Nanomaterial-Modified Capacitive Field-Effect Biosensors
- The coupling of charged molecules, nanoparticles, and more generally, inorganic/organic nanohybrids with semiconductor field-effect devices based on an electrolyte–insulator–semiconductor (EIS) system represents a very promising strategy for the active tuning of electrochemical properties of these devices and, thus, opening new opportunities for label-free biosensing by the intrinsic charge of molecules. The simplest field-effect sensor is a capacitive EIS sensor, which represents a (bio-)chemically sensitive capacitor. In this chapter, selected examples of recent developments in the field of label-free biosensing using nanomaterial-modified capacitive EIS sensors are summarized. In the first part, we present applications of EIS sensors modified with negatively charged gold nanoparticles for the label-free electrostatic detection of positively charged small proteins and macromolecules, for monitoring the layer-by-layer formation of oppositely charged polyelectrolyte (PE) multilayers as well as for the development of an enzyme-based biomolecular logic gate. In the second part, examples of a label-free detection by means of EIS sensors modified with a positively charged weak PE layer are demonstrated. These include electrical detection of on-chip and in-solution hybridized DNA (deoxyribonucleic acid) as well as an EIS sensor with pH-responsive weak PE/enzyme multilayers for enhanced field-effect biosensing.
Author: | Arshak PoghossianORCiD, Michael Josef SchöningORCiD |
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DOI: | https://doi.org/10.1007/5346_2017_2 |
Parent Title (English): | Springer Series on Chemical Sensors and Biosensors (Methods and Applications) |
Publisher: | Springer |
Place of publication: | Berlin, Heidelberg |
Document Type: | Part of a Book |
Language: | English |
Year of Completion: | 2017 |
Tag: | Biomolecular logic gate; DNA; Enzyme biosensor; Field-effect sensor; Gold nanoparticle |
First Page: | 1 |
Last Page: | 25 |
Link: | https://doi.org/10.1007/5346_2017_2 |
Zugriffsart: | campus |
Institutes: | FH Aachen / Fachbereich Medizintechnik und Technomathematik |
collections: | Verlag / Springer |