Refine
Year of publication
- 2016 (157) (remove)
Institute
- Fachbereich Medizintechnik und Technomathematik (41)
- Fachbereich Chemie und Biotechnologie (29)
- IfB - Institut für Bioengineering (27)
- Fachbereich Elektrotechnik und Informationstechnik (26)
- Fachbereich Luft- und Raumfahrttechnik (22)
- Fachbereich Bauingenieurwesen (13)
- INB - Institut für Nano- und Biotechnologien (13)
- Fachbereich Maschinenbau und Mechatronik (12)
- MASKOR Institut für Mobile Autonome Systeme und Kognitive Robotik (11)
- Fachbereich Energietechnik (9)
Has Fulltext
- no (157) (remove)
Language
- English (157) (remove)
Document Type
- Article (79)
- Conference Proceeding (62)
- Part of a Book (7)
- Book (3)
- Conference: Meeting Abstract (3)
- Report (2)
- Doctoral Thesis (1)
Keywords
- Technical Operations Research (2)
- Additive Manufacturing (1)
- Annulus Fibrosus (1)
- Archeology (1)
- Assessment (1)
- Asymptotic efficiency (1)
- Bacillus atrophaeus (1)
- Balance (1)
- Balanced hypergraph (1)
- Building Culture (1)
- Building Systems (1)
- Business Simulations (1)
- Cardiac myocytes (1)
- Cardiac tissue (1)
- Cartography (1)
- CellDrum (1)
- Censored data (1)
- Co-managed care (1)
- Collaborative robot (1)
- Computational biomechanics (1)
- Controller Parameter (1)
- DNA biosensor (1)
- Disc Degeneration (1)
- Diversity (1)
- Drinking Water Supply (1)
- Drug simulation (1)
- Duality (1)
- Elderly (1)
- Electromechanical modeling (1)
- Engineering Education (1)
- Eutectic Silver Copper alloy (1)
- External knee adduction moments (1)
- Fall prevention (1)
- Field effect (1)
- Frequency adaption (1)
- Gamification (1)
- Gender (1)
- Ground-level falls (1)
- Hall’s Theorem (1)
- Heart tissue culture (1)
- Higher Education (1)
- Hodgkin–Huxley models (1)
- Homogenization (1)
- Human-Robot interaction (1)
- Hypergraph (1)
- Induced pluripotent stem cells (1)
- Infrastructures (1)
- Inotropic compounds (1)
- Intervertebral Disc (1)
- Intradiscal Pressure (1)
- Inverse dynamic problem (1)
- Inverse kinematic problem (1)
- Ion channels (1)
- Koenig’s Theorem (1)
- LAPS (1)
- Label-free detection (1)
- Land Survey and Measurement Systems (1)
- Layer-by-layer adsorption (1)
- Level Control System (1)
- Manipulated variables (1)
- Matching (1)
- Mixed Integer Programming (1)
- Mixed-Integer Nonlinear Optimisation (1)
- Mobility (1)
- Mobility tests (1)
- Musculoskeletal model (1)
- Nucleus Pulposus (1)
- Optimal Closed Loop (1)
- Optimal Topology (1)
- Optimization (1)
- Parametric Design (1)
- Parametric Modelling (1)
- Path planning (1)
- Pharmacology (1)
- Poly(allylamine hydrochloride) (1)
- Porositat (1)
- Product-integration (1)
- Reference Process Model (1)
- Response Surface Method (1)
- SLM (1)
- Safety concept (1)
- Semi-parametric random censorship model (1)
- Serious Games (1)
- Solver Per- formance (1)
- Structuralist Architecture (1)
- Subject-oriented Business Process Management (1)
- Survival analysis (1)
- System Design (1)
- System Design Problem (1)
- Technical Operation Research (1)
- Telecommunications Industry. (1)
- Tinetti test (1)
- Vertex cover (1)
- Volterra integral equation (1)
- Workspace monitoring (1)
- biosensors (1)
- building industry (1)
- chemical sensor (1)
- diversity (1)
- eTOM (1)
- endospores (1)
- energy disspation (1)
- engineering education (1)
- friction (1)
- hiPS cardiomyocytes (1)
- immobilization (1)
- impulsive effects (1)
- industrial research (1)
- ingot (1)
- innovation (1)
- iron and steel industry (1)
- light-addressable potentiometric sensor (1)
- liquid-storage tank (1)
- liquid-structure interaction (1)
- materials technology (1)
- metal structure (1)
- organosilanes (1)
- plug-based microfluidic device (1)
- research project (1)
- research report (1)
- resistance of materials (1)
- seismic response (1)
- silanization (1)
- social responsible engineering (1)
- steel (1)
- structure-soil-structure interaction (1)
- wave run-up (1)
Optimization of the immobilization of bacterial spores on glass substrates with organosilanes
(2016)
Spores can be immobilized on biosensors to function as sensitive recognition elements. However, the immobilization can affect the sensitivity and reproducibility of the sensor signal. In this work, three different immobilization strategies with organosilanes were optimized and characterized to immobilize Bacillus atrophaeus spores on glass substrates. Five different silanization parameters were investigated: nature of the solvent, concentration of the silane, silanization time, curing process, and silanization temperature. The resulting silane layers were resistant to a buffer solution (e.g., Ringer solution) with a polysorbate (e.g., Tween®80) and sonication.
Pure analytical or experimental methods can only find a control strategy for technical systems with a fixed setup. In former contributions we presented an approach that simultaneously finds the optimal topology and the optimal open-loop control of a system via Mixed Integer Linear Programming (MILP). In order to extend this approach by a closed-loop control we present a Mixed Integer Program for a time discretized tank level control. This model is the basis for an extension by combinatorial decisions and thus for the variation of the network topology. Furthermore, one is able to appraise feasible solutions using the global optimality gap.
Nach Stand von Wissenschaft und Technik werden Komponenten hinsichtlich ihrer Eigenschaften, wie Lebensdauer oder Energieeffizienz, optimiert. Allerdings können selbst hervorragende Komponenten zu ineffizienten oder instabilen Systemen führen, wenn ihr Zusammenspiel nur unzureichend berücksichtigt wird. Eine Systembetrachtung schafft ein größeres Optimierungspotential - dem erhöhten Potential steht jedoch auch ein erhöhter Komplexitätsgrad gegenüber. Die vorliegende Arbeit ist im Rahmen des Sonderforschungsbereichs 805 entstanden, dessen Ziel die Beherrschung von Unsicherheit in Systemen des Maschinenbaus ist. Die Arbeit zeigt anhand eines realen Systems aus dem Bereich der Hydraulik, wie Unsicherheit in der Entwicklungsphase beherrscht werden kann. Hierbei ist neu, dass die durch den späteren Betrieb zu erwartende Systemdegradation eines jeden möglichen Systemvorschlags antizipiert werden kann. Dadurch können Betriebs- und Wartungskosten vorausgesagt und minimiert werden und durch eine optimale Betriebs- und Wartungsstrategie die Verfügbarkeit des Systems garantiert werden. Wesentliche Fragen bei der optimalen Auslegung des betrachteten hydrostatischen Getriebes sind dessen physikalische Modellierung, die Darstellung des Optimierungsproblems als gemischt-ganzzahliges lineares Programm, und dessen algorithmische Behandlung zur Lösungsfindung. Hierzu werden Heuristiken zum schnelleren Auffinden sinnvoller Systemtopologien vorgestellt und mittels mathematischer Dekomposition eine Bewertung des dynamischen Verschleiß- und Wartungsverlaufs möglicher Systemvorschläge vorgenommen. Die Arbeit stellt die Optimierung technischer Systeme an der Schnittstelle von Mathematik, Informatik und Ingenieurwesen sowohl gründlich als auch anschaulich und nachvollziehbar dar.
Retinal Vessel Analysis (RVA) in the context of subarachnoid hemorrhage: A proof of concept study
(2016)
Background
Timely detection of impending delayed cerebral ischemia after subarachnoid hemorrhage (SAH) is essential to improve outcome, but poses a diagnostic challenge. Retinal vessels as an embryological part of the intracranial vasculature are easily accessible for analysis and may hold the key to a new and non-invasive monitoring technique. This investigation aims to determine the feasibility of standardized retinal vessel analysis (RVA) in the context of SAH.
Methods
In a prospective pilot study, we performed RVA in six patients awake and cooperative with SAH in the acute phase (day 2–14) and eight patients at the time of follow-up (mean 4.6±1.7months after SAH), and included 33 age-matched healthy controls. Data was acquired using a manoeuvrable Dynamic Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and neurovascular coupling.
Results
Image quality was satisfactory in the majority of cases (93.3%). In the acute phase after SAH, retinal arteries were significantly dilated when compared to the control group (124.2±4.3MU vs 110.9±11.4MU, p<0.01), a difference that persisted to a lesser extent in the later stage of the disease (122.7±17.2MU, p<0.05). Testing for neurovascular coupling showed a trend towards impaired primary vasodilation and secondary vasoconstriction (p = 0.08, p = 0.09 resp.) initially and partial recovery at the time of follow-up, indicating a relative improvement in a time-dependent fashion.
Conclusion
RVA is technically feasible in patients with SAH and can detect fluctuations in vessel diameter and autoregulation even in less severely affected patients. Preliminary data suggests potential for RVA as a new and non-invasive tool for advanced SAH monitoring, but clinical relevance and prognostic value will have to be determined in a larger cohort.
In the field of biotechnology and molecular biology, the use of small liquid volumes has significant advantages. In particular, screening and optimization runs with acceptable amounts of expensive and hardly available catalysts, reagents, or biomolecules are feasible with microfluidic technologies. The presented new microfluidic system is based on the inclusion of small liquid volumes by a protective shell of magnetizable microparticles. Hereby, discrete aqueous microreactor drops with volumes of 1–30 μL can be formed on a simple planar surface. A digital movement and manipulation of the microreactor is performed by overlapping magnetic forces. The magnetic forces are generated by an electrical coil matrix positioned below a glass plate. With the new platform technology, several discrete reaction compartments can be moved simultaneously on one surface. Due to the magnetic fields, the reactors can even be merged to initiate reactions by mixing or positioned above surface-immobilized catalysts and then opened by magnetic force. Comparative synthesis routes of the magnetizable shell particles and superhydrophobic glass slides including their performance and stability with the reaction platform are described. The influence of diffusive mass transport during the catalyzed reaction is discussed by evaluation finite element model of the microreactor. Furthermore, a first model dye reaction of the enzyme laccase has been established.
For the successful implementation of microfluidic reaction systems, such as PCR and electrophoresis, the movement of small liquid volumes is essential. In conventional lab-on-a-chip-platforms, solvents and samples are passed through defined microfluidic channels with complex flow control installations. The droplet actuation platform presented here is a promising alternative. With it, it is possible to move a liquid drop (microreactor) on a planar surface of a reaction platform (lab-in-a-drop). The actuation of microreactors on the hydrophobic surface of the platform is based on the use of magnetic forces acting on the outer shell of the liquid drops which is made of a thin layer of superhydrophobic magnetite particles. The hydrophobic surface of the platform is needed to avoid any contact between the liquid core and the surface to allow a smooth movement of the microreactor. On the platform, one or more microreactors with volumes of 10 µL can be positioned and moved simultaneously. The platform itself consists of a 3 x 3 matrix of electrical double coils which accommodate either neodymium or iron cores. The magnetic field gradients are automatically controlled. By variation of the magnetic field gradients, the microreactors' magnetic hydrophobic shell can be manipulated automatically to move the microreactor or open the shell reversibly. Reactions of substrates and corresponding enzymes can be initiated by merging the microreactors or bringing them into contact with surface immobilized catalysts.
L.setulosus is offered for creation of biopreparation «Setulin», possesing he- mostatic action, the basic reactant of biopreparation is diterpen – lagochirzin. Results under the maintenance and dynamics of diterpen lagochirzin accumula- tion in various parts of L.setulosus are presented: in roots, stalks, leaves, flowers and calyx lobes during the growing season, and also results on conditions of cultivation L.setulosus in the conditions of a typical sierozem are resulted. From the obtained data is visible, that the given species of a plant is endemic. It is established, that dynamics of accumulation of lagochirzin in phytomass accrues from the beginning to the middle of the growing season. The chemical analysis of L.setulosus on a localization of lagochirzin in various organs of a plant, has shown, that the greatest quantity of lagochirzin collects in calyx lobes of the plants. Also it is established, that L.setulosus can be cultivated in the conditions of the typical sierozem, a mineral food is necessary for the given species of plants of Lagochilus genus, except nitric fertilizers. Comparative studying of wild-growing and cultural forms of L.setulosus has shown, that in the cultivated phytomass of plants the maintenance of lagochirzin on 17-20 % higher than in the wild-growing species.