Collagen fibril reinforcement in connective tissue extracellular matrices
- The connective tissues such as tendons contain an extracellular matrix (ECM) comprising collagen fibrils scattered within the ground substance. These fibrils are instrumental in lending mechanical stability to tissues. Unfortunately, our understanding of how collagen fibrils reinforce the ECM remains limited, with no direct experimental evidence substantiating current theories. Earlier theoretical studies on collagen fibril reinforcement in the ECM have relied predominantly on the assumption of uniform cylindrical fibers, which is inadequate for modelling collagen fibrils, which possessed tapered ends. Recently, Topçu and colleagues published a paper in the International Journal of Solids and Structures, presenting a generalized shear-lag theory for the transfer of elastic stress between the matrix and fibers with tapered ends. This paper is a positive step towards comprehending the mechanics of the ECM and makes a valuable contribution to formulating a complete theory of collagen fibril reinforcement in the ECM.
Author: | Kheng Lim Goh, Murat Topçu, Gopal S. P. Madabhushi, Manfred StaatORCiD |
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DOI: | https://doi.org/10.1007/978-3-031-56363-8_6 |
ISBN: | 978-3-031-56362-1 (Print) |
ISBN: | 978-3-031-56363-8 (Online) |
Parent Title (English): | Handbook of the extracellular matrix |
Publisher: | Springer Nature |
Place of publication: | Cham |
Editor: | Fatima Raquel Azevedo Maia, J. Miguel Oliveira, Rui L. Reis |
Document Type: | Part of a Book |
Language: | English |
Year of Completion: | 2024 |
Tag: | Collagen fibrils; Connective tissues; Extracellular matrix (ECM); Mechanical stability; Tapered ends |
Length: | 20 Seiten |
First Page: | 89 |
Last Page: | 108 |
Link: | https://doi.org/10.1007/978-3-030-92090-6_6-1 |
Zugriffsart: | bezahl |
Institutes: | FH Aachen / IfB - Institut für Bioengineering |
collections: | Verlag / Springer Nature |