Label-free sensing of biomolecules with field-effect devices for clinical applications
- Among the variety of transducer concepts proposed for label-free detection of biomolecules, the semiconductor field-effect device (FED) is one of the most attractive platforms. As medical techniques continue to progress towards diagnostic and therapies based on biomarkers, the ability of FEDs for a label-free, fast and real-time detection of multiple pathogenic and physiologically relevant molecules with high specificity and sensitivity offers very promising prospects for their application in point-of-care and personalized medicine for an early diagnosis and treatment of diseases. The presented paper reviews recent advances and current trends in research and development of different FEDs for label-free, direct electrical detection of charged biomolecules by their intrinsic molecular charge. The authors are mainly focusing on the detection of the DNA hybridization event, antibody-antigen affinity reaction as well as clinically relevant biomolecules such as cardiac and cancer biomarkers.
Author: | Arshak PoghossianORCiD, Michael Josef SchöningORCiD |
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DOI: | https://doi.org/10.1002/elan.201400073 |
ISSN: | 1521-4109 (E-Journal); 1040-0397 (Print) |
Parent Title (English): | Electroanalysis |
Publisher: | Wiley-VCH |
Place of publication: | Weinheim |
Document Type: | Article |
Language: | English |
Year of Completion: | 2014 |
Date of the Publication (Server): | 2014/05/12 |
Volume: | 26 |
Issue: | 6 |
First Page: | 1197 |
Last Page: | 1213 |
Link: | https://doi.org/10.1002/elan.201400073 |
Zugriffsart: | campus |
Institutes: | FH Aachen / Fachbereich Medizintechnik und Technomathematik |
FH Aachen / INB - Institut für Nano- und Biotechnologien | |
collections: | Verlag / Wiley-VCH |