Treating arterial hypertension in a cell culture well
- Hypertension describes the pathological increase of blood pressure, which is most commonly associated with the increase of vascular wall stiffness [1]. Referring to the “Deutsche Bluthochdruck Liga” this pathology shows a growing trend in our aging society. In order to find novel pharmacological and probably personalized treatments, we want to present a functional approach to study biomechanical properties of a human aortic vascular model. In this method review we will give an overview of recent studies which were carried out with the CellDrum technology [2] and underline the added value to already existing standard procedures known from the field of physiology. Herein described CellDrum technology is a system to measure functional mechanical properties of cell monolayers and thin tissue constructs in-vitro. Additionally, the CellDrum enables to elucidate the mechanical response of cells to pharmacological drugs, toxins and vasoactive agents. Due to its highly flexible polymer support, cells can also be mechanically stimulated by steady and cyclic biaxial stretching.
Author: | Robin BayerORCiD, Jürgen Hescheler, Gerhard ArtmannORCiD, Aysegül Temiz ArtmannORCiD |
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DOI: | https://doi.org/10.17185/duepublico/48750 |
ISBN: | 978-3-940402-22-6 |
Parent Title (English): | 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW |
Publisher: | Universität Duisburg-Essen |
Place of publication: | Duisburg |
Editor: | Manfred StaatORCiD, Daniel Erni |
Document Type: | Conference Proceeding |
Language: | English |
Year of Completion: | 2019 |
Creating Corporation: | MedTech Symposium |
Contributing Corporation: | Young Researchers Academy |
First Page: | 5 |
Last Page: | 6 |
Link: | https://doi.org/10.17185/duepublico/48750 |
Zugriffsart: | weltweit |
Institutes: | FH Aachen / Fachbereich Medizintechnik und Technomathematik |
FH Aachen / IfB - Institut für Bioengineering | |
open_access (DINI-Set): | open_access |
collections: | Verlag / Universität Duisburg-Essen |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung |