Characterization of biodegradable polymers with capacitive field-effect sensors
- In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(D,L-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta₂O₅-gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance–voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor.
Author: | Sebastian Schusser, Arshak PoghossianORCiD, Matthias Bäcker, Marcel Leinhos, Patrick Wagner, Michael Josef SchöningORCiD |
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DOI: | https://doi.org/10.1016/j.snb.2012.07.099 |
ISSN: | 0925-4005 |
Parent Title (English): | Sensors and actuators B: Chemical |
Publisher: | Elsevier |
Place of publication: | Amsterdam |
Document Type: | Article |
Language: | English |
Year of Completion: | 2012 |
Tag: | (Bio)degradation; C–V method; Field-effect sensor; Impedance spectroscopy; Poly(d,l-lacticacid); Real-time monitoring |
Volume: | 187 |
First Page: | 2 |
Last Page: | 7 |
Note: | Part of special issue "Selected Papers from the 14th International Meeting on Chemical Sensors" |
Link: | https://doi.org/10.1016/j.snb.2012.07.099 |
Zugriffsart: | campus |
Institutes: | FH Aachen / Fachbereich Medizintechnik und Technomathematik |
FH Aachen / INB - Institut für Nano- und Biotechnologien | |
collections: | Verlag / Elsevier |
Licence (German): | Urheberrechtlich geschützt |