ihr das Leben beeinflusst, zeigt die Reihe an monothematischen Magazinen »about time«. Das Thema wird aus unterschiedlichsten Blickwinkeln beleuchtet und soll so eine gewisse Sensibilität für den Umgang mit der eigenen Zeit schaffen — denn sie ist am Ende das Wertvollste, das bleibt.
Optical Fibers as Dosimeter Detectors for Mixed Proton/Neutron Fields - A Biological Dosimeter
(2023)
In recent years, proton therapy has gained importance as a cancer treatment modality due to its conformality with the tumor and the sparing of healthy tissue. However, in the interaction of the protons with the beam line elements and patient tissues, potentially harmful secondary neutrons are always generated. To ensure that this neutron dose is as low as possible, treatment plans could be created to also account for and minimize the neutron dose. To monitor such a treatment plan, a compact, easy to use, and inexpensive dosimeter must be developed that not only measures the physical dose, but which can also distinguish between proton and neutron contributions. To that end, plastic optical fibers with scintillation materials (Gd₂O₂S:Tb, Gd₂O₂S:Eu, and YVO₄:Eu) were irradiated with protons and neutrons. It was confirmed that sensors with different scintillation materials have different sensitivities to protons and neutrons. A combination of these three scintillators can be used to build a detector array to create a biological dosimeter.
Aspergillus oryzae is an industrially relevant organism for the secretory production of heterologous enzymes, especially amylases. The activities of potential heterologous amylases, however, cannot be quantified directly from the supernatant due to the high background activity of native α-amylase. This activity is caused by the gene products of amyA, amyB, and amyC. In this study, an in vitro CRISPR/Cas9 system was established in A. oryzae to delete these genes simultaneously. First, pyrG of A. oryzae NSAR1 was mutated by exploiting NHEJ to generate a counter-selection marker. Next, all amylase genes were deleted simultaneously by co-transforming a repair template carrying pyrG of Aspergillus nidulans and flanking sequences of amylase gene loci. The rate of obtained triple knock-outs was 47%. We showed that triple knockouts do not retain any amylase activity in the supernatant. The established in vitro CRISPR/Cas9 system was used to achieve sequence-specific knock-in of target genes. The system was intended to incorporate a single copy of the gene of interest into the desired host for the development of screening methods. Therefore, an integration cassette for the heterologous Fpi amylase was designed to specifically target the amyB locus. The site-specific integration rate of the plasmid was 78%, with exceptional additional integrations. Integration frequency was assessed via qPCR and directly correlated with heterologous amylase activity. Hence, we could compare the efficiency between two different signal peptides. In summary, we present a strategy to exploit CRISPR/Cas9 for gene mutation, multiplex knock-out, and the targeted knock-in of an expression cassette in A. oryzae. Our system provides straightforward strain engineering and paves the way for development of fungal screening systems.
§ 1 | Geltungsbereich der Prüfungsordnung
§ 2 | Ziel des Studiums, Zweck der Prüfung, Abschlussgrad
§ 3 | Beginn, Dauer, Umfang und Gliederung des Studiums
§ 4 | Zugang zum Studium, Praktikum
§ 5 | Prüfungsausschuss
§ 6 | Studien- und Prüfungselemente
§ 7 | Zulassung zu den Prüfungen
§ 8 | Durchführung von Prüfungen
§ 9 | Verbesserungsversuch
§ 10 | Anrechnung von Studienzeiten, Studien- und Prüfungsleistungen
§ 11 | Praxissemester
§ 12 | Mobilitätssemester (Auslandssemester)
§ 13 | Bachelorprojekt§ 14 | Gesamtnote, Zeugnis, Bachelorurkunde
§ 15 | Inkrafttreten, Veröffentlichung
Anlage 1 | Studienplan Kernstudium
Anlage 2 | Allgemeine Kompetenzen
The first and last mile of a railway journey, in both freight and transit applications, constitutes a high effort and is either non-productive (e.g. in the case of depot operations) or highly inefficient (e.g. in industrial railways). These parts are typically managed on-sight, i.e. with no signalling and train protection systems ensuring the freedom of movement. This is possible due to the rather short braking distances of individual vehicles and shunting consists. The present article analyses the braking behaviour of such shunting units. For this purpose, a dedicated model is developed. It is calibrated on published results of brake tests and validated against a high-definition model for low-speed applications. Based on this model, multiple simulations are executed to obtain a Monte Carlo simulation of the resulting braking distances. Based on the distribution properties and established safety levels, the risk of exceeding certain braking distances is evaluated and maximum braking distances are derived. Together with certain parameters of the system, these can serve in the design and safety assessment of driver assistance systems and automation of these processes.
Damit Sie als Moderator effektiv und professionell moderieren können, sollten Sie die entsprechenden Methoden kennen.
Mit den richtigen Methoden können Sie Diskussionen leiten, Konflikte lösen, die Teilnehmer motivieren und dafür sorgen, dass die Ziele der Veranstaltung erreicht werden. Außerdem helfen sie Ihnen, eine positive Atmosphäre zu schaffen und das Interesse der Teilnehmer zu halten.
In diesem zweiten Beitrag der mehrteiligen Serie lernen Sie die grundsätzlichen Methoden kennen, um erfolgreiche Teamsitzungen, Arbeitsgruppentreffen, Kick-offs und Meetings durchzuführen.
Damit Sie als Moderator effektiv und professionell moderieren können, sollten Sie die entsprechenden Methoden kennen.
Mit den richtigen Methoden können Sie Diskussionen leiten, Konflikte lösen, die Teilnehmer motivieren und dafür sorgen, dass die Ziele der Veranstaltung erreicht werden. Außerdem helfen sie Ihnen, eine positive Atmosphäre zu schaffen und das Interesse der Teilnehmer zu halten.
In diesem zweiten Beitrag der mehrteiligen Serie lernen Sie die grundsätzlichen Methoden kennen, um erfolgreiche Teamsitzungen, Arbeitsgruppentreffen, Kick-offs und Meetings durchzuführen.
With the prevalence of glucosamine- and chondroitin-containing dietary supplements for people with osteoarthritis in the marketplace, it is important to have an accurate and reproducible analytical method for the quantitation of these compounds in finished products. NMR spectroscopic method based both on low- (80 MHz) and high- (500–600 MHz) field NMR instrumentation was established, compared and validated for the determination of chondroitin sulfate and glucosamine in dietary supplements. The proposed method was applied for analysis of 20 different dietary supplements. In the majority of cases, quantification results obtained on the low-field NMR spectrometer are similar to those obtained with high-field 500–600 MHz NMR devices. Validation results in terms of accuracy, precision, reproducibility, limit of detection and recovery demonstrated that the developed method is fit for purpose for the marketed products. The NMR method was extended to the analysis of methylsulfonylmethane, adulterant maltodextrin, acetate and inorganic ions. Low-field NMR can be a quicker and cheaper alternative to more expensive high-field NMR measurements for quality control of the investigated dietary supplements. High-field NMR instrumentation can be more favorable for samples with complex composition due to better resolution, simultaneously giving the possibility of analysis of inorganic species such as potassium and chloride.
In times of social climate protection movements, such as Fridays for Future, the priorities of society, industry and higher education are currently changing. The consideration of sustainability challenges is increasing. In the context of sustainable development, social skills are crucial to achieving the United Nations Sustainable Development Goals (SDGs). In particular, the impact that educational activities have on people, communities and society is therefore coming to the fore. Research has shown that people with high levels of social competence are better able to manage stressful situations, maintain positive relationships and communicate effectively. They are also associated with better academic performance and career success. However, especially in engineering programs, the social pillar is underrepresented compared to the environmental and economic pillars.
In response to these changes, higher education institutions should be more aware of their social impact - from individual forms of teaching to entire modules and degree programs. To specifically determine the potential for improvement and derive resulting change for further development, we present an initial framework for social impact measurement by transferring already established approaches from the business sector to the education sector. To demonstrate the applicability, we measure the key competencies taught in undergraduate engineering programs in Germany.
The aim is to prepare the students for success in the modern world of work and their future contribution to sustainable development. Additionally, the university can include the results in its sustainability report. Our method can be applied to different teaching methods and enables their comparison.