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Magnetic detection structure for Lab-on-Chip applications based on the frequency mixing technique

  • A magnetic frequency mixing technique with a set of miniaturized planar coils was investigated for use with a completely integrated Lab-on-Chip (LoC) pathogen sensing system. The system allows the detection and quantification of superparamagnetic beads. Additionally, in terms of magnetic nanoparticle characterization ability, the system can be used for immunoassays using the beads as markers. Analytical calculations and simulations for both excitation and pick-up coils are presented; the goal was to investigate the miniaturization of simple and cost-effective planar spiral coils. Following these calculations, a Printed Circuit Board (PCB) prototype was designed, manufactured, and tested for limit of detection, linear response, and validation of theoretical concepts. Using the magnetic frequency mixing technique, a limit of detection of 15 µg/mL of 20 nm core-sized nanoparticles was achieved without any shielding.

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Author:Amine Rabehi, Benjamin Garlan, Stefan AchtsnichtORCiD, Hans-Joachim Krause, Andreas Offenhäusser, Kieu Ngo, Sophie Neveu, Stephanie Graff-Dubois, Hamid Kokabi
Parent Title (English):Sensors
Place of publication:Basel
Document Type:Article
Year of Completion:2018
Date of the Publication (Server):2023/06/21
Tag:Lab-on-Chip; frequency mixing; magnetic beads; magnetic sensing; superparamagnetic nanoparticles
Length:14 Seiten
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / INB - Institut für Nano- und Biotechnologien
collections:Verlag / MDPI
Open Access / Gold
Licence (German):License LogoCreative Commons - Namensnennung