A New Class of Biosensors Based on Tobacco Mosaic Virus and Coat Proteins as Enzyme Nanocarrier
- A new approach for the development of electrochemical biosensors using tobacco mosaic virus (TMV) nanotubes and coat protein (CP) aggregates as enzyme nanocarriers is presented. The generic approach has been demonstrated by realizing amperometric glucose sensors combining an array of Pt electrodes loaded with glucose oxidase (GOD)-modified TMV nanotubes and CPs as a model system. The presence of TMV nanotubes or CPs on the sensor surface allows binding of a high amount of enzymes without substantial loss of their activity. The obtained results underline the potential of integrating biomolecule/virus hybrids with electronic transducers for applications in biosensorics.
| Author: | Matthias Bäcker, Claudia Koch, Fania Geiger, Fabian Eber, Hartmut Gliemann, Arshak PoghossianORCiD, Michael Josef SchöningORCiD |
|---|---|
| DOI: | https://doi.org/10.1016/j.proeng.2016.11.228 |
| ISSN: | 1877-7058 |
| Parent Title (English): | Procedia Engineering |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam |
| Document Type: | Conference Proceeding |
| Language: | English |
| Year of Completion: | 2016 |
| Tag: | amperometric sensor; enzyme nanocarrier; glucose biosensor; tobacco mosaic virus |
| Volume: | 168 |
| First Page: | 618 |
| Last Page: | 621 |
| Note: | Proceedings of the 30th anniversary Eurosensors Conference – Eurosensors 2016, 4-7. Sepember 2016, Budapest, Hungary |
| Link: | https://doi.org/10.1016/j.proeng.2016.11.228 |
| Zugriffsart: | weltweit |
| Institutes: | FH Aachen / Fachbereich Medizintechnik und Technomathematik |
| FH Aachen / INB - Institut für Nano- und Biotechnologien | |
| open_access (DINI-Set): | open_access |
| collections: | Verlag / Elsevier |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung |
